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  • somatic
  • Paroxysmal nocturnal hemoglobinuria (PNH) is a rare, acquired clonal hematopoietic stem cell disorder, which is caused by a somatic mutation in the phosphatidylinositol glycan-complementation class A gene, with an estimated prevalence of 1-2 cases per million people in the United States (1-2). (thefreelibrary.com)
  • therapy
  • In this scenario, cell therapy is envisaged as an effective alternative to surgery. (intechopen.com)
  • The promising preclinical and clinical data that we review below suggest that cell therapy could represent a major advance in the clinical management of this difficult problem. (intechopen.com)
  • It is as a result of these inadequacies in current treatment strategies that cell therapy has arisen as a complementary option [ 14 ]. (intechopen.com)
  • The specific genetic mutations present within the cancer cells may guide therapy, as well as determine how long that person is likely to survive. (wikipedia.org)
  • chemotherapy
  • Other chemotherapy agents, specifically epipodophyllotoxins and anthracyclines, have also been associated with treatment-related leukemias, which are often associated with specific chromosomal abnormalities in the leukemic cells. (wikipedia.org)
  • tissue
  • Immune cells (white blood cells) in the donated tissue (the graft) recognize the recipient (the host) as foreign (nonself). (wikipedia.org)
  • Glioblastoma multiforme tumors are characterized by the presence of small areas of necrotizing tissue that are surrounded by anaplastic cells. (wikipedia.org)
  • In plant chimeras, however, the distinct types of tissue may originate from the same zygote, and the difference is often due to mutation during ordinary cell division. (wikipedia.org)
  • 2017
  • The use of UpToDate content is governed by Thursday, December 21, 2017 - 15:09 Epstein Barr Virus and Its Role in MS, Lupus EBV causes MS in genetically susceptible individuals by infecting a white blood cell, these infected cell seed the nervous system where they produce pathogenic autoantibodies and promote the survival of autoimmue T cells that would normally be eliminated. (jnmspecialists.com)
  • cytokines
  • Two cytokines that down modulate FLT3 activity (& block FLT3-induced hematopoietic activity) are: TNF-Alpha (Tumor necrosis factor-alpha) TGF-Beta (Transforming growth factor-beta) TGF-Beta especially, decreases FLT3 protein levels and reverses the FLT3L-induced decrease in the time that hematopoietic progenitors spend in the G1-phase of the cell cycle. (wikipedia.org)
  • The T cells produce an excess of cytokines, including TNF-α and interferon-gamma (IFNγ). (wikipedia.org)
  • donor T-cells
  • GvHD is thought to be caused by donor T cells reacting against host allo-antigens: this may well be the case, but the mechanism underlying such immune reaction are quite complex (Teshima & Ferrara, 2002a). (slideshare.net)
  • generate
  • At the same time, many methodologies to generate iPS cells have been reported, and are comprised mainly of viral methods and non-viral methods. (jove.com)
  • propagate
  • This initial phosphorylation event further activates the intrinsic tyrosine kinase activity, which in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. (wikipedia.org)
  • immature
  • A myeloid sarcoma (chloroma, granulocytic sarcoma, extramedullary myeloid tumor), is a solid tumor composed of immature white blood cells called myeloblasts. (wikipedia.org)
  • genetically
  • HLA-identical siblings or HLA-identical unrelated donors often have genetically different proteins (called minor histocompatibility antigens) that can be presented by Major histocompatibility complex (MHC) molecules to the donor's T-cells, which see these antigens as foreign and so mount an immune response. (wikipedia.org)
  • An animal chimera is a single organism that is composed of two or more different populations of genetically distinct cells that originated from different zygotes involved in sexual reproduction. (wikipedia.org)
  • varying degrees of intersex differences may result if one set of cells is genetically female and another genetically male. (wikipedia.org)
  • fibroblasts
  • Induced pluripotent stem (iPS) cells were created from mouse fibroblasts by induced expression of Yamanaka factors, Oct3/4, Sox2, Klf4, and c-Myc. (jove.com)
  • Skin fibroblasts forced to express HLA class II, were recognized by only two MiHA specific CD4 T-cell clones. (frontiersin.org)
  • Of the 7 clones that failed to recognize fibroblasts, two targeted MiHA were encoded by genes not expressed in fibroblasts, presentation of one MiHA was dependent on HLA-DO, which is absent in fibroblasts, and T-cells recognizing the remaining 4 MiHA had an avidity that was apparently too low to recognize fibroblasts, despite clear recognition of hematopoietic cells. (frontiersin.org)
  • vivo
  • The pathways of cell delivery are discussed with respect to specific clinical situations, including delivery of ex vivo manipulated cells via local and systemic routes, as well as activation and migration of endogenous reservoirs of reparative cells. (springer.com)
  • In vivo activated T-cells were clonally isolated after CD4 DLI. (frontiersin.org)
  • antigens
  • The presentation of host antigens by host APC can be further enhanced by host gamma/delta T cells, as recently shown in the mouse (Maeda et al, 2005). (slideshare.net)
  • populations
  • Most chimeras composed of both male and female cells probably do not have an intersex condition, as might be expected if the two cell populations were evenly blended throughout the body. (wikipedia.org)
  • chromosomes
  • For example, the chimera may have a liver composed of cells with one set of chromosomes and have a kidney composed of cells with a second set of chromosomes. (wikipedia.org)
  • embryos
  • Chimeras are formed from at least four parent cells (two fertilised eggs or early embryos fused together). (wikipedia.org)
  • Isolating the embryoblast or inner cell mass (ICM) results in destruction of the blastocyst, which raises ethical issues, including whether or not embryos at the pre-implantation stage should be considered to have the same moral or legal status as embryos in the post-implantation stage of development. (wikipedia.org)
  • implementation
  • This manufacturing process is GMP-compliant and should ensure the broader implementation of T-cell immunotherapy beyond specialized centers. (jove.com)
  • factors
  • It also presents cell modulation using growth factors, molecular factors, epigenetic approaches, changes in biophysical environment, cellular co-culture and other elements of the cellular microenvironment. (springer.com)
  • distinct
  • A genetic chimerism or chimera (also spelled chimaera) is a single organism composed of cells with distinct genotypes. (wikipedia.org)
  • types
  • In animals, this means an individual derived from different zygotes, which can include possessing both female and male sex organs, blood cells of two blood types, or subtle variations in form. (wikipedia.org)
  • Current research focuses on differentiating ES into a variety of cell types for eventual use as cell replacement therapies (CRTs). (wikipedia.org)
  • However, the derivation of such cell types from ESs is not without obstacles and hence current research is focused on overcoming these barriers. (wikipedia.org)
  • white bloo
  • I-2 Kristian Berge "Procalcitonin concentrations are superior to C-reactive protein and white blood cell count to diagnose concurrent pneumonia. (heartfailure.no)
  • graft-versus-
  • citation needed] In the oral cavity, chronic graft-versus-host-disease manifests as lichen planus with a higher risk of malignant transformation to oral squamous cell carcinoma in comparison to the classical oral lichen planus. (wikipedia.org)
  • clinical
  • Clinical observations of post-Ebola uveitis indicate involvement of retinal pigment epithelial cells. (arvojournals.org)
  • We discuss counter strategies that may be adopted to augment the efficacy of NK cell anti-tumor surveillance, the clinical trials that have been undertaken so far in solid malignancies, critically weighing the challenges and opportunities with this approach. (frontiersin.org)
  • gene
  • Present results in the gene editing of hematopoietic stem cells. (intechopen.com)
  • The availability of these tools has allowed a precise gene editing, such as knockout of a specific gene or the correction of a defective gene by means of homologous recombination (HR), taking advantage of the endogenous cell repair machinery. (intechopen.com)
  • Apart from the proper design of the nucleases to recognize and cut the selected site in the cell genome, two main goals need to be adequately addressed to optimize its function: the delivery of the tools into the desired cells and the selection of those where the gene editing process has occurred correctly. (intechopen.com)
  • Determine the effects of this regimen on the global gene expression pattern in CLL cells of these patients. (bioportfolio.com)
  • To interrogate transcriptional responses of infected cells, we combined RNA sequencing with in silico pathway, gene ontology, transcription factor binding site, and network analyses. (arvojournals.org)
  • Tumors
  • Glioblastoma multiforme tumors are characterized by the presence of small areas of necrotizing tissue that are surrounded by anaplastic cells. (wikipedia.org)
  • molecules
  • This initial phosphorylation event further activates the intrinsic tyrosine kinase activity, which in turn phosphorylates and activates signal transduction molecules that propagate the signal in the cell. (wikipedia.org)
  • epithelial
  • The only tissue removed from the host is the extremely thin epithelial cell layer on the outside of the host cornea. (thefreedictionary.com)
  • We inoculated ARPE-19 human retinal pigment epithelial cells with EBOV, and followed course of infection by immunocytochemistry and measurement of titer in culture supernatant. (arvojournals.org)
  • Human retinal pigment epithelial cells were permissive to infection with EBOV, and supported viral replication and release of virus in high titer. (arvojournals.org)
  • therapeutic
  • 16. The method of claim 15, wherein the therapeutic agent is a growth factor, a protein, a chemotherapeutic agent, a vitamin, a mineral, an antimicrobial agent, a small organic molecule, or a biological cell. (patentsencyclopedia.com)
  • Due to the mode of NK cell killing, requiring one-to-one target engagement and site-directed release of cytolytic granules, the therapeutic potential of NK cells has been most extensively explored in hematological malignancies. (frontiersin.org)
  • However, their ability to precisely kill antibody coated cells, cancer stem cells, and genotoxically altered cells, while maintaining tolerance to healthy cells makes them appealing therapeutic effectors for all cancer forms, including metastases. (frontiersin.org)
  • hepatic
  • Interleukin-6 signaling in liver-parenchymal cells suppresses hepatic inflammation and improves systemic insulin action. (uni-koeln.de)
  • myeloid
  • CD135 is important for lymphocyte (B cell and T cell) development, but not for the development of other blood cells (myeloid development). (wikipedia.org)
  • A myeloid sarcoma (chloroma, granulocytic sarcoma, extramedullary myeloid tumor), is a solid tumor composed of immature white blood cells called myeloblasts. (wikipedia.org)
  • therapies
  • Current research focuses on differentiating ES into a variety of cell types for eventual use as cell replacement therapies (CRTs). (wikipedia.org)
  • peripheral blood
  • A prospective study of a large cohort of Japanese inhabitants followed up for 11 years uncovered an association of low natural cytotoxicity of peripheral blood natural killer (NK) cells with approximately 40% increased cancer risk compared to individuals with high cytotoxicity activity ( 10 ). (frontiersin.org)
  • patients
  • PURPOSE: This phase II trial is studying how well giving bryostatin 1 together with rituximab works in treating patients with B-cell non-Hodgkin's lymphoma or chronic lymphocytic leukemia that has not responded to previous treatment with rituximab. (bioportfolio.com)
  • Determine the feasibility and safety of bryostatin 1 and rituximab in patients with rituximab-refractory indolent B-cell non-Hodgkin's lymphoma or chronic lymphocytic leukemia (CLL). (bioportfolio.com)
  • The purpose of this study is to assess the effects of the combination of all-trans retinoic acid in combination with one of two schedules of Bryostatin 1 in patients with myelodysplasia an. (bioportfolio.com)
  • This is reinforced by findings of decreased NK-cell activity among relatives of patients diagnosed with familial melanoma ( 11 ), implicating NK cells in tumor surveillance. (frontiersin.org)
  • High levels of wild-type FLT3 have been reported for blast cells of some AML patients without FLT3 mutations. (wikipedia.org)
  • However, it has been shown that genes responsible for cytokine signaling, inflammatory response, and regulation of cell cycle are differentially expressed in patients with fatal GvHD versus "indolent" GvHD. (wikipedia.org)
  • receptor
  • Although our understanding of the receptor ligand interactions that regulate NK cell functionality has evolved remarkably, the diversity of ligands and receptors is complex, as is their mechanistic foundations in regulating NK cell function. (frontiersin.org)
  • CD16 is a low affinity receptor for IgG which functions in phagocytosis and ADCC, as well as in signal transduction and NK cell activation. (healthandwellnesssource.org)
  • regulate
  • Neph-Nephrin proteins bind the Par3-Par6-atypical protein kinase C (aPKC) complex to regulate podocyte cell polarity. (uni-koeln.de)
  • molecular
  • Success of Ebola virus (EBOV) as a human pathogen relates at the molecular level primarily to blockade the host cell type I interferon (IFN) antiviral response. (arvojournals.org)
  • Heightened interest in applicability of NK cells for cancer immunotherapy has been evoked by improved methodologies for their purification, molecular and phenotypic characterization. (frontiersin.org)
  • human
  • Sunlight exposure has been shown to alter DNA methylation patterns across several human cell-types, including T-lymphocytes. (jove.com)
  • Human ES cells measure approximately 14 μm while mouse ES cells are closer to 8 μm. (wikipedia.org)
  • cancers
  • Natural killer (NK) cells are innate lymphoid cells that hold tremendous potential for effective immunotherapy for a broad range of cancers. (frontiersin.org)
  • A novel little molecule reversible inhibitor of CRM1 was also reported to get activity against multiple myeloma.14 This shows that newer CRM1 inhibitors with high specificity, cancers cell selectivity and low toxicity are expected. (healthandwellnesssource.org)
  • potential
  • and hematologic malignancies.17,18 Within this proof-of-concept research, we investigated the anti-cancer potential of selective inhibitors of nuclear export (SINE) against NHL cell lines and corresponding xenograft models. (healthandwellnesssource.org)
  • type
  • Unexpectedly, 28% of 560 upregulated transcripts in EBOV-infected cells were type I IFN responsive, indicating a robust type I IFN response. (arvojournals.org)
  • Often, most or all of the cells of a single cell type will be composed of a single cell line, i.e. the blood may be composed predominantly of one cell line, and the internal organs of the other cell line. (wikipedia.org)
  • Because of the similarities in immunostaining of glial cells and glioblastoma, it has long been assumed that gliomas such as glioblastoma originate from glial type cells. (wikipedia.org)
  • assess the effects
  • The purpose of this study was to assess the effects of sunlight exposure on CD4+ T-cell methylation patterns on an epigenome-wide scale in a North American population of European origin (n? (jove.com)
  • blood cells
  • In animals, this means an individual derived from different zygotes, which can include possessing both female and male sex organs, blood cells of two blood types, or subtle variations in form. (wikipedia.org)