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  • HSCT
  • This response is mediated largely by cytotoxic T lymphocytes (CTL) but it can be employed by natural killers (NK cells) as separate effectors, particularly in T-cell-depleted HLA-haploidentical HSCT. (wikipedia.org)
  • tumor
  • The biology of GvT response still isn't fully understood but it is probable that the reaction with polymorphic minor histocompatibility antigens expressed either specifically on hematopoietic cells or more widely on a number of tissue cells or tumor-associated antigens is involved. (wikipedia.org)
  • leukemia
  • Alemtuzumab is a drug that is designed to specifically attack some types of leukemia and lymphoma cells. (knowcancer.com)
  • The rationale behind the NST strategy is to induce optimal graft-versus-leukemia (GVL) effects for the elimination of all malignant cells by alloreactive immunocompetent cells from a matched donor as an alternative to standard high-dose myeloablative chemo radiotherapy. (clinicaltrials.gov)
  • Among those affected, the majority develops cancer, most often acute myelogenous leukemia, and 90% develop bone marrow failure (the inability to produce blood cells) by age 40. (wikipedia.org)
  • citation needed] As FA is now known to affect DNA repair, specifically nonhomologous end joining, and given the current knowledge about dynamic cell division in the bone marrow, finding patients are more likely to develop bone marrow failure, myelodysplastic syndromes, and acute myeloid leukemia (AML) is not surprising. (wikipedia.org)
  • Specific terms which overlap with granulocytic sarcoma include: Leukemia cutis, describing infiltration of the dermis (skin) by leukemic cells, which is also referred to as cutaneous granulocytic sarcoma. (wikipedia.org)
  • Meningeal leukemia, or invasion of the subarachnoid space by leukemic cells, is usually considered distinct from chloroma, although very rarely occurring solid central nervous system tumors composed of leukemic cells can be termed chloromas. (wikipedia.org)
  • pediatric
  • Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)
  • 2000
  • Because of the genetic defect in DNA repair, cells from people with FA are sensitive to drugs that treat cancer by DNA crosslinking, such as mitomycin C. The typical age of death was 30 years in 2000. (wikipedia.org)
  • blood
  • Bone marrow stem cells turn into red blood cells , white blood cells , or platelets to help your body stay healthy. (adventisthealthcare.com)
  • If your bone marrow is damaged or destroyed, it can no longer make normal blood cells. (adventisthealthcare.com)
  • The growth factor G-CSF may be used to stimulate the growth of new stem cells so they spill over into the blood. (adventisthealthcare.com)
  • The blood is removed from the vein and passed through a machine that takes out the stem cells. (adventisthealthcare.com)
  • Later, when you get healthy stem cells from a donor, those new cells will go to the marrow and be able to take over the job of making new blood cells. (adventisthealthcare.com)
  • The stem cells travel through the catheter into your blood, and to your bone marrow, where they will begin to produce new cells in 1 to 3 weeks. (adventisthealthcare.com)
  • Your blood will be tested often to check the levels of red blood cells, white blood cells, and platelets in your body. (adventisthealthcare.com)
  • You may need to receive several transfusions of blood cells and platelets until your body begins to produce its own. (adventisthealthcare.com)
  • G-CSF helps the new stem cells do their normal work in the body;making new blood cells. (knowcancer.com)
  • You will receive G-CSF each day until your blood cell counts begin to recover to a certain level. (knowcancer.com)
  • You might be given blood transfusions if blood cell counts remain low. (knowcancer.com)
  • G-CSF, a growth factor that promotes the production of blood cells, will be injected under the skin once a day until your blood cell counts recover to a certain level. (knowcancer.com)
  • Stem cell source was bone marrow (n = 11) and peripheral blood (n = 16). (lww.com)
  • Number of patients with donor chimerism - percentage of donor cells in the patient via the peripheral blood or bone marrow. (clinicaltrials.gov)
  • The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood cell production. (wikipedia.org)
  • Evans syndrome is an autoimmune disease in which an individual's antibodies attack their own red blood cells and platelets. (wikipedia.org)
  • Autoimmune hemolytic anemia is a condition in which the red blood cells that normally carry oxygen and carbon dioxide are destroyed by an autoimmune process. (wikipedia.org)
  • Immature blood cells hematopoietic stem cells in the circulating blood that are similar to those in the bone marrow are collected by apheresis from a potential donor (PBSC collection). (wikipedia.org)
  • This allows the bone marrow to recover, proliferate and continue producing healthy blood cells. (wikipedia.org)
  • Granulocyte colony stimulating factor (GCSF) are naturally occurring glycoproteins that stimulate white blood cell proliferation. (wikipedia.org)
  • Recently, the method was further developed to be used for cell selection from whole blood or other single cell suspensions. (wikipedia.org)
  • IBA has developed an affinity chromatography system for non-magnetic isolation of peripheral blood mononuclear cells, T cells, B cells and other cells of interest. (wikipedia.org)
  • In 1924, Russian-born morphologist Alexander A. Maximow used extensive histological findings to identify a singular type of precursor cell within mesenchyme that develops into different types of blood cells. (wikipedia.org)
  • However MSCs are found in much higher concentration in the Wharton's jelly compared to cord blood, which is a rich source of hematopoietic stem cells. (wikipedia.org)
  • Australian company Cynata claims the ability to mass-produce MSCs from induced pluripotent stem cells obtained from blood cells. (wikipedia.org)
  • Because macrocytosis usually precedes a low platelet count, patients with typical congenital anomalies associated with FA should be evaluated for an elevated red blood cell mean corpuscular volume. (wikipedia.org)
  • Because of the failure of hematologic components to develop-white blood cells, red blood cells, and platelets-the body's capabilities to fight infection, deliver oxygen, and form clots are all diminished. (wikipedia.org)
  • While at birth, blood count is usually normal, macrocytosis/megaloblastic anemia, defined as unusually large red blood cells, is the first detected abnormality, often within the first decade of life (median age of onset is 7 years). (wikipedia.org)
  • Within the next 10 years, over 50% of patients presenting haematological abnormalities will have developed pancytopenia, defined as abnormalities in two or more blood cell lineages. (wikipedia.org)
  • Both cell types are white blood cells. (wikipedia.org)
  • This is attributed to the IgM monoclonal protein increasing the viscosity of the blood by forming aggregates to each other, binding water through their carbohydrate component and by their interaction with blood cells. (wikipedia.org)
  • Multiple myeloma, also known as plasma cell myeloma, is a cancer of plasma cells, a type of white blood cell normally responsible for producing antibodies. (wikipedia.org)
  • The underlying mechanism involves abnormal plasma cells producing abnormal antibodies which can cause kidney problems and overly thick blood. (wikipedia.org)
  • Multiple myeloma is diagnosed based on blood or urine tests finding abnormal antibodies, bone marrow biopsy finding cancerous plasma cells, and medical imaging finding bone lesions. (wikipedia.org)
  • It results from the replacement of normal bone marrow by infiltrating tumor cells and inhibition of normal red blood cell production (hematopoiesis) by cytokines. (wikipedia.org)
  • Myeloma cells produce monoclonal proteins of varying types, most commonly immunoglobulins (antibodies) and free light chains, resulting in abnormally high levels of these proteins in the blood. (wikipedia.org)
  • JAK2 mutations are significant because JAK2 plays a role in controlling production of blood cells from hematopoietic stem cells. (wikipedia.org)
  • The decrease in hematopoietic tissue impairs the patient's ability to generate new blood cells, resulting in progressive pancytopenia, a shortage of all blood cell types. (wikipedia.org)
  • The result is extramedullary hematopoiesis, i.e. blood cell formation occurring in sites other than the bone marrow, as the haemopoetic cells are forced to migrate to other areas, particularly the liver and spleen. (wikipedia.org)
  • Another complication of extramedullary hematopoiesis is poikilocytosis, or the presence of abnormally shaped red blood cells. (wikipedia.org)
  • immune
  • In addition, it weakens the immune system, helping to prevent the rejection of donor marrow or stem cells. (knowcancer.com)
  • Here, microRNAs (miRs) represent an interesting tool since miRs have been recently reported to be an important regulator of various cells, including immune cells such as T cells. (springer.com)
  • The leukemic patient's bone marrow and immune system is then "rescued" by means of the transplanted stem cells. (cancerguide.org)
  • Typically, diagnosis involves several preliminary tests of immune function, including basic evaluation of the humoral immune system and the cell-mediated immune system. (wikipedia.org)
  • Therefore
  • Olfactory receptor neurons have an average lifespan of 6-8 weeks and therefore must be replaced by cells differentiated from the stem cells that are within a layer at the nearby epithelium's base. (wikipedia.org)
  • therapy
  • The main risk factor for HAdV infection is prolonged immunosuppression, attributable either to in vivo or ex vivo T-cell depletion, prolonged lymphopenia, or to GvHD-associated immunosuppressive posttransplant therapy. (springer.com)
  • The patient receives immunosuppressive therapy ( 1 week in the hospital) with subsequent IV transfer of stem cells from the donor. (clinicaltrials.gov)
  • GVHD
  • Unfortunately, T lymphocytes are the same cells that cause graft versus host disease (GVHD) . (lls.org)
  • Recent findings suggested that p-preDCs are tolerogenic DCs because the presence of these cells in the BM graft correlated with a decreased occurrence of GVHD ( 20 - 22 ). (rupress.org)
  • CD4+CD25+ regulatory T cells (Treg) can be used to suppress GvHD without loss of beneficial GvT effect. (wikipedia.org)
  • clinical
  • Stem cell selection is another technique being studied in clinical trials that can reduce the number of T lymphocytes that a patient receives. (lls.org)
  • This allows embryonic stem cells to be employed as useful tools for both research and regenerative medicine, because they can produce limitless numbers of themselves for continued research or clinical use. (wikipedia.org)
  • involves
  • The WM spectrum of dysplasias differs from other spectrums of plasma cell dyscrasias in that it involves not only aberrant plasma cells but also aberrant lymphoplasmacytoid cells and that it involves IgM while other plasma dyscrasias involve other antibody isoforms. (wikipedia.org)
  • donor T cells
  • Besides their well-characterized immunogenic function, DCs have been demonstrated to play a role in the induction of tolerance by tolerizing donor T cells to self-antigen ( 17 , 18 ). (rupress.org)
  • radiation
  • 6. The method of claim 1, wherein the mononuclear cells are treated by exposure to a source of ionizing radiation. (google.com)