• As such, innovative reduced intensity conditioning (RIC) or non-myeloablative stem cell transplantation (NST) was pioneered by Slavin for safer stem cell transplantation for the treatment of malignant and life-threatening non-malignant disorders correctable by using stem cells and post-transplant immunotherapy if indicated for all patients in need. (wikipedia.org)
  • Departmental bone marrow transplant services offer essential medical expertise and complementary services to patients with complex health conditions. (tasmc.org.il)
  • The Bone Marrow Transplant (BMT) Survivorship Program aims to improve the experience and outcomes of BMT survivors and families through focused clinical care and research. (massgeneral.org)
  • The percent of total CD3 + CD5 - cells correlated with the presence of graft versus host disease and with time following transplant, but did not correlate with age, diagnosis, preparative regimen, T-cell depletion of the marrow, major histocompatibility complex compatibility, or the presence or absence of interstitial pneumonitis. (mssm.edu)
  • Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
  • Early transplantation, careful donor selection and improving post-transplant liver events were crucial to optimise outcomes. (bvsalud.org)
  • A stem cell transplant is when cells are taken out of the blood for use in a transplant. (differencebetween.net)
  • A bone marrow transplant is when stem cells are removed from the bone marrow for transplant. (differencebetween.net)
  • Umbilical cord blood stem cells are only used for transplant into children since there are not enough cells present to be of any use for transplant into an adult patient. (differencebetween.net)
  • A bone marrow transplant is when stem cells are removed from a donor's bone marrow for transplant into a patient. (differencebetween.net)
  • A bone marrow transplant is when stem cells are harvested directly from the bone marrow. (differencebetween.net)
  • A 22-yr-old man with acute myelocytic leukemia received a bone marrow transplant from a genotypically HLA-identical female sibling after cyclophosphamide preparation. (notifylibrary.org)
  • At 34 mo after transplant, marrow relapse and chloroma were documented. (notifylibrary.org)
  • All metaphase cells and karyotypes from peripheral blood and marrow samples showed no evidence of host cells from 3 wk after transplant through the time of marrow relapse. (notifylibrary.org)
  • The patient received a second bone marrow transplant from the same donor after preparation with busulfan and cyclophosphamide and attained a complete remission with full hematologic engraftment. (notifylibrary.org)
  • People with life-threatening cancers, such as leukemia , lymphoma , and myeloma can be treated with a bone marrow transplant or, sometimes, a stem cell transplant. (medlineplus.gov)
  • Autologous bone marrow transplant is when people donate their own bone marrow. (medlineplus.gov)
  • Allogenic bone marrow transplant is when another person donates bone marrow. (medlineplus.gov)
  • But only about 30% of people who need a bone marrow transplant can find a matching donor in their own family. (medlineplus.gov)
  • Doctors can then use the registry to find a matching donor for a person who needs a bone marrow transplant. (medlineplus.gov)
  • If a donor's HLAs match well with a person who needs a transplant, the donor must give a new blood sample to confirm the match. (medlineplus.gov)
  • These cells inhibited T cell proliferation in a standard in vitro mixed lymphocyte assay and, moreover, attenuated the development of vasculopathy mediated by autologous peripheral blood mononuclear cells in a functionally relevant humanized mouse transplant model. (lu.se)
  • Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
  • PHILADELPHIA (February 8, 2017) - The Fox Chase-Temple University Hospital Bone Marrow Transplant Program has received internationally-recognized reaccreditation by the Foundation for the Accreditation of Cellular Therapy (FACT) at the University of Nebraska Medical Center. (foxchase.org)
  • The bone marrow transplant program has been found to be in compliance with these rigorous Standards as well as governmental regulations. (foxchase.org)
  • Late-occurring Venous Thromboembolism in Allogeneic Blood or Marrow Transplant Survivors - a BMTSS-HiGHS2 Risk Model. (stembook.org)
  • Follistatin and Soluble Endoglin Predict 1-year Non-Relapse Mortality after Allogeneic Hematopoietic Cell Transplant. (stembook.org)
  • Biol Blood Marrow Transplant. (stembook.org)
  • p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
  • Transplant outcomes of the triple-negative NPM1/FLT3-ITD/CEBPA mutation subgroup are equivalent to those of the favourable ELN risk group, but significantly better than the intermediate-I risk group after allogeneic transplant in normal-karyotype AML. (cdc.gov)
  • Is a matched unrelated donor search needed for all allogeneic transplant candidates? (cdc.gov)
  • For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
  • An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
  • Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
  • Acute graft versus host disease (aGVHD) is a common complication following allogeneic hematopoietic stem cell transplantation (AHSCT) caused by cellular and inflammatory factors, including those arising from monocytes and dendritic cells as integral parts of the immune system. (magiran.com)
  • Despite the numerous advantages of allogeneic hematopoietic stem cell transplants (allo-HSCT), there exists a notable association with risks, particularly during the preconditioning period and predominantly post-intervention, exemplified by the occurrence of graft-versus-host disease (GVHD). (bvsalud.org)
  • Our hypothesis about a splenic stem cell contributionor maintained survival compared to bone marrow transplants, to PBSCT also derives from the observation that G-CSF mobilizationsalthough graft versus host disease (GVHD) still occurs [1]. (fliphtml5.com)
  • The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)
  • The most common adverse event following allogeneic hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GVHD), which can increase morbidity and mortality in HSCT patients. (oncologynurseadvisor.com)
  • Allogeneic HSCT carries significant risks such as rejection of the graft, infection, graft versus host disease (GVHD), and potential long-term side effects, translating into a 50% morbidity and mortality rate at 3 years post HSCT. (smart-immune.com)
  • Peripheral Blood versus Bone Marrow from Unrelated Donors: Bone Marrow allografts have improved Long-term Overall and Graft-versus-Host Disease, Relapse-Free Survival. (stembook.org)
  • 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
  • This study aimed to assess haematopoietic stem cell transplantation (HSCT) safety and efficacy while exploring strategies for optimising outcomes in patients with hepatitis-associated aplastic anaemia (HAAA). (bvsalud.org)
  • We retrospectively reviewed 35 HAAA patients who underwent HSCT at a large Chinese blood disease hospital between 2008 and 2022. (bvsalud.org)
  • Human adenovirus (HAdV) infections remain a significant cause of morbidity and mortality after hematopoietic stem cell transplantation (HSCT). (biomedcentral.com)
  • Human adenovirus (HAdV) infection constitutes a major cause of morbidity and mortality in patients undergoing allogeneic hematopoietic stem cell transplantation (HSCT). (biomedcentral.com)
  • The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
  • This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
  • The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
  • Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)
  • What is hematopoietic stem cell transplantation (HSCT)? (smart-immune.com)
  • HSCT is the transplantation of stem cells, usually derived from the bone marrow, peripheral blood, or umbilical cord blood, to produce additional normal healthy blood cells, including T-cells. (smart-immune.com)
  • HSCT may be autologous (the patient's stem cells are used) or allogeneic (the stem cells come from a donor). (smart-immune.com)
  • Smart Immune's ProTcell platform is designed to reconstitute a T-cell compartment in around three months , compared with 12-18 months through the standard HSCT approach, significantly reducing the time to full immune recovery and possibly opening access to allogeneic medicine to more patients. (smart-immune.com)
  • There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
  • are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
  • Neupogen is indicated for the mobilisation of peripheral blood progenitor cells (PBPCs). (medicines.org.uk)
  • CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
  • Flow cytometric enumeration of CD34+ HSCs and progenitor cells is an established method for the evaluation of bone marrow and stem cell grafts. (bdbiosciences.com)
  • In three placebo-controlled studies enrolling a total of 156 patients after autologous BMT or peripheral blood progenitor cell transplantation, events reported in at least 10% of patients who received IV LEUKINE or placebo were as reported in Table 6 . (druglib.com)
  • By demonstrating compliance with the FACT-JACIE International Standards for Cellular Therapy Product Collection, Processing and Administration , the joint program of Fox Chase Cancer Center and Temple has earned FACT reaccreditation for adult allogeneic and autologous hematopoietic progenitor cell transplantation, peripheral blood cellular therapy product collection, and cellular therapy product processing with minimal manipulation. (foxchase.org)
  • Smart Immune is the first company to develop thymus-empowered allogeneic T-cell therapies and advance them into clinical testing through its T-cell progenitor platform, ProTcell. (smart-immune.com)
  • Smart Immune announced in October 2022 that SMART102, a human T-cell progenitor cell injection derived from cord blood using the ProTcell platform, has entered clinical testing with the first adult patient treated. (smart-immune.com)
  • This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
  • Globally, it is estimated that 120 000 corneal transplantations and 18 000 transplantations of allogeneic haematopoietic progenitor cells took place in the year 2000. (who.int)
  • The Pediatric Hemato-oncology Department performs a full array of bone marrow transplants (BMT) for children, sourced by self-donated (autologous) marrow, peripheral blood donations and donations from related or unrelated donors (allogeneic). (tasmc.org.il)
  • Interestingly, thiscell transplants (PBSCTs) from donors given granulocyte-colony- immature peripheral phenotype was similar to bone marrow transplantsstimulating-factor (G-CSF) has decreased relapse rates and improved before G-CSF. (fliphtml5.com)
  • These substances include, for instance, granulocyte- colony-stimulating factor (G-CSF), which is added so that the donors own bone marrow will make and produce more stem cells that will end up in the bloodstream. (differencebetween.net)
  • Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
  • Infections following Transplantation of Bone Marrow or Peripheral-Blood Stem Cells from Unrelated Donors. (stembook.org)
  • The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)
  • Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
  • In 1985, when tests for HIV antibody became available, screening prospective donors of blood, organs, and other tissues also began (2,3). (cdc.gov)
  • Organ Transplantation.2 These Guiding Principles - whose emphases include voluntary donation, noncommercialization, genetic relation of recipients to donors and a preference for cadavers over living donors as sources - have considerably influenced professional codes, national, state and provincial legislation, and the policies of intergovernmental organizations. (who.int)
  • Peripheral blood mononuclear cells (PBMCs) were isolated by Ficoll-Hypaque gradient from the blood samples collected at days 0, 7, 14, 28, and final day of transplantation. (magiran.com)
  • In contrast, the ability of unstimulated peripheral blood mononuclear cells (PBMC) to respond to recombinant interleukin-2 (rIL-2) is relatively intact, most likely reflecting early functional reconstitution of the NK cell population. (ashpublications.org)
  • Peptides were synthesized and tested for in vivo immunogenicity by screening peripheral blood mononuclear cells from healthy volunteers (n = 64) and HAdV-infected stem cell recipients (n = 26) for memory T cells recognizing the candidate epitopes in the context of most common HLA alleles. (biomedcentral.com)
  • In the present study, we examined immune function after BMT in a series of patients who had received HLA compatible sibling marrow grafts purged of T cells with anti-CD6 monoclonal antibody and complement. (ashpublications.org)
  • eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
  • These observations that confirmed the therapeutic benefits of cell therapy led to the development of new concepts for the treatment of hematologic malignancies and solid tumors focusing on utilizing well-tolerated non-myeloablative stem cell transplantation as a platform for cell therapy of cancer targeting killer cells against chemotherapy-resistant malignant cells. (wikipedia.org)
  • We have analyzed CD5 expression on repopulating T cells in the peripheral blood of patients after allogeneic bone marrow transplantation (BMT). (mssm.edu)
  • The number of viable CD45+/CD34+ cells will determine the quality of the harvested specimen for transplantation. (bdbiosciences.com)
  • TheIntroduction later step is unique to splenic function since splenectomy results in similar accumulations of naïve B cells, reduction of memory B cells and Treatment of malignancies with allogeneic peripheral blood stem well-known susceptibilities to select infections [12]. (fliphtml5.com)
  • The blood cells are harvested from the blood about 6 days later. (differencebetween.net)
  • Further benefits are that the platelets and neutrophil cells (one of the white blood cells) are more easily able to recover if this method is used compared with the bone marrow procedure. (differencebetween.net)
  • Bone marrow transplants involve cells that are taken out of the bone marrow. (differencebetween.net)
  • Data from autosomal and sex chromosome studies indicate that the marrow relapse occurred in cells of donor origin. (notifylibrary.org)
  • Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
  • These aberrant lymphoblasts proliferate, reducing the number of the normal marrow elements that produce other blood cell lines (red blood cells, platelets, and neutrophils). (medscape.com)
  • Characterization of effector cells of graft vs leukemia following allogeneic bone marrow transplantation in mice inoculated with murine B-cell leukemia. (ox.ac.uk)
  • Detection of residual tumor cells, an indicator for efficacy of GVL, was carried out by adoptive transfer of peripheral blood or spleen cells obtained from treated chimeras into secondary naive BALB/c recipients at different time intervals following bone marrow transplantation. (ox.ac.uk)
  • Induction of GVL effects by allogeneic cells tolerant of host MHC suggests that these effects may be independent of graft vs host disease. (ox.ac.uk)
  • Sargramostim is a colony stimulating factor that is FDA approved for the treatment of granulocytopenia following induction chemotherapy in acute myelogenous leukemia , mobilization and following transplantation of autologous peripheral blood progentior cells, myeloid reconstitution after autologous bone marrow transplantation, myeloid reconstitution after allogeneic bone marrow transplantation and bone marrow transplantation failure or engraftment delay. (wikidoc.org)
  • Patients should not receive Sargramostim until the post marrow infusion ANC is less than 500 cells/mm3. (wikidoc.org)
  • The cells or blood is then tested for special proteins, called human leukocytes antigens (HLAs). (medlineplus.gov)
  • The red blood cells are returned to the donor through an IV in the other arm. (medlineplus.gov)
  • Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
  • One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
  • Regulatory T cells (T(regs)) manipulated ex vivo have potential as cellular therapeutics in autoimmunity and transplantation. (lu.se)
  • Although it is possible to expand naturally occurring T(regs), an attractive alternative possibility, particularly suited to solid organ and bone marrow transplantation, is the stimulation of total T cell populations with defined allogeneic antigen-presenting cells (APCs) under conditions that lead to the generation or expansion of donor-reactive, adaptive T(regs). (lu.se)
  • Here we demonstrate that stimulation of mouse CD4(+) T cells by immature allogeneic dendritic cells combined with pharmacological inhibition of phosphodiesterase 3 (PDE) resulted in a functional enrichment of Foxp3(+) T cells. (lu.se)
  • Notably, PDE inhibition also enhanced the enrichment of human Foxp3(+) CD4(+) T cells driven by allogeneic APCs. (lu.se)
  • Chemotherapy, radiation, or both are initiated prior to transplantation to enable engraftment of the transplanted cells, decrease tumor size, and reduce immunoreactivity of the recipient. (oncologynurseadvisor.com)
  • 1 After transplantation, donor T cells are activated by antigen-presenting cells. (oncologynurseadvisor.com)
  • The cancer can spread to almost any organ or tissue in the body, including the liver, bone marrow (the spongy tissue inside the large bones of the body that makes blood cells), and spleen. (marystolfacancerfoundation.org)
  • Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
  • p>Blood has three main cell types: red blood cells (which carry oxygen), white blood cells (which fight infection) and platelets (which clot the blood). (nemours.org)
  • RIC or NST made it possible to apply much safer curative stem cell transplantation for every patient in need with no lower or upper age restriction, including patients with less than optimal clinical conditions that would not be eligible for the standard myeloablative stem cell transplantation. (wikipedia.org)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • The workup in patients with possible myelodysplastic syndrome (MDS) includes a complete blood count with differential, peripheral blood smear, and bone marrow studies. (medscape.com)
  • Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
  • 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
  • The recommended dose is 250 mcg/m2/day administered IV over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. (wikidoc.org)
  • Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
  • Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
  • Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse. (cdc.gov)
  • Full hematopoietic engraftment was reported in one case after bone marrow transplantation without conditioning for a SCID patient. (nih.gov)
  • In the two cases with ABO incompatibility, erythroid engraftment was evidenced by blood group conversion from recipient to donor type. (nih.gov)
  • Patients who undergo allogeneic bone marrow transplantation (BMT) are clinically immunodeficient for a prolonged period after engraftment. (ashpublications.org)
  • [ 1 ] Acute GVHD describes a distinctive syndrome of dermatitis (see the image below), hepatitis, and enteritis developing within 100 days after allogeneic hematopoietic cell transplantation (HCT). (medscape.com)
  • The median time for onset of stage 3-4 gut GVHD was 35 (4-135) days after allogeneic HCT. (nature.com)
  • The chance of recovery (prognosis) and choice of treatment depend on the stage of the cancer (whether it is just in one area or has spread throughout the body), the size of the swollen areas, the results of blood tests, the type of symptoms, and the patient's age, sex, and overall condition. (marystolfacancerfoundation.org)
  • Successful transplantation of organs and living tissues depends on continued medical follow-up and the patient's compliance with a regimen of immunosuppressive drugs. (who.int)
  • To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)
  • 5 however, it has been used to treat many pediatric hematologic conditions, including chronic immune thrombocytopenic purpura, posttransplant lymphoproliferative disease, juvenile rheumatoid arthritis, and other blood dyscrasias. (oncologynurseadvisor.com)
  • The Dana-Dwek Children's Hospital Pediatric Hemato-oncology and Bone Marrow Transplantation Department treats infants, children, and adolescents suffering from acute and chronic blood diseases and from malignant hematological and non-hematological disorders. (tasmc.org.il)
  • This department provides medical care for patients with heart disorders, disorders of the aortas and peripheral vessels, and hypertension. (japanhospitalsearch.org)
  • p>In addition to childhood cancers and blood disorders, Nemours treats nonmalignant bone marrow disorders, immune system deficiencies and some metabolic disorders with allogeneic blood and bone marrow transplantation. (nemours.org)
  • Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
  • For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
  • Access to transplantation entails more than the surgery itself, because success is measured by longer survival of the patient and a long-term improvement in the quality of life. (who.int)
  • Before apheresis, the donor's blood count showed mild thrombocytopenia after G-CSF mobilization. (cdc.gov)
  • Bone marrow biopsy is performed in addition to aspiration to assess cellularity qualitatively and quantitatively. (medscape.com)
  • The patient had undergone autologous peripheral blood stem-cell transplantation to treat ovarian cancer. (medscape.com)
  • When a patient is diagnosed with a blood cancer or chronic blood condition, it is often the start of a new journey that will be the beginning of great change. (rochester.edu)
  • Bone marrow transplants work best if the HLAs from the donor and the patient are a close match. (medlineplus.gov)
  • Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
  • Baxter International recognized the potential of cell therapy and signed an agreement which resulted in significant investment with Slavin at Hadassah Medical Center for further development of new approaches based on cell therapy for the treatment of cancer, autoimmune diseases, and organ transplantation based on new methods for regulation rather than non-specific suppression of the immune system. (wikipedia.org)
  • EPF has been reported in association with infections, in particular AIDS, medications, autoimmune diseases, as well as autologous peripheral blood stem cell and allogeneic bone marrow transplantation. (pgdue.com)
  • Cytomegalovirus (CMV) infection is the most critical infectious complication in recipients of hematopoietic cell transplantation (HCT) in the period between a therapeutic hematoablative treatment and the hematopoietic reconstitution of the immune system. (bvsalud.org)
  • It is a therapeutic option for treating several serious blood cancers and some other conditions. (smart-immune.com)
  • Self-donation transplants are performed for malignant conditions, such as recurrent lymphoma, metastasized bone cancers, high-risk neuroblastoma, and specific types of brain tumors. (tasmc.org.il)
  • The failure of the immune system to function as it should, can result from immune deficiencies present at birth, acquired diseases such as blood cancers, medications that suppress or damage the immune system, unnecessary or over-the-top immune responses such as allergies, or immune responses to one's self, called autoimmunity. (smart-immune.com)
  • Smart Immune is working to improve the prognosis of immune-compromised patients with life-threatening diseases such as high-risk blood cancers and primary immunodeficiencies. (smart-immune.com)
  • ProTcell is Smart Immune's thymus-empowered T-cell therapy platform to fully and rapidly re-arm the immune system, aimed at enabling next-generation allogeneic T-cell therapies for all. (smart-immune.com)
  • This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
  • In 1975-1978, Slavin trained in clinical immunology/rheumatology at the Division of Immunology, Stanford University School of Medicine and later on in 1978, trained in clinical bone marrow transplantation under the late E.D. Thomas at the Fred Hutchinson Cancer Research Center in Seattle, Washington. (wikipedia.org)
  • A second apheresis or a bone marrow collection was considered, but neither was performed because the clinical condition of the donor worsened. (cdc.gov)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
  • Nonetheless, the transplantation of organs and tissues does raise ethical concerns. (who.int)
  • The aim of this study was to assess whether the lnc-DC plays a role in patients with aGVHD by measuring its expression levels compared to non-aGVHD patients on specific time intervals following transplantation. (magiran.com)