TransplantLymphocytic leukemiaGraft-versus-Multiple myelomaLeukemiaLymphoblasticTransplantsComplete remissionMyeloid reconstitution after autologousCompared with Consolidation ChemotherapyLymphomaHSCTAspiration and biopsyDonorPeripheral blood stemLeukaemiaOutcomesProcedureCancersBiopsyGVHDPatient'sDonorsHealthy bone marrowFlow cytometryAdultPediatricInductionRenal cell carcInfections in acute-care hospitalsCordChemotherapy or radiationProliferationBloodDiseasesHigh-doseVersusEngraftmentIntensiveTherapiesOrganRelapse
Transplant39
- Dr. Smitha has received her fellowship training in Haemato Oncology & Bone Marrow Transplant (BMT) from a reputed institute in Bengaluru. (hcgoncology.com)
- Bone marrow transplant is the most widely used stem cell therapy, but some therapies derived from umbilical cord blood are also in use. (allstemcells.com)
- Total marrow and lymphoid irradiation may allow a greater dose of radiation to be delivered to the bone marrow as a preparative regimen before hematopoietic cell transplant while causing less side effects to normal organs than standard total body irradiation. (survivornet.com)
- TRANSPLANT: Patients undergo hematopoietic cell transplantation on day 0. (survivornet.com)
- HDC with transplant is now standard therapy in multiple myeloma, acute myeloid leukemia in first remission, and intermediate-grade non-Hodgkin's lymphoma. (bdbiosciences.com)
- Chemotherapy, radiation therapy, targeted therapy, and stem cell or bone marrow transplant are common treatment options for leukemia. (medicalnewstoday.com)
- Performance status and comorbidity predict transplant-related mortality after allogeneic hematopoietic cell transplantation. (uchicago.edu)
- Phase I study of dose-escalated busulfan with fludarabine and alemtuzumab as conditioning for allogeneic hematopoietic stem cell transplant: reduced clearance at high doses and occurrence of late sinusoidal obstruction syndrome/veno-occlusive disease. (uchicago.edu)
- Feasibility of clofarabine cytoreduction before allogeneic transplant conditioning for refractory AML. (uchicago.edu)
- Allogeneic stem cell transplant in renal failure: engraftment and prolonged survival, but high incidence of neurologic toxicity. (uchicago.edu)
- Phase II study of immunomodulation with granulocyte-macrophage colony-stimulating factor, interleukin-2, and rituximab following autologous stem cell transplant in patients with relapsed or refractory lymphomas. (uchicago.edu)
- T-cell-depleted allogeneic transplant without donor leukocyte infusions results in excellent long-term survival in patients with multiply relapsed Lymphoma. (uchicago.edu)
- Second autologous stem cell transplantation for relapsed lymphoma after a prior autologous transplant. (uchicago.edu)
- Pilot study of comprehensive geriatric assessment (CGA) in allogeneic transplant: CGA captures a high prevalence of vulnerabilities in older transplant recipients. (uchicago.edu)
- Since July 2016, Dr He has been appointed as the medical lead in Bone Marrow Transplant at the Olivia Newton-John Centre in Austin Hospital after the successful establishment of Victoria's third adult allogeneic transplant unit. (epworth.org.au)
- The Koru Hospital Bone Marrow Transplant Center is a state-of-the-art medical facility that offers advanced stem cell therapy for a range of hematological disorders. (koruhastanesi.com)
- At the Koru Hospital Bone Marrow Transplant Center, we provide comprehensive care to our patients, from pre-transplant evaluation to post-transplant follow-up care. (koruhastanesi.com)
- The increasing success of intensive consolidation chemotherapy (CCT) as an alternative to bone marrow transplant (BMT) in acute myeloid leukaemia (AML) necessitates comparison of the impact on quality of life (QoL) of these two treatment modalities. (ox.ac.uk)
- A stem cell transplant is often the best option to treat blood cancers, such as leukemia , lymphoma and multiple myeloma , as well as bone marrow failure syndromes like myelodysplastic syndrome . (mdanderson.org)
- An autologous stem cell transplant uses the patient's own cells for treatment. (mdanderson.org)
- An allogeneic stem cell transplant is similar, but we take cells from someone other than the patient. (mdanderson.org)
- Where do allogeneic stem cell transplant donor cells come from? (mdanderson.org)
- With a bone marrow transplant, the donor receives general anesthesia , and the bone marrow is extracted in a 1-2-hour procedure. (mdanderson.org)
- With a peripheral blood cell transplant, the donor receives growth factor shots to stimulate the bone marrow to push the stem cells into the blood. (mdanderson.org)
- Professor Ma holds leadership or scientific membership positions in a number of national and international scientific communities including the World Network for Blood & Marrow Transplantation (a WHO affiliated NGO), the AsiaPacific BM Transplant and the Royal College of Pathology of Australasian Quality Assurance Programme. (edu.au)
- She needs a bone marrow transplant, not available in the Gaza Strip, and has not been able to access the treatment she needs since March 2020. (who.int)
- An initial appointment was scheduled for 22 March 2020 at An-Najah Hospital in Nablus, in the West Bank, but the hospital only offers autologous transplantation (using the patient's own bone marrow), while Saja needed an allogeneic transplant (with bone marrow from a donor). (who.int)
- Throughout efforts to refer Saja for bone marrow transplant, she has been receiving chemotherapy at Rantisi Hospital in Gaza City. (who.int)
- Departmental bone marrow transplant services offer essential medical expertise and complementary services to patients with complex health conditions. (tasmc.org.il)
- The transplant of blood stem cells or bone marrow will be infused one to three days after the last chemotherapy or radiation dose. (ucsfhealth.org)
- Stem cell transplant - also called bone marrow transplant, in this procedure a donor's stem cells are transfused into your blood. (bidmc.org)
- A bone marrow transplant is a procedure to replace damaged or diseased bone marrow with healthy bone marrow stem cells. (medlineplus.gov)
- Autologous bone marrow transplant -- The term auto means self. (medlineplus.gov)
- Allogeneic bone marrow transplant -- The term allo means other. (medlineplus.gov)
- Umbilical cord blood transplant -- This is a type of allogeneic transplant. (medlineplus.gov)
- Haploidentical transplant -- This is a type of allogeneic transplant, in which the donor is not completely matched with the recipient. (medlineplus.gov)
- A bone marrow transplant replaces bone marrow that is either not working properly or has been destroyed (ablated) by chemotherapy or radiation. (medlineplus.gov)
- Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
- 202. Autologous stem cell transplant within 6 weeks of planned KTE-X19 or axicabtagene ciloleucel infusion. (who.int)
Lymphocytic leukemia6
- It was approved by the FDA in March 1991 under the trade name Leukine for acceleration of white blood cell recovery following autologous bone marrow transplantation in patients with non-Hodgkin's lymphoma, acute lymphocytic leukemia, or Hodgkin's disease. (wikipedia.org)
- Acute lymphoblastic leukemia (acute lymphocytic leukemia, ALL) is a malignant (clonal) disease of the bone marrow in which early lymphoid precursors proliferate and replace the normal hematopoietic cells of the marrow. (medscape.com)
- Allogeneic bone marrow transplantation for therapy-related acute lymphocytic leukemia after autologous hematopoietic stem cell transplantation for multiple myeloma. (myeloma.org.uk)
- Acute lymphocytic leukemia (ALL) occurs mostly in children. (healthline.com)
- Furthest along as of October, according to an update posted on the company's website, is CIK-CAR.CD19, a pre-IND cancer immunotherapy being developed for acute lymphocytic leukemia and non-Hodgkin's lymphoma post-bone marrow transplantation. (genengnews.com)
- Acute lymphoblastic leukemia (ALL), also called acute lymphocytic leukemia, is a cancer of the white blood cells. (bidmc.org)
Graft-versus-6
- An acute graft-versus-host disease activity index to predict survival after hematopoietic cell transplantation with myeloablative conditioning regimens. (nature.com)
- Prospective evaluation for upper gastrointestinal tract acute graft-versus-host disease after hematopoietic stem cell transplantation. (nature.com)
- Initial therapy of acute graft-versus-host disease with low-dose prednisone does not compromise patient outcomes. (nature.com)
- Oral beclomethasone dipropionate for the treatment of gastrointestinal acute graft-versus-host disease (GVHD). (nature.com)
- Total body irradiation can lower the relapse rate but has some fatal side effects such as irreversible damage to normal internal organs and graft-versus-host disease (a complication after transplantation in which donor's immune cells recognize the host as foreign and attack the recipient's tissues). (survivornet.com)
- Autologous graft-versus-host disease: harnessing anti-tumor immunity through impaired self-tolerance. (uchicago.edu)
Multiple myeloma5
- Indications for CAR T-cell therapy are aggressive lymphomas, acute lymphoblastic leukemia, and advanced multiple myeloma. (bookinghealth.com)
- This type of treatment can be used in patients with acute or chronic leukemia, multiple myeloma, myelodysplastic syndromes, myeloproliferative neoplasms, and severe aplastic anemia. (bookinghealth.com)
- BMT is used in combination with chemotherapy as a treatment for multiple myeloma, a cancer that affects the plasma cells in bone marrow. (koruhastanesi.com)
- Autologous BMT is commonly used in combination with chemotherapy to treat multiple myeloma. (koruhastanesi.com)
- Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
Leukemia41
- It is also used to treat neutropenia induced by chemotherapy during the treatment of acute myeloid leukemia. (wikipedia.org)
- See also Acute Lymphoblastic Leukemia Staging . (medscape.com)
- Multiple-gated acquisition (MUGA) scans or echocardiograms are needed when the diagnosis of ALL is confirmed, because almost all treatment regimens for acute leukemia include anthracyclines (eg, daunorubicin, doxorubicin), which are potentially cardiotoxic. (medscape.com)
- Acute lymphoblastic leukemia (ALL): Bone marrow shows proliferation of large and heterogeneous lymphoblasts consistent with pre-B-cell ALL (French-American-British L2 morphology). (medscape.com)
- See the Childhood Acute Lymphoblastic Leukemia: Diagnosis, Management, and Complications slideshow to help recognize and treat this disease and its associated complications. (medscape.com)
- See also Pediatric Acute Lymphoblastic Leukemia and Acute Myeloid Leukemia (AML) . (medscape.com)
- Although outcomes of children and adolescents with newly diagnosed acute myeloid leukemia (AML) have improved significantly over the past two decades, more than one-third of patients continue to relapse and experience suboptimal long-term outcomes. (haematologica.org)
- Patients with acute myelogenous leukemia (AML) present with symptoms resulting from bone marrow failure, symptoms resulting from organ infiltration with leukemic cells, or both. (medscape.com)
- In fact, myocardial infarction may be the first presenting symptom of acute leukemia in an older patient. (medscape.com)
- Acute myelogenous leukemia (AML) is a malignant disease of the bone marrow in which hematopoietic precursors are arrested in an early stage of development. (medscape.com)
- Clofarabine increases the eradication of minimal residual disease of primary B-precursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome. (uke.de)
- METHODS: A cross-sectional study of sexual health and infertility was conducted in 479 patients with acute myeloid leukemia (AML) in first complete remission (CR) who were entered into the UK MRC AML 10 trial comparing allogeneic BMT (Allo-BMT), autologous BMT (A-BMT), and intensive consolidation chemotherapy (CCT). (ox.ac.uk)
- The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. (ashpublications.org)
- In Section III, Dr. Martin Tallman describes the evaluation and management of patients with acute promyelocytic leukemia, a notable example of therapeutic progress in a molecularly defined entity of leukemia. (ashpublications.org)
- The term acute myeloid leukemia (AML) collectively refers to a mixture of distinct diseases that differ with regard to their pathogenetic evolution, genetic abnormalities, clinical features, response to therapy, and prognosis. (ashpublications.org)
- This phase II trial studies how well total marrow and lymphoid irradiation works as a conditioning regimen before hematopoietic cell transplantation in patients with myelodysplastic syndrome or acute leukemia. (survivornet.com)
- Sargramostim is a colony stimulating factor that is FDA approved for the treatment of granulocytopenia following induction chemotherapy in acute myelogenous leukemia , mobilization and following transplantation of autologous peripheral blood progentior cells, myeloid reconstitution after autologous bone marrow transplantation, myeloid reconstitution after allogeneic bone marrow transplantation and bone marrow transplantation failure or engraftment delay. (wikidoc.org)
- Stem cell transplantation, or bone marrow transplantation, is a treatment option for leukemia and other blood cancers. (medicalnewstoday.com)
- Learn about remission from acute myeloid leukemia (AML). (medicalnewstoday.com)
- Impact of disease burden at time of allogeneic stem cell transplantation in adults with acute myeloid leukemia and myelodysplastic syndromes. (uchicago.edu)
- Allogeneic stem cell transplantation with alemtuzumab-based conditioning for patients with advanced chronic myelogenous leukemia. (uchicago.edu)
- Identifying familial myelodysplastic/acute leukemia predisposition syndromes through hematopoietic stem cell transplantation donors with thrombocytopenia. (uchicago.edu)
- I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
- Role of signal transduction inhibition in treatment of acute myelogenous leukemia/myelodysplasia. (rochester.edu)
- This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
- The onset of leukemia can be acute (sudden onset) or chronic (slow onset). (healthline.com)
- In acute leukemia, cancer cells multiply quickly. (healthline.com)
- Acute myeloid leukemia (AML) can occur in children and adults. (healthline.com)
- BMT is a common treatment for acute and chronic leukemia. (koruhastanesi.com)
- Depending on the type of leukemia, autologous or allogeneic BMT may be recommended. (koruhastanesi.com)
- Allogeneic BMT is used as a curative therapy for acute and chronic leukemia. (koruhastanesi.com)
- PBSCT is used as a treatment option for acute and chronic leukemia. (koruhastanesi.com)
- Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all- trans retinoic acid (ATRA). (nature.com)
- The disease is now considered to be the most curable subtype of acute myeloid leukemia (AML) in adults. (nature.com)
- Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML), with the first description as a distinct entity in 1957. (nature.com)
- Acute lymphoblastic leukemia is similar to acute myeloid leukemia (AML) , except that AML affects the myeloid white blood cells instead of lymphocytes. (bidmc.org)
- Acute lymphoblastic leukemia survival rates vary significantly depending on the person's age, ALL sub-type, and other factors. (bidmc.org)
- Acute Lymphoblastic Leukemia progresses rapidly, so once diagnosed, it should be treated quickly. (bidmc.org)
- Acute promyelocytic leukemia (APL) is a distinct variant of acute myeloid leukemia (AML). (medscape.com)
- Autologous versus allogeneic hematopoietic cell transplantation for older patients with acute lymphoblastic leukemia. (bvsalud.org)
- An analysis from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation. (bvsalud.org)
Lymphoblastic2
Transplants8
- Administration of bone marrow transplantation - including autologous, allogeneic, haploidentical and cord blood transplants. (hcgoncology.com)
- BK virus infection is associated with hematuria and renal impairment in recipients of allogeneic hematopoetic stem cell transplants. (uchicago.edu)
- Stem cell transplants fall into two categories: autologous and allogeneic. (mdanderson.org)
- The Pediatric Hemato-oncology Department performs a full array of bone marrow transplants (BMT) for children, sourced by self-donated (autologous) marrow, peripheral blood donations and donations from related or unrelated donors (allogeneic). (tasmc.org.il)
- Self-donation transplants are performed for malignant conditions, such as recurrent lymphoma, metastasized bone cancers, high-risk neuroblastoma, and specific types of brain tumors. (tasmc.org.il)
- Advances in the treatment of cancer and improvements in supportive care over the past 10 years have improved the results and tolerability of blood and marrow transplants (BMT). (ucsfhealth.org)
- Identical twin allogeneic transplants are called syngeneic transplants. (ucsfhealth.org)
- Autologous stem cell transplants , which are stem cells that come from your own bone marrow or blood. (bidmc.org)
Complete remission3
- Recent advances in flow cytometric and molecular measurable residual disease detection have further enhanced modern risk-stratified approaches to chemotherapy and allocation to allogeneic hematopoietic stem cell transplantation (HSCT) in first complete remission (CR1) when indicated. (haematologica.org)
- The associations of cytogenetics with complete remission (CR) rates, overall survival (OS), and outcomes after CR were studied in 609 previously untreated AML patients younger than 56 years old in a clinical trial comparing 3 intensive postremission therapies: intensive chemotherapy, autologous transplantation (ABMT), or allogeneic bone marrow transplantation (alloBMT) from matched related donors. (elsevierpure.com)
- Estimate rates of acute and chronic GvHD, infections, complete remission and neutrophil recovery. (survivornet.com)
Myeloid reconstitution after autologous1
- Sargramostim is primarily used for myeloid reconstitution after autologous or allogeneic bone marrow transplantation. (wikipedia.org)
Compared with Consolidation Chemotherapy1
- Severe adverse impact on sexual functioning and fertility of bone marrow transplantation, either allogeneic or autologous, compared with consolidation chemotherapy alone: analysis of the MRC AML 10 trial. (ox.ac.uk)
Lymphoma5
- d) treatment for a range of serious blood disorders in acute leukaemia, chronic leukaemia, myelodysplasia, myeloma and lymphoma. (epworth.org.au)
- Autologous BMT is used as a salvage therapy for patients with relapsed or refractory Hodgkin's lymphoma. (koruhastanesi.com)
- Autologous BMT is used as a consolidation therapy for patients with high-risk non-Hodgkin's lymphoma. (koruhastanesi.com)
- Allogeneic BMT is used as a salvage therapy for certain types of lymphoma, such as Hodgkin's lymphoma and non-Hodgkin's lymphoma. (koruhastanesi.com)
- In the present study, the case of a patient diagnosed with diffuse large B‑cell lymphoma, who received chemotherapy and autologous hematopoietic stem cell transplantation is presented. (spandidos-publications.com)
HSCT7
- 30,000 patients with blood-related malignancies receive HDC, which, if the response is satisfactory, could subsequently be followed by hematopoietic stem cell transplantation (HSCT). (bdbiosciences.com)
- this is used in both autologous and allogenic HSCT. (bdbiosciences.com)
- His research focus is on haematopoietic stem cell transplantation (HSCT) and translational research of normal and malignant stem cells. (edu.au)
- Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
- HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
- Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
- In the section on aspergillosis, the revised recommendations include the use of a room with high-efficiency particulate air filters rather than laminar airflow as the protective environment for allogeneic HSCT recipients and the use of high-efficiency respiratory-protection devices (e.g. (cdc.gov)
Aspiration and biopsy1
- The workup for AML includes blood tests, bone marrow aspiration and biopsy (the definitive diagnostic tests), and analysis of genetic abnormalities. (medscape.com)
Donor10
- Allogeneic stem cell transplantation uses donor stem cells to treat and sometimes cure certain blood disorders and blood cancers. (clevelandclinic.org)
- While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
- Allogeneic transplantation involves using stem cells from a donor - often a family member but sometimes a nonrelative. (medicalnewstoday.com)
- Identification by random forest method of HLA class I amino acid substitutions associated with lower survival at day 100 in unrelated donor hematopoietic cell transplantation. (uchicago.edu)
- Allogeneic BMT involves the use of stem cells from a compatible donor, which can be a family member or an unrelated donor. (koruhastanesi.com)
- The pipeline is based on a non-viral, allogeneic CIK CAR™ technology platform designed to leverage T cell and Natural Killer cell functionality within one effector cell population, sourced from healthy donor peripheral or cord blood. (genengnews.com)
- Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
- Many patients find matched unrelated donors through the National Marrow Donor Program. (mdanderson.org)
- For allogeneic transplantation, the patient receives bone marrow or blood stem cells from a tissue-matched (HLA-matched) donor who may or may not be a relative. (ucsfhealth.org)
- Leukapheresis -- First, the donor is given several days of shots to help stem cells move from the bone marrow into the blood. (medlineplus.gov)
Peripheral blood stem3
- We offer a range of stem cell therapy options, including bone marrow transplantation (BMT), peripheral blood stem cell transplantation (PBSCT), and cord blood transplantation. (koruhastanesi.com)
- Peripheral blood stem cell transplantation (PBSCT) involves the collection of stem cells from the patient's blood and their subsequent infusion after chemotherapy or radiation therapy. (koruhastanesi.com)
- EPF has been reported in association with infections, in particular AIDS, medications, autoimmune diseases, as well as autologous peripheral blood stem cell and allogeneic bone marrow transplantation. (pgdue.com)
Leukaemia4
- Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
- Following induction and consolidation treatment for acute myeloid leukaemia the duration of treatment may be substantially longer (up to 38 days) depending on the type, dose and schedule of cytotoxic chemotherapy used. (medicines.org.uk)
- 14 September 2020 - Saja is a 9-year-old girl who was diagnosed with acute myeloid leukaemia in May 2019. (who.int)
- Saja's mother is from Morocco, and she was diagnosed with acute myeloid leukaemia during a family visit to Rabat, Morocco, in May 2019. (who.int)
Outcomes4
- Outcomes of patients with AML and MDS who relapse or progress after reduced intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)
- Fludarabine-melphalan conditioning for AML and MDS: alemtuzumab reduces acute and chronic GVHD without affecting long-term outcomes. (uchicago.edu)
- Pretreatment C-reactive protein is a predictor for outcomes after reduced-intensity allogeneic hematopoietic cell transplantation. (uchicago.edu)
- Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)
Procedure4
- Bone marrow transplantation (BMT) is a procedure that involves replacing a patient's damaged or destroyed bone marrow with healthy bone marrow stem cells. (koruhastanesi.com)
- Insertion of central venous catheters in children undergoing bone marrow transplantation: is there a platelet level for a safe procedure? (springeropen.com)
- Bone marrow transplantation (BMT) is a therapeutic procedure for the management of several hematological diseases and malignancies in pediatric population. (springeropen.com)
- and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
Cancers3
- What cancers are treated with allogeneic stem cell transplantation? (clevelandclinic.org)
- Not all cancers or blood diseases respond to stem cell transplantation, including allogeneic stem cell transplantation. (clevelandclinic.org)
- Doctors extract stem cells from your blood or bone marrow, place them in frozen storage, and re-infuse them back into your body following high-dose chemotherapy to eliminate blood cancers. (bidmc.org)
Biopsy1
- biopsy - either a bone marrow biopsy to examine blood cells, or a surgical or CT-guided biopsy to obtain lymph node tissue samples. (bidmc.org)
GVHD5
- We hypothesized that clinical risk factors could be identified within 2 weeks of onset of severe (stage 3 or 4) acute gut GVHD for identifying a patient population with a very poor outcome. (nature.com)
- Among 1462 patients who had allogeneic hematopoietic cell transplantation (HCT) between January 2000 and December 2005, 116 (7.9%) developed stage 3-4 gut GVHD. (nature.com)
- The median time for onset of stage 3-4 gut GVHD was 35 (4-135) days after allogeneic HCT. (nature.com)
- She also has a special interest in the management of Acute and Chronic GVHD. (hcgoncology.com)
- Complications: including acute/chronic GVHD, infection and delayed engraftment. (survivornet.com)
Patient's4
- Total body irradiation is a form of radiotherapy that involves irradiating the patient's entire body in an attempt to suppress the immune system, prevent rejection of the transplanted bone marrow and/or stem cells and to wipe out any remaining cancer cells. (survivornet.com)
- I. Characterize minimal residual disease from bone marrow aspirates and investigate the possible association between TMLI-based regimen and patient's disease status. (survivornet.com)
- Stem cell transplantation is performed after high-dose chemotherapy (HDC) to restore a cancer patient's blood and immune cell production capacity. (bdbiosciences.com)
- Autologous BMT involves collecting and storing a patient's own healthy stem cells, which are later transplanted back into the patient's body after chemotherapy or radiation therapy. (koruhastanesi.com)
Donors2
- Donors who are not related to you, yet still match, may be found through national bone marrow registries. (medlineplus.gov)
- In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
Healthy bone marrow1
- This also kills all healthy bone marrow that remains, and allows new stem cells to grow in the bone marrow. (medlineplus.gov)
Flow cytometry1
- We have specialized laboratories for the disgnostics of hematologic diseases, like bone marrow cytology, bone marrow cytochemistry, flow cytometry, cytogenetics and molecular genetics. (uniklinikum-dresden.de)
Adult2
- In order to eliminate the interference from the transplanted cells themselves, fetal stem cells were used for transplantation because the proliferation and differentiation potentials of fetal stem cells are superior to the adult ones ( 8 ). (ijbs.com)
- Ma DD , 2007 , 'Expression of Neurofilament Proteins in Adult Bone Marrow Mesenchymal Stem Cells and Embryonic Stem Cells and Their Clinical Potential' , in Davenport LP (ed. (edu.au)
Pediatric2
- The Dana-Dwek Children's Hospital Pediatric Hemato-oncology and Bone Marrow Transplantation Department treats infants, children, and adolescents suffering from acute and chronic blood diseases and from malignant hematological and non-hematological disorders. (tasmc.org.il)
- Hematological investigations and diagnostics including bone marrow testing and spinal taps: These tests are performed pain-free with the help of the Tel Aviv Sourasky Medical Center's Dream Service (pediatric service that helps children undergo treatment and testing under sedation). (tasmc.org.il)
Induction1
- the ATO dosage is 0.15 mg/kg/day IV until bone marrow remission occurs (maximum induction, 60 doses). (medscape.com)
Renal cell carc2
- Long-term follow-up of nonmyeloablative allogeneic stem cell transplantation for renal cell carcinoma: The University of Chicago Experience. (uchicago.edu)
- Phase I/II study of vaccination with electrofused allogeneic dendritic cells/autologous tumor-derived cells in patients with stage IV renal cell carcinoma. (nwbio.com)
Infections in acute-care hospitals1
- The new guidelines are designed to reduce the incidence of pneumonia and other severe, acute lower respira- tory tract infections in acute-care hospitals and in other health-care settings (e.g., ambulatory and long-term care institu- tions) and other facilities where health care is provided. (cdc.gov)
Cord2
- Cord blood transplantation involves the use of stem cells from umbilical cord blood, which is collected and stored at birth. (koruhastanesi.com)
- Cord blood transplantation is used to treat certain genetic disorders that affect the production of blood cells, such as sickle cell anemia and thalassemia. (koruhastanesi.com)
Chemotherapy or radiation1
- Autologous transplantation involves extracting a person's stem cells from the bone marrow or blood and freezing them before a person has chemotherapy or radiation therapy. (medicalnewstoday.com)
Proliferation2
- Second, the rapid proliferation of these cells, along with a reduction in their ability to undergo programmed cell death (apoptosis), results in their accumulation in the bone marrow, the blood, and, frequently, the spleen and liver. (medscape.com)
- There are multiple mechanisms and differential diagnosis includes: artifactual thrombocytopenia, accelerated platelet destruction (intra- or extra-corpuscular anomalies), deficient production (bone marrow failure, disordered proliferation or thrombopoietin deficiency), and abnormal distribution (disorders associated with splenomegaly or dilution in massive transfusions) ( 1 ). (spandidos-publications.com)
Blood26
- These aberrant lymphoblasts proliferate, reducing the number of the normal marrow elements that produce other blood cell lines (red blood cells, platelets, and neutrophils). (medscape.com)
- Most AML subtypes are distinguished from other related blood disorders by the presence of more than 20% blasts in the bone marrow. (medscape.com)
- 2 HSCs are primarily found in bone marrow niches, but a small fraction of HSCs can also be found in the peripheral blood. (bdbiosciences.com)
- 3 Following exogenous stimulation, such as chemotherapy or using growth factors such as granulocyte colony stimulating factor (G-CSF) and filgrastim, the number of HSCs in the peripheral blood increases, either becoming on par or even exceeding the number in the bone marrow. (bdbiosciences.com)
- This pharmacologically induced egress of HSCs into peripheral blood, called mobilization, is utilized as the preferred strategy for generating HSCs for transplantation. (bdbiosciences.com)
- 3 Autologous stem cell transplantation almost exclusively uses peripheral blood, while for allogeneic SCT, T-lymphocytes in the peripheral blood could pose some danger. (bdbiosciences.com)
- CD34, a transmembrane phosphoglycoprotein, is present on immature hematopoietic precursor cells and all hematopoietic colony-forming cells in bone marrow and blood, including unipotent and pluripotent progenitor cells. (bdbiosciences.com)
- An autologous stem cell transplantation uses your own blood stem cells. (clevelandclinic.org)
- Allogeneic stem cell transplantation may cure some blood disorders FA causes. (clevelandclinic.org)
- Allogeneic stem cell transplantation replaces damaged white blood cells. (clevelandclinic.org)
- Healthcare providers consider several factors before recommending allogeneic stem cell transplantation to treat blood disorders or cancer. (clevelandclinic.org)
- Does Erythrocyte Blood Transfusion Prevent Acute Kidney Injury? (asahq.org)
- Allogeneic blood cell transplantation following reduced-intensity conditioning is effective therapy for older patients with myelofibrosis with myeloid metaplasia. (uchicago.edu)
- Allogeneic BMT is used as a curative therapy for MDS, a group of disorders that affect the production of blood cells in bone marrow. (koruhastanesi.com)
- The platform is intended to overcome practical and therapeutic limitations related to existing CAR-T approaches that include viral transfection, autologous blood, and T cells, according to Formula. (genengnews.com)
- In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
- Bone marrow, the spongy tissue inside our bones, is the factory for blood cells. (mdanderson.org)
- The stem cells of the transplanted marrow will travel to the bones, reseed the marrow space, and go through a growth process before the mature cells are released from the bone marrow into the blood stream. (ucsfhealth.org)
- It takes approximately two to three weeks for your marrow to start producing white blood cells, red blood cells and platelets. (ucsfhealth.org)
- Engraftment is the term used to describe when your new marrow begins to function and produce blood cells. (ucsfhealth.org)
- While awaiting engraftment, no mature cells leave the marrow and enter the blood stream. (ucsfhealth.org)
- In ALL, the bone marrow (the soft, spongy center of bones) produces too many lymphocytes, a type of white blood cells that do not mature as they should. (bidmc.org)
- The transplanted stem cells go from your blood to your bone marrow. (bidmc.org)
- The bone marrow produces blood cells. (medlineplus.gov)
- Stem cells in the bone marrow give rise to all of your different blood cells. (medlineplus.gov)
- The stem cells travel through the blood into the bone marrow. (medlineplus.gov)
Diseases3
- Bone marrow transplantation (BMT) is currently considered as a practiced and a well-established modality for the treatment of several hematological diseases and malignancies in children [ 1 ]. (springeropen.com)
- This department provides medical care for patients with acute and chronic kidney diseases, kidney failure, dysfunction and tumors of endocrine organs, and hypertension. (japanhospitalsearch.org)
- The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
High-dose3
- Forty infants have subsequently been treated on a protocol incorporating further intensification with an option for high-dose chemotherapy and autologous or allogeneic bone marrow transplantation. (nih.gov)
- Only three of 11 children treated by high-dose chemotherapy and transplantation remain alive in remission. (nih.gov)
- He was treated with chemotherapy (8 R-CHOP protocols) with partial response, followed by high-dose chemotherapy and autologous hematopoietic stem cell transplantation, with a complete response, and was stable for the previous 4 years. (spandidos-publications.com)
Versus1
- Kidney transplantation is a far more favourable treatment modality versus dialysis in terms of survival, quality of life and cost-effectiveness. (who.int)
Engraftment1
- V. Cellular and molecular assessment of TMLI effect on bone marrow environment and TMLI effect on the engraftment and disease relapse. (survivornet.com)
Intensive3
- For example, people who have stem cell transplantation go through intensive chemotherapy before treatment. (clevelandclinic.org)
- Acute kidney injury is a common occurrence in intensive care unit patients with a reported incidence of 11-67% and is associated with an increased risk of death. (asahq.org)
- ACUTE kidney injury (AKI) is a common occurrence in intensive care unit (ICU) patients with a reported incidence of 11-67% depending on the population studied and the definition employed. (asahq.org)
Therapies1
- The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (who.int)
Organ1
- Organ transplantation is often the best, if not the only, treatment for acute and chronic organ failure. (who.int)
Relapse2
- National Cancer Institute's First International Workshop on the Biology, Prevention, and Treatment of Relapse after Allogeneic Hematopoietic Stem Cell Transplantation: summary and recommendations from the organizing committee. (uchicago.edu)
- Vaccination of prostatectomized prostate cancer patients in biochemical relapse, with autologous dendritic cells pulsed with recombinant human PSA. (nwbio.com)