TransplantTransplantsHSCTHaematopoieticChemotherapyEngraftmentAplastic AnemiaTotal body irradiPatient'sSibling donorsUmbilicalGVHDMalignanciesRelapsePatients undergoingOutcomesMobilization2018Multiple myelomaPerson'sLeukemiaDonor'sGraftsCancerAutologous hematopoieticCurativePeripheral blood stemTherapiesBlood cells and plateletsDiffuse Large B-CancersMyeloidTherapeuticsBiopsyOrgans2000AdultsImmunologyOpportunistic infectionsPlateletStromalSevereImmature blood cellsLymphomaReactivationRecipients
Transplant33
- Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. (cdc.gov)
- An allogeneic transplant uses someone else's stem cells. (medlineplus.gov)
- Methods Center for International Blood and Marrow Transplant Research data from 184 adults who completed the Functional Assessment of Cancer Therapy-Bone Marrow Transplant (FACT-BMT) before undergoing alloHCT and at day 100 were used. (cdc.gov)
- Regret was measured using a FACT-BMT item not included in scoring: "I regret having the bone marrow transplant. (cdc.gov)
- Are you considering a blood stem cell transplant? (nih.gov)
- This study is investigating a new method for collecting blood stem cells from donors to see if it reduces transplant complications, such as rejection, in patients who have blood diseases. (nih.gov)
- Have you received a stem cell transplant? (nih.gov)
- This study aims to monitor the long-term health of patients who have received a donor stem cell transplant from the NIH Clinical Center. (nih.gov)
- Are you scheduled for a stem cell transplant with cord blood? (nih.gov)
- HLA testing for possible future bone marrow transplant. (oncolink.org)
- some patients will need ongoing maintenance therapy depending on how much consolidation treatment they have received, as well as if they had a stem cell transplant. (oncolink.org)
- Biol Blood Marrow Transplant. (stembook.org)
- Infusion of donor-derived CD19-redirected-virus-specific T cells for B-cell malignancies relapsed after allogeneic stem cell transplant: a phase I study. (stembook.org)
- The Dana-Farber/Boston Children's Stem Cell Transplant Center offers autologous and allogeneic stem cell transplants and is active in researching new stem cell techniques. (dana-farber.org)
- Transplant Cell Ther 2021. (harvard.edu)
- Defibrotide: Real World Management of Veno-Occlusive Disease/ Sinusoidal Obstructive Syndrome after Stem Cell Transplant. (harvard.edu)
- The report also includes clinical guidance for adults who have received 7-valent PCV (PCV7) only and adults who are hematopoietic stem cell transplant recipients. (cdc.gov)
- The Bone Marrow Transplant (BMT) Survivorship Program aims to improve the experience and outcomes of BMT survivors and families through focused clinical care and research. (massgeneral.org)
- Graft versus host disease (GVHD), a severe immunogenic complication of allogeneic hematopoietic stem cell transplantation (HSCT), represents the most frequent cause of transplant-related mortality (TRM). (hindawi.com)
- Ramos CA " Striking the right balance: optimizing conditioning regimens for unrelated donor bone marrow transplant for severe aplastic anemia. . (bcm.edu)
- Mayo Clinic scientists are actively studying ways to improve bone marrow transplant outcomes. (mayoclinic.org)
- Learn more about research in the Bone Marrow Transplant Program . (mayoclinic.org)
- See a list of publications about bone marrow transplant by Mayo Clinic doctors on PubMed, a service of the National Library of Medicine. (mayoclinic.org)
- Hematopoietic stem cell transplant. (mayoclinic.org)
- http://www.cancer.gov/about-cancer/treatment/types/stem-cell-transplant/stem-cell-fact-sheet. (mayoclinic.org)
- The program, which is accredited by the Foundation for the Accreditation of Cellular Therapy , has pioneered a tandem stem cell transplant for Hodgkin lymphoma, reduced intensity conditioning treatments utilizing the drug mitoxantrone, ara-C and pentostatin and refrigerated marrow storage techniques that have led to wide acclaim. (nymc.edu)
- Allogeneic transplants involve grafts from a genetically nonidentical donor of the same species and are the transplant type most often used in children. (oncologynurseadvisor.com)
- Transplant outcomes of the triple-negative NPM1/FLT3-ITD/CEBPA mutation subgroup are equivalent to those of the favourable ELN risk group, but significantly better than the intermediate-I risk group after allogeneic transplant in normal-karyotype AML. (cdc.gov)
- Is a matched unrelated donor search needed for all allogeneic transplant candidates? (cdc.gov)
- Haematopoietic stem cell transplants have been performed in more than 1 500 000 patients (both autologous and allogeneic) to date.1 Although haematological cancers remain the main indication, haematopoietic stem cell transplants are increasingly considered in the treatment of non-malignant disorders and genetic diseases such as haemoglobinopathies (sickle cell anaemia, thalassaemia) that can benefit greatly from this type of transplant. (who.int)
- Hopefully, following the recommendations made in the guidelines will reduce morbidity and mortality from opportunistic infections in hematopoietic stem cell transplant recipients. (cdc.gov)
- For the purposes of this document, HSCT is defined of the CDC, the Infectious Diseases Society of America, as any transplantation of blood or marrow-derived he- and the American Society of Blood and Marrow Trans- matopoietic stem cells, regardless of transplant type plantation," which was published in the Morbidity and (allogeneic or autologous) or cell source (bone marrow, Mortality Weekly Report [1]. (cdc.gov)
- 202. Autologous stem cell transplant within 6 weeks of planned KTE-X19 or axicabtagene ciloleucel infusion. (who.int)
Transplants5
- Blood-forming stem cell transplants. (mayoclinic.org)
- Bone marrow transplantation, begun in 1983, and stem cell transplantation have grown to encompass allogeneic, unrelated, cord blood, autologous transplants and mini-allogeneic (reduced intensity conditioning) transplantation strategies. (nymc.edu)
- Northside Hospital Cancer Institute's Immunotherapy Program is part of our nationally recognized treatment center for blood and marrow transplants. (northside.com)
- Each year, more than 50,000 allogeneic transplants are performed worldwide. (cdc.gov)
- The growing need for haematopoietic stem cell transplantation (HSCT) is reflected in the increasing number of transplants performed globally each year. (bvsalud.org)
HSCT14
- Allogeneic bone marrow transplantation Allogeneic HSCT Allogeneic stem cell transplantation Myelodysplasia Stem Cell. (karger.com)
- Recently, we and others have shown that allogeneic hematopoietic stem cell transplantation (allo-HSCT) may represent a valid treatment option in leukemic myeloid sarcoma. (haematologica.org)
- Serum citrulline was quantified by liquid chromatography in blood samples collected from consecutive patients who received an allogeneic HSCT in our institution between July 2014 and November 2019. (confex.com)
- Allogeneic hematopoietic stem cell transplantation (HSCT) offers the only curative modality for many hematological disorders. (hindawi.com)
- Right now, hematopoietic stem cell transplantation (HSCT) is the foremost dependable healing treatment with amazing comes about for patients with HLAmatched family or disconnected givers. (alliedacademies.org)
- We performed a review chart audit of 12 children who experienced allogeneic HSCT for WAS to report our involvement. (alliedacademies.org)
- The year 2020 marked the 30th anniversary of the Nobel Prize in Medicine awarded to E. Donnall Thomas for the development of allogeneic hematopoietic stem cell transplantation (allo-HSCT) to treat hematologic malignancies and other blood disorders. (broadinstitute.org)
- The most common adverse event following allogeneic hematopoietic stem cell transplantation (HSCT) is graft-versus-host disease (GVHD), which can increase morbidity and mortality in HSCT patients. (oncologynurseadvisor.com)
- Hematopoietic stem cell transplantation (HSCT) affects serious risks for the patient, including death. (bvsalud.org)
- HSCT make it an aggressive process, causing consists of painless intravenous infusion of healthy toxicity and can generate significant complications hematopoietic stem cells (HSC) extracted from bone and several side effects adding feelings of worry, marrow (BM), peripheral blood (PB) and placental anguish, anxiety, among others (KUBA et al. (bvsalud.org)
- Also, drastic changes in daily living habits, qualified and responsible for the implementation of changes in body image, long duration of treatment, HSCT since 2004, agreed to the Brazilian Unified periods of hospitalization and protective isolation, Health System, which meets the needs of the feeling of loss of control, fear of death and lack of patients with an indication for transplantation. (bvsalud.org)
- Opportunistic infections (OIs) are defined as any in- the infusion of hematopoietic stem cells from a donor fections that occur with increased frequency or severity into a patient who has received chemotherapy, which in HSCT patients. (cdc.gov)
- There pediatric and adult autologous and allogeneic HSCT patients. (cdc.gov)
- are basically 3 phases of immune recovery for HSCT patients, The purposes of the guidelines are (1) to summarize the beginning at day 0, the day of transplantation. (cdc.gov)
Haematopoietic1
- Patients can be cured with bone marrow transplantations of haematopoietic stem cells. (lu.se)
Chemotherapy8
- T-prolymphocytic leukemia (T-PLL) is an aggressive mature T-cell neoplasm that responds poorly to conventional chemotherapy and has a dismal outcome. (haematologica.org)
- Treatment includes chemotherapy and often stem cell transplantation , either from the patient's own bone marrow (autologous) or sometimes from another person's bone marrow (allogeneic). (dana-farber.org)
- Conventional chemotherapy drugs kill cancer cells by working on the "machinery" inside of cells and causing the cells to die. (northside.com)
- Chemotherapy, radiation, or both are initiated prior to transplantation to enable engraftment of the transplanted cells, decrease tumor size, and reduce immunoreactivity of the recipient. (oncologynurseadvisor.com)
- An environment for GVHD is formed when antigen-presenting cells are activated by the patient's disease and the pretreatment destruction of cells caused by chemotherapy and radiotherapy. (oncologynurseadvisor.com)
- Correlation of Bridging Therapy (BT) and Lymphodepleting Chemotherapy (LDC) with clinical outcomes in patients (pts) with relapsed/refractory Diffuse Large B-cell Lymphoma (r/r DLBCL) treated with tisagenlecleucel. (uni-koeln.de)
- Because of the patient's risk status, the physicians intended to perform allogeneic stem cell transplantation after induction and consolidation chemotherapy, which was scheduled to end in January 2013, and a conditioning chemotherapy regimen, which was planned to be given in March. (cdc.gov)
- Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)
Engraftment5
- Successful stem cell transplantation for patients with severe combined immunodeficiency (SCID) from matched family donors without conditioning results in engraftment of T lymphocytes. (nih.gov)
- Full hematopoietic engraftment was reported in one case after bone marrow transplantation without conditioning for a SCID patient. (nih.gov)
- In contrast to the expected mixed chimerism that usually occurs in the absence of conditioning, we found in our patients 100% donor cell engraftment based on fluorescence in situ hybridization (FISH) and microsatellite techniques. (nih.gov)
- Chimerism analysis - testing of short tandem repeat regions to assess donor bone marrow engraftment. (ouh.nhs.uk)
- Kamble RT, Guo S, Ramos CA, Carrum G " Acute gout at engraftment following hematopoietic transplantation. . (bcm.edu)
Aplastic Anemia1
- The first patient was received an allogeneic bone marrow transplantation and subsequent allogeneic peripheral blood stem cell transplantation for severe aplastic anemia from his sister. (koreamed.org)
Total body irradi1
- Since approximately 30% of leukemia patients relapse after allogeneic BMT using total body irradiation (TBI)-based preparative regimens, treatment intensity may be suboptimal. (nature.com)
Patient's2
- Patients who undergo bone marrow transplantation are generally immunosuppressed with a dose of cyclophosphamide which is usually calculated based on the patient's weight. (slideshare.net)
- Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)
Sibling donors1
- Donor CTLA-4 genotype influences clinical outcome after T cell-depleted allogeneic hematopoietic stem cell transplantation from HLA-identical sibling donors. (cdc.gov)
Umbilical4
- The three sources of stem cells include bone marrow, umbilical cord blood, and peripheral blood. (oncologynurseadvisor.com)
- and umbilical cord blood (PUCB), capable of 2017), associated with the results of the procedure restoring spinal cord function and immunology of and require a process of hospitalization and patients with indication for transplantation, with the prolonged hospital recovery. (bvsalud.org)
- Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
- The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)
GVHD6
- We have a series of clinical trials available to evaluate several different strategies to prevent GVHD, such as T cell depletion and the use of novel immunosuppressive agents. (harvard.edu)
- The histocompatibility differences between the donor and the recipient, the presence of donor's immunocompetent cells, and the inability of the recipient to reject these cells were defined as the basic pathogenic prerequisites for GVHD development by Billingham in 1966 [ 10 ]. (hindawi.com)
- Cytotoxic T lymphocytes were determined as the cellular effectors of GVHD, and the key role of antigen-presenting cells (APCs) in T-lymphocyte activation was established during the following years [ 11 , 12 ]. (hindawi.com)
- Treatment focuses on blocking the expansion of donor T cells, as GVHD develops from the expansion of these cells. (oncologynurseadvisor.com)
- CD20 antagonists deregulate B cells, which are believed to contribute to the pathogenesis of GVHD. (oncologynurseadvisor.com)
- When CD20 antagonists decrease the amount of circulating B cells, the body may not produce as many cytotoxic T cells that can potentially induce GVHD. (oncologynurseadvisor.com)
Malignancies2
- Outcomes of mismatched related allogeneic stem cell transplantation for chronic lymphocytic leukemia: a retrospective study on behalf of the chronic malignancies working party of the EBMT. (uni-koeln.de)
- Hematopoietic stem cell transplantation has become a major treatment option for patients with hematopoietic malignancies and immune deficiencies. (cdc.gov)
Relapse3
- however, nearly all cases eventually relapse, and allogeneic stem cell transplantation remains the only curative treatment option for a small subset of patients. (haematologica.org)
- Over-expression of PD-1 does not predict leukemic relapse after allogeneic stem cell transplantation. (stembook.org)
- Influence of molecular subgroups on outcome of acute myeloid leukemia with normal karyotype in 141 patients undergoing salvage allogeneic stem cell transplantation in primary induction failure or beyond first relapse. (cdc.gov)
Patients undergoing1
- Seven eighty six patients undergoing allogeneic (n=550) or autologous (n=236) BMT were evaluated by physical examination, history, rest and exercise ECG, chest x-ray, two-dimensional echocardiography, and radionuclide ventriculography (RNV) before BMT, and monitored for 5 months thereafter. (slideshare.net)
Outcomes3
- Prevalence of decisional regret among patients who underwent allogeneic hematopoietic stem cell transplantation and associations with quality of life and clinical outcomes. (cdc.gov)
- Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
- Outcomes of corneal transplantation in Europe: report by the European Cornea and Cell Transplantation Registry. (who.int)
Mobilization3
- The stem cell mobilization result was poor. (cdc.gov)
- The CXCL12-3'A allele is associated with a higher mobilization yield of CD34 progenitors to the peripheral blood of healthy donors for allogeneic transplantation. (cdc.gov)
- Association of stromal cell-derived factor-1-3'A polymorphism to higher mobilization of hematopoietic stem cells CD34+ in Tunisian population. (cdc.gov)
20181
- In June 2018, the Secretariat established the WHO Task Force on Donation and Transplantation of Human Organs and Tissues as an advisory group composed of experts from all WHO regions. (who.int)
Multiple myeloma7
- Multiple myeloma is a blood cancer that starts in the plasma cells in the bone marrow. (medlineplus.gov)
- In people with multiple myeloma, abnormal plasma cells grow out of control in the bone marrow and form tumors in the areas of solid bone. (medlineplus.gov)
- Plasma cell neoplasms (including multiple myeloma) treatment (PDQ) - health professional version. (medlineplus.gov)
- Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
- Bone marrow aspirate demonstrating plasma cells of multiple myeloma. (medscape.com)
- Symptom experience of multiple myeloma (syMMex) patients treated with autologous stem cell transplantation following high-dose melphalan: a descriptive longitudinal study. (zhaw.ch)
- Of these, 27.91% had a main diagnosis indicating the transplantation of Multiple Myeloma (MM), and 58.14 received autologous transplantation. (bvsalud.org)
Person's1
- An autologous bone marrow or stem cell transplantation is performed using a person's own stem cells. (medlineplus.gov)
Leukemia20
- The killing of leukemia cells is proportional to the radiation absorbed dose. (nature.com)
- Chronic myelogenous leukemia (CML), also known as chronic myeloid leukemia, is a myeloproliferative disorder characterized by increased proliferation of the granulocytic cell line without the loss of their capacity to differentiate. (medscape.com)
- Create healthcare diagrams like this example called Leukemia - Stem Cell Transplantation in minutes with SmartDraw. (smartdraw.com)
- Myeloproliferative diseases are a heterogeneous group of disorders characterized by cellular proliferation of one or more hematologic cell lines in the peripheral blood, distinct from acute leukemia. (medscape.com)
- Bone marrow fibrosis is also detected in the spent phase of chronic myelogenous leukemia and polycythemia vera. (medscape.com)
- Hematopoietic stem cell transplantation can be considered in young patients with chronic myelogenous leukemia in chronic phase if a human leukocyte antigen (HLA)-matched donor is available. (medscape.com)
- Acute myelogenous leukemia (AML) is a blood cancer that affects white blood cells, red blood cells, and/or platelets. (oncolink.org)
- A lumbar puncture (spinal tap) to see if there are any leukemia cells in your spinal fluid. (oncolink.org)
- The treatment is designed to wipe out the abnormally functioning leukemia cells. (oncolink.org)
- 1 T-PLL cells commonly demonstrate rearrangements involving T-cell leukemia/lymphoma 1 (TCL1) family genes TCL1A, MTCP1 (mature T-cell proliferation), or TCL1B as molecular hallmarks. (haematologica.org)
- The second patient underwent allogeneic bone marrow transplantation for acute myelogeneous leukemia from his sister. (koreamed.org)
- Leukemia can refer to all cancers affecting the white blood cells. (healthline.com)
- Leukemia is a cancer of the blood cells. (healthline.com)
- Leukemia can also cause symptoms in organs that have been infiltrated or affected by the cancer cells. (healthline.com)
- In acute leukemia, cancer cells multiply quickly. (healthline.com)
- Leukemia is also classified according to the type of cell that's affected. (healthline.com)
- Leukemia involving myeloid cells is called myeloid or myelogenous leukemia. (healthline.com)
- Hairy cell leukemia is a very rare subtype of CLL. (healthline.com)
- [ 1 ] First described in 1848, MM is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance ( MGUS ) to plasma cell leukemia. (medscape.com)
- The versatile drug is now also approved for the treatment of B-cell Hodgkin lymphoma, non-Hodgkin lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis in the adult population. (oncologynurseadvisor.com)
Donor's1
- Northside Hospital Cancer Institute (NHCI) has been providing cancer immunotherapy for decades in the form of allogeneic stem cell transplantation, in which a donor's bone marrow or blood is transplanted into a patient to cure aggressive blood cancers. (northside.com)
Grafts1
- eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)
Cancer20
- As the cancer cells grow in the bone marrow, you may have bone pain, most often in the ribs or back. (medlineplus.gov)
- The cancer cells can weaken bones. (medlineplus.gov)
- If your provider suspects this type of cancer, a bone marrow biopsy will be performed. (medlineplus.gov)
- Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
- Cancer Care provides free, professional support services for people affected by cutaneous T-cell lymphoma, as well as cutaneous T-cell lymphoma treatment information and additional resources. (cancercare.org)
- It is classified based on genetic abnormalities (changes) in the cancer cells. (oncolink.org)
- Post-essential thrombocythaemia myelofibrosis is a debilitating disease that is long-lasting and may be life-threatening because it can lead to severe anaemia (low red-blood-cell counts) and infections, and can result in leukaemia (cancer of the white blood cells). (europa.eu)
- National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines also recommend the use of serum free light chain assay and plasma cell fluorescence in situ hybridization (FISH) on bone marrow: del 13, del 17p13, t(4;14), t(11;14), t(14;16), t(14;20), 1q21 amplification, 1p deletion as part of the initial diagnostic workup. (medscape.com)
- On the other hand, the infiltration of organs by a monoclonal population of aberrant cells, the possibility of lethal evolution, and the cancer-based modalities of successful treatment are all consistent with a neoplastic process. (medscape.com)
- 60 Years Young: The Evolving Role of Allogeneic Hematopoietic Stem Cell Transplantation in Cancer Immunotherapy. (broadinstitute.org)
- Dr. Thomas, "father of bone marrow transplantation," first developed and reported this technique in 1957, and in the ensuing decades, this seminal study has impacted fundamental work in hematology and cancer research, including advances in hematopoiesis, stem cell biology, tumor immunology, and T-cell biology. (broadinstitute.org)
- We've screened more than 1,275 cancer cell lines as part of the Cancer Dependency Map (DepMap). (broadinstitute.org)
- However, with cancer, the immune system has trouble eliminating these cancer cells because of the way cancer cells are able to hide and trick the immune system in order to survive. (northside.com)
- Stopping or slowing the growth of cancer cells. (northside.com)
- Boosting the immune system's ability to get rid of cancer cells. (northside.com)
- An immune checkpoint inhibitor is a drug - often made of antibodies - that unleashes an immune system attack on cancer cells. (northside.com)
- Cytokines are man-made versions of the natural proteins interferon and interleukin found in the body that activate the immune system to help it attack cancer cells. (northside.com)
- Bispecific monoclonal antibodies are biologic agents (proteins) given by IV that attach to both immune cells and cancer cells and bring them together in proximity to strengthen the immune system's ability to fight cancer. (northside.com)
- With immunotherapy, instead of directly targeting cancer cells themselves, we indirectly boost one's immune system to fight the cancer. (northside.com)
- Northside Hospital Cancer Institute is among select centers in the country offering chimeric antigen receptor (CAR) T-cell therapy, one of the most promising cell-based cancer immunotherapies available. (northside.com)
Autologous hematopoietic3
- and those transplanted with autologous hematopoietic stem cells. (cancernetwork.com)
- Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
- There are no contraindications to autologous hematopoietic stem cell transplantation. (msdmanuals.com)
Curative1
- Background: Allogeneic hematopoietic stem cell transplantation (alloHCT) is potentially curative but with known negative effects on quality of life. (cdc.gov)
Peripheral blood stem1
- Here, we report transmission of dengue virus to a peripheral blood stem cell recipient by a donor who had recently traveled to an area to which the virus is endemic. (cdc.gov)
Therapies3
- Ramos CA, Asgari Z, Liu E, Yvon E, Heslop HE, Rooney CM, Brenner MK, Dotti G " An inducible caspase 9 suicide gene to improve the safety of mesenchymal stromal cell therapies. . (bcm.edu)
- The present report aims to provide a comprehensive analysis of the current situation and facilitate a forward-looking discussion on actions for improving access to transplantation therapies. (who.int)
- Gene and cell therapies present novel alternatives to disease management, offering the promise of a single treatment and a lifelong cure. (bvsalud.org)
Blood cells and platelets2
- Evans syndrome is an autoimmune disease in which an individual's immune system attacks their own red blood cells and platelets, the syndrome can include immune neutropenia. (wikipedia.org)
- It also makes it harder for the bone marrow to make healthy blood cells and platelets. (medlineplus.gov)
Diffuse Large B-3
- The most common non-Hodgkin lymphoma diagnoses in children are Burkitt lymphoma, diffuse large B-cell lymphoma, lymphoblastic lymphoma, and anaplastic large cell lymphoma. (dana-farber.org)
- Primary central nervous system lymphoma in children is usually of the diffuse large B-cell lymphoma type. (dana-farber.org)
- Correlative analyses of patient and clinical characteristics associated with efficacy in tisagenlecleucel-treated relapsed/refractory diffuse large B-cell lymphoma patients in the JULIET trial. (uni-koeln.de)
Cancers1
- Myelodysplastic syndromes (MDS) are a group of blood cancers in which your bone marrow doesn't make enough healthy blood cells. (healthline.com)
Myeloid4
- Subset analysis of the engrafted cells using a multiparametric system enabling a combined analysis of morphology, immunophenotyping and FISH showed that both T and B lymphocytes and myeloid cells were of donor origin in two patients, while T lymphocytes and myeloid cells were of donor origin in the third. (nih.gov)
- Myeloid sarcoma (MS), also known as granulocytic sarcoma or chloroma, is a rare extramedullary tumor composed of immature myeloid cells at different stages of differentiation which can involve any site of the body. (haematologica.org)
- Myeloid cells are immature blood cells that would normally become granulocytes or monocytes. (healthline.com)
- Long term maintenance of myeloid leukemic stem cells cultured with unrelated human mesenchymal stromal cells. (stembook.org)
Therapeutics1
- Although challenges remain, investment in the field has started to bear fruit, with a number of gene and cell therapeutics reaching the market in the past decade. (bvsalud.org)
Biopsy2
- Additional tests used to eliminate the possibility of other conditions include a computed tomography (CT) scan and a biopsy of bone marrow. (wikipedia.org)
- Bone marrow aspiration and biopsy with cytogenetic studies are required in most, but not all, patients. (medscape.com)
Organs6
- In myelofibrosis, some immature blood cells migrate from the bone marrow to other organs, such as the spleen and liver, where they mature. (europa.eu)
- Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
- A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
- This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
- The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
- The transplantation of human tissues, organs or cells is an established form of treatment that has been acknowledged as the best and very often only life-saving therapy for several serious and life-threatening congenital, inherited and acquired diseases and injuries. (who.int)
20001
- Bone Marrow Transplantation (2000) 25, 807-813. (nature.com)
Adults4
- Bone marrow is the soft, spongy tissue found inside most bones in children and in the front chest bone (sternum) and the pelvis bones in adults. (medlineplus.gov)
- There are also rare T-cell lymphomas that are more frequently seen in adults but occasionally occur in children. (dana-farber.org)
- A potential future source of stem cells is induced pluripotent stem cells (certain cells taken from adults and reprogrammed to act like stem cells). (msdmanuals.com)
- The benefits of human tissue transplantation can be seen in both children and adults, including in survival rates following severe burn trauma, recovery of movement, closure of chronic wounds, rehabilitation of heart function and restoration of sight. (who.int)
Immunology1
- The aim of the academic journal is to provide a platform for researchers, scientists, physicians, and other health professionals to find latest research information in the areas of stem cell research, transplantations such as stem cell transplantation, transplantation immunology, kidney transplantation and its treatment. (slideshare.net)
Opportunistic infections1
- This article contains highlights of "Guidelines for Pre- allogeneic or autologous, depending on the source of venting Opportunistic Infections among Hematopoi- the transplanted hematopoietic progenitor cells. (cdc.gov)
Platelet1
- Gurkan E, Patah PA, Saliba RM, Ramos CA, Anderson BS, Champlin R, de Lima M, Lichtiger B " Efficacy of prophylactic transfusions using single donor apheresis platelets versus pooled platelet concentrates in AML/MDS patients receiving allogeneic hematopoietic stem cell transplantation. . (bcm.edu)
Stromal1
- 6 In addition, independent annexin V/Hoechst assays of primary T-PLL cells on NK-Tert stromal support demonstrated modest single-agent activity of ibrutinib ( Figure 1D , Online Supplementary Figure S2A ). (haematologica.org)
Severe1
- Paroxysmal nocturnal hemoglobinuria (PNH) is a rare hematological disorder characterized by complement-mediated intravascular hemolysis, bone marrow failure, and severe thrombophilia ( 1 ). (frontiersin.org)
Immature blood cells2
- MDS is also associated with high levels of immature blood cells called blasts. (healthline.com)
- Myelofibrosis is a disease in which the bone marrow (the spongy tissue inside the large bones) becomes dense and fibrous, and starts producing abnormal immature blood cells that replace the normal blood cells. (europa.eu)
Lymphoma2
- Oncology social workers help you cope with the emotional and practical challenges of cutaneous t-cell lymphoma. (cancercare.org)
- These diseases include mycosis fungoides and subcutaneous panniculitis-like T-cell lymphoma. (dana-farber.org)
Reactivation1
- One concern about the procedure is that immune cells in cord blood do not have experience with the viruses responsible for latent infections, leading to a higher percentage of naive T cells and thus increased vulnerability to reactivation of cytomegalovirus or Epstein-Barr virus infection. (msdmanuals.com)
Recipients2
- In May 2010, the Sixty-third World Health Assembly adopted resolution WHA63.22,1 in which it endorsed the updated WHO Guiding Principles on Human Cell, Tissue and Organ Transplantation and provided strategic directions to support progress in human organ, tissue and cell donation with the aim of maximizing the benefits of transplantation, meeting the needs of recipients, protecting donors and ensuring the dignity of all involved. (who.int)
- Corneal disease (scarring or perforation) can be successfully addressed through transplantation in 80% of affected individuals.3 Tissue transplantation allows many recipients to return to economically productive lives and promotes their independence. (who.int)