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  • Total Body Irradi
  • The goal of this clinical research study is to find out the best dose of cyclophosphamide that can be given with fludarabine, antithymocyte globulin (ATG), and low-dose total body irradiation (TBI) to patients before a bone marrow transplant to decrease the risks related to the transplant while not decreasing the effectiveness of the transplant from an unrelated donor. (clinicaltrials.gov)
  • These so-called myeloablative conditioning regimens most commonly use the marrow-toxic agents busulfan or total body irradiation (TBI), usually in combination with high-dose cyclophosphamide. (oncologynurseadvisor.com)
  • HSCT
  • In recent years, especially after the advent of reduced intensity conditioning in the late 1990s, allogeneic HSCT is increasingly used in older patients and as an effective salvage strategy for patients with lymphoma or myeloma not responding to chemotherapy or autologous HSCT. (omicsonline.org)
  • Infection and graft-versus-host disease are major complications of allogeneic HSCT. (wikipedia.org)
  • However, for other cancers such as acute myeloid leukemia, the reduced mortality of the autogenous relative to allogeneic HSCT may be outweighed by an increased likelihood of cancer relapse and related mortality, and therefore the allogeneic treatment may be preferred for those conditions. (wikipedia.org)
  • graft
  • 11,Recipients of T-cell-depleted bone marrow allografts have a decreased risk of developing graft-vs-host disease,[17,but experience delayed immune reconstitution and have an increased risk of infections, graft failure, and relapse. (cancernetwork.com)
  • chemotherapy
  • It involves the administration of lymphohematopoietic cells after immunosuppressive chemotherapy or radiochemotherapy, to establish new donor-derived bone marrow and immune functions. (oncologynurseadvisor.com)
  • Treatment may involve some combination of chemotherapy, radiation therapy, targeted therapy, and bone marrow transplant, in addition to supportive care and palliative care as needed. (wikipedia.org)
  • The patient is then treated with high-dose chemotherapy with or without radiotherapy with the intention of eradicating the patient's malignant cell population at the cost of partial or complete bone marrow ablation (destruction of patient's bone marrow's ability to grow new blood cells). (wikipedia.org)
  • leukemia
  • Acute myeloblastic leukemia (AML) is a group of malignant bone marrow neoplasms of myeloid precursors of white blood cells. (wikipedia.org)
  • Leukemia, also spelled leukaemia, is a group of cancers that usually begin in the bone marrow and result in high numbers of abnormal white blood cells. (wikipedia.org)
  • By 1963 he "shook the medical world" when he announced he had cured a patient of leukemia by means of a bone marrow transplant. (wikipedia.org)
  • grafts
  • Over time, it becomes clear that several immunosuppressive drugs such as cyclophosphamide and fludarabine, would allow engraftment of allogeneic grafts in the absence of myeloablation. (oncologynurseadvisor.com)
  • myeloid
  • This divides leukemias into lymphoblastic or lymphocytic leukemias and myeloid or myelogenous leukemias: In lymphoblastic or lymphocytic leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. (wikipedia.org)
  • In myeloid or myelogenous leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (wikipedia.org)
  • malignant
  • 1 Frequent neurological sequelae in the early period after allogeneic BMT include encephalopathy, cerebrovascular accidents, central nervous system (CNS) infections, and recurrence of the malignant disease. (ahajournals.org)
  • A diagnosis of Waldenström's macroglobulinemia depends on a significant monoclonal IgM spike evident in blood tests and malignant cells consistent with the disease in bone marrow biopsy samples. (wikipedia.org)
  • puncture
  • Bone marrow aspiration is carried out by a puncture on the level of the sternum or the posterior iliac peaks under local anesthesia by the doctor. (omicsonline.org)
  • relapse
  • For those diseases curable with conventional dose therapy, such as aggressive lymphomas and many acute leukemias, allogeneic BMT is reserved for, and is often the treatment of choice, at initial relapse. (oncologynurseadvisor.com)
  • 1968
  • This significant discovery led to the first human bone marrow transplant by E. Donnal Thomas in 1968, which although successful in saving lives, has generated much controversy since. (wikipedia.org)
  • Methods
  • Diagnostic methods include blood analysis, bone marrow aspirate for cytochemical, immunological and cytogeneticalanalysis, and cerebrospinal fluid (CSF) investigations. (wikipedia.org)