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  • 2016
  • In 2006 Eaves retired as required by provincial law at that time, becoming Professor Emeritus of Hematology and spending more time on several companies he founded to further the fields of cellular therapy and regenerative medicine - STEMCELL Technologies, STEMSOFT Software Inc. and Malachite Management Inc. These companies continue to grow under his leadership and by 2016, STEMCELL had over 900 employees making Canada's largest biotechnology company. (wikipedia.org)
  • In 2016, STEMCELL was awarded overall Exporter of the Year, as well as won in the Advancing Technology & Innovation category, while Dr. Eaves won in the Leadership category at the BC Export Awards. (wikipedia.org)
  • aplastic anemia
  • Candidates for HSCTs include pediatric cases where the patient has an inborn defect such as severe combined immunodeficiency or congenital neutropenia with defective stem cells, and also children or adults with aplastic anemia who have lost their stem cells after birth. (wikipedia.org)
  • Aplastic anemia is a rare disease in which the bone marrow and the hematopoietic stem cells that reside there are damaged. (wikipedia.org)
  • Aplastic anemia involves all different cell lines. (wikipedia.org)
  • The following tests aid in determining differential diagnosis for aplastic anemia: Bone marrow aspirate and biospy: to rule out other causes of pancytopenia (i.e. neoplastic infiltration or significant myelofibrosis). (wikipedia.org)
  • hematologic
  • Because of the failure of hematologic components to develop-white blood cells, red blood cells, and platelets-the body's capabilities to fight infection, deliver oxygen, and form clots are all diminished. (wikipedia.org)
  • differentiation
  • ABCG2 is a selectable marker for enhanced multilineage differentiation potential in periodontal ligament stem cells. (stembook.org)
  • Hematopoietic stem cell (HSC) fate decisions between self-renewal and commitment toward differentiation are tightly regulated in vivo. (semanticscholar.org)
  • Septin 6 regulates engraftment and lymphoid differentiation potential of murine long-term hematopoietic stem cells. (amedeo.com)
  • This atypical molecular pattern includes the coexpression of cell surface markers clusters of differentiation 5 (CD5) and 23. (wikipedia.org)
  • In CLL, the lymphocytes are genetically clonal, of the B cell lineage (expressing marker molecules clusters of differentiation 19 and 20), and characteristically express the marker molecules CD5 and CD23. (wikipedia.org)
  • In Cooperation with Karl Welte and his colleagues at MSKCC the purification and molecular and biological characterization of cytokines, important regulators of cell division, differentiation and migration, were the focus of his work in the following years at MSKCC. (wikipedia.org)
  • multipotent
  • In this paradigm multipotent or unipotent cells differentiate into a specific cell type in the lab or after reaching the site of injury (via local or systemic administration). (wikipedia.org)
  • gene
  • The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells. (wikipedia.org)
  • The lack of recognition of a T cell to this self antigen is the reason why allogeneic stem cell transplantation for an HLA matched gene or a developing fetus's MiHAs during pregnancy may not be recognized by T cells and marked as foreign leading to an immune response. (wikipedia.org)
  • The male bone marrow cells were found to be presenting a peptide in the MHC groove encoded by a gene on Y chromosome. (wikipedia.org)
  • Gene therapy is the therapeutic delivery of nucleic acid into a patient's cells as a drug to treat disease. (wikipedia.org)
  • The first attempt, an unsuccessful one, at gene therapy (as well as the first case of medical transfer of foreign genes into humans not counting organ transplantation) was performed by Martin Cline on 10 July 1980. (wikipedia.org)
  • Mertelsmann is known for his scientific works in the fields of hematology, oncology, gene therapy and stem cell transplantation. (wikipedia.org)
  • induce
  • The recognition of a mature T cell to this self antigen should not induce an immune response. (wikipedia.org)
  • Pharmacological activation of endogenous neural stem cells has been reported to induce neuroprotection and behavioral recovery in adult rat models of neurological disorder. (wikipedia.org)
  • chronic
  • Iron overload due to multiple transfusions for chronic anemia (eg, thalassemia or sickle cell disorder) can be treated with chelation therapy. (medscape.com)
  • Although we mostly deal with candidiasis and aspergillosis, the pivotal and sequential roles of the various populations of Treg cells that we discuss here may not be an exception but the rule because most fungal-but also nonfungal and chronic-infections proceed through various stages and therefore require various layers of regulation ( 6 , 7 , 8 ). (jimmunol.org)
  • Chronic lymphocytic leukemia (CLL) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell). (wikipedia.org)
  • blood
  • By reducing the number of white blood cells included in the blood taken during the stem cell collection process, and replacing them with a smaller amount of white blood cells collected prior to stem cell donation, the stem cell transplant may be less likely to cause severe complications for the recipient. (clinicaltrials.gov)
  • After the initial donation, donors will receive injections of filgrastim to release bone marrow cells into the blood. (clinicaltrials.gov)
  • After 5 days of filgrastim injections, donors will have apheresis again to donate stem cells that are present in the blood. (clinicaltrials.gov)
  • Recipients will provide an initial donation of white blood cells to be used for research purposes only. (clinicaltrials.gov)
  • After the initial chemotherapy, participants will receive the donated white blood cells and stem cells as a single infusion. (clinicaltrials.gov)
  • After the stem cell and white blood cell transplant, participants will have regular doses of cyclosporine and methotrexate to prevent rejection of the donor cells. (clinicaltrials.gov)
  • Persistent changes in circulating white blood cell populations after splenectomy. (amedeo.com)
  • It is best to administer packed red blood cells slowly to avoid cardiac stress. (medscape.com)
  • Therefore, one should slowly transfuse half units of packed red blood cells to prevent rapid destruction of transfused blood. (medscape.com)
  • A transfusion requirement in the absence of blood loss or bone marrow aplasia would suggest hemolysis. (medscape.com)
  • The Red Blood Cell Membrane and Its Disorders: Hereditary Spherocytosis, Elliptocytosis, and Related Diseases. (medscape.com)
  • Biology of Blood and Marrow Transplantation. (wikipedia.org)
  • CLL results in the build up of B cell lymphocytes in the bone marrow, lymph nodes, and blood. (wikipedia.org)
  • These cells do not function well and crowd out healthy blood cells. (wikipedia.org)
  • Diagnosis is typically based on blood tests finding high numbers of mature lymphocytes and smudge cells. (wikipedia.org)
  • Most people are diagnosed without symptoms as the result of a routine blood test that shows a high white blood cell count. (wikipedia.org)
  • Less commonly, CLL may present with enlarged lymph nodes without a high white blood cell count or no evidence of the disease in the blood. (wikipedia.org)
  • CLL is usually first suspected by a diagnosis of lymphocytosis, an increase in a type of white blood cell, on a complete blood count test. (wikipedia.org)
  • Most often the lymphocyte count is greater than 5000 cells per microliter (µl) of blood, but can be much higher. (wikipedia.org)
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • Treatment with androgens and hematopoietic (blood cell) growth factors can help bone marrow failure temporarily, but the long-term treatment is bone marrow transplant if a donor is available. (wikipedia.org)
  • While at birth, blood count is usually normal, macrocytosis/megaloblastic anemia, defined as unusually large red blood cells, is the first detected abnormality, often within the first decade of life (median age of onset is 7 years). (wikipedia.org)
  • The Worldwide Network for Blood and Marrow Transplantation reported the millionth transplant to have been undertaken in December 2012. (wikipedia.org)
  • The patient's own stored stem cells are then transfused into his/her bloodstream, where they replace destroyed tissue and resume the patient's normal blood cell production. (wikipedia.org)
  • This causes a deficiency of all three blood cell types (pancytopenia): red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). (wikipedia.org)
  • Aplastic refers to inability of the stem cells to generate mature blood cells. (wikipedia.org)
  • Low white blood cell counts (leukocytopenia) if present leads to an increased risk of infections which can be severe. (wikipedia.org)
  • Because it infects red blood cells as a result of the affinity for the P antigen, Parvovirus causes complete cessation of red blood cell production. (wikipedia.org)
  • In most cases, this goes unnoticed, as red blood cells live on average 120 days, and the drop in production does not significantly affect the total number of circulating red blood cells. (wikipedia.org)
  • citation needed] More frequently parvovirus B19 is associated with aplastic crisis which involves only the red blood cells ( despite the name). (wikipedia.org)
  • Intact females, if not mated, will remain in heat, and after some time the high levels of estrogen will cause the bone marrow to stop producing red blood cells. (wikipedia.org)
  • In recognition of his research accomplishments and leadership in moving basic science discoveries in stem cell biology into the clinic, he was elected President of the International Society of Cellular Therapy (1995-1997), Treasurer of the Foundation for the Accreditation of Cellular Therapy (1995-2002) and President of the American Society of Blood and Marrow Transplantation (1999-2000). (wikipedia.org)
  • These donated white blood cells contain cells of the immune system that can recognize and destroy cancer cells. (wikipedia.org)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • Pavletic's research also includes pioneering work on the use of peripheral blood cells in allogeneic stem cell transplantation as a form of cancer treatment, as opposed to the use of stem cells from the bone marrow. (wikipedia.org)
  • immune
  • Najar M, Raicevic G, Fayyad-Kazan H, Bron D, Toungouz M, Lagneaux L. Mesenchymal stromal cells and immunomodulation: a gathering of regulatory immune cells. (springer.com)
  • Immune-related antigens, surface molecules and regulatory factors in human-derived mesenchymal stromal cells: the expression and impact of inflammatory priming. (springer.com)
  • It also stops the patient's immune system from rejecting the donor's stem cells. (clinicaltrials.gov)
  • Certain immune cells, called T cells, contained in the donor HCT graft can cause a "graft versus leukemia" (GVL) effect which eliminates leukemic cells. (damonrunyon.org)
  • Therapies that use cancer-recognizing immune T cells are especially promising. (damonrunyon.org)
  • Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells. (bioportfolio.com)
  • In this article we review evidence supporting opposing roles for IDO-dependent immune regulation-including the generation of regulatory T (Treg) 3 cells ( 4 , 5 )-and the IL-23/Th17 axis in controlling inflammation to specific fungi. (jimmunol.org)
  • The inflammatory response, initiated by cells of the innate immune system, is followed by adaptive immunity, which responds to and at the same time regulates signals emanating from the innate system. (jimmunol.org)
  • In these cases, the recipient's immune system is usually destroyed with radiation or chemotherapy before the transplantation. (wikipedia.org)
  • These antigens are either ubiquitously expressed in most tissue like skin and intestines or restrictively expressed in the immune cells. (wikipedia.org)
  • Although B cell receptors can also recognize MHCs, immune responses seem to only be elicited by T cells. (wikipedia.org)
  • The consequences of an immune response are seen in allogeneic hematopoietic stem cell transplantation (HCT) when the peptides encoded by polymorphic genes differ between the recipient and the donor T cells. (wikipedia.org)
  • The significance of MiHAs in an immune response was recognized following transplantation. (wikipedia.org)
  • The paracrine soluble factors produced by stem cells, known as the stem cell secretome, has been found to be the predominant mechanism by which stem cell-based therapies mediate their effects in degenerative, auto-immune and inflammatory diseases. (wikipedia.org)
  • clonal
  • Bone-marrow studies showed myelodysplasia, erythroblastosis, and clonal evolution of del(20)(q11.2q13.3). (springer.com)
  • In addition, all the CLL cells within one individual are clonal, that is, genetically identical. (wikipedia.org)