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  • GVHD
  • It then moves on to discuss the immunobiology mechanisms that influence graft-versus-host disease (GVHD), graft-versus-leukemia effect, and transplantation success. (elsevier.com)
  • To test this hypothesis in preclinical settings, we have previously developed several experimental models of GVHD using TK+ T-cells in mice. (bioportfolio.com)
  • A low incidence of acute GVHD could be obtained by the use of Rituximab before and after the transplantation as reported by the MD Anderson's experience in several hematological malignancies including follicular lymphoma. (knowcancer.com)
  • Because of their immunomodulatory and anti-inflammatory effects, mesenchymal stem cells (MSCs) have been considered as potential therapeutic agents for treating immune-related or autoimmune diseases, such as graft-versus-host disease (GVHD). (frontiersin.org)
  • It may be an immune disorder involving immune complex deposition, B cells, regulatory T cells (Tregs), and Th1 cytokines and be a manifestation of chronic GVHD. (frontiersin.org)
  • CD4+CD25+ regulatory T cells (Treg) can be used to suppress GvHD without loss of beneficial GvT effect. (wikipedia.org)
  • As a result, the donor T cells can target the recipients cells called graft-versus-host disease (GVHD). (wikipedia.org)
  • Some of these antigens are ubiquitiouly expressed in nucleated male cells, and the presence of these antigens has been associated with a greater risk of developing GVHD allogeneic stem cell transplantation for a HLA matched gene when there's a male recipient and female donor. (wikipedia.org)
  • Tumor
  • The biology of GvT response still isn't fully understood but it is probable that the reaction with polymorphic minor histocompatibility antigens expressed either specifically on hematopoietic cells or more widely on a number of tissue cells or tumor-associated antigens is involved. (wikipedia.org)
  • A myeloid sarcoma (chloroma, granulocytic sarcoma, extramedullary myeloid tumor), is a solid tumor composed of immature white blood cells called myeloblasts. (wikipedia.org)
  • A single cancer cell is invisible to the naked eye but can regrow into a new tumor, a process called recurrence. (wikipedia.org)
  • monoclonal
  • Some cases of reactivation of the disease have been reported Alemtuzumab is a recombinant DNA-derived humanized IgG1 kappa monoclonal antibody that is directed against the 21-28 kDa cell surface glycoprotein CD52. (wikipedia.org)
  • irradiation
  • Radiation therapy (also called radiotherapy, X-ray therapy, or irradiation) is the use of ionizing radiation to kill cancer cells and shrink tumors. (wikipedia.org)
  • patient and donor
  • With advances in DNA sequencing technology we now have the capacity to perform genome-wide analysis in a high throughput fashion, permitting a detailed genetic analysis of patient and donor prior to transplantation. (bloodjournal.org)
  • The favored hypothesis is a depletion of patient and donor B cells reducing the presentation of minor histocompatibility alloantigens. (knowcancer.com)
  • transplants
  • Bone marrow transplants have been found to be effective, along with some other kinds of human cell therapy - for example in treating damaged knee cartilage. (wikipedia.org)
  • bone marrow failure
  • citation needed] As FA is now known to affect DNA repair, specifically nonhomologous end joining, and given the current knowledge about dynamic cell division in the bone marrow, finding patients are more likely to develop bone marrow failure, myelodysplastic syndromes, and acute myeloid leukemia (AML) is not surprising. (wikipedia.org)
  • Biological
  • These metabolic processes are important for cellular respiration-the conversion of biochemical energy from nutrients into adenosine triphosphate (ATP) which can then be used to carry out numerous biological reactions within a cell. (wikipedia.org)
  • contrast
  • In contrast, and indeed the main difference between the two molecules, ICAM molecules are involved with naive T-cell re-circulation. (wikipedia.org)
  • In contrast, pure red cell aplasia is characterized by reduction in red cells only. (wikipedia.org)
  • In contrast, proteins from outside cell is internalized and then binds to MHC class II molecule. (wikipedia.org)
  • markers
  • This atypical molecular pattern includes the coexpression of cell surface markers clusters of differentiation 5 (CD5) and 23. (wikipedia.org)
  • It is positive for the B-cell markers CD10, CD19, CD22, and usually CD20, but almost always negative for CD5. (wikipedia.org)
  • gene
  • We have developed a strategy of alloreactive T-cell depletion, using T-cells expressing the Herpes simplex thymidine kinase (TK) suicide gene combined with a ganciclovir (GCV) treatment. (bioportfolio.com)
  • Addressin also known as mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a protein that in humans is encoded by the MADCAM1 gene. (wikipedia.org)
  • The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4 / beta7), L-selectin, and VLA-4 (alpha4 / beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. (wikipedia.org)
  • Killer cell immunoglobulin-like receptor 3DL3 is a protein that in humans is encoded by the KIR3DL3 gene. (wikipedia.org)
  • The lack of recognition of a T cell to this self antigen is the reason why allogeneic stem cell transplantation for an HLA matched gene or a developing fetus's MiHAs during pregnancy may not be recognized by T cells and marked as foreign leading to an immune response. (wikipedia.org)
  • The male bone marrow cells were found to be presenting a peptide in the MHC groove encoded by a gene on Y chromosome. (wikipedia.org)
  • Lymphoma
  • The lack of the normal distribution of these B cells is one basis for demonstrating clonality, the key element for establishing a diagnosis of any B cell malignancy (B cell non-Hodgkin lymphoma). (wikipedia.org)
  • Alemtuzumab is a drug used in the treatment of chronic lymphocytic leukemia (CLL), cutaneous T-cell lymphoma (CTCL) and T-cell lymphoma under the trade names Campath, MabCampath and Campath-1H, and in the treatment of multiple sclerosis as Lemtrada. (wikipedia.org)
  • It is defined as a lymphoma of follicle center B-cells (centrocytes and centroblasts), which has at least a partially follicular pattern. (wikipedia.org)
  • Grade 3 is further subdivided into: grade 3A (centrocytes still present) grade 3B (the follicles consist almost entirely of centroblasts) The WHO 2008 update classifies grades 1 and 2 now as low grade follicular lymphoma, grade 3A as high grade follicular lymphoma, and grade 3B as Diffuse Large B Cell Lymphoma (DLBCL). (wikipedia.org)
  • Healthcare
  • In mainstream medicine, cell therapy is supported by a distinct healthcare industry which sees strong prospects for future growth. (wikipedia.org)
  • undergo
  • This includes cells that naturally secrete the relevant therapeutic factors, or which undergo epigenetic changes or genetic engineering that causes the cells to release large quantities of a specific molecule. (wikipedia.org)
  • treatment
  • In recent times, cell therapy using human material has been recognized as an important field in the treatment of human disease. (wikipedia.org)
  • The experimental field of Stem cell therapy has shown promise for new types of treatment. (wikipedia.org)
  • leukemic cells
  • in other words, it is a solid collection of leukemic cells occurring outside of the bone marrow. (wikipedia.org)
  • Specific terms which overlap with granulocytic sarcoma include: Leukemia cutis, describing infiltration of the dermis (skin) by leukemic cells, which is also referred to as cutaneous granulocytic sarcoma. (wikipedia.org)
  • Meningeal leukemia, or invasion of the subarachnoid space by leukemic cells, is usually considered distinct from chloroma, although very rarely occurring solid central nervous system tumors composed of leukemic cells can be termed chloromas. (wikipedia.org)
  • mononuclear cells
  • The present invention provides a method of transplanting hematopoietic system reconstituting cells from a donor into an allogeneic recipient comprising administering to the recipient, prior to the administration of the hematopoietic system reconstituting cells, an amount of mononuclear cells which are. (google.com)
  • 2. The method of claim 1, wherein the mononuclear cells are T cells. (google.com)
  • 6. The method of claim 1, wherein the mononuclear cells are treated by exposure to a source of ionizing radiation. (google.com)
  • 12. The method of claim 1, wherein the treated mononuclear cells are administered to the recipient up to ten days prior to administration of the hematopoietic system reconstituting cells. (google.com)
  • 13. The method of claim 1, wherein the treated mononuclear cells are administered to the recipient between one and five days prior to the administration of the hematopoietic system reconstituting cells. (google.com)
  • 14. The method of claim 1, wherein the hematopoietic system reconstituting cells and the treated mononuclear cells are from the same donor source. (google.com)
  • 15. The method of claim 1, wherein the amount of treated mononuclear cells administered to the recipient is between 0.05 10 6 and 30 10 6 cells/kg of the recipient's body weight. (google.com)
  • tissue
  • To measure the decay of persisting HIV by sequencing and quantitating HIV RNA in plasma, and HIV DNA and RNA in peripheral blood cells including CD4+ T cells and CD4+ T cell subsets, as well as in tissue cells derived from fine needle lymph node aspirates, and/or bone marrow aspirates, and/or rectal tissue. (clinicaltrials.gov)
  • These cells then integrate into the site of injury, replacing damaged tissue, and thus facilitate improved function of the organ or tissue. (wikipedia.org)
  • For this reason, the pathologist will examine the surgical specimen to determine if a margin of healthy tissue is present, thus decreasing the chance that microscopic cancer cells are left in the patient. (wikipedia.org)
  • Radiation therapy injures or destroys cells in the area being treated (the "target tissue") by damaging their genetic material, making it impossible for these cells to continue to grow and divide. (wikipedia.org)
  • multipotent
  • In this paradigm multipotent or unipotent cells differentiate into a specific cell type in the lab or after reaching the site of injury (via local or systemic administration). (wikipedia.org)
  • Therapy
  • Transplantation of OEG into the spinal cord has become a possible therapy for spinal cord damage and other neural diseases in animal models. (wikipedia.org)
  • Cell therapy originated in the nineteenth century when scientists experimented by injecting animal material in an attempt to prevent and treat illness. (wikipedia.org)
  • Today two distinct categories of cell therapy are recognized. (wikipedia.org)
  • The first category is cell therapy in mainstream medicine. (wikipedia.org)
  • Cell therapy can be defined as therapy in which cellular material is injected into a patient. (wikipedia.org)
  • The origins of cell therapy can perhaps be traced to the nineteenth century, when Charles-Édouard Brown-Séquard (1817-1894) injected animal testicle extracts in an attempt to stop the effects of aging. (wikipedia.org)
  • In 1931 Paul Niehans (1882-1971) - who has been called the inventor of cell therapy - attempted to cure a patient by injecting material from calf embryos. (wikipedia.org)
  • In allogeneic cell therapy the donor is a different person to the recipient of the cells. (wikipedia.org)
  • blood
  • Mild regimens are associated with no significant neutropenia (average neutrophil nadirs of ∼1,000/μl) and have minimal requirements for platelet or red blood cell transfusions. (wiley.com)
  • While at birth, blood count is usually normal, macrocytosis/megaloblastic anemia, defined as unusually large red blood cells, is the first detected abnormality, often within the first decade of life (median age of onset is 7 years). (wikipedia.org)
  • Autoimmune hemolytic anemia is a condition in which the red blood cells that normally carry oxygen and carbon dioxide are destroyed by an autoimmune process. (wikipedia.org)
  • These cells do not function well and crowd out healthy blood cells. (wikipedia.org)
  • Most people are diagnosed without symptoms as the result of a routine blood test that shows a high white blood cell count. (wikipedia.org)
  • Less commonly, CLL may present with enlarged lymph nodes without a high white blood cell count or no evidence of the disease in the blood. (wikipedia.org)
  • CLL is usually first suspected by a diagnosis of lymphocytosis, an increase in a type of white blood cell, on a complete blood count test. (wikipedia.org)
  • Most often the lymphocyte count is greater than 5000 cells per microliter (µl) of blood, but can be much higher. (wikipedia.org)
  • This causes a deficiency of all three blood cell types (pancytopenia): red blood cells (anemia), white blood cells (leukopenia), and platelets (thrombocytopenia). (wikipedia.org)
  • Aplastic refers to inability of the stem cells to generate mature blood cells. (wikipedia.org)
  • Low white blood cell counts (leukocytopenia) if present leads to an increased risk of infections which can be severe. (wikipedia.org)
  • One known cause is an autoimmune disorder in which white blood cells attack the bone marrow. (wikipedia.org)
  • Because it infects red blood cells as a result of the affinity for the P antigen, Parvovirus causes complete cessation of red blood cell production. (wikipedia.org)
  • In most cases, this goes unnoticed, as red blood cells live on average 120 days, and the drop in production does not significantly affect the total number of circulating red blood cells. (wikipedia.org)
  • citation needed] More frequently parvovirus B19 is associated with aplastic crisis which involves only the red blood cells ( despite the name). (wikipedia.org)
  • Intact females, if not mated, will remain in heat, and after some time the high levels of estrogen will cause the bone marrow to stop producing red blood cells. (wikipedia.org)
  • dose
  • In case of previous std-DLI received, the DLI-TK cell dose is adjusted to be below or equal to the maximal cell dose previously received in std-DLI. (bioportfolio.com)