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  • multiple myeloma
  • Similar to other plasma cell dyscrasias that, for example, lead to multiple myeloma, WM is commonly preceded by two clinically asymptomatic but progressively more pre-malignant phases, IgM monoclonal gammopathy of undetermined significance (i.e. (wikipedia.org)
  • differentiate
  • Stem cells have the potential of multi-directional differentiations, and they can differentiate into specialized cells to repair injured tissues under certain conditions [ 1 ]. (medsci.org)
  • Animal experiments have demonstrated that in anoxic environment, implanted stem cells can differentiate and promote neovascularization which effectively increase the blood perfusion in ischemic tissues, and thus inhibit further necrosis of tissues [ 2 , 3 ]. (medsci.org)
  • Mesenchymal stem cells (MSCs) are multipotent stem cells that can differentiate into a variety of cell types. (medsci.org)
  • There are cells in the human body that are capable to renew themselves and differentiate to a diverse range of specialized cell types. (clinicaltrials.gov)
  • In many laboratory studies, it is observed that human bone marrow derived mesenchymal stem cells, transplanted to animals with induced liver damage, differentiate into the albumin producing hepatocytes without fusion. (clinicaltrials.gov)
  • In this paradigm multipotent or unipotent cells differentiate into a specific cell type in the lab or after reaching the site of injury (via local or systemic administration). (wikipedia.org)
  • Since pluripotent stem cells have the ability to differentiate into any type of cell, they are used in the development of medical treatments for a wide range of conditions. (wikipedia.org)
  • citation needed] Possible mechanisms of recovery include: Generation of heart muscle cells Stimulation of growth of new blood vessels to repopulate damaged heart tissue Secretion of growth factors Assistance via some other mechanism It may be possible to have adult bone-marrow cells differentiate into heart muscle cells. (wikipedia.org)
  • treatment
  • The main focuses of research, diagnosis and treatment are on leukemia and lymphomas, malignancies of the gastrointestinal tract, tumors of germ cells (e.g. testicles) and malignancies of bone and connective tissues. (bookinghealth.com)
  • Recently, stem cell transplantation has been a focus in the treatment of some diseases. (medsci.org)
  • He is best known for his research on chronic GVHD, the most common late effect in cancer survivors who underwent allogeneic stem cell transplantations as a form of treatment. (wikipedia.org)
  • The United States Embassy in Zagreb, Croatia, granted Pavletic a United States Government stipend to spend six weeks at the University Hospital Centre Zagreb, Croatia, in 2013, to assist in the establishment of a multidisciplinary center for the treatment of chronic GVHD resulting from allogeneic stem cell transplantations. (wikipedia.org)
  • In recent times, cell therapy using human material has been recognized as an important field in the treatment of human disease. (wikipedia.org)
  • The experimental field of Stem cell therapy has shown promise for new types of treatment. (wikipedia.org)
  • Stem-cell therapy for treatment of myocardial infarction usually makes use of autologous bone-marrow stem cells (a specific type or all), however other types of adult stem cells may be used, such as adipose-derived stem cells. (wikipedia.org)
  • However, for other cancers such as acute myeloid leukemia, the reduced mortality of the autogenous relative to allogeneic HSCT may be outweighed by an increased likelihood of cancer relapse and related mortality, and therefore the allogeneic treatment may be preferred for those conditions. (wikipedia.org)
  • Oncology
  • He is Head of the Division of Hematologic Oncology, Alan Houghton Chair in Immunology, Attending Physician on the Adult Bone Marrow Transplantation Service, and Member at Memorial Sloan Kettering Cancer Center (MSKCC) in New York, New York. (wikipedia.org)
  • He then served as Chief of the Adult Allogeneic Bone Marrow Transplantation Service from 2004-2008 In 2008, van den Brink was named Head of the Division of Hematologic Oncology. (wikipedia.org)
  • He is presently also an Adjunct Professor of Medicine and Oncology at Lombardi Cancer Center, Georgetown University, Washington, D.C. Pavletic's main area of research is in the field of hematopoietic stem cell transplantation for hematologic malignancies, chronic Graft-versus-host disease (GVHD) and transplantation for autoimmune disease, with a particular interest in addressing late effects in cancer therapy survivors. (wikipedia.org)
  • genetically
  • In addition, all the CLL cells within one individual are clonal, that is, genetically identical. (wikipedia.org)
  • In CLL, the lymphocytes are genetically clonal, of the B cell lineage (expressing marker molecules clusters of differentiation 19 and 20), and characteristically express the marker molecules CD5 and CD23. (wikipedia.org)
  • It is contrasted with autotransplantation (from one part of the body to another in the same person), syngeneic transplantation (grafts transplanted between two genetically identical individuals of the same species) and xenotransplantation (from other species). (wikipedia.org)
  • regimen
  • Safety and feasibility of allogeneic transplantations between individuals without need of immunosuppressive drug regimen are proven. (clinicaltrials.gov)
  • In the FLAG-IDA regimen (also called FLAG-Ida, IDA-FLAG, or Ida-FLAG), idarubicin-an anthracycline antibiotic that is able to intercalate DNA and prevent cell division (mitosis)-is added to the standard FLAG regimen. (wikipedia.org)
  • lung
  • GATA2 has recently been implicated in non-small-cell lung cancer - specifically those tumours that are driven by a faulty Ras protein. (wikipedia.org)
  • Examples of surgical procedures for cancer include mastectomy for breast cancer, prostatectomy for prostate cancer, and lung cancer surgery for non-small cell lung cancer. (wikipedia.org)
  • Most recently Dr Moore has been studying the cancer stem cell in lung cancer and ovarian cancer and has developed some novel methods for growing human cancer stem cells in vitro allowing extensive molecular analysis and identification of targets for therapy designed to eliminate this rare cell population that is responsible for aggressive tumor growth and relapse. (wikipedia.org)
  • tissues
  • In order to ensure the quality of donor tissue and reduce contamination and disease transmission risks, three regulations addressing manufacturing activities associated with human cells, tissues, and cellular and tissue-based products (HCT/Ps) were promulgated in May 2005: The first requires companies producing and distributing HCT/Ps to register with the FDA. (wikipedia.org)
  • differentiation
  • In the field of cell transplantation, MSCs have many advantages over other cell types such as easy isolation and culture, rapid in vitro amplification, differentiation potential, and easy collection [ 2 ]. (medsci.org)
  • In Cooperation with Karl Welte and his colleagues at MSKCC the purification and molecular and biological characterization of cytokines, important regulators of cell division, differentiation and migration, were the focus of his work in the following years at MSKCC. (wikipedia.org)
  • This atypical molecular pattern includes the coexpression of cell surface markers clusters of differentiation 5 (CD5) and 23. (wikipedia.org)
  • MSCs
  • MSCs were labeled with green fluorescent protein (GFP) in vitro and injected into nude mice via vena caudalis, and the distribution of MSCs was dynamically monitored at 0, 6, 24, 48, 72 and 96 h after transplantation. (medsci.org)
  • Two weeks after the establishment of a rabbit model of femoral head necrosis, GFP labeled MSCs were injected into these rabbits via ear vein, immunological rejection and graft versus host disease were observed and necrotic and normal femoral heads, bone marrows, lungs, and livers were harvested at 2, 4 and 6 w after transplantation. (medsci.org)
  • Furthermore, the number of MSCs peaked at 6 w after transplantation. (medsci.org)
  • Thus, it is feasible and safe to treat femoral head necrosis by intravenous transplantation of allogeneic MSCs. (medsci.org)
  • Experiments demonstrate the implanted MSCs can not only survive but proliferate in the necrotic femoral head after transplantation, promoting the repair of injured femoral head [ 5 ]. (medsci.org)
  • MSCs are purified from the marrow, cultured and packaged, with up to 10,000 doses derived from a single donor. (wikipedia.org)
  • tumour
  • During his medical training he was greatly influenced by Dr. Ross Langley, a research-oriented hematologist who suggested that Eaves do a PhD at the Princess Margaret Hospital in Toronto where Dr. Robert Bruce was collaborating with Drs. James Till and Ernest McCulloch (Lasker Award) on how different types of cancer chemotherapeutic agents killed tumour stem cells while sparing normal stem cells. (wikipedia.org)
  • undergo
  • This includes cells that naturally secrete the relevant therapeutic factors, or which undergo epigenetic changes or genetic engineering that causes the cells to release large quantities of a specific molecule. (wikipedia.org)
  • induce
  • Pharmacological activation of endogenous neural stem cells has been reported to induce neuroprotection and behavioral recovery in adult rat models of neurological disorder. (wikipedia.org)
  • graft
  • Moreover, no immunological rejection and graft versus host disease were found after transplantation in rabbits. (medsci.org)
  • Molecular mechanisms of B-cell neoplasias were investigated together with Binder, Trepel and Dierks, the pathogenic significance of granulocytes in Graft-versus-host disease with Zeiser and his colleagues. (wikipedia.org)
  • Newer research indicates that other graft-versus-host-disease target organs include the immune system (the hematopoietic system, e.g., the bone marrow and the thymus) itself, and the lungs in the form of immune-mediated pneumonitis. (wikipedia.org)
  • An immuno-competent graft is administered, with viable and functional immune cells. (wikipedia.org)
  • Currently, he is the Head of the Graft-versus-host disease (GVHD) and Autoimmunity Unit and Senior Clinician at the Experimental Transplantation and Immunology Branch of the National Cancer Institute's (NCI) Center for Cancer Research at the U.S. National Institutes of Health (NIH). (wikipedia.org)
  • Another stem-cell therapy called Prochymal, was conditionally approved in Canada in 2012 for the management of acute graft-vs-host disease in children who are unresponsive to steroids. (wikipedia.org)