DoxorubicinChemotherapyHemorrhagic cystitisFludarabineUnusual or allergic reactionSevere allergic reactionAdriamycinDoseAlkylatingAdverse reactionsBone marrowCisplatinHypersensitivityNeutropeniaMethotrexateMedicationsOccurHivesGraftRednessZofranImmunityComplicationsInfectionsDosageSide effectsCancersKidneyAutoimmuneCancerTreatmentLiverClinicalDrugsTreatMedicalGrowthDoctor
Doxorubicin9
- Cyclophosphamide increases the occurrence of heart failure that is caused by doxorubicin ( Adriamycin ), increases the action of blood thinners such as warfarin ( Coumadin ), and decreases the effectiveness of quinolone antibiotics ciprofloxacin ( Cipro , Cipro XR , Proquin XR). (hdkino.org)
- You may experience a serious allergic reaction while you receive a dose of doxorubicin lipid complex injection. (medlineplus.gov)
- Biocon Biologics Ltd), BT-ON013 - following adjuvant chemotherapy with doxorubicin and cyclophosphamide, in combination with paclitaxel or docetaxel - in combination with adjuvant chemotherapy consisting of docetaxel and carboplatin. (who.int)
- This phase I trial studies the side effect and best dose of ibrutinib in combination with rituximab, etoposide, prednisone, vincristine sulfate, cyclophosphamide, and doxorubicin hydrochloride in treating patients with human immunodeficiency virus (HIV)-positive stage II-IV diffuse large B-cell lymphomas. (ucsf.edu)
- Drugs used in chemotherapy, such as etoposide, prednisone, vincristine sulfate, cyclophosphamide, and doxorubicin hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (ucsf.edu)
- To assess the safety and tolerability of ibrutinib and rituximab (R)-dose adjusted (da)-etoposide, prednisone, vincristine sulfate, cyclophosphamide, and doxorubicin hydrochloride (EPOCH) in participants with acquired immunodeficiency syndrome (AIDS)-related lymphomas (ARL). (ucsf.edu)
- Patients receive rituximab intravenously (IV) on day 1 (for CD20 positive patients only), etoposide IV over 96 hours on days 1-4, doxorubicin hydrochloride IV over 96 hours on days 1-4, vincristine sulfate IV over 96 hours on days 1-4, prednisone orally (PO) daily on days 1-5, cyclophosphamide IV over 1 hour on day 5, and ibrutinib PO once daily (QD) on days 1-21. (ucsf.edu)
- Polatuzumab vedotin-piiq injection is also used together with other medicines (eg, rituximab, cyclophosphamide, doxorubicin, and prednisone) to treat previously untreated diffuse large B-cell lymphoma (DLBCL), not otherwise specified (NOS) or high-grade B-cell lymphoma (HGBL), and who have an International Prognostic Index score of 2 or more. (mayoclinic.org)
- She completed first-line treatment with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone and achieved complete remission. (cdc.gov)
Chemotherapy5
- Cyclophosphamide (CP), also known as cytophosphane among other names, is a medication used as chemotherapy and to suppress the immune system. (wikipedia.org)
- The main use of cyclophosphamide is with other chemotherapy agents in the treatment of lymphomas, some forms of brain cancer, neuroblastoma, leukemia and some solid tumors. (wikipedia.org)
- Adverse drug reactions from cyclophosphamide are related to the cumulative medication dose and include chemotherapy-induced nausea and vomiting, bone marrow suppression, stomach ache, hemorrhagic cystitis, diarrhea, darkening of the skin/nails, alopecia (hair loss) or thinning of hair, changes in color and texture of the hair, lethargy, and profound gonadotoxicity. (wikipedia.org)
- When the MAGE-A10ᶜ⁷⁹⁶T cells are available, subjects will undergo lymphodepleting chemotherapy with cyclophosphamide and fludarabine, followed by T cell infusion. (bcan.org)
- Give lymphodepleting chemotherapy (cyclophosphamide 300mg/m 2 /day IV + fludarabine 30mg/m 2 /day IV) for 3 days. (empr.com)
Hemorrhagic cystitis4
- Cyclophosphamide may cause inflammation of the urinary bladder with bleeding (hemorrhagic cystitis ). (hdkino.org)
- Very bad and sometimes deadly urinary tract problems like hemorrhagic cystitis have happened with this medicine (cyclophosphamide capsules). (edrugswiki.com)
- Discontinue cyclophosphamide therapy in case of severe hemorrhagic cystitis. (edrugswiki.com)
- Mesna is used to prevent hemorrhagic cystitis in patients treated with lymphosphamide and cyclophosphamide. (caspianpharma.com)
Fludarabine1
- 4. Subject has history of allergic reactions attributed to compounds of similar chemical or biologic composition to fludarabine, cyclophosphamide or other agents used in the study. (bcan.org)
Unusual or allergic reaction1
- Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. (mayoclinic.org)
Severe allergic reaction2
- Severe allergic reaction. (medicalnewstoday.com)
- A more severe allergic reaction is rare but possible. (medicalnewstoday.com)
Adriamycin1
- I had four treatments of the AC-T (Adriamycin, Cyclophosphamide & Taxol) regimen. (mannorlawgroup.com)
Dose8
- The use of a high dose cyclophosphamide post-transplant in a half matched or haploidentical donor hematopoietic stem cell transplantation reduces GVHD, even after using a reduced conditioning regimen. (wikipedia.org)
- High-dose intravenous cyclophosphamide can cause the syndrome of inappropriate antidiuretic hormone secretion (SIADH) and a potentially fatal hyponatremia when compounded by intravenous fluids administered to prevent drug-induced cystitis. (wikipedia.org)
- The usual initial dose of cyclophosphamide for adults and children is 40-50 mg/kg administered intravenously over 2-5 days in divided doses. (hdkino.org)
- For dose preparation/administration and management of severe adverse reactions: see full labeling. (empr.com)
- Monitoring of complete blood counts is essential during cyclophosphamide treatment so that the dose can be adjusted, if needed. (edrugswiki.com)
- Cyclophosphamide treatment may not be indicated, or should be interrupted, or the dose reduced, in patients who have or who develop a serious infection. (edrugswiki.com)
- We also hypothesized that oral low-dose metronomic cyclophosphamide (mCy) would be safe, would reduce circulating regulatory T cells (T-regs) and would further enhance immunogenicity. (bmj.com)
- To calculate the percentage of participants who receive two or more cycles of R-da-EPOCH, and are able to continue on a minimum dose level of cyclophosphamide of -1 and above after dose adjustments for hematologic toxicities. (ucsf.edu)
Alkylating3
- Cyclophosphamide is in the alkylating agent and nitrogen mustard family of medications. (wikipedia.org)
- Like other alkylating agents, cyclophosphamide is teratogenic and contraindicated in pregnant women (pregnancy category D) except for life-threatening circumstances in the mother. (wikipedia.org)
- Cyclophosphamide is an alkylating agent that prevents cell division by cross-linking DNA strands and thus interfering with DNA replication. (medscape.com)
Adverse reactions7
- Epinephrine, corticosteriods, and antihistamines have been effectively employed to alleviate symptoms (see PACKAGE INSERT for WARNINGS and ADVERSE REACTIONS sections). (globalrph.com)
- KEYTRUDA is a monoclonal antibody that belongs to a class of drugs that bind to either the programmed death receptor-1 (PD-1) or the programmed death ligand 1 (PD-L1), blocking the PD-1/PD-L1 pathway, thereby removing inhibition of the immune response, potentially breaking peripheral tolerance and inducing immune-mediated adverse reactions. (keytrudahcp.com)
- Immune-mediated adverse reactions, which may be severe or fatal, can occur in any organ system or tissue, can affect more than one body system simultaneously, and can occur at any time after starting treatment or after discontinuation of treatment. (keytrudahcp.com)
- Important immune-mediated adverse reactions listed here may not include all possible severe and fatal immune-mediated adverse reactions. (keytrudahcp.com)
- Monitor patients closely for symptoms and signs that may be clinical manifestations of underlying immune-mediated adverse reactions. (keytrudahcp.com)
- In cases of suspected immune-mediated adverse reactions, initiate appropriate workup to exclude alternative etiologies, including infection. (keytrudahcp.com)
- Consider administration of other systemic immunosuppressants in patients whose adverse reactions are not controlled with corticosteroid therapy. (keytrudahcp.com)
Bone marrow3
- Cyclophosphamide suppresses production of blood cells from the bone marrow, including white blood cells (leukopenia), red blood cells ( anemia ) and platelets ( thrombocytopenia ). (hdkino.org)
- Allopurinol (Zyloprim) enhances the ability of cyclophosphamide to reduce production of blood cells from the bone marrow. (hdkino.org)
- Cyclophosphamide can cause myelosuppression (leukopenia, neutropenia, thrombocytopenia and anemia), bone marrow failure, and severe immunosuppression which may lead to serious and sometimes fatal infections, including sepsis and septic shock. (edrugswiki.com)
Cisplatin2
- Anaphylactic-like reactions to cisplatin have been reported. (globalrph.com)
- Due to its unique chemical structure, the chlorine atoms of cisplatin are more subject to chemical displacement reactions by nucleophiles, such as water or sulfhydryl groups, than to enzyme-catalyzed metabolism. (nih.gov)
Hypersensitivity2
- Cyclosporine is a cyclic polypeptide that suppresses some humoral immunity and, to a greater extent, cell-mediated immune reactions such as delayed hypersensitivity, allograft rejection, experimental allergic encephalomyelitis, and graft versus host disease for a variety of organs. (medscape.com)
- Overview of Allergic Reactions Allergic reactions (hypersensitivity reactions) are inappropriate responses of the immune system to a normally harmless substance. (msdmanuals.com)
Neutropenia2
- Additional relative contraindications to the use of cyclophosphamide include lactation, active infection, neutropenia or bladder toxicity. (wikipedia.org)
- G-CSF may be administered to reduce the risks of neutropenia complications associated with cyclophosphamide use. (edrugswiki.com)
Methotrexate1
- Patients receiving glucocorticoids in combination with methotrexate or cyclophosphamide should be treated with T/S three times weekly to reduce the risk for P. carinii pneumonia . (symptoma.com)
Medications2
- Because of its potential side effects such as amenorrhea or ovarian failure, cyclophosphamide is used for early phases of treatment and later substituted by other medications, such as mycophenolic acid or ACA. (wikipedia.org)
- The condition can occur either on its own, or may be linked to certain other factors like immune system disorders, infections (hepatitis B or C), allergic reactions to medications, and certain types of cancers (such as leukemia and lymphoma). (outsourcestrategies.com)
Occur2
- While SIADH has been described primarily with higher doses of cyclophosphamide, it can also occur with the lower doses used in the management of inflammatory disorders. (wikipedia.org)
- Severe allergic reactions also may occur. (hdkino.org)
Hives1
- Allergic reaction is also possible: hives, swelling, rash. (open24hr-online.com)
Graft1
- Graft-versus-host disease (GVHD) is a major barrier for allogeneic stem cell transplant because of the immune reactions of donor T cell against the person receiving them. (wikipedia.org)
Redness1
- As an anti-inflammatory medication, dexamethasone is particularly helpful in reducing swelling and redness from allergic reactions as well as pain from conditions such as arthritis. (imprimedicine.com)
Zofran2
- Do not use this medicine if you are allergic to any ingredients in Zofran. (pharmapassport.com)
- Antineoplastic agents (eg, cyclophosphamide) because their effectiveness may be decreased by Zofran. (metodosanticonceptivos.online)
Immunity3
- The purpose of this study was to investigate whether the Dictyophora echinovolvata spore polysaccharides (DESP) affect the immunity in immunocompromised mice induced by cyclophosphamide (CTX). (bvsalud.org)
- To date, there is no curative treatment for sarcoidosis, but only anti-inflammatory drugs limiting the pathologic impact of sarcoidosis in reducing enhanced immunity reactions, granulomatous formation, and their consequences. (medscape.com)
- [ 1 ] Management is still based on either therapeutic abstention (when the disease is self-limited) or anti-inflammatory drugs that are able to slow down the enhanced immunity reaction responsible for granulomatous process but with only a suppressive effect. (medscape.com)
Complications1
- Allergic reactions, diarrhea, nausea and vomiting are common complications of old age. (caspianpharma.com)
Infections1
- Cyclophosphamide suppresses the immune system which may result in serious and sometimes fatal infections. (hdkino.org)
Dosage1
- What is the dosage for cyclophosphamide? (hdkino.org)
Side effects4
- Other severe side effects include an increased future risk of cancer, infertility, allergic reactions, and pulmonary fibrosis. (wikipedia.org)
- What are the side effects of cyclophosphamide? (hdkino.org)
- What are some other side effects of Cyclophosphamide Capsules? (edrugswiki.com)
- They would also administer Pepcid and Benadryl to help with the side effects and allergic reactions. (mannorlawgroup.com)
Cancers1
- Cyclophosphamide is used to treat cancers and autoimmune diseases. (wikipedia.org)
Kidney2
- Cyclophosphamide causes kidney failure , and it also may affect the heart and lungs . (hdkino.org)
- Mesna binds to the metabolites of cyclophosphamide and ifosfamide in the kidney and reduces their toxic effects. (caspianpharma.com)
Autoimmune2
- Cyclophosphamide decreases the immune system's response, and although concerns about toxicity restrict its use to patients with severe disease, it remains an important treatment for life-threatening autoimmune diseases where disease-modifying antirheumatic drugs (DMARDs) have been ineffective. (wikipedia.org)
- This response is called an autoimmune reaction. (msdmanuals.com)
Cancer2
- First trimester exposure to cyclophosphamide for the treatment of cancer or lupus displays a pattern of anomalies labeled "cyclophosphamide embryopathy", including growth restriction, ear and facial abnormalities, absence of digits and hypoplastic limbs. (wikipedia.org)
- Cyclophosphamide is a drug that is used primarily for treating several types of cancer . (hdkino.org)
Treatment1
- Cyclophosphamide, used in combination with thalidomide or lenalidomide and dexamethasone has documented efficacy as an off-label treatment of AL amyloidosis. (wikipedia.org)
Liver2
- In order to work, cyclophosphamide first is converted by the liver into two chemicals, acrolein and phosphoramide. (hdkino.org)
- Cyclophosphamide is a prodrug that must be metabolized by the liver into active metabolites. (medscape.com)
Clinical1
- It isn't known whether allergic reactions occurred clinical trials of this drug or how often they may have happened. (medicalnewstoday.com)
Drugs2
- Which drugs or supplements interact with cyclophosphamide? (hdkino.org)
- As with most drugs, some people can have an allergic reaction after taking Mestinon. (medicalnewstoday.com)
Treat1
- Cyclophosphamide is also used to treat minimal change disease, severe rheumatoid arthritis, granulomatosis with polyangiitis, Goodpasture syndrome and multiple sclerosis. (wikipedia.org)
Medical1
- Cyclophosphamide was approved for medical use in the United States in 1959. (wikipedia.org)
Growth1
- In addition to slowing the growth of cancerous cells, cyclophosphamide also suppresses the immune system and is referred to as immunosuppressive. (hdkino.org)
Doctor1
- Call your doctor right away if you have an allergic reaction to Mestinon, as the reaction could become severe. (medicalnewstoday.com)