• CONCLUSION: Not only did dietary intervention with 1% GOS during sensitization and challenge prevent the induction of airway eosinophilia and Th2-related cytokine and chemokine concentrations in the lung equally effective as budesonide treatment, it also prevented AHR development in HDM-allergic mice. (uu.nl)
  • JAK3 plays an important role in pulmonary eosinophilia in the allergic mouse model. (lclabs.com)
  • Tofacitinib, as a JAK3 inhibitor, represents a potential therapy for treatment of allergic conditions associated with airway eosinophilia including asthma and rhinitis. (lclabs.com)
  • Changes in IgE/IgG1 and mucin levels, airway eosinophilia and hyperreactivity to methacholine were determined by ELISA, differential cell counting and whole-body plethysmography, respectively. (utmb.edu)
  • 0.001) decreased IgE/IgG1 production, airway eosinophilia, mucin production and hypersensitivity induced by allergenic extracts from ragweed pollen grains and house dust mites. (utmb.edu)
  • In an ovalbumin (OVA)-induced murine model of allergic lung disease, CBA/Ca mice develop much lower levels of lung eosinophilia, lung oedema, mucus hypersecretion and airways obstruction than BALB/c and C57BL/6 strains. (sahmri.org.au)
  • Amish dust extracts, however, were able to significantly inhibit ovalbumin-induced airway hyperresponsiveness, bronchoalveolar lavage eosinophilia , and serum ovalbumin-specific IgE. (medscape.com)
  • Vitamin A supplement after neonatal S. pneumoniae pneumonia significantly promoted Foxp3 + Treg and Th1 productions, decreased Th2 and Th17 cells expressions, alleviated airway hyperresponsiveness (AHR) and inflammatory cells infiltration during AAD. (nature.com)
  • Asthma is a heterogeneous disease characterized by airway chronic inflammation together with airway hyperresponsiveness 1 . (nature.com)
  • BACKGROUND: Allergic asthma is strongly associated with the exposure to house dust mite (HDM) and is characterized by eosinophilic pulmonary inflammation and airway hyperresponsiveness (AHR). (uu.nl)
  • Asthma is a reversible airway obstruction that is characterized by constriction of airway smooth muscle, Abstract hyper secretion of mucus, edema and airway hyper responsiveness (AHR), mucus secretion and thickening of the basement membrane underlying the airway epithelium. (cdc.gov)
  • C57BL/6 mice were either OVA sensitized/aerosol-exposed or saline (Sal) sensitized/aerosol-challenged. (cdc.gov)
  • BALB/c → C57BL/6 allografts were reconstituted with iPSC-derived MSCs (2 million/transplant/at d0), and allografts were examined for regulatory T cells (Tregs), oxygenation, microvascular blood flow, airway epithelium, and collagen deposition during rejection. (biomedcentral.com)
  • A high-fructose diet caused the hippocampal neuroinflammatory response, reactive gliosis, and neuronal loss in C57BL/6N mice. (biomedcentral.com)
  • Our findings reveal that gut dysbiosis is a critical factor for a high-fructose diet-induced hippocampal neuroinflammation in C57BL/6N mice possibly mediated by impairing intestinal epithelial barrier. (biomedcentral.com)
  • We aimed to study the role of neutrophils in BALB/c and C57BL/6 mice exposed to Alternaria alternata (Alt). (ugent.be)
  • C57BL/6 mice exposed to Alt responded with eosinophilic infiltration and the characteristic IL-5 upregulation. (ugent.be)
  • Lung eotaxin-1 levels and expression of CD18 on eosinophils recovered by bronchoalveolar lavage (BAL) were least pronounced in CBA/Ca mice, whereas mRNA for L-selectin was highest in eosinophils from C57BL/6 mice. (sahmri.org.au)
  • In addition, although the level of pathology that developed in C57BL/6 and BALB/c mice was similar, some of the underlying mechanisms are likely to differ. (sahmri.org.au)
  • Non-lethal S. pneumoniae pneumonia was established by intranasal inoculation of neonatal (1-week-old) female BALB/c mice with D39. (nature.com)
  • Surprisingly, Th1 cells did not attenuate Th2 cell-induced airway hyperreactivity and inflammation in either SCID mice or in OVA-immunized immunocompetent BALB/c mice, but rather caused severe airway inflammation. (jci.org)
  • Allergic asthma was induced in female BALB/c mice by intraperitoneal administration of ovalbumin (OVA) on days 0 and 14, followed by intratracheal challenge with 1% OVA six times between days 22 and 30. (blogspot.com)
  • METHODS: BALB/c mice were intranasally sensitized with 1 μg HDM on day 0 followed by daily intranasal challenge with PBS or 10 μg HDM on days 7 to 11. (uu.nl)
  • In contrast, the inflammatory response to Alt extract in BALB/c mice was characterized by a neutrophilic response, high levels of G-CSF, and elastase in the lungs. (ugent.be)
  • The lack of neutrophils affected the processing of IL-33 in BALB/c mice, as was demonstrated by depletion of neutrophils through intraperitoneal injections of anti-Ly6G antibody. (ugent.be)
  • BALB/c mice expressed the highest levels of the eosinophil growth and survival factor interleukin (IL)-5 in the lungs and BAL eosinophils from these animals expressed more of the anti-apoptotic proteins Bcl-x L and Bcl-2 than cells from the other strains. (sahmri.org.au)
  • BALB/c mice expressed the highest levels of the eosinophil growth and survival factor interleukin (IL)-5 in the lungs and BAL eosinophils from these animals expressed more of the anti-apoptotic proteins Bcl-xL and Bcl-2 than cells from the other strains. (sahmri.org.au)
  • Asthma results from complex interactions among inflammatory cells, their mediators, airway epithelium and smooth muscle, and the nervous system. (medscape.com)
  • We demonstrated that iPSC-derived MSC treatment leads to significant increases in hTSG-6 protein, followed by an upregulation of mouse Tregs and IL-5, IL-10, and IL-15 cytokines, which augments graft microvascular blood flow and oxygenation, and thereby maintained a healthy airway epithelium and prevented the subepithelial deposition of collagen at d90 post transplantation. (biomedcentral.com)
  • We analyse mechanisms of response to viral infection in experimental in vivo rhinovirus infection in healthy controls and patients with asthma, and in in vitro experiments with house dust mite, rhinovirus and SARS-CoV-2 in human primary airway epithelium. (bvsalud.org)
  • Hence, we studied expression of ACE2 messenger RNA (mRNA) and protein isoforms, together with its glycosylation and spatial localization in primary human airway epithelium upon allergic inflammation and viral infection. (bvsalud.org)
  • Modulating the cytokine network in thickening of the basement membrane underlying the respiratory diseases such as asthma, with expected airway epithelium. (cdc.gov)
  • The World Health Organization (WHO) and GOLD 2023 have developed an updated definition of COPD as, "a heterogeneous lung condition characterized by chronic respiratory symptoms (dyspnea, cough, expectoration, exacerbations) due to abnormalities of the airway (bronchitis, bronchiolitis) and/or alveoli (emphysema) that cause persistent, often progressive, airflow obstruction. (qxmd.com)
  • Most congenital neck masses are asymptomatic in the neonatal period, but depending on the location and the size, they can cause airway obstruction and serious complications at birth. (qxmd.com)
  • This chapter provides an overview of some common applications of flow cytometry in characterizing mouse models of allergic airway disease. (socmucimm.org)
  • We will extend our studies from parasitic infections into mouse models of allergic asthma to test the roles of these genes. (lung.org)
  • The current authors investigated the effects of naphthoquinone (NQ), one of the extractable chemical compounds of DEP, on antigen-related airway inflammation, local expression of cytokine proteins, and antigen-specific immunoglobulin (Ig) production in mice. (ersjournals.com)
  • Cytokine/chemokine levels varied with exposure to OVA-ODE reflecting an additive mixture of the pro- and allergic-inflammatory profiles. (cdc.gov)
  • Cytokines are important in asthma and play a critical role in orchestrating the allergic inflammatory response, although the precise role of each cytokine remains to be determined. (cdc.gov)
  • Pathophysiologically, asthma exert different effects at different concentrations, can is characterized by constriction of airway smooth synergize or antagonize the effects of other cytokines muscle, hyper secretion of mucus, edema and airway and regulated in a complex manner and function via hyper responsiveness (AHR),[3] mucus secretion and cytokine cascade. (cdc.gov)
  • 4] After allergen exposure, that produced exceptionally large quantities of airway inflammation is orchestrated mainly by cytokine IL-9. (cdc.gov)
  • Methods Wild-type or cytokine-deficient (IL-13 -/- or IL-4 -/- ) eosinophils treated with cytokines (GM-CSF, IL-4, IL-33) were adoptively transferred into eosinophil-deficient recipient mice subjected to allergen provocation using established models of respiratory inflammation. (elsevierpure.com)
  • However, exposure of eosinophils to GM-CSF, IL-4, and IL-33 prior to transfer induced not only immune events in the LDLN, but also allergen-mediated increases in airway Th2 cytokine/chemokine levels, the subsequent accumulation of CD4 + T cells as well as alternatively activated (M2) macrophages, and the induction of pulmonary histopathologies. (elsevierpure.com)
  • Conclusion The data demonstrate the differential activation of eosinophils as a function of cytokine exposure and suggest that eosinophil-specific IL-13 expression by activated cells is a necessary component of the subsequent allergic Th2 pulmonary pathologies. (elsevierpure.com)
  • Bronchoalveolar lavage fluid (BALF) and lungs were collected to examine airway remodeling, inflammation, mucous production, cellular influx, and cytokine responses at 1 day and 21 days post final exposure. (cdc.gov)
  • Four weeks after pneumonia, mice were sensitized and challenged with OVA to induce allergic airway disease (AAD). (nature.com)
  • The mice were exposed to Alt extract for twelve hours or ten days to induce allergic airway inflammation. (ugent.be)
  • Cysteinyl (cys) LTs C 4 , D 4 , and E 4 are long known to contribute to airway contractile responses via ligation of the cysLT1 receptor, and cysLT1 antagonists are beneficial in some patients with asthma. (springer.com)
  • Research advances over the past several years suggest that cysLT1 also mediates the ability of cysLTs to modulate inflammation, immune responses, and airway remodeling. (springer.com)
  • He performed some of the first studies to identify transcription factors that regulate the gene expression and differentiation of eosinophils, which are known to play a major role in allergic and asthmatic responses. (ubc.ca)
  • The next wave of truly transformative therapeutics should aspire to provide a cure by selectively suppressing pathogenic autoantigen-specific immune responses while leaving the rest of the immune system intact to control infectious diseases and malignancies. (frontiersin.org)
  • These findings have significant implications with regard to current therapeutic goals in asthma and allergy and suggest that conversion of Th2-dominated allergic inflammatory responses into Th1-dominated responses may lead to further problems. (jci.org)
  • which in turn promotes T helper lymphocyte Th2 responses and stimulates the formulation of immunoglobulin E. As dietary fat intake patterns have changed over the past few decades, with an increase in saturated and omega-6 fat consumption, and a reduction in polyunsaturated omega-3 fat intake, this may be an important factor in the increasing prevalence of asthma and possibly other allergic diseases. (ispub.com)
  • These cells can participate in inflammatory responses by releasing mediators that attract or activate other cells, contributing to the pathogenesis of allergic and non-allergic diseases. (mdpi.com)
  • Advances in fl ow cytometric instrumentation, software, and reagents are occurring at a rapid pace, and flow cytometric methods are increasingly being applied to better understand cellular responses associated with a diverse array of disease conditions. (socmucimm.org)
  • Here, we show that the modular transcriptional signature in the blood of susceptible mice infected with a clinical isolate of M. tuberculosis resembles that of active human TB disease, with dominance of a type I interferon response and neutrophil activation and recruitment, together with a loss in B lymphocyte, natural killer and T cell effector responses. (imperial.ac.uk)
  • We can explore how our protective immune responses to chitin may influence our allergic reactions in asthma. (lung.org)
  • These results suggest TIEG and Itch contribute to a ubiquitin-dependent nonproteolytic pathway that regulates inducible Foxp3 expression and the control of allergic responses. (nih.gov)
  • IL-33 activates group 2 innate lymphoid cells (ILC2) to produce the type 2 cytokines IL-5 and IL-13 that initiate innate immunity-driven allergic responses. (justia.com)
  • Butyrate has been shown to reduce intestinal permeability to dietary antigens in a mouse model of food allergy and induce regulatory T cells, which suppress immune responses. (stellarhw.com)
  • Objective: The aim of this study was to investigate potential allergic responses to CLN and its impact on allergic sensitization and inflammation caused by common allergens. (utmb.edu)
  • however, it is effective in preventing allergic responses to known indoor and outdoor allergens. (utmb.edu)
  • In vivo, administration of Ag in the form of an immune complex during priming of the immune response inhibited resultant adaptive immune responses in an NLRP3-dependent model of allergic airway disease. (aai.org)
  • The study looked at asthma prevalence and the clinical and immunologic characteristics of atopic disease of children in both groups, and assessed the human and mouse model responses to house dust. (medscape.com)
  • Therefore, murine airway CD8 + T cell-responses to aspiration of Aspergillus conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. (cdc.gov)
  • He has delineated the function of these molecules in diverse set of biological processes including: 1) gut and kidney formation, 2) vascular permeability, 3) mucosal inflammatory disease, 4) stem cell homing and migration, and 5) epithelial tumor progression. (ubc.ca)
  • Collectively, these data confirmed that iPSC-derived MSC-mediated immunosuppression has potential to establish immune tolerance and rescue allograft from sustained hypoxic/ischemic phase, and subsequently limits long-term airway epithelial injury and collagen progression, which therapeutically warrant a study of Cymerus iPSC-derived MSCs as a potential management option for immunosuppression in transplant recipients. (biomedcentral.com)
  • Gut microbiota compositional alteration, short-chain fatty acids (SCFAs) reduction, intestinal epithelial barrier impairment, NOD-like receptor family pyrin domain-containing 6 (NLRP6) inflammasome dysfunction, high levels of serum endotoxin, and FITC-dextran were observed in fructose-fed mice. (biomedcentral.com)
  • Of note, SCFAs, as well as pioglitazone (a selective peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist), shaped the gut microbiota and ameliorated intestinal epithelial barrier impairment and NLRP6 inflammasome dysfunction in fructose-fed mice. (biomedcentral.com)
  • The Endogenous Cannabinoid Anandamide Increases Human Airway Epithelial Cell Permeability through an Arachidonic Acid Metabolite. (leaf411.org)
  • Airway hyper-responsiveness (AHR) to methacholine, bronchiolar lavage fluid, lung tissues, and serum were collected. (cdc.gov)
  • Model mice for allergic airway inflammation were intranasally administered recombinant adenovirus that express SCGB3A2, and the effect of overexpressed SCGB3A2 on antigen-induced airway inflammation was investigated. (biovendor.com)
  • The objective of this study was to investigate the airway inflammatory response to organic dust extract (ODE) in mice with established ovalbumin (OVA)-induced experimental asthma. (cdc.gov)
  • The researchers report in the journal Nature Communications the unexpected finding that the common yeast Candida albicans, a type of fungus, can cross the blood-brain barrier and trigger an inflammatory response that results in the formation of granuloma-type structures and temporary mild memory impairments in mice. (bcm.edu)
  • However, no studies have reported the effect of GLP-1R agonists on lung IL-33 expression or release, the effect of GLP-1R agonists on the innate allergic inflammatory response that is mediated by ILC2, or the effect of GLP-1R agonists on respiratory syncytial virus (RSV) infection. (justia.com)
  • However, anti-TNF-α therapies have limitations, including known adverse safety risk, loss of therapeutic efficacy due to drug resistance, and lack of efficacy in numerous autoimmune diseases, including multiple sclerosis. (frontiersin.org)
  • therefore, there has been growing therapeutic interest of MSCs as an option for many incurable diseases [ 11 ]. (biomedcentral.com)
  • These results suggest that SCGB3A2 may have a potential to be used as a therapeutic agent in treating patients suffering from lung diseases or promoting lung development in premature infants in future. (biovendor.com)
  • AIM: We investigated the preventive capacity of dietary galacto-oligosaccharides (GOS) compared to an intra-airway therapeutic treatment with budesonide on the development of HDM-induced allergic asthma in mice. (uu.nl)
  • Gut microbiome manipulation represents a promising new therapeutic strategy to protect individuals against both pulmonary infection and allergic airway disease," said Lynch. (allergicliving.com)
  • Therefore, IL-33 is a central mediator of both innate and adaptive immunity regulated allergic inflammation in the lung that have a role in the pathogenesis of conditions such as asthma, and IL-33 has been deemed to be an important therapeutic target in inhibiting allergic diseases. (justia.com)
  • Allergic asthma, which is present in as many as 10% of individuals in industrialized nations, is characterized by chronic airway inflammation and hyperreactivity induced by allergen-specific Th2 cells secreting interleukin-4 (IL-4) and IL-5. (jci.org)
  • Further, it has been reported that liraglutide attenuated bleomycin-induced pulmonary fibrosis and OVA-induced chronic airway inflammation. (justia.com)
  • When tested in vivo, a chemerin SMAL decreased allergic airway inflammation and attenuated neuropathic pain in mice. (nih.gov)
  • These results provide the first experimental evidence that naphthoquinone can enhance antigen-related airway inflammation in vivo , and that naphthoquinone can, to some extent, partly play a role in the pathogenesis of diesel exhaust particle toxicity on the condition. (ersjournals.com)
  • DEP enhance the antigen-specific immunoglobulin (Ig)E response 5 , 6 and aggravate airway inflammation induced by repetitive intratracheal instillation of antigen in vivo 7 - 10 . (ersjournals.com)
  • However, detailed studies concerning the component(s) of DEP responsible for their effects on the respiratory system and/or pulmonary diseases remain unsatisfied, which is particularly the case for in vivo studies. (ersjournals.com)
  • NQ contributes to DEP toxicity through the reduction of superoxide dismutase activity in vitro 26 , which raises the possibility that NQ may facilitate airway inflammatory conditions in vivo . (ersjournals.com)
  • A classification that sufficiently covers their phenotypic heterogeneity and plasticity during homeostasis and disease does not yet exist because cell culture-based phenotypes often do not match those found in vivo . (hindawi.com)
  • Anti-Siglec-8 antibody administration in vivo to humanized and transgenic mice selectively expressing Siglec-8 on mouse eosinophils and mast cells confirmed the in vitro findings, and identified additional anti-inflammatory effects. (mdpi.com)
  • Functionally, 'TGF-beta-converted' T(reg) cells generated from TIEG1-deficient mice were unable to suppress airway inflammation in vivo. (nih.gov)
  • Specific pathogen may play a critical role in the allergic airway diseases (AAD) pathogenesis by affecting the immune system 5 . (nature.com)
  • The prevalence of asthma and allergic sensitization was 4 and 6 times lower in the Amish population, with higher median endotoxin levels in house dust. (medscape.com)
  • Two weeks prior to the first sensitization and throughout the experiment mice were fed a control diet or a diet containing 1% GOS. (uu.nl)
  • Palmitoylethanolamide Supplementation during Sensitization Prevents Airway Allergic Symptoms in the Mouse. (leaf411.org)
  • The results clearly show that something in Amish house dust is capable of preventing allergic sensitization, probably owing to endotoxin or other microbial products. (medscape.com)
  • Conidia from the genus Aspergillus have been associated with allergic sensitization as well as exacerbation of allergy and asthma in otherwise healthy individuals [2] , [3] . (cdc.gov)
  • Intranasal inhalation of ODE in OVA-treated (asthmatic) mice (OVA-ODE) increased AHR and total cellular influx marked by elevated neutrophil and eosinophil counts. (cdc.gov)
  • GOS might be useful for the prevention and/or treatment of symptoms in asthmatic disease. (uu.nl)
  • Furthermore, the suppression was associated with a significant decrease in the production of Th2 cytokines, such as IL-4, IL-5, and IL-13, and a reduction in the number of total cells, including eosinophils, macrophages, and neutrophils in the airway. (blogspot.com)
  • Inflammatory cellular infiltrates, including lymphocytes, eosinophils, and mast cells, are found in the airways of patients with asthma, even during periods of clinical stability 1 . (ispub.com)
  • Background Eosinophils are hallmark cells of allergic Th2 respiratory inflammation. (elsevierpure.com)
  • Results In contrast to the transfer of untreated blood eosinophils to the lungs of recipient eosinophil deficient mice, which induced no immune/inflammatory changes either in the lung or in the lung draining lymph nodes (LDLN), pretreatment of blood eosinophils with GM-CSF prior to transfer elicited trafficking of these eosinophils to LDLN. (elsevierpure.com)
  • Significantly, this allergic respiratory inflammation was dependent on eosinophil-derived IL-13, whereas IL-4 expression by eosinophils had no significant role. (elsevierpure.com)
  • The accumulation of eosinophils is a common feature of allergic airway inflammation and correlates with disease severity. (sahmri.org.au)
  • In this study these strains have been examined to identify mechanisms that control the recruitment and survival of eosinophils in the allergic lung. (sahmri.org.au)
  • Following immunization with OVA, CBA/Ca mice developed a robust systemic allergic response, with high levels of total and OVA-specific IgE and increases in peripheral blood eosinophils. (sahmri.org.au)
  • A combination of lower levels of recruitment and rapid apoptosis may therefore limit the accumulation of eosinophils and pathology in the lungs of CBA/Ca mice. (sahmri.org.au)
  • Risk factors for asthma include a family history of allergic disease, the presence of allergen-specific immunoglobulin E (IgE), viral respiratory illnesses , exposure to aeroallergens , cigarette smoke, obesity , and lower socioeconomic status. (medscape.com)
  • IL-4 producing TFH cells are critical in generating IgE antibody, which is a defining feature of allergic disease (another monoclonal antibody treatment used for asthma patients recognizes IgE). (lung.org)
  • [ 3 ] In Western countries, the financial burden on patients ranges from $300 to $1,300 per patient year, increasing with more severe disease. (medscape.com)
  • more than half of all expenditures are attributed to the 10-20% of patients with the most severe disease. (medscape.com)
  • Th1, Th2, and Th0 lines were generated from ovalbumin (OVA)-specific T-cell receptor (TCR) transgenic mice and transferred into lymphocyte-deficient, OVA-treated severe combined immunodeficiency (SCID) mice. (jci.org)
  • Pneumonia is a severe inflammatory disease of the lung. (spandidos-publications.com)
  • The researchers began their investigation by developing a mouse model of a low-grade fungus infection with the common yeast C. albicans that would not cause severe disease, but might carry implications for brain function. (bcm.edu)
  • Future precision medicine requires further clarifying the mechanisms of inflammation in the severe endotypes of chronic airway diseases such as asthma and chronic rhinosinusitis (CRS). (ugent.be)
  • The presence of neutrophils in the airways is often associated with severe airway inflammation, while their precise contribution to the severe inflammation is largely unknown. (ugent.be)
  • The inventors found that GLP-1R agonists inhibited IL-33 expression and release from the lungs of mice in response to an airway challenge the allergen extract of the aeroallergen Alternaria alternata , an aeroallergen which has protease activity and which is associated with severe asthma exacerbations. (justia.com)
  • The influence of pre-existing airway inflammation on the infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely unknown. (bvsalud.org)
  • Th17 cell may have a role in severe asthma and chronic obstructive pulmonary disease (COPD). (cdc.gov)
  • At this time, treatment of severe RSV disease consists of supportive care, such as hydration and oxygenation. (biomedcentral.com)
  • For patients at high risk for progression to severe disease, treatment should be administered early in the course of illness along with supportive care and pain control. (cdc.gov)
  • Exposure to molds can cause human disease through several well-defined mechanisms. (medscape.com)
  • Although we have developed new drugs to control asthma, we are still learning about the underlying mechanisms that cause this disease. (lung.org)
  • 2 Division of Asthma, Allergy and Lung Biology, Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, King's College London, Guy's Campus, London, United Kingdom. (jci.org)
  • Molecular, genetic and cellular mechanisms underlying Asthma & Chronic Obstructive Pulmonary Disease. (nottingham.ac.uk)
  • There have been significant advances in the genetic epidemiology of lung function, but the causal genetic variants and causal genes, and the mechanisms by which they influence lung function, chronic obstructive pulmonary disease (COPD) and other respiratory diseases remain incompletely understood. (nottingham.ac.uk)
  • This will inform in-depth mechanistic assays at the cell, tissue and organ scales to identify the key mechanisms underpinning regulation of lung function in health and disease. (nottingham.ac.uk)
  • The 2023 Global Initiative for Chronic Obstructive Lung Disease (GOLD) report includes relevant topics from the clinician's perspective and evidence published on chronic obstructive pulmonary disease (COPD) since GOLD 2017. (qxmd.com)
  • S. pneumoniae pneumonia mice were supplemented with or without all-trans retinoic acid 24 hours after infection. (nature.com)
  • We stated that serum vitamin A levels in neonatal S. pneumoniae pneumonia mice were lower than 0.7µmol/L from day 2-7 post infection, while pulmonary vitamin A productions were significantly lower than those in the control mice from day 7-28 post infection. (nature.com)
  • Although mouse infection models have been extensively used to study the host response to Mycobacterium tuberculosis, their validity in revealing determinants of human tuberculosis (TB) resistance and disease progression has been heavily debated. (imperial.ac.uk)
  • Fungal infections are emerging as a major medical challenge, and a team led by researchers at Baylor College of Medicine has developed a mouse model to study the short-term consequences of fungal infection in the brain. (bcm.edu)
  • Interestingly, the granulomas share features with plaques found in Alzheimer's disease, supporting future studies on the long-term neurological consequences of sustained C. albicans infection. (bcm.edu)
  • They found that infected mice had impaired spatial memory, which reversed when the infection cleared. (bcm.edu)
  • The present disclosure relates to glucagon-like peptide-1 receptor (GLP-1R) agonists and methods of treating or preventing allergic inflammation and/or methods of treating or preventing respiratory syncytial virus (RSV) infection. (justia.com)
  • On day 14, AHR was measured by nebulizing increasing doses of methacholine into the airways. (uu.nl)
  • CLN induces neurite outgrowth of pheochromocytoma cells, extends the lifespan of diploid fibroblast cells, inhibits β-amyloid-induced apoptosis and improves cognitive functions when administered to Alzheimer's disease patients. (utmb.edu)
  • OVA-specific Th2 and Th0 cells induced significant airway hyperreactivity and inflammation. (jci.org)
  • These mediators are potent bronchoconstricting agents and induce other features typical of asthma, including airway-wall edema and mucus hypersecretion 5 . (ispub.com)
  • In this study, we established a neonatal non-lethal S. pneumoniae pneumonia mice model and monitored vitamin A levels in lung, serum and liver until early adulthood. (nature.com)
  • Using an adoptive transfer system, we assessed the roles of Th1, Th2, and Th0 cells in a mouse model of asthma and examined the capacity of Th1 cells to counterbalance the proasthmatic effects of Th2 cells. (jci.org)
  • In the mouse model, recombinant human SCGB3A2 exhibited anti-fibrotic and growth factor activities comparable to those of recombinant mouse SCGB3A2. (biovendor.com)
  • Using a mouse model of asthma triggered by the mold Aspergillus fumigatus, we focused our attention to CD4 T cells, which are known to produce cytokines critical in asthma (these include IL-4, IL-5 and IL-13 targets for monoclonal antibodies used to treat asthma patients). (lung.org)
  • Chi3l1 deficient mice respond with fewer TFH cells in the lung draining lymph nodes during the Aspergillus asthma model, and they also have less inflammatory cells in their airways. (lung.org)
  • CB2 receptors regulate natural killer cells that limit allergic airway inflammation in a murine model of asthma. (leaf411.org)
  • Brain region- and age-dependent dysregulation of p62 and NBR1 in a mouse model of Huntington's disease. (nih.gov)
  • Methods: We used a well-characterized mouse model of allergic airway inflammation. (utmb.edu)
  • Using a murine asthma model the experimental data show both, an asthma-reducing effect after direct exposure of adult mice to n-butyl paraben (nBuP) as well as an asthma-promoting effect after maternal exposure to ethyl paraben (EtP) in the female offspring. (ufz.de)
  • To investigate the suspicion that the house dust was in itself the immune-modifying agent, the investigators compared the effects of Amish vs Hutterite house dust in a classic ovalbumin mouse model of allergic asthma . (medscape.com)
  • dashed line histograms) or Alexa Fluor® 488 Mouse Anti-Human ICOS (CD278) antibody (Cat. (bdbiosciences.com)
  • When they came into contact with these chemicals, they produced fewer immune cells, showed less inflammation in their airways, and had less immunoglobulin E (IgE)-an antibody associated with allergic diseases like asthma and atopic dermatitis. (the-scientist.com)
  • The aim of the present study was to elucidate the effects of NQ on airway inflammation, the local expression of cytokines such as IL-4 and IL-5 and chemokines such as eotaxin, macrophage chemoattractant protein (MCP)-1, and keratinocyte chemoattractant (KC) and Ig production related to antigen exposure. (ersjournals.com)
  • Collectively, ODE increased airway inflammatory cells and chemotactic mediator release in allergic (OVA) sensitized mice to suggest that persons with allergy/asthma be identified and warned prior to the occupational exposure of potentially worsening airway disease. (cdc.gov)
  • Therefore, we investigated the effect of paraben exposure on asthma development in mice and humans. (ufz.de)
  • Interestingly, exposure of mice to a mixture of EtP and nBuP starting prenatally until the end of asthma induction in the adult offspring was without effect on allergic airway inflammation. (ufz.de)
  • Consequently, not only the time point of exposure but also multiple exposure scenarios to parabens should be considered in the evaluation of individuals' specific disease risk. (ufz.de)
  • The surge in atopic disease has been ascribed to reduced childhood viral infections owing to vaccination, increased antibiotic use, reduced helminth exposure, and urban living. (medscape.com)
  • However, repeated exposure to large numbers may result in persistence of conidia and induction of airway inflammation. (cdc.gov)
  • Our data identifies the key role of neutrophils in airway inflammation through IL-33 cleavage in the Alt-induced airway inflammation in mice, which could potentially underline the different endotypes in human disease. (ugent.be)
  • Also, DEP have been implicated to modulate allergic reactions 3 , 4 . (ersjournals.com)
  • When the mice ingested the dog dust, they were less likely to show allergic reactions to varied substances, including cockroach allergens and a protein found in egg whites. (the-scientist.com)
  • Using genetic approaches from parasitic infections that cause similar immune system activation to allergic disease, we have identified genes that are important in the interactions between the cells that initiate and maintain allergic inflammation (dendritic cells) and the effector cells that cause inflammatory damage during allergic reactions (T cells). (lung.org)
  • The composition and function of the gut microbiome strongly influences immune reactions and presents a novel avenue for development of therapeutics for both allergic asthma and a range of other diseases," said Susan Lynch, lead study author and associate professor with the division of gastroenterology at UC San Francisco. (allergicliving.com)
  • Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
  • OVA-TCR transgenic Th cells migrate to the lungs of recipient mice. (jci.org)
  • Furthermore, A. fumigatus particles exhibited greater persistence in the lungs of recipient mice when compared to non-viable A. fumigatus or A. versicolor , and this correlated with increased maintenance of airway memory-phenotype CD8 + T cells. (cdc.gov)
  • A randomized controlled pilot trial published in 2011 showed that allergic patients who consumed birch pollen honey had 60 percent reduced allergy symptoms and twice as many asymptomatic days during birch pollen season ( 23 ). (stellarhw.com)
  • We observed a significant increase in IFN-γ-producing CD8 + T cells in bronchoalveolar lavage fluid (BALF) of immunocompetent mice that repeatedly aspirated A. fumigatus conidia in contrast to mice challenged with A. versicolor , a species that is not typically associated with invasive, disseminated disease. (cdc.gov)
  • Flow cytometry analysis further demonstrated that populations of CD11chi dendritic cells (DC), CD3+ T cells, CD19+ B cells, and NKp46+ group 3 innate lymphoid cells (ILC3) were increased in lavage fluid of OVA-ODE mice as compared to ODE or OVA alone. (cdc.gov)
  • During the process of airway inflammation, complex interactions of innate and adaptive immune cells as well as structural cells and their cytokines have many important roles. (cdc.gov)
  • Cannabinoid receptor 2 augments eosinophil responsiveness and aggravates allergen induced pulmonary inflammation in mice. (leaf411.org)
  • Co-morbidities of asthma include sinusitis, nasal polyposis, gastro-esophageal reflux disease (GERD) and allergic rhinitis. (medscape.com)
  • Allergic disorders such as asthma, aller- by mothers during pregnancy has been was made based on the child's history, gic rhinitis, atopic dermatitis and even shown to be associated with a lower risk family history, physical examination and chronic urticaria have a high prevalence of wheeze and asthma in the child ( 12 ). (who.int)
  • yet, repeated exposures later in life are associated with chronic bronchitis and obstructive pulmonary diseases. (cdc.gov)
  • Rahman, Adeeb H. "Flow Cytometric Methods for the Assessment of Allergic Disease - Springer. (socmucimm.org)
  • Disclosed herein are methods of treating allergic disorders and respiratory syncytial virus (RSV) infections with a glucagon-like peptide-1 receptor (GLP-1R) agonist. (justia.com)
  • METHODS: Mice were repeatedly exposed to an immunogenic dose of C. neoformans or V. victoriae via oropharyngeal aspiration. (cdc.gov)
  • Anti-inflammatory properties of cannabidiol, a non-psychotropic cannabinoid, in experimental allergic contact dermatitis. (leaf411.org)
  • Tofacitinib dose-dependently reduced endpoints of disease in both RA models. (lclabs.com)
  • For these reasons, if we better understand how our immune system deals with this kind of constant threat and what are the weaknesses in our immunological armor that occur with aging that allow fungal disease to take root, then we would likely increases the possibility of finding ways to fight back, " Corry said. (bcm.edu)
  • They injected C. albicans into the blood stream of mice and were surprised to discover that the yeast can cross the blood-brain barrier, a robust protective mechanism the brain employs to exclude all kinds of large and small molecules, as well as a number of microorganisms that can potentially damage the brain. (bcm.edu)
  • These findings suggest that the role fungi play in human illness potentially goes well beyond allergic airway disease or sepsis," Corry said. (bcm.edu)
  • Endotracheal intubation and invasive mechanical ventilation are fundamental components for the resuscitation of neurocritically ill patients to achieve various goals which include ensuring the protection of the airway, participating in tissue oxygen delivery and indirectly modulating cerebral vascular reactivity. (qxmd.com)
  • It was found that allergic asthma-related lung inflammation was greatly reduced in the mice that had been exposed to the dog dust, compared with mice exposed to dust from homes without pets, and those not exposed to any house dust at all. (allergicliving.com)
  • Host proteases have been shown to play important roles in many viral activities such as entry, uncoating, viral protein production and disease induction. (biomedcentral.com)
  • However, the relative importance of eosinophil activation and the induction of effector functions such as the expression of IL-13 to allergic Th2 pulmonary disease remain to be defined. (elsevierpure.com)