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  • genotype
  • We published the first molecular HLA association study in childhood ALL and showed a convincing association for a homozygous genotype of the DQA1 locus by RFLP analysis 4 . (dorak.info)
  • This genotype more or less corresponds to homozygosity for HLA-DR53 and the current research specifically examined this genotype by PCR analysis against a newborn control group (as opposed to an adult control group in the previous RFLP study). (dorak.info)
  • Children with high-risk type 1 diabetes HLA genotype have increased risk of high relative birthweight (HrBW), while cord blood islet autoantibodies decrease the risk. (springer.com)
  • HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin. (springer.com)
  • It might be due to the high error rate of PacBio (about 15-20%), which makes it more difficult to genotype polymorphic regions such as HLA. (biomedcentral.com)
  • genotypes
  • HLA-DR and MT1, MT2, MT3 genotypes have been investigated in 123 Type 1 (insulin-dependent) diabetic subjects and their families. (springer.com)
  • HLA genotypes and autoantibodies to glutamic acid decarboxylase, insulinoma-associated protein 2 and insulin were determined in cord blood of children born to non-diabetic mothers in the Diabetes Prediction in Skåne (DiPiS) study. (springer.com)
  • In this work, we tried to understand whether combined genotypes of CCR5-▵32, CCR2-64I, SDF1-3′A and HLA alleles can predict the LT-NP status. (bloodjournal.org)
  • Among the chemokine receptor genotypes, only the frequency of the CCR5-▵32 allele was significantly higher in LT-NP compared with the group of standard progressors. (bloodjournal.org)
  • In this report, we studied chemokine receptors (CCR2, CCR5), chemokine (SDF1), and HLA class I and II genotypes in LT-NP and attempted to find out whether any particular pattern of host genetics could be implicated in the LT-NP phenotype. (bloodjournal.org)
  • 11 Genetic mapping involved a comparison of HLA genotypes for 44 patients with Stevens-Johnson syndrome or toxic epidermal necrolysis with those of 101 controls who had taken carbamazepine for at least 3 months without development of any skin reaction, and 93 healthy individuals. (mja.com.au)
  • DQA1
  • The data available on DQ2-negative CD patients indicate that they almost invariably are HLA-DQ8 positive (DQA1 ∗ 0301/DQB1 ∗ 0302). (biomedcentral.com)
  • DR53
  • An exception has been reported as an unexpected expression of HLA-DR53 in a DR7 (Dw11) : DQ9 - positive leukemia patient 12 . (dorak.info)
  • Two British studies examined HLA-DR antigens in adult leukaemias and reported the involvement of HLA-DR53 or its members in adult ALL 11 and chronic lymphoid leukaemia (CLL) 12 . (dorak.info)
  • commonest
  • In Caucasians and also in patients with rheumatoid arthritis, the commonest DRB4 allele is DRB4*01:03 25 . (dorak.info)
  • homozygosity
  • We believe that the reasons are the general negligence of HLA supertypes, homozygosity and the gender effect. (dorak.info)
  • novel
  • HLA-DM-mediated editing contributes significantly to immunodominance and is exploited in discovering immunodominant epitopes from novel or previously uncharacterized antigens, particularly antigens associated with pathogens, tumors or autoimmune diseases. (freepatentsonline.com)
  • genetically
  • In December 2007, the United States Food and Drug Administration announced that, because of the associated risk of Stevens-Johnson syndrome and toxic epidermal necrolysis, people of Asian descent should be genetically tested for the HLA-B*1502 allele before starting therapy with carbamazepine. (mja.com.au)
  • antibodies
  • A paired kidney analysis on the impact of pre-transplant anti-HLA antibodies on graft survival. (nih.gov)
  • Pretransplant C3d-Fixing Donor-Specific Anti-HLA Antibodies Are Not Associated with Increased Risk for Kidney Graft Failure. (nih.gov)
  • Differential effects of donor-specific HLA antibodies in living versus deceased donor transplant. (nih.gov)
  • Caucasians
  • Although Stevens-Johnson syndrome with carbamazepine also occurs among Caucasians, HLA-B*1502 has not been found in this group. (mja.com.au)
  • carbamazepine
  • HLA-B*1502 was present in all the case patients, in 3% of control patients taking carbamazepine and in 9% of the healthy controls (see Box 2 ). (mja.com.au)
  • inheritance
  • Recent reports have suggested that Common Variable Immunodeficieny (CVID) can present as an autosomal dominant trait dependent on the inheritance of a set of uncommon mutations/alleles of TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor) involving exons 3 or 4. (beds.ac.uk)
  • heterozygous
  • The DR antigen combinations of the parents leading to DR3, DR4 heterozygous and to DR3 and DR4 homozygous offspring were analysed. (springer.com)
  • found
  • The latest list of officially recognized HLA-DRB alleles can be found at the ANRC site . (dorak.info)
  • HLA-DR7 was also found increased in childhood ALL in another study 10 . (dorak.info)
  • HLA *B44 was also found to be over-represented among patients who presented to our clinic with adult-onset recurrent sinopulmonary infections (RESPI) and normal serum immunoglobulin levels, a cohort that included first and second degree relatives of patients with CVID. (beds.ac.uk)
  • The association of HLA with PsA is more complex than that found in psoriasis. (hindawi.com)
  • disease
  • Why, then, in a disease which has attracted much attention for an HLA association since Lilly's original paper on mouse leukaemia in 1964 (Ref.2), and the first HLA association paper in childhood leukaemia 3 , no other strong HLA association has been reported? (dorak.info)
  • Ninety-eight percent of probands possessed either DR3 (relative risk = 5.0), or DR4 (relative risk = 6.8) or both antigens (relative risk = 14.3), emphasizing the strong association of the disease with these two antigens. (springer.com)
  • Batchelor JR, Morris PJ (1977) Joint report on HLA and disease: juvenile onset diabetes. (springer.com)
  • Bodmer WF (1980) The HLA system and disease. (springer.com)
  • Combination of HLA class I (HLA-A1, HLA-A2, HLA-B14, HLA-B17, HLA-B27) and class II antigens (HLA-DR5 and HLA-DR6) have been correlated with low rates of disease progression. (bloodjournal.org)
  • Other HLA class I alleles associated with the disease (i.e. (hindawi.com)
  • Specific
  • In addition, exposure to airborne endotoxins, which is common in workplaces associated with HP, potentiates antigen-specific airway inflammation and allergen responses . (worldallergy.org)
  • A specific HLA-A surface antigen subtype. (healthmatics.info)
  • Allele-specific oligonucleotides are then used to detect single base changes in the DNA samples. (biomedcentral.com)
  • Other HLA associations are not sufficiently specific for translation but are still of interest in relation to underlying mechanisms for the reactions. (biomedcentral.com)
  • methods
  • The next generation sequencing (NGS) technologies could be used for high throughput HLA typing but in silico methods are still needed to correctly assign the alleles of a sample. (biomedcentral.com)
  • 1977
  • The HLA complex is divided into three regions: class I, II, and III regions as first proposed by Jan Klein in 1977 57 . (dorak.info)