Allele hla dqa1. Medical search. Frequent questions

DQA1*0101 is commonly linked to haplotypes of DQB1*05, the common DQA1*0101:DQB1*0501 haplotype which is part of a broader DR1-DQ1 haplotype. (wikipedia.org)
DQA1*0102:DQB1*0502 has a bimodal distribution. (wikipedia.org)
DQA1*0102:DQB1*0602 is a very common haplotype in Eurasia, with higher frequency in central Asia relative to elsewhere. (wikipedia.org)
DQA1*0102:DQB1*0604 much less frequently found but spread widely. (wikipedia.org)
DQA1*0103 (*0103) shows a negative (protective) association with many autoimmune disease, this association is apparent in Japanese studies in the *0103:DQB1*0601 haplotype, and in Europe with the *0103:DQB1*0603 haplotype, indicating the protective effect is influenced by the alpha chain of DQ. (wikipedia.org)
DQA1*0103:DQB1*0601 is part of a multigene haplotype (DRB1*1502:DRB5*0102:DQA1*0103:DQB1*0601:DPA1*02:DPB1*0901) linked to Takayasu's arteritis in Japanese. (wikipedia.org)
DQA1*0103:DQB1*0603 is part of a DR-DQ haplotype (DR13-DQ1) that increases for primary sclerosing cholangitis The same haplotype shows a negative association with rheumatic heart disease, DQA1*0104:DQB1*0503 is part of a multigene haplotype DR14-DQ5 that is associated with MuSK positive Myasthenia gravis. (wikipedia.org)
The protein produced from the HLA-DQA1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQB1 . (medlineplus.gov)
One of these haplotypes, known as DQ2, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*05:01 or HLA-DQA1*05:05 bound to the protein produced from HLA-DQB1 gene variants known as HLA-DQB1*02:01 or HLA-DQB1*02:02 . (medlineplus.gov)
The other haplotype, known as DQ8, is composed of the protein produced from HLA-DQA1 gene variants known as HLA-DQA1*03:01 or HLA-DQA1*03:02 bound to the protein produced from the HLA-DQB1 gene variant known as HLA-DQB1*03:02 . (medlineplus.gov)
Type 1 diabetes risk is most increased by two HLA haplotypes involving variations of the HLA-DQA1 and HLA-DQB1 genes and another HLA gene called HLA-DRB1 . (medlineplus.gov)
One haplotype, written as DRB1*03:01-DQA1*05:01-DQB1*02 , is called DR3. (medlineplus.gov)
The other haplotype, written as DRB1*04:01/02/04/05/08-DQA1*03:01-DQB1*02 , is called DR4. (medlineplus.gov)
The genes encoding the HLA-DQ heterodimer molecules, DQB1 and DQA1, have been found to have the strongest association with IDDM risk, although there is cumulative evidence for the effect of other gene loci within the major histocompatibility complex gene region. (diabetesjournals.org)
Susceptibility and resistance alleles of human leukocyte antigen (HLA) DQA1 and HLA DQB1 are shared in endocrine autoimmune disease. (umbrella-scientific.us)
Differential Frequencies of HLA-DRB1, DQA1, and DQB1 Alleles and Haplotypes Are Observed in the Arbovirus-Related Neurological Syndromes. (cdc.gov)
Finally, gold nanoparticles functionalized with two molecular beacons targeting the DQA1*05* and DQB1*02* alleles allowed the low-resolution typing of the DQ2 gene at the nanomolar level. (diva-portal.org)
Conversely, there was significant dissimilarity in the MHC class II region, near the HLA-DQA1 and - DQB1 genes. (biomedcentral.com)
Here we present 4.25 Mb of the human haplotype QBL (HLA-A26-B18-Cw5-DR3-DQ2) and compare it with the MHC reference haplotype and with a second haplotype, COX (HLA-A1-B8-Cw7-DR3-DQ2), that shares the same HLA-DRB1, -DQA1, and -DQB1 alleles. (ox.ac.uk)
We characterized HPV-16 variants by PCR in 107 ICC cases, which were typed for HLA-DQA1 , DRB1 and DQB1 genes and compared to 257 controls. (biomedcentral.com)
Conversely, analyses also identified HLA alleles (HLA class II DQB1*03:02 und HLA class I B*15:01) not associated with such benefit in the patient cohort of this study. (biomedcentral.com)
Incidence and epitope specificity of HLA DQA1 and DQB1 antibodies in renal transplant recipients. (cnr.it)
Genvinset® HLA CELIAC is an in vitro diagnostic kit designed for the detection of the HLA-DQB1*02, DQB1*03:02 and DQA1*05 alleles in genomic DNA extracted from whole blood, and the consequent determina-tion of the DQ2 and DQ8 antigens, associated with celiac disease predisposition. (bioactiva.com)
The kit is able to determine the homozygosity or heterozygosity status for the DQB1*02 alleles. (bioactiva.com)
The role of human leukocyte antigen (HLA) DQ2 heterodimer (DQA1*0501-DQB1*0201) in presenting gluten peptides to effectors T cells in celiac disease (CD) has been well documented. (ac.ir)
Dogs were genotyped for allelic variation at DLA-DRB1, -DQA1, -DQB1 loci using DNA sequence-based typing. (biomedcentral.com)
Our results suggested that the effect of the DRB1*1501,DQA1*0102,DQB1*0602 haplotype on the susceptibility to MS is additive, perhaps reflecting that development of the disease is facilitated by a high density surface expression of the antigen presenting molecules encoded by this haplotype. (birmingham.ac.uk)

Study on the correlation between chronic asymptomatic HBV carriers of yin asthenia constitution and genotypes of HLA-DRB1 and HLA DQA1 alleles]. (cdc.gov)
When HLA-B alleles were analyzed, strong associations between the presence of specific B alleles and DRB1*04 subtypes were detected. (diabetesjournals.org)
Genome-wide meta-analysis associates HLA-DQA1/DRB1 and LPA and lifestyle factors with human longevity. (ox.ac.uk)
Here, using genome-wide association meta-analysis of 606,059 parents' survival, we discover two regions associated with longevity (HLA-DQA1/DRB1 and LPA). (ox.ac.uk)
Using genetic data of parental lifespan, the authors identify associations at HLA-DQA/DRB1 and LPA and find that genetic variants that increase educational attainment have a positive effect on lifespan whereas increasing BMI negatively affects lifespan. (ox.ac.uk)
We observed similar proportions of HLA DRB1*1302 carriers in E-P positive cases and controls, but interestingly, this allele was not found in AA cases (p = 0.03, Fisher exact test). (biomedcentral.com)
Univariate HLA analyses identified putatively protective HLA alleles (HLA class II DRB1*01:01 and HLA class I B*35:01, with a trend for DRB1*03:01). (biomedcentral.com)
The current study shows that the presence of HLA class II DRB1*01:01 and HLA class I B*35:01 is of even stronger association with reduced disease duration in mild and moderate COVID-19 than age or any other potential risk factor assessed. (biomedcentral.com)
HLA-DRB1*03:01 was significantly associated with both sub-phenotypes. (cdc.gov)
Conditional analyses showed that anti-Ro and anti-La subsets are independently associated with HLA-DRB1*0301, and that the HLA-DRB1*03:01 association with SLE is largely but not completely driven by the association of this allele with these sub-phenotypes. (cdc.gov)
Our results provide strong evidence for a multilevel risk model for HLA-DRB1*03:01 in SLE, where the association with anti-Ro and anti-La antibody-positive SLE is much stronger than SLE without these autoantibodies. (cdc.gov)
12 - 15 These studies focused mainly on major histocompatibility complex (MHC) class II genes, and found evidence that class II alleles such as HLA-DRB1*03:01 are associated with auto-antibody production. (cdc.gov)
Results We detected SNPs at HLA-DRB1, and African-specific SNPs at ZNF649 and LSAMP, with associations of genome-wide significance for UC. (njit.edu)

HLA-DQ1 is a serotype that covers a broad range of HLA-DQ haplotypes. (wikipedia.org)
At least two specific combinations of HLA gene variants (HLA haplotypes) have been found to increase the risk of developing celiac disease, a disorder in which inflammation damages the intestinal tract and other organs and tissues. (medlineplus.gov)
Other HLA haplotypes only mildly increase the risk of type 1 diabetes, while some haplotypes seem to protect against developing this condition. (medlineplus.gov)
³ Haplotype Association - Find HLA haplotypes with this allele. (allelefrequencies.net)
Analysis of the two DR3 haplotypes allowed delineation of the shared sequence between two HLA class II-related haplotypes differing in disease associations and the identification of at least one of the sites that mediated the original recombination event. (ox.ac.uk)
HLA- DQ2 and HLA-DQ8 testing is valuable because CD is unlikely if both haplotypes are negative. (vdocuments.net)

Genetic variation in the HLADQA1-HLADRB1*07:01 haplotype is strongly associated with azathioprine (AZA)-induced pancreatitis in inflammatory bowel disease (IBD). (ecco-ibd.eu)
Then, click "Search" to find HLA Haplotype frequencies that match your criteria. (allelefrequencies.net)
The rs10947262 and rs7775228 variants are not associated with risk of knee OA in European descent populations and they do not appear tag the same HLA class II haplotype as they do in Japanese individuals. (warwick.ac.uk)

The HLA-DQA1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. (medlineplus.gov)
The HLA-DQA1 gene belongs to a group of MHC genes called MHC class II. (medlineplus.gov)
Combinations of variations in the HLA-DQA1 gene and other HLA genes affect the risk of type 1 diabetes. (medlineplus.gov)
The results demonstrate that DQ and DR genes cannot explain all of the HLA-linked susceptibility to IDDM, and that the existence of a susceptibility locus telom-eric to DR is probable. (diabetesjournals.org)
DNA sequence variation within human leukocyte antigen (HLA) genes mediate susceptibility to a wide range of human diseases. (nih.gov)
For amino acid polymorphisms within HLA genes, we achieve 98.6% and 99.3% accuracy using the Affymetrix GeneChip 500 K and Illumina Immunochip, respectively. (nih.gov)
In a speed-dating context, women, but not men, showed preferences for partners based on Major Histocompatibility Complex (MHC) complementarity through SNP analysis, with different SNPs influencing attraction directionally based on proximity to major HLA genes, and MHC-based indices held comparable influence to self-reported personality attributes in predicting second date offers for both genders. (dnaromance.com)
Several of these genes, such as TNC (near TNFSF15), CXCR6, and genes associated with IBD at the HLA locus, contained SNPs with unique association patterns with African-specific alleles. (njit.edu)

Long-range linkage disequilibrium between HLA loci and SNP markers across the major histocompatibility complex (MHC) region offers an alternative approach through imputation to interrogate HLA variation in existing GWAS data sets. (nih.gov)
Multiple Hodgkin lymphoma-associated loci within the HLA region at chromosome 6p21.3. (ox.ac.uk)
Using SNP data to impute alleles at classic HLA loci, we have conducted an integrated analysis of HL risk within the HLA region in 582 early-onset HL cases and 4736 controls. (ox.ac.uk)
These data suggest that multiple independent loci within the HLA class II region contribute to the risk of developing early-onset HL. (ox.ac.uk)

After the HLA-DQ locus, the HLA-DR locus has been suggested most often as contributing to the disease susceptibility. (diabetesjournals.org)
MHC alleles do not predict autoantibody specificity and 21-hydroxylase gene polymorphism has no independent role in disease susceptibility. (umbrella-scientific.us)
HLA class II polymorphisms are also associated with genetic susceptibility to ICC. (biomedcentral.com)
Novel HLA allele associations with susceptibility, staging, symptomatic state, autoimmune hepatitis and hepatocellular carcinoma events for primary biliary cholangitis in the Japanese population , Front Immunol . (csml.org)

The goal of the current study was to assess the association of COVID-19 clinical courses controlled by patients' adaptive immune responses without progression to severe disease with patients' Human Leukocyte Antigen (HLA) genetics, AB0 blood group antigens, and the presence or absence of near-loss-of-function delta 32 deletion mutant of the C-C chemokine receptor type 5 (CCR5). (biomedcentral.com)
The impact of different HLA genotypes, AB0 blood group antigens, and the CCR5 mutant CD195 were investigated for their role in the clinical course of COVID-19. (biomedcentral.com)
Antidonor-HLA antibodies and soluble HLA antigens after kidney transplant. (cnr.it)

We conducted a meta-analysis of four independent European SLE case collections for associations between SLE sub-phenotypes and MHC single-nucleotide polymorphism genotypes, human leukocyte antigen (HLA) alleles and variant HLA amino acids. (cdc.gov)
13 Our study substantially expands this work by not only analysing imputed classical human leukocyte antigen (HLA) alleles, but also examining variant HLA amino-acid positions in conjunction with single-nucleotide polymorphism (SNP) genotypes across the extended MHC region (chromosome 6: 26-34 Mb). (cdc.gov)

The most frequently found within this group are: DQA1*0101, *0102, *0103, and *0104. (wikipedia.org)

2022 Allele Frequencies Website. (allelefrequencies.net)

Highest genetic risk is associated with particular Major Histocompatibility Complex (MHC) alleles, specifically Human Leukocyte Antigen (HLA)-DR3 and HLA-DR4. (umbrella-scientific.us)
ss-cell autoantibodies, human leukocyte antigen II alleles, and type 1 diabetes in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. (umbrella-scientific.us)
We present a fluorescent genosensor, exploiting molecular-beacon-functionalized gold nanoparticles, for the identification of human leukocyte antigen (HLA) DQ2 gene, a key genetic factor in coeliac disease. (diva-portal.org)
Since an association between the human leukocyte antigen (HLA) region and Hodgkin lymphoma (HL) was first reported in 1967, many studies have reported associations between HL risk and both single nucleotide polymorphism (SNP) and classic HLA allele variation in the major histocompatibility complex. (ox.ac.uk)
Familial clustering occurs, and human leukocyte antigen (HLA) subtypes are associated with myositis. (msdmanuals.com)
Hierarchical testing by Cox regression analyses confirmed the significance of the protective effect of the HLA alleles identified (when assessed in composite) in terms of disease duration, whereas AB0 blood group antigen heterozygosity was found to be significantly associated with disease severity (rather than duration) in our cohort. (biomedcentral.com)
This study evaluates the association in Caucasian populations of two single nucleotide polymorphisms (SNPs) mapping to the Human Leukocyte Antigen (HLA) region and deriving from a genome wide association scan (GWAS) of knee OA in Japanese populations. (warwick.ac.uk)
Multiple sclerosis (MS) has been associated with the human leukocyte antigen DR15 allele in Caucasians of North and Central European origin. (birmingham.ac.uk)
During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)

In the illustration on the right, DQ1 serotyping antibodies recognizes the DQ α (magenta), where antibodies to DQA1* gene products bind variable regions close to the peptide binding pocket. (wikipedia.org)
HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease. (ox.ac.uk)
CONCLUSIONS:In an observational study, we found a genome-wide significant association between HLA-DQA1*05 and the development of antibodies against anti-TNF agents. (ox.ac.uk)
Monitoring after transplantation in liver and kidney transplant recipients with anti-donor HLA antibodies. (cnr.it)
Public epitope specificity of HLA class I antibodies induced by a failed kidney transplant: alloantibody characterization by flow citometric techniques. (cnr.it)
Clinical Significance of de novo production of HLA of donor-specific antibodies in kidney transplantation. (cnr.it)

The HLA-DQA1 gene provides instructions for making a protein that plays a critical role in the immune system. (medlineplus.gov)
The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. (medlineplus.gov)
Researchers have identified hundreds of different versions (alleles) of the HLA-DQA1 gene, each of which is given a particular number (such as HLA-DQA1*05:01 ). (medlineplus.gov)
Phenotype Frequency: Percentage of individuals who have the allele or gene (Individuals / n). (allelefrequencies.net)
The CYP2D6 gene in DNA from 179 cell lines including rare and/or difficult to analyze alleles and/or diplotypes were characterized by the GeT-RM using a variety of methods ( J Mol Diag 2019 21:1034-1052 ). (cdc.gov)

Our results suggest that the association between HLA polymorphism and risk of ICC might be influenced by the distribution of HPV-16 variants. (biomedcentral.com)

Data were technically validated using published algorithms to evaluate donor relatedness, ancestry, imputed HLA, and T1D genetic risk score. (nature.com)
Jokiniemi A, Magris M, Ritari J, Kuusipalo L, Lundgren T, Partanen J and Kekäläinen J (2020) Post-copulatory genetic matchmaking: HLA-dependent effects of cervical mucus on human sperm function Proc Biol Sci. (dnaromance.com)
We developed a framework for inference of germline variants from tumor panel sequencing, including imputation, quality control, inference of genetic ancestry, germline polygenic risk scores, and HLA alleles. (biomedcentral.com)

¹ IMGT/HLA Database - For more details of the allele. (allelefrequencies.net)
All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (3). (alleles.org)

Prospective studies in larger patient populations also including novel SARS-CoV-2 variants will be required to assess the impact of HLA genetics on the capacity of mounting protective vaccination responses in the future. (biomedcentral.com)
HLA-DQA1*05 and upstream variants of PPARGC1B are associated with infliximab persistence in Japanese Crohn's disease patients , Pharmacogenomics J . 23(6):141-148, 2023. (csml.org)

In this study we analyzed at the population level the effect of DR4 subtypes and class I, HLA-B alleles, on IDDM risk when the influence of the DQ locus was stratified. (diabetesjournals.org)
We confirm that the strongest signal of association comes from an SNP located in the class II region, rs6903608 (odds ratio [OR] = 1.79, P = 6.63 × 10(-19)), which is unlikely to be driven by association to HLA-DRB, DQA, or DQB alleles. (ox.ac.uk)

Allele Frequencies shown in green were calculated from Phenotype Frequencies assuming Hardy-Weinberg proportions. (allelefrequencies.net)

We imputed HLA alleles in an independent data set from the British 1958 Birth Cohort (N = 918) with gold standard four-digit HLA types and SNPs genotyped using the Affymetrix GeneChip 500 K and Illumina Immunochip microarrays. (nih.gov)

The list below shows all populations in AFND that contains the allele. (allelefrequencies.net)

conversely the lowest rates of immunogenicity, 10% at 1 year, were observed in patients treated with adalimumab combination therapy who did not carry HLA-DQA1*05. (ox.ac.uk)

For immunization/vaccination trials or to aid the clinical diagnosis of diseases strongly associated with the HLA-DR locus. (aruplab.com)

The alleles tested using genotyping assays can be viewed here . (cdc.gov)
GeT-RM used targeted and whole genome sequencing analysis to recharacterize 137 DNA samples that were previously characterized using a variety of targeted genotyping assays to identify star allele diplotypes for CYP2C8, CYP2C9, and CYP2C19. (cdc.gov)
The data from each test method and consensus diplotypes for each sample, assays used, and alleles tested can be viewed here . (cdc.gov)

Conclusion: A positive association was found between HLA DQ2/8 and Iranian celiac disease. (ac.ir)

Methods: This case-control study was conducted on 25 celiac patients and 25 matched healthy controls for HLA typing of DQ2/DQ8. (ac.ir)

p = 0.42) for the allele associated with risk in the Japanese GWAS. (warwick.ac.uk)

Risk HLA-DQA1 and PLA2R1 Alleles in Idiopathic Membranous Nephropathy" 1 was published in the February 3, 2011 edition of The New England Journal of Medicine using samples from Great Britain which had been collected over a 10-year span. (goldenhelix.com)
We aimed to evaluate the utility of pre-emptive HLA DQA1-HLADRB1*07:01 screening to reduce the risk of AZA-induced pancreatitis in an IBD population. (ecco-ibd.eu)
Pre-emptive HLA DQA1-HLADRB1*07:01 screening may reduce the risk of pancreatitis during AZA treatment in patients with IBD. (ecco-ibd.eu)

Allele Frequency: Total number of copies of the allele in the population sample (Alleles / 2n) in decimal format. (allelefrequencies.net)

The serotype is positive in individuals who bear the DQA1*01 alleles. (wikipedia.org)

The following sequences have been submitted to the Nomenclature Committee since the June 2017 nomenclature update and, following agreed policy, have been assigned official allele designations. (alleles.org)

DQA1*0103 is protective against Behçet's disease,pemphigus vulgaris,juvenile diabetes, steroid-sensitive nephrotic syndrome,myasthenia graviscoeliac diseasemultiple sclerosis, chronic active hepatitis C, and Vogt-Koyanagi-Harada syndrome. (wikipedia.org)

ª Notes - See notes for ambiguous combinations of alleles. (allelefrequencies.net)

The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria. (medlineplus.gov)
This matchmaking approach matches parents with different alleles for immune system performance, resulting in more genetically diverse offspring compared to the average, thus reducing the potential for health complications. (dnaromance.com)

As negative and predictive values were high, HLA typing may be considered a beneficial test for diagnosis confirmation. (ac.ir)

Meuleman T, Lashley LE, Dekkers OM, van Lith J, Claas FH and Bloemenkamp KW (2015) HLA associations and HLA sharing in recurrent miscarriage: A systematic review and meta-analysis Hum Immunol. (dnaromance.com)
Shankarkumar U, Pawar A, Gaonkar P, Parasannavar D, Salvi V, and Ghosh K (2008) HLA allele associations in idiopathic recurrent spontaneous abortion patients from India J Hum Reprod Sci. (dnaromance.com)

a listing of recent publications that describe new HLA sequences is given in Table 3. (alleles.org)

A prospective cohort study is ongoing in IBD patients being considered for AZA therapy who are assigned to pre-treatment HLA DQA1-HLADRB1*07:01 (rs2647087) screening ( n = 372 currently recruited) and compared with historical controls who have received AZA standard of care ( n = 373). (ecco-ibd.eu)

Allele reported 27 time(s) and present in 27 population(s). (allelefrequencies.net)

Anatomy6

Organisms8

Diseases10

Chemicals and Drugs54

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes63

Disciplines and Occupations1

Information Science4

Named Groups4

Health Care7

Geographicals3

DQB127

DRB113

Haplotypes6

Haplotype3

Genes8

Loci4

Susceptibility4

Antigens3

Genotypes2

01011

20221

Antigen9

Antibodies6

Gene5

Polymorphism1

Genetic3

IMGT2

Variants2

Class2

Frequencies1

SNPs1

Populations1

Conversely1

Locus1

Assays3

Association1

Celiac1

GWAS1

Risk3

Frequency1

Individuals1

20171

Disease1

Combinations1

Immune system2

TYPING1

Associations2

Sequences1

Cohort1

Population1