Pathogenic human thyroglobulin peptides in HLA-DR3 transgenic mouse model of autoimmune thyroiditis. (musc.edu)
Methods Homocitrullinated peptides were identified and assessed in vitro for HLA-A2 binding and in vivo in human leukocyte antigen (HLA) transgenic mouse models for immunogenicity. (bmj.com)
There is the possibility that this haplotype is a recent (Holocene) arrival from Africa or the Middle East to Central Asia as this best explains the alleles within the haplotype. (wikipedia.org)
DRB15
HLA-DR7 (DR7) is a HLA-DR serotype that recognizes the DRB1*0701 to *0705 gene products. (wikipedia.org)
Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. (thermofisher.com)
The polymorphisms associated with the "shared epitope" are located on the α-helical rim (DRB1 chain) of the peptide-binding cleft, where they may interact with either the bound peptide antigen or the T cell receptor. (musculoskeletalkey.com)
Genotype2
The analysis of genetic factors other than CFTR may help our understanding of genotype-phenotype relationships in CF. As human leukocyte antigen (HLA) class II polymorphism has been associated with a number of diseases including autoimmune and inflammatory diseases, asthma, and allergy, we investigated the possibility that HLA polymorphism contributes to CF-associated pulmonary inflammation. (nih.gov)
Based on the product of single gene variant odds ratios, the risk of developing asthma was assigned to genotype profiles, and the frequency of each profile was estimated for the general population. (cdc.gov)
Polymorphism2
HLA class II polymorphism in cystic fibrosis. (nih.gov)
HLA-DR and HLA-DQ polymorphism in human thyroglobulin-induced autoimmune thyroiditis: DR3 and DQ8 transgenic mice are susceptible. (musc.edu)
02011
DR7:DQA1*0201:DQB1*0202 is associated with Graves' disease. (wikipedia.org)
Genetics2
There are a few interesting genetics with DR7. (wikipedia.org)
In addition to influencing immune response patterns, many of these alleles are associated with susceptibility to a wide spectrum of autoimmune diseases, making the MHC an essential starting point for anyone wanting to understand the genetics of rheumatic diseases. (musculoskeletalkey.com)
Haplotypes2
The most frequent A-B-DR-DQ haplotypes in Korea are found at ~3/4 the Korean frequencies in Japan, except A33-Cw7-B44-DR7-DQ2, which indicates that DR7 likely spread into Korea after the Japan's Yayoi migration when most of the Korean contribution occurred. (wikipedia.org)
HLA- DQ2 and HLA-DQ8 testing is valuable because CD is unlikely if both haplotypes are negative. (vdocuments.net)
Linkage disequilibrium1
D′ can therefore take on values between 0 and 1, and it is a measure of linkage disequilibrium that is normalized for variations in allele frequencies at the two loci. (musculoskeletalkey.com)
Antibodies4
DR53-DR7 may be associated with sclerosis/lupus associated anti-apolipoprotein antibodies. (wikipedia.org)
The association between aPL antibodies and particular human leukocyte antigen (HLA) alleles and HLA-linked epitopes has been reported in studies of patients with lupus erythematous (eg, HLA-DR7, HLA-DR4). (medscape.com)
The HLA-DR3 phenotypes seem to predispose to the formation of aCL antibodies and antinuclear antibodies (ANAs), but this has not been confirmed in patients, and particular HLA alleles associated with recurrent miscarriage have not been reported. (medscape.com)
Following this model, the human immune system is divided into two major classes: Cellular Immunity, located in the mucous membranes of the gastrointestinal and respiratory tracts and their respective lymph nodes (outer defenses), and Humoral Immunity, with production of antigen-specific antibodies by plasma cells in the bone marrow (inner defenses). (medicalveritas.org)
Lupus1
In the case of systemic lupus erythematosus (SLE) and related illnesses, many of the HLA class II alleles are associated with the presence of specific autoantibodies or clinical phenotypes. (musculoskeletalkey.com)
Subtypes1
Here is a map showing the allele frequency of HLA-A3, which is divided in two subtypes : A3:01 and A3:02. (eupedia.com)
Chains1
HLA class II molecules consist of noncovalently associated α (32 kD) and β (28 kD) chains, both of which are encoded within the MHC. (musculoskeletalkey.com)
Peptide1
Modified peptides showed enhanced binding to HLA-A2 compared with the native sequences and immunization of HLA-A2 transgenic mice generated high avidity modification specific CD8 responses that killed peptide expressing target cells. (bmj.com)
Human2
During this time, the perception of CD has changed from a rather uncommon enteropathy to a common multi- organ disease with a strong genetic predisposition that is associated mainly with human leukocyte antigen (HLA)-DQ2 and HLA-DQ8. (vdocuments.net)
Description: The LN3 mAb reacts with the human major histocompatibility complex (MHC) class II, HLA-DR. HLA-DR is expressed on the surface of human antigen presenting cells (APC) including B cells, monocytes, macrophages, DCs, and activated T cells. (thermofisher.com)
MeSH1
HLA-DR3 Antigen" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (musc.edu)
Autoimmune1
Coexpression of susceptible and resistant HLA class II transgenes in murine experimental autoimmune thyroiditis: DQ8 molecules downregulate DR3-mediated thyroiditis. (musc.edu)
Psoriasis2
DR7 is positively associated with psoriasis vulgaris. (wikipedia.org)
In PsA, the onset of arthritis and psoriasis was more prevalent in HLA-B27-negative patients, while initiation with axial manifestations was more predominant in HLA-B27-positive patients. (bvsalud.org)
Surface1
HLA class I and class II molecules are cell surface glycoproteins, anchored to the membrane by hydrophobic transmembrane segments. (musculoskeletalkey.com)
Class3
HLA-DR, like other MHC class II molecules, is a transmembrane glycoprotein composed of a 36 kDa alpha chain (DRA) and 27 kDa beta chain (DRB). (thermofisher.com)
Background Post-translational modification of proteins has the potential to alter the ability of T cells to recognize major histocompatibility complex (MHC) class -I and class-II restricted antigens, thereby resulting in altered immune responses. (bmj.com)
HLA class I molecules consist of a 45-kD α chain encoded within the MHC that is noncovalently associated with the 12-kD β 2 -microglobulin chain (encoded on chromosome 15). (musculoskeletalkey.com)
Profiles1
Below are the most recent publications written about "HLA-DR3 Antigen" by people in Profiles. (musc.edu)
Patients3
OBJECTIVE: To describe and analyse the initial symptoms attributable to patients with spondyloarthritis (SpA) and their association with HLA-B27 status. (bvsalud.org)
In AS patients, the absence of HLA-B27 seems to be related to an increase in the probability of starting the disease with cervical pain and peripheral manifestations. (bvsalud.org)
RESULTS: The distribution frequencies of the minor alleles of nucleotides 16304C (p = .037), 16311C (p = .027), and 152C (p = .034) were remarkably higher in AS patients than in healthy controls, which indicated that the16304C, 16311C, and 152C alleles were correlated with an increased risk of AS. (bvsalud.org)
Major3
This graph shows the total number of publications written about "HLA-DR3 Antigen" by people in this website by year, and whether "HLA-DR3 Antigen" was a major or minor topic of these publications. (musc.edu)
The allelic variations among different HLA molecules are a major factor accounting for differences in the types of antigenic peptides to which an individual responds or in the types of T cells that are used in an immune response. (musculoskeletalkey.com)
Interestingly, the recent data in RA indicate that the major HLA-DR associations are with anti-CCP antibody positive disease, suggesting that control of autoantibody responses may be a primary mechanism underlying these associations in RA as well. (musculoskeletalkey.com)
Risk2
DR7-DQ2/DR5-DQ7 phenotype (transhaplotype encoded isoform DQα5β2) is the primary risk DQ isoform in celiac disease. (wikipedia.org)
DR7-DQ2/DR5-DQ7 (/DR11-DQ7 or /DR12-DQ7) is a clarifying identifier for the at risk transhaplotype. (wikipedia.org)
Presence1
CONCLUSION: In this SpA population, MMs were the most prevalent initial symptoms, with differences across diagnoses and depending on the presence of the HLA-B27 antigen. (bvsalud.org)
Show1
The A19 (A29, A30, A31, A32, A33, A74) serotypes are very much enriched in sub-saharan and Western Africa, including Iberia, and disequilibrated components of DR7 show a tendency to be linked to A19 serotypes. (wikipedia.org)
Cells2
HLA-DR is expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. (thermofisher.com)
In each individual, T cells are generally restricted to recognize antigens presented by the person's own HLA molecules. (musculoskeletalkey.com)
Central Asia1
The former is mostly found in Europe, with lower frequencies across the Middle East, Central Asia (Uygurs), India and even isolated parts of Africa (Cameroon). (eupedia.com)
Found1
It is overall an North Asian HLA type, although it is also found in Lebanon and the Maghreb (but Lebanese do have 1-2% of North Asian DNA associated with Y-DNA haplogroup Q1b). (eupedia.com)