• We investigated sequence-specific DNA alkylation using conjugates between the N-methylpyrrole (Py)-N-methylimidazole (Im) polyamide and the DNA alkylating agent, chlorambucil, or 1-(chloromethyl)-5-hydroxy-1, 2-dihydro-3H-benz[e]indole (seco-CBI). (nii.ac.jp)
  • Comparative analysis of DNA alkylation by conjugates between pyrrole-imidazole hairpin polyamides and chlorambucil or seco-CBI. (nii.ac.jp)
  • Denaturing PAGE analysis revealed that DNA alkylation activity of polyamide-seco-CBI conjugate 5 was similar to that of polyamide-chlorambucil conjugates 1 and 2. (nii.ac.jp)
  • Abstract Isobutene/olefin alkylation is a major refinery process in which light hydrocarbons (isobutene and, mainly, C3 and C4 olefins) are converted to a high octane gasoline feedstock. (sbir.gov)
  • abstract = "Reductive alkylation of methyl 3, 5-dimethoxybenzoate with the dibromoalkane and the bromochloroalkane derivatives (4a-d) and (4e-g) afforded, after acid hydrolysis, the corresponding methyl 1- (haloalkyl)-3-methoxy-5-oxocyclohex-3-ene-1-carboxylate derivatives (6a-g). (monash.edu)
  • DuPont Clean Technologies (DuPont) is pleased to announce that Hengli Petrochemical Company (Hengli), based in Dalian, China, has awarded DuPont a contract to supply the alkylation and spent acid regeneration (SAR) technologies for the new, grassroots refinery in the Changxing Island Harbor Industrial Zone. (prweb.com)
  • The grassroots refinery complex, with the addition of STRATCO® alkylation technology, will allow Hengli to produce a high quality alkylate product (used as a blending component in the gasoline pool) from a 100% isobutylene feed stream. (prweb.com)
  • In an oil refinery it is referred to as a sulfuric acid alkylation unit (SAAU) or a hydrofluoric alkylation unit, (HFAU). (wikidoc.org)
  • Alkylation has become an important refinery process because of increasing demand for high octane and low vapor pressure gasoline blending components. (ihs.com)
  • An East Coast refinery test was conducted by Aggreko's Process Services (APS) group and the DuPont Clean Technologies division where chiller systems were installed in the reactor feed section of the STRATCO alkylation unit. (hydrocarbonprocessing.com)
  • The case explored in this paper, cleaner production approaches to reduce fluorine use and waste in the alkylation process at a specific UK oil refinery, illustrates the need to broaden the issues and trade-offs considered in assessing processing and waste management options. (thefreedictionary.com)
  • DuPont STRATCO Refinery Solutions, "HF Alkylation Course," (2006). (thefreedictionary.com)
  • However, the conventional enolate alkylation approach remains problematic due to lack of regioselectivity, risk of overalkylation, and the need for strongly basic conditions and expensive alkyl halide reagents. (sciencemag.org)
  • Alkylation , in petroleum refining , chemical process in which light, gaseous hydrocarbons are combined to produce high-octane components of gasoline . (britannica.com)
  • Alkylation units were installed in petroleum refineries in the 1930s, but the process became especially important during World War II , when there was a great demand for aviation gasoline. (britannica.com)
  • For upgrading of petroleum, alkylation produces synthetic C7-C8[further explanation needed] alkylate, which is a premium blending stock for gasoline. (wikipedia.org)
  • For upgrading of petroleum , alkylation produces a premium blending stock for gasoline. (wikipedia.org)
  • The unique feed stream (100-percent isobutylene) available from the Hengli Petrochemical facility marks the beginning of a new era for alkylation in the gasoline market as the butane-to-alkylate movement grows around the world. (prweb.com)
  • Alkylation is used by the petroleum refining industry to produce a low-vapor-pressure, high-octane gasoline blendstock. (doe.gov)
  • P h − O − + M e 2 − S O 4 ⟶ P h − O − M e + M e − S O 4 − {\displaystyle \mathrm {Ph{-}O^{-}\ +\ Me_{2}{-}SO_{4}\ \longrightarrow \ Ph{-}O{-}Me\ +\ Me{-}SO_{4}^{-}} } (with Na+ as a spectator ion) On the contrary, the alkylation of amines introduces the problem that the alkylation of an amine makes it more nucleophilic. (wikipedia.org)
  • Microwave assisted N-alkylation of amine functionalized crystal-like mesoporous phenylene-silica. (nih.gov)
  • a) O xidation with Jones Reagent (Aldehydes) b) Bayer-Villiger o xidation (Ketones) b) En amine formation 4. (coursehero.com)
  • For alkylation at carbon, the electrophilicity of alkyl halides is enhanced by the presence of a Lewis acid such as aluminium trichloride . (wikipedia.org)
  • Examples of N-alkylation with alkyl halides are the syntheses of benzylaniline, 1-benzylindole, and azetidine. (wikipedia.org)
  • Secondary alkyl halides can be tricky to prepare in the lab because the intermediates en route to making them tend to rearrange. (acs.org)
  • The same can be said for using secondary alkyl halides as reactants in the Friedel-Crafts alkylation. (acs.org)
  • The conventional a-alkylation of carbonyl compounds is performed by utilizing stoichiometric amounts of metal enolates for addition to alkyl halides. (docme.ru)
  • Alkylation of α-oxygenated aryl ketones with various alkyl halides proved successful with a cinchonidine catalyst, giving products with high yield and enantioselectivity. (byu.edu)
  • Silicotungstic acid is used to manufacture ethyl acetate by the alkylation of acetic acid by ethylene: C2H4 + CH3CO2H → CH3CO2C2H5 It has also been commercialized for the oxidation of ethylene to acetic acid: C2H4 + O2 → CH3CO2H Methylation is the most common type of alkylation, being associated with the transfer of a methyl group. (wikipedia.org)
  • Methylation is the most common type of alkylation, being associated with the transfer of a methyl group . (wikidoc.org)
  • This project will develop a novel reactor approach to solid-catalyzed isobutene/olefin alkylation in which olefin polymerization at the catalytic surface is limited, thereby avoiding the primary issue with solid catalyzed alkylation. (sbir.gov)
  • This results in high levels of catalyst consumption, making solid catalytic alkylation economically and environmentally unacceptable. (doe.gov)
  • Direct Catalytic Intermolecular -Allylic Alkylation of Aldehydes by Combination of Transition-Metal and Organocatalysis. (docme.ru)
  • There are a few methods for the catalytic intermolecular a-alkylation of nonactivated aldehydes and ketones. (docme.ru)
  • For example, Tamaru and co-workers reported that the a-allylic alkylation of aldehydes is possible in the presence of a catalytic amount of palladium and a slight excess of Et3B. (docme.ru)
  • Herein, we report the first direct intermolecular a-alkylation of aldehydes, which involves catalytic enamine intermediates. (docme.ru)
  • The contract includes the license and engineering design packages for the STRATCO® alkylation and MECS® SAR units. (prweb.com)
  • As part of DuPont's commitment to innovation, the alkylation unit at Hengli will utilize the patented XP2 technology in the STRATCO® Contactor™ reactor. (prweb.com)
  • STRATCO® alkylation technology is licensed and marketed by DuPont as part of its Clean Technologies portfolio in Overland Park, Kansas. (prweb.com)
  • The Kumada coupling employs both a nucleophilic alkylation step subsequent to the oxidative addition of the aryl halide (L = Ligand , Ar = Aryl ). (wikipedia.org)
  • However the adoption of zeolites on large scale Friedel-Crafts alkylation has been hampered by the high cost of zeolite production from commercial sources. (uwc.ac.za)
  • Inspired by the work of Trost and Tsuji on allylic alkylations, the use of previously reported two-component catalyst systems with Pd, and our experience from initial experiments, we decided to pursue a different highly challenging strategy for the a-alkylation of aldehydes and cyclic ketones: the one-pot combination of transition-metal and enamine catalysis (Scheme 1). (docme.ru)
  • Adverse outcome pathway development from protein alkylation to liver fibrosis. (wikipathways.org)
  • Carbonyl reductase inactivation may contribute to mouse lung tumor promotion by electrophilic metabolites of butylated hydroxytoluene: protein alkylation in vivo and in vitro. (ucdenver.edu)
  • The main emphasis of this work is to utilize Pd catalyzed allylic alkylation to synthesize new heterocycles including furans, isoxazolines and new cyclopentane amino-acid analogs in an enantioselective manner. (usf.edu)
  • Currently the only proven alternative is sulphuric acid (see Existing Alkylation Process and Waste Management Section) and the trade-offs are such that there is no general preference for one process over the other (Chapin et al. (thefreedictionary.com)
  • Catalyst production is treated as part of the Background because both HF and sulphuric acid are bulk commodities so that any change in use for this alkylation plant would represent no more than a marginal change in demand. (thefreedictionary.com)
  • The origin of the diastereoselective alkylation of enolates of oxazolopiperidones is studied by means of theoretical calculations and experimental assays. (ub.edu)
  • According to the mode of activation, the Review is divided into two sections: alkylation via C-H activation and alkylation via olefin activation. (rti.org)
  • Transtutors has a vast panel of experienced chemistry tutors who specialize in alkylation of alcohol and can explain the different concepts to you effectively. (transtutors.com)
  • However, when the angular carbon adopts an S configuration, the preference for the exo alkylation stems from the intermolecular steric hindrance between the enolate and the alkylating reagent. (ub.edu)
  • In parallel experiments, the effects of pretreatment with PB, Aroclor 1254, pregnenolone-16α-carbonitrile, butylated hydroxytoluene, β-naphthoflavone, and ethanol on DMN-induced alkylation of liver DNA were studied at a DMN dose of 5 µg/kg body weight. (aacrjournals.org)
  • We have earlier reported that alkylation of DNA by the chemical carcinogen dimethyl sulphate, which mainly alkylates N-7 of guanine and N-3 of adenine, causes the formation of partially denatured regions in double-stranded DNA (Rizvi RY, Alvi NK & Hadi SM, Biosci. (portlandpress.com)
  • Taken together, this work reveals a novel, noncanonical mechanism by which an OTU family deubiquitinase regulates its substrates, and provides multiple new targets for alkylation chemotherapy sensitization of tumors. (embopress.org)
  • These results establish that N -alkylation of prosthetic heme during attempted metabolism of olefinic bonds is the cause of cytochrome P -450 destruction. (aspetjournals.org)