Alkaloid of areca nut. Medical search. Frequent questions

The main alkaloid is arecoline, which accounts for over 50% of the total alkaloid content. (wikipedia.org)
Arecoline Arecaidine Guvacoline Guvacine The total alkaloid content of the nuts increases during ripening and decreases upon subsequent drying. (wikipedia.org)
A roasting of dried nuts increases the proportion of arecoline in the total alkaloid content. (wikipedia.org)
Nine alkaloids constitute the active ingredients of betel nut ( Reference Farnworth Farnworth, 1976 ), the most abundant of which is arecoline - a potent muscarinic agonist that rapidly crosses the blood-brain barrier and induces a range of parasympathetic effects ( Reference Asthana, Greig and Holloway Asthana et al , 1996 ). (cambridge.org)
Also, SMAD-2 was phosphorylated following treatment of HaCaT cells by Catechin, Tannin and alkaloids namely Arecoline, Arecaidine and Guvacine. (iisc.ac.in)
What would be the proper procedure to extract and isolate arecoline, an alkaloid ester, from the seed of the Areca nut, and is it possible to mass produce arecoline using that method? (stackexchange.com)
A double-blind study found that inhalation of arecoline (the major constituent of nut) caused bronchoconstriction in 6 of 7 asthmatics, and 1 of 6 healthy control subjects (See reference number 1). (vibore.com)
It is chewed for euphoric effects of major constituent, arecoline, a cholinergic alkaloid, which appears to be absorbed through mucous membrane of mouth. (vibore.com)
The areca nut is rich in alkaloids such as arecoline, a widely used stimulant akin to tobacco, alcohol, and caffeine [ 1 ]. (biomedcentral.com)
The nut contains a stimulating alkaloid, arecoline, and tannins, which give it an astringent taste. (innvista.com)
Four alkaloids have been found in Areca Nut - Arecoline, Arecain, Guracine, and a fourth existing in very small quantity. (findmeacure.com)
The seed contains alkaloids such as arecaidine and arecoline . (ceylonorganictaste.com)

To investigate the possible mechanism and the compound(s) responsible for the antiplatelet and acetylcholinesterase (AChE) inhibitory effects of Areca catechu crude extract (Ac.Cr). (jcimjournal.com)
Effects of betel nut crude and pure compounds on human platelet aggregation Concentration-response curves show the inhibitory effect of (A) betel nut 70% aqueous-methanolic extract and (B) (+)-catechin, against platelet aggregation induced by agonists such as arachidonic acid (AA, 1.7 mmol/L), adenosine diphosphate (ADP, 4.3 μmol/L), platelet-activating factor (PAF, 8 nmol/L), epinephrine (20 μmol/L) and Ca2+-ionophore (10 μmol/L) in human venous blood. (jcimjournal.com)
In an attempt to understand the role of areca nut constituents in the manifestation of OSF, we studied the global gene expression profile in epithelial cells (HaCaT) following treatment with areca nut water extract or TGF-beta. (iisc.ac.in)
Interestingly, 64% of the differentially regulated genes by areca nut water extract matches with the TGF-beta induced gene expression profile. (iisc.ac.in)
Areca nut water extract treatment induced p-SMAD2 and TGF-beta downstream targets in HaCaT cells but not in human gingival fibroblast cells (hGF), suggesting epithelial cells could be the source of TGF-beta in promoting OSF. (iisc.ac.in)
Water extract of areca nut consists of polyphenols and alkaloids. (iisc.ac.in)
Chin Ayessa A, Fernandez Clariza D, Sanchez Renalyn B, Santos Beatriz Marie S, Tolentino Regin, Masangkay Frederick R. Antimicrobial performance of ethanolic extract of Areca catechu L. seeds against mixed oral flora from tooth scum and gram negative laboratory isolates. (ijcmph.com)
Hung Y, Hou L, Wong M. The effects of areca nut extract and nicotine on selected periodontal pathogens: in vitro study. (ijcmph.com)
The mixture of this quid, or chew, is a combination of the areca nut (fruit of the Areca catechu palm tree, erroneously termed betel nut) and betel leaf (from the Piper betel, a pepper shrub), tobacco, slaked lime (calcium hydroxide), and catechu (extract of the Acacia catechu tree). (medscape.com)
The dried nuts are crushed with lime and catechu, a scarlet and astringent extract made by boiling chips of wood from the areca palm, plus some spices. (innvista.com)
Of the Fluid Extract of Areca Nut, 1 drachm. (findmeacure.com)
Areca Nut Extract,Areca Nut P.E.,Areca Nut Extract Powder, Betel Nut Extract, Betel Nut Extract powder Product Name: Areca Nut Extract Latin name: Pericarpium Arecae Appearance: Light yellow powder Specification: 5:1 TLC,alkaloid 2.7% 5% Part Used: The Peel. (chinalane.org)
The research aimed was to evaluated the quality of Limousin bull sperms used skim egg yolk extender supplemental with extract of betel nut (Areca catechu L.) freezing at -80ºC. (ub.ac.id)
The treatments were T0 (100% skim egg yolk + 0% extract of betel nut), T1 (100% skim egg yolk + 1% extract of betel nut), T2 (100% skim egg yolk + 3% extract of betel nut) and T3 (100% skim egg yolk + 5% extract of betel nut). (ub.ac.id)
It could be concluded that was addition of extract betel nut up to 5% was not affected to semen quality. (ub.ac.id)

Need to enhance the awareness activities regarding the health concern due to consumption of areca nut. (ijcmph.com)
Ko YC, Huang YL, Lee CH, Chen MJ, Lin LM, Tsai CC. Betel nut chewing, cigarette smoking and alcohol consumption related to oral cancer in Taiwan. (ijcmph.com)
Role of areca nut consumption in the cause of oral cancers. (ijcmph.com)
Betel leaf and Areca nut consumption in the world. (medicinalherbinfo.org)
Areca nut is widely used in India and the consumption has increased over the past two decades, with availability in new dry packaged forms ( pan masala, gutka, mawa ). (brjnmims.org)
Recent reports of increasing mouth cancer incidence have suggested an association with areca nut consumption. (brjnmims.org)
Raw areca nut (RAN) consumption induces oral, esophageal and gastric cancers, which are significantly associated with the overexpression of pituitary tumor transforming gene 1/securin and chromosomal instability (CIN). (biomedcentral.com)
single enzymes, which can be used to soften the betel fiber during betel nut processing, reduce the physical damage to the oral cavity caused by betel nut consumption, and improve the quality of the product. (chinalane.org)

Areca nut seed contains bioactive components like alkaloids and tannins. (ijcmph.com)
The active components responsible for the adverse impact of AN are primarily alkaloids, polyphenols and tannins. (remedypublications.com)

Oral submucous fibrosis (OSF) is a chronic inflammatory disease characterized by the accumulation of excess collagen, and areca nut chewing has been proposed as an important etiological factor for disease manifestation. (iisc.ac.in)
Areca nut and its role in oral submucous fibrosis. (ijcmph.com)
The areca nut component of betel quid plays a major role in the pathogenesis of oral submucous fibrosis. (medscape.com)
[ 9 , 10 ] In a 2004 study, a clear dose-dependent relationship was observed for both frequency and duration of chewing areca nut (without tobacco) in the development of oral submucous fibrosis. (medscape.com)
[ 12 ] but their addition to areca nut chewing can be a risk for oral submucous fibrosis. (medscape.com)
[ 12 ] Commercially freeze-dried products such as pan masala, guthka, and mawa have higher concentrations of areca nut per chew and appear to cause oral submucous fibrosis more rapidly than self-prepared conventional betel quid, which contains smaller amounts of areca nut. (medscape.com)
Oral submucous fibrosis (OSF) is a chronic and latent malignant disease, which poses a global and regional problem to public health, especially in East and Southeast Asia where areca nut chewing is popular. (fortunejournals.com)

Sudha S, Mythili B, Balachandar V. Mixture of betel leaf, areca nut and tobacco chewing is a risk factor for cytogenetic damage in construction workers from south India. (ijcmph.com)
Tobacco and areca nut. (ijcmph.com)
Bhat SJS, Blank MD, Robert L, Balster RL, Mimi Nichter M, Nichter M. Areca nut dependence among chewers in a South Indian community who do not also use tobacco. (ijcmph.com)
Mawa (kharra): This is a crude combination of areca, tobacco, and lime. (medscape.com)
Mainpuri tobacco: Popular in parts of northern India, Mainpuri tobacco is a mixture of areca nut, tobacco, lime, and various condiments. (medscape.com)
For the treatment of this disease, the first choice is to fast betel nut, spicy, tobacco and other stimulants. (fortunejournals.com)
A dry, preparation of betel leaf, tobacco, areca nut, catechu, and slanked lime which is used like chewing tobacco and has similar negative health effects. (unt.edu)
Gutka is a preparation of crushed areca nut (also called betel nut), tobacco, catechu, paraffin, slaked lime and sweet or savory flavorings. (manashhospital.com)

Tujuan dari penelitian ini adalah untuk mengetahui kualitas spermatozoa sapi pejantan Limousin dengan penambahan ekstrak biji pinang (Areca catechu L.) dalam media susu skim kuning telur pada penyimpanan suhu -80ºC. (ub.ac.id)
Hasil penelitian ini diharapkan mampu menjadi dasar untuk mengetahui pengaruh pemberian ekstrak biji pinang (Areca catechu L.) terhadap kualitas spermatozoa sapi pejantan Limousin pada penyimpanan suhu -80ºC. (ub.ac.id)

Symptom ratings measured by the Positive and Negative Syndrome Scale (PANSS) and Extrapyramidal Symptom Rating Scale (ESRS), and demographic and substance-use data, were compared for 40 chewers and 30 non-chewers of betel nut. (cambridge.org)
The prevalence of betel-nut use is about 10 %, with about 600 million users all over the world ( Reference Gupta and Warnakulasuriya 5 , 6 ) , and most betel-nut chewers in Taiwan are male. (cambridge.org)

Guvacine hydrochloride, an alkaloid from the nut of Areca catechu, acts as an inhibitor of GABA transporter, and dispalys modest selectivity for cloned GABA transporters with IC50 values of 14 μM (human GAT-1), 39 μM (rat GAT-1), 58 μM (rat GAT-2), 119 μM (human GAT-3), 378 μM (rat GAT-3), and 1870 μM (human BGT-3). (csnpharm.cn)

Betel chewing' describes the practice of masticating a quid of ingredients, including the seed of the Areca catechu palm (betel nut), the leaf of the creeping vine Piper betle and lime, usually in the form of burnt shell or coral. (cambridge.org)

Constituents of areca are potentially carcinogenic. (findmeacure.com)
Constituents- Areca Nut contains a large quantity of tannin, also gallic acid, a fixed oil gum, a little volatile oil, lignin, and various saline substances. (findmeacure.com)

Areca nuts are cultivated in India and East Asia. (wikipedia.org)
In India the nut has long been used as a taenifuge for tapeworm. (findmeacure.com)

The condition is well recognized for its malignant potential and is particularly associated with areca nut chewing, the main component of betel quid. (medscape.com)

Betel nut is humanity's fourth most widely used drug after nicotine, ethanol and caffeine, and is chewed by millions of people living between the east coast of Africa and the western Pacific ( Reference Marshall and Lindstrom Marshall, 1987 ). (cambridge.org)

Current epidemiological studies and evidence indicate that betel nut chewing is one of the most significant risk factors for OSF. (fortunejournals.com)
Here we have reviewed the evidence for carcinogenicity of areca nut, including epidemiological studies, several animal studies and mechanistic evidence. (brjnmims.org)

Moreover, both polyphenols and alkaloids induced TGF-beta 2 and THBS1 (activator of latent TGF-beta) in HaCaT cells suggesting areca nut mediated activation of p-SMAD2 involves up-regulation and activation of TGF-beta. (iisc.ac.in)

Alcaloide que se obtiene de la nuez de betel (Areca catechu), fruto de una palmera. (bvsalud.org)

Betel nut quids consist of areca nut ( Areca catechu ) wrapped in betel vine leaf ( Piper betle ) and smeared with a paste of burnt (slaked) lime. (vibore.com)

Areca, a genus of palms bearing betel nut. (3dict.net)

Areca nut in pathogenesis of oral sub mucous fibrosis: revisited. (ijcmph.com)
Even though the exact etiology and pathogenesis of OSF have not yet been elucidated totally, the currently recognized pathogenic factor is areca nut. (fortunejournals.com)

Out of the tested compounds, none of the compounds in betel nut showed any antiplatelet effect except for catechin that was the most potent against epinephrine-induced aggregation. (jcimjournal.com)

One out of 4 other asthmatic patients who regularly chewed betel nuts developed severe bronchoconstriction (a 30 % fall in FEV1) on two occasions when given betel nuts to chew,and all 4 patients said that prolonged betel nut chewing induced coughing and wheezing. (vibore.com)
The natives chew these nuts all day. (findmeacure.com)

Both polyphenol and alkaloid fractions of areca nut were able to induce TGF-beta signaling and its downstream targets. (iisc.ac.in)
The most abundant alkaloid in areca nut, has been proven to induce buccal mucosa fibroblast activation [2-3]. (fortunejournals.com)

Areca Nut is aromatic and astringent and is said to intoxicate when first taken. (findmeacure.com)
In this country Areca Nut is made into a dentrifrice on account of its astringent properties. (findmeacure.com)

also, Areca palms can be seen in along the canals and large paddy fields . (ceylonorganictaste.com)

It is normally added to a heap of areca nut as well as betel leaf to maintain the alkaloid stimulants synthetically accessible to enter the circulation system by means of sublingual assimilation. (shreeindiachemicals.com)

Joshi M, Gaonkar K, Mangoankar S, Satarkar S. Pharmacological investigation of Areca catechu extracts for evaluation of learning, memory and behavior in rats. (ijcmph.com)

Areca alkaloids are a group of piperidine alkaloids found in the areca nut, the seeds of the areca palm (Areca catechu). (wikipedia.org)
An alkaloid obtained from the betel nut (Areca catechu), fruit of a palm tree. (bvsalud.org)
The Areca Nut Palm. (ijcmph.com)
It is the fruit of the areca palm, which grows wild in Sumatra and the Philippines, but is cultivated in other regions. (innvista.com)
The free-growing areca palm grows to about 10-15 feet (usually within 4-5 years) and begins to produce fruit. (ceylonorganictaste.com)
Usually, an areca palm tree grows up to 30 to 50 feet high. (ceylonorganictaste.com)

Betel nut alkaloids include potent muscarinic cholinomimetics: recent research suggests that these agents may be therapeutic in schizophrenia. (cambridge.org)

The nuts are gathered according to preference, either green or ripe, and then dried. (innvista.com)
In the case of biting bees , the juice of a ripe areca nut is used to the coating on the place of biting. (ceylonorganictaste.com)

Out of these, expression of 57% of genes was compromised in the presence of ALK5 (T beta RI) inhibitor and 7% were independently induced by areca nut, highlighting the importance of TGF-beta in areca nut actions. (iisc.ac.in)

The betel nut is a popular stimulant in the Indian subcontinent and Southeast Asia. (innvista.com)

The vermifuge function of areca preparations is used today only in veterinary medicine. (wikipedia.org)

Betel nuts are chewed for their effects as a mildly euphoric stimulant, attributed to the presence of relatively high levels of psychoactive alkaloids and terpeneols. (findmeacure.com)

Areca alkaloids are isolated from the areca nut, which are hemispherical seeds and are approximately 3 cm in size. (wikipedia.org)
Black Pepper's pungent bite comes from the Alkaloids-piperine and Piperidine-and resins found mostly in the seeds. (tattvasherbs.com)

Our principal hypothesis is that the muscarinic action of betel nut may exert a beneficial effect on the symptoms of people with schizophrenia. (cambridge.org)

Besides the nut from the Areca catechu , other species are also used in the same manner including A. concinna , A. nagensis , A. glandiformis , A. valiso , A. ipot , A. macrocalyx , A. pumila , and A. triandra . (innvista.com)

however asthmatic subjects seem to be particularly sensitive to bronchoconstrictor effects of this alkaloid and possibly other substances contained in nut. (vibore.com)

This study shows the possible antiplatelet and AChE inhibitory potential of betel nut while further studies are needed to confirm and identify more compounds in betel nut for these actions. (jcimjournal.com)

A survey in 61 asthmatic patients found that 22 of 34 patients who still chewed betel nut, either for occasional use or regularly, reported that it worsened their asthma (See reference number 3). (vibore.com)
A total of 677 (20·7 %) men were found to have CKD and 427 (13·1 %) participants reported a history of betel-nut use. (cambridge.org)

D) Kaplan-Meier survival curves of overall survival rates were schemed in terms of LC3B expression and areca nut usage in OSCC patients, Mouse monoclonal to ALDH1A1 separately. (cancercurehere.com)

In an attempt to find the responsible compound(s) in betel nut for antiplatelet and anti-AChE activities, different commercially available betel nut compounds were tested. (jcimjournal.com)
Betel nut is commercially available in dried, cured and natural forms. (findmeacure.com)

In addition a variety of compounds have been isolated (alkaloids, glycosides, terpenes, flovonoids, etc) but further studies need to be done so as these 'leads' to develop into clinically useful medicines. (gotomydoctor.com)

Small pieces of betel nut are generally use with betel leaf after meals in a day or on any festival. (ijcmph.com)

Effects of chewing betel nut (Areca catechu) on the. (cambridge.org)
ANE) and its containing alkaloids have genotoxic and cytotoxic effects and also have the potential for carcinogenesis [7,9,10]. (cancercurehere.com)

Chewing betel nuts increases the capacity to work, also causes a hot sensation in the body, heightened alertness and sweating[citation needed]. (findmeacure.com)

The prevalence (24·8 %) of CKD in betel-nut users was significantly higher than that (11·3 %) of participants without betel-nut use ( P = 0·026). (cambridge.org)
LC3 expression was significantly higher in OSCC patients associated with areca nut chewing (Figure 1B). (cancercurehere.com)

However, the association between betel-nut chewing and risk for chronic kidney disease (CKD) is unknown. (cambridge.org)

Anatomy3

Organisms7

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Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Psychiatry and Psychology3

Phenomena and Processes1

Technology, Industry, Agriculture2

Geographicals4

Arecoline12

Extract15

Consumption8

Tannins2

Oral submucous7

Tobacco8

Pinang2

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Guvacine1

Catechu palm1

Constituents2

India2

Quid1

19871

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Polyphenols1

Nuez1

Vine1

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Catechin1

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Palm6

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Southeast Asia1

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