Alkaline sphingomyelinase (Alk-SMase) is a key enzyme in the intestinal tract for digestion of dietary sphingomyelin (SM), which generates lipid messengers with cell-cycle regulating effects. (lu.se)
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) also known as alkaline sphingomyelin phosphodiesterase (Alk-SMase) or intestinal alkaline sphingomyelinase is an enzyme that in humans is encoded by the ENPP7 gene. (wikipedia.org)
ENPP7 is a new name for an old enzyme whose activity was originally identified in 1969 by Nilsson as a type of sphingomyelinase that hydrolyses sphingomyelin to ceramide in the intestinal tract. (wikipedia.org)
and named alkaline sphingomyelinase (alk-SMase), as the optimal pH of the enzyme was 9.0 and its main substrate is sphingomyelin. (wikipedia.org)
Ceramides (N-acylsphingosine) are one of the hydrolysis byproducts of sphingomyelin by the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis (PMID 25935) and many other tissues. (foodb.ca)
Neutral1
Description: A sandwich quantitative ELISA assay kit for detection of Human Neutral Sphingomyelinase (NSMASE) in samples from tissue homogenates or other biological fluids. (myelisakit.com)
Enzyme2
Expression of Alkaline Sphingomyelinase in Yeast Cells and Anti-inflammatory Effects of the Expressed Enzyme in a Rat Colitis Model. (lu.se)
Like alkaline phosphates, NPP isoforms require divalent metal cations for catalytic activity but it is not clearly known whether the divalent metals play both a function and structural role within the enzyme. (memphis.edu)
Intestinal tract1
Nucleotide pyrophosphatase/phosphdiesterase (NPP) 7 , also known as alkaline sphingomyelinase (Alk-SMase) is a membrane-anchored ectoenzyme initially discovered in the intestinal tract in 1969. (memphis.edu)
Hydrolysis1
Once the pH reaches alkaline levels betanin degrades by hydrolysis, resulting in a yellow-brown color. (openfoodfacts.org)
Acid1
A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. (harvard.edu)
Protein1
Sphingomyelinase D is thought to be the protein component responsible for most of the tissue destruction and hemolysis caused by brown recluse spider envenomation. (medscape.com)
Levels1
This study shows, using the alkaline comet assay, that lower levels of DNA damage are induced following FLASH irradiation, an effect that is modulated by the oxygen tension, and increases with the total dose and dose rate of irradiation, indicating that an oxygen related mechanism, e.g. transient radiation-induced oxygen depletion, may contribute to the tissue sparing effect of FLASH irradiation. (knoblauchpublishing.com)
Acid sphingomyelinase3
BACKGROUND: Enzyme replacement therapy (ERT) with olipudase alfa, a recombinant human acid sphingomyelinase (rhASM), is being developed to treat patients with ASM deficiency (ASMD), commonly known as Niemann-Pick disease (NPD) types A or B. This study assessed the effect of ERT on lipid parameters and inflammatory markers. (bvsalud.org)
The first is due to the deficient activity of the enzyme acid sphingomyelinase (ASM). (bvsalud.org)
A zebrafish model of Combined Saposin Deficiency identifies acid sphingomyelinase as a potential therapeutic target. (harvard.edu)
Sphingomyelin phosphodiesterase1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 (E-NPP 7) also known as alkaline sphingomyelin phosphodiesterase (Alk-SMase) or intestinal alkaline sphingomyelinase is an enzyme that in humans is encoded by the ENPP7 gene. (wikipedia.org)
Known as alkaline1
For example, ENPP7 also known as alkaline sphingomyelinase (Alk-SMase) is responsible for the digestion of dietary sphingomyelin by hydrolyzing sphingomyelin into ceramide and phosphorylcholine. (rndsystems.com)
Cutaneous1
We suggest that the synergistic interaction of nonhemolytic enterotoxin and sphingomyelinase might have a role in the development of cutaneous lesions. (cdc.gov)
Activity2
AD performed sphingomyelinase activity dosage. (bmj.com)
Disturbance of sphingolipid composition at the plasma membrane due to increased activity of alkaline ceramidase 2 (ACER2) increases levels of sphingosine (Sph), which, together with increased activity of sphingosine kinases 1 and 2 (SPHK1/2), leads to increased production of S1P. (scientificarchives.com)
Responsible1
Sphingomyelinase D is thought to be the protein component responsible for most of the tissue destruction and hemolysis caused by brown recluse spider envenomation. (medscape.com)