• The use of SO 2 F 2 as a reagent enables a rapid, simple and mild dehydration of aldoximes to give the corresponding nitriles. (organic-chemistry.org)
  • A variety of (hetero)arene, alkene, alkyne and aliphatic aldoximes can be converted to nitriles in excellent yields with great functional group compatibilities in acetonitrile under ambient conditions. (organic-chemistry.org)
  • Herbivore-induced poplar cytochrome P450 enzymes of the CYP71 family convert aldoximes to nitriles which repel a generalist caterpillar. (mpg.de)
  • The dehydrating POP systems were exploited in the conversion of aldoximes into nitriles. (uaeu.ac.ae)
  • The easily prepared heterogeneous nanocatalyst demonstrated a significant catalytic performance for the transformation of aldoximes to nitriles that is far superior to previously reported methods. (ac.ir)
  • In enzymology, an aliphatic aldoxime dehydratase (EC 4.99.1.5) is an enzyme that catalyzes the chemical reaction an aliphatic aldoxime ⇌ {\displaystyle \rightleftharpoons } an aliphatic nitrile + H2O This dehydratase converts an aldoxime on an aliphatic substrate to a nitrile as the product structure with water as byproduct. (wikipedia.org)
  • Oximes are condensation products of hydroxylamines with aldehydes (forming aldoxime), ketones (forming ketoxime), or quonone. (chemicalland21.com)
  • Componds like RR'C=NOH, where R is an organic side-chain and R' may be hydrogen, forming an aldoxime, or another organic group, forming a ketoxime. (inra.fr)
  • Diacetyl monoxime, pralidoxime chloride, pralidoxime iodide, pyridine aldoxime methane sulphonate and pyridine aldoxy methiodate given 1-2gmi.v.as 5 percentsolution in isotonic saline. (pediatriconcall.com)
  • Novel aldoxime dehydratase involved in carbon-nitrogen triple bond synthesis of Pseudomonas chlororaphis B23. (wikipedia.org)
  • Aldoxime dehydratase co-existing with nitrile hydratase and amidase in the iron-type nitrile hydratase-producer Rhodococcus sp. (wikipedia.org)
  • Aldoximes are amino acid derivatives that serve as intermediates for numerous specialized metabolites including cyanogenic glycosides, glucosinolates, and auxins. (biorxiv.org)
  • Glucosinolates are amino acid-derived thioglucosides with a sulfated aldoxime moiety and variable side chains (Figure 1 A) that are present in the Brassicales [ 11 - 13 ]. (biomedcentral.com)
  • Mitochondria and fatty acid metabolism were also likely targets of 3-hydroxy-2-pyridine aldoximes with tetrahydroisoquinoline moiety, due to increased phosphorylation of acetyl-CoA carboxylase. (bvsalud.org)
  • Overall, if the absence of significant toxicity for piperidine bearing aldoxime highlights the potential of its further studies in medical counter-measures, the observed biological activity of aldoximes with tetrahydroisoquinoline moiety could be indicative for future design of compounds either in a negative context in OP antidotes design, or in a positive one for design of compounds for the treatment of other phenomena like cell proliferating malignancies. (bvsalud.org)
  • Two Oxime Varieties Hydroxylamine combines with aldehydes1 or ketones2 to form aldoximes or ketoximes, respectively. (quirkyscience.com)
  • Background Plants create a band of aldoxime metabolites that are popular as volatiles so that as intermediates in cyanogenic glycoside and glucosinolate biosynthesis specifically seed families. (cancer-pictures.org)
  • Aldoxime biosynthesis in the cereal sorghum ( Sorghum bicolor ) is not well characterized. (biorxiv.org)
  • A phylogenetic analysis of CYP79 showed that SbCYP79A61 formed a subclade with maize ZmCYP79A61, previously characterized to be involved in aldoxime biosynthesis. (biorxiv.org)
  • Alkyl-bridged quaternary amines (e.g. bis-pyridinium aldoximes) did not show metabolic N-dealkylation or alkyl transfer to another compound. (otka-palyazat.hu)
  • The uncharged 3-hydroxy-2-pyridine aldoximes with protonatable tertiary amines are studied as antidotes in toxic organophosphates (OP) poisoning. (bvsalud.org)
  • Aldoxime formation is mainly catalyzed by cytochrome P450 monooxygenases of the 79 family (CYP79s) that can have broad or narrow substrate specificity. (biorxiv.org)
  • Some phenols have been converted to ortho-hydroxybezaldehyd by ortho-formylation using MgO nanoparticles and (CH2O)n in xylene and subsequently treated with aqueous NH2OH.HCl, affording the corresponding aldoxime in a one-pot procedure. (orgchemres.org)
  • para‐ and ortho‐Pyridinium aldoximes in reaction with acetylthiocholine. (bmc-rm.org)
  • Two herbivore-induced cytochrome P450 enzymes CYP79D6 and CYP79D7 catalyze the formation of volatile aldoximes involved in poplar defense. (mpg.de)
  • The systematic name of this enzyme class is aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming). (wikipedia.org)
  • The development of myopathy in vitro was shown to be nerve-mediated and to require a functional acetylcholine receptor for its development It was successfully treated therapeutically in vivo by pyridine-2-aldoxime methiodide and prophylactically by pyridostigmine bromide. (aston.ac.uk)
  • CYP79D enzymes contribute to jasmonic acid-induced formation of aldoximes and other nitrogenous volatiles in two Erythroxylum species. (mpg.de)
  • 2-PAM (2-pyridine aldoxime methyl chloride) - also called pralidoxime - is one of a class of chemicals, called oximes that reverse the binding of cholinesterase inhibitors with acetylcholinesterase. (cdc.gov)
  • In the case of hydroxylamines, the resulting imine products that are formed from their interaction with a carbonyl in acidic conditions results in the formation of a special subset of imines known as oximes (from aldehyde - aldoxime/from ketone - ketoxime). (blogspot.com)
  • 18. New quaternary pyridine aldoximes as casual antidotes against nerve agents intoxications. (nih.gov)
  • A concentration of 10 mM pyridine 2-aldoxime methochloride (2-PAM Cl) was incubated with intact red blood cells (RBCs) and assayed virtually free of interfering oxime and hemoglobin (Hb). (cdc.gov)
  • fig, preparations and dosage: pyridine-1 aldoxime chloride (p-1-am. (riversideortho.com)
  • We thus show that rational design based on structural studies permits the refinement of new-generation pyridine aldoxime reactivators that may be more effective in the treatment of nerve agent intoxication. (inrae.fr)
  • The uncharged 3-hydroxy-2-pyridine aldoximes with protonatable tertiary amines are studied as antidotes in toxic organophosphates (OP) poisoning. (bvsalud.org)
  • Mitochondria and fatty acid metabolism were also likely targets of 3-hydroxy-2-pyridine aldoximes with tetrahydroisoquinoline moiety, due to increased phosphorylation of acetyl-CoA carboxylase. (bvsalud.org)
  • Herbivore-induced poplar cytochrome P450 enzymes of the CYP71 family convert aldoximes to nitriles which repel a generalist caterpillar. (mpg.de)
  • The systematic name of this enzyme class is aliphatic aldoxime hydro-lyase (aliphatic-nitrile-forming). (wikipedia.org)
  • Catalysis of the reaction: an aliphatic aldoxime = an aliphatic nitrile + H2O. (yeastrc.org)
  • A highly efficient strategy for chemoselective oxidation of aldoximes to nitrile oxides by iodosobenzene in neutral aqueous media is reported. (typeset.io)
  • 10. Synthesis, Biological Evaluation, and Docking Studies of Novel Bisquaternary Aldoxime Reactivators on Acetylcholinesterase and Butyrylcholinesterase Inhibited by Paraoxon. (nih.gov)
  • Overall, if the absence of significant toxicity for piperidine bearing aldoxime highlights the potential of its further studies in medical counter-measures, the observed biological activity of aldoximes with tetrahydroisoquinoline moiety could be indicative for future design of compounds either in a negative context in OP antidotes design, or in a positive one for design of compounds for the treatment of other phenomena like cell proliferating malignancies. (bvsalud.org)
  • Other names in common use include OxdA, and aliphatic aldoxime hydro-lyase. (wikipedia.org)
  • Butanal oxime was chosen for toxicology testing as a representative of the aldoxime class. (nih.gov)
  • K-269 and K-347 are relatively apolar pyridinium aldoximes, they have an extremely short stay in rats' bodies. (otka-palyazat.hu)