Aldehyde precursors. Medical search. Frequent questions

Coniferyl aldehyde is reduced to coniferyl alcohol by the action of dehydrogenase enzymes. (wikipedia.org)
This protein belongs to the aldehyde dehydrogenase family of proteins. (nih.gov)
Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. (nih.gov)
Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. (nih.gov)
Aldehyde dehydrogenase 2 rs671 genetic polymorphisms are associated with chemotherapy-induced nausea and vomiting]. (nih.gov)
Aldehyde dehydrogenase (Ald) is required for IAA synthesis from a tryptophan (Trp) precursor in Ustilago maydis. (nih.gov)
[ 3 ] Subsequent studies identified a defect in fatty aldehyde dehydrogenase (FALDH), a component of the fatty alcohol:NAD oxidoreductase enzyme complex. (medscape.com)
Aldehyde dehydrogenase 1 (ALDH1), a human stem-cell marker, is an enzyme responsible for converting retinaldehydes to retinoic acids (RAs) to modulate cell differentiation. (bepress.com)
Aldehyde dehydrogenase activity identifies a population of human skeletal muscle cells with high myogenic capacities. (medecinesciences.org)
Aldehyde dehydrogenase activity promotes survival of human muscle precursor cells. (medecinesciences.org)
This study also aimed to assess the expression of ALDH1 (aldehyde dehydrogenase 1) enzyme activity on the isolated cells. (bvsalud.org)

Various aryne precursors, sodium arenesulfinates, and aromatic aldehydes can be effectively converted to the desired products in 40-84% yields (29 examples). (rsc.org)
The condensation of DAMN with different aromatic aldehydes can form 1:1 and/or 1:2 Schiff base ligands [ 14 ]. (springer.com)

The genetic defect in Sjögren-Larsson syndrome results in deficient activity of FALDH, which catalyzes the oxidation of fatty aldehyde to fatty acid. (medscape.com)
[ 8 ] FALDH is a component of the fatty alcohol:NAD oxidoreductase enzyme complex that catalyzes the sequential oxidation of fatty alcohol to aldehyde and fatty acid. (medscape.com)
[ 8 ] FALDH is involved in the oxidation of fatty aldehydes produced by catabolism of ether glycerolipids (plasmalogens), which are prominent phospholipids in myelin. (medscape.com)

The products of such reactions were aldehydes, ketones, and organic acids, which may be more toxic than the precursor alkene. (cdc.gov)
however, δ13C values for meteoritic aldehydes and ketones (Strecker precursors) have not yet been reported. (macewan.ca)
As such, the distribution of aldehydes and ketones in the cosmos and their role in prebiotic reactions have not been fully investigated. (macewan.ca)
δ13C values, ranging from −10.0‰ to +66.4‰, were more 13C‐depleted than would be expected for aldehydes and ketones derived from the interstellar medium, based on interstellar 12C/13C ratios. (macewan.ca)
These relatively 13C‐depleted values suggest that chemical processes taking place in asteroid parent bodies (e.g., oxidation of the IOM) may provide a secondary source of aldehydes and ketones in the solar system. (macewan.ca)
Comparisons between δ13C compositions of meteoritic aldehydes and ketones and other organic compound classes were used to evaluate potential structural relationships and associated reactions, including Strecker synthesis and alteration‐driven chemical pathways. (macewan.ca)
Danielle N. Simkus, Jose C. Aponte, Robert W. Hilts and Christopher D.K Herd, Compound-specific carbon isotope compositions of aldehydes and ketones in the Murchison Meteorite. (macewan.ca)

Recent discovery of an enzyme known as aldehyde-deformylating oxygenase (ADO), which naturally makes alkanes from precursors in certain bacteria, stimulated interest in harnessing this enzyme's action to make liquid biofuels. (bnl.gov)
The key ingredient that made it all possible was the discovery of an enzyme called aldehyde ferredoxin oxidoreductase (AOR) in a recently-discovered bacterium called Aromaticum aromatoleum , which is able to break down petroleum. (singularityhub.com)
This enzyme is able to take the electrons from an electrode and bind up their energy in an aldehyde bond that is added to a precursor chemical called propionate. (singularityhub.com)

Second is unveiling the fate of acetaldehyde, Strecker aldehydes and polyfunctional mercaptans , highlighting their relationship with wine oxidation, sulfur dioxide and the grape amino acid and polyphenolic profiles. (asev.org)

Volatile aldehydes are enriched in esophageal adenocarcinoma (EAC) patients' breath and could improve early diagnosis, however the mechanisms of their production are unknown. (nature.com)
Third is the analysis, fate and remediation of hydrogen sulfide and volatile mercaptans and their corresponding precursors, responsible for the development of sulfury off-odors during wine bottle storage. (asev.org)
The uptake of aldehydes could nevertheless be an important SOA formation pathway for less volatile or more reactive aldehydes than pinonaldehyde. (hal.science)
Carbonyls, especially aldehydes, are a group of harmful volatile organic compounds that are found in tobacco smoke. (cdc.gov)

Therefore, patients with Sjögren-Larsson syndrome have deficient activity of FALDH and fatty alcohol:NAD oxidoreductase, which results in defective metabolism of both fatty aldehyde and fatty alcohol. (medscape.com)

Formaldehyde is an important precursor to many other materials and chemical compounds. (iimcopetrochemicals.com)
The main reaction products of α-pinene/ozone reactions are formaldehyde and other aldehydes, such as pinonaldehyde (Grosjean et. (cdc.gov)

These parameterizations cover secondary organic aerosol (SOA) formation from biogenic and anthropogenic precursors, NOx dependency, oligomerization and the reactive uptake of pinonaldehyde. (hal.science)

2,3-Diamino-cis-2-butenedinitrile (diaminomaleonitrile: DAMN) is an attractive precursors to nucleotides and is considered as an intermediate in the synthesis of a wide variety of heterocyclic compounds [ 13 ]. (springer.com)

This stereocenter is a bit too remote to direct alkylation of the aldehyde, so Jamison used diamylzinc and a trans -cyclohexane-1,2-diamine to provide very high d.r. in good yield ( citing Yoshioka ). (organic-chemistry.org)

The pathway of formation for these aromatic precursors is speculated to involve four important steps: enzymatic oxidation, metabolic processing of unsaturated fatty acids, cysteinlated or glutathionylated conjugation to aldehydes, and a β-lyase cleavage during alcoholic fermentation to release the aromatic compound. (ucdavis.edu)
Fatty alcohol and aldehyde may likewise alter the normal integrity of myelin membranes in the brain, leading to white-matter disease and spasticity. (medscape.com)
Accumulation of fatty aldehydes, which are highly reactive molecules, can form covalent Schiff-base derivatives with phosphatidylethanolamine, which may influence myelin membrane properties and alter the function of membrane-bound proteins. (medscape.com)

Furthermore, siRNA knockdown of ALDH1A1 significantly decreased RAR expression and induced cell apoptosis via suppression of the phosphoinositide 3-kinase (PI3K) pathway and activation of caspase signals.Our findings indicate that ALDH1(+) cells represent a pool of endocrine precursors in the developing human pancreas and that ALDH1 activity is required during endocrine cell differentiation. (bepress.com)

In this project, our efforts were directed to the synthesis and characterization of nickel(II) and zinc(II) complexes with tetradentate N 2 O 2 -Schiff base ligands based on diaminomaleonitrile and various aldehydes such as 2-hydroxybenzaldehyde, 3-methoxy-2-hydroxybenzaldehyde and 2-hydroxy-1-naphthaldehyde. (springer.com)
The C4' aminomethyl functionalized furanoside precursors have potentials for new nucleoside analogue synthesis. (miun.se)
Initially an attempt was made to reproduce an earlier successful racemic synthesis of a fused carbocyclic compound using a chiral precursor. (bl.uk)
Gluconeogenesis is a synthesis pathway of glucose from noncarbohydrate precursors. (easyomics.org)

In cells today, amino acids are generated from precursors called α-keto acids using both nitrogen and specialized proteins called enzymes. (scitechdaily.com)
[ 16 ] Schiff-base aldehyde adducts with other amino-containing molecules, including key membrane enzymes and proteins, may also be detrimental to their function. (medscape.com)

Coniferyl aldehyde is an organic compound with the formula HO(CH3O)C6H3CH=CHCHO. (wikipedia.org)

Exogenous agents are also impli- aldehyde) to form various pro-mu- tion, resisting cell death, enabling cated in the generation of reactive tagenic exocyclic adduct s (Bartsch replicative immortality, inducing oxygen. (who.int)

The pathway also supplies important precursor metabolites including 2-oxoglutarate. (easyomics.org)

Gamma-glutamylcysteine (γ-Glutamylcysteine), a dipeptide containing cysteine and glutamic acid, is a precursor to glutathione (GSH). (medchemexpress.com)
The Precursor to Glutathione (GSH), γ-Glutamylcysteine (GGC), Can Ameliorate Oxidative Damage and Neuroinflammation Induced by Aβ40 Oligomers in Human Astrocytes. (medchemexpress.com)
These precursors include S-3-(hexan-1-ol)-L-cysteine (Cys-3MH), S-4-(4-methylpentan-2- one)-L-cysteine (Cys-4MMP), [S-3-(hexan-1-ol)- glutathione (Glut-3MH) and S-4-(4-methylpentan-2-one)-glutathione (Glut-4MMP) for 3MH and 4MMP. (ucdavis.edu)

Chalcones are the principal precursors for the biosynthesis of flavonoids and isoflavonoids. (afpm.org.my)

The oxo reaction is performed under hydroformylation conditions in the presence of a carbonylation catalyst or catalyst precursor such as dicobaltoctacarbonyl, and results in the formation of a compound e.g. an aldehyde which has one more carbon atom in its molecular structure than the feedstock. (europa.eu)
From this, it has been identified that direct precursors become cysteinlated or glutathionylated for each compound during fermentation. (ucdavis.edu)

A coupling with an alkynyl acid provided the cyclisation precursor in short order. (organic-chemistry.org)
In the final phase of this investigations it was explored the use of chiral derivatives of the chiral pool molecule citronellal as well as an achiral analogue in an effort to afford novel chiral aldehydes for propargylation and cyclisation. (bl.uk)

Here, we show that weak aldehyde detoxification characterizes EAC, which is sufficient to cause endogenous aldehyde accumulation in vitro. (nature.com)
Thus, we present a model for increased exhaled aldehydes based on endogenous accumulation from reduced detoxification, which also causes therapeutically actionable genotoxicity. (nature.com)

The laboratory work has focused on obtaining the rotational spectra of the simplest three-carbon ketose sugar, 1,3-dihydroxyacetone, and its structural isomers methyl glycolate and dimethyl carbonate, as well as aminoethanol, the predicted interstellar precursor to alanine. (caltech.edu)
Such aldehyde abstraction reactions should be considered as pathways to complex carbonyl-containing species on interstellar grain surfaces. (caltech.edu)

Chapter V is about a new chiral amine-catalyzed C4' α-aminomethyl-ation of furanoside and nucleoside derived C5' aldehydes. (miun.se)
Highly enantioselective Michael addition of silyl nitronates to alpha,beta-unsaturated aldehydes has been accomplished by the utilization of designer N-spiro C2-symmetric chiral quaternary ammonium bifluoride 1 as an efficient catalyst, providing direct access to both optically active gamma-nitro aldehydes, a very useful precursor to various complex organic molecules including aminocarbonyls, and their enol silyl ethers, a Mukaiyama donor of potential synthetic utility for further selective transformations. (unboundmedicine.com)

Whether a bond is a strategic one depends on whether the bond cut leads to structural simplification in the precursors (topological criteria), and on whether the resultant precursors can easily be converted into the target by chemical reactions that have a broad scope. (uni-erlangen.de)

Chalcones are the condensation products of aromatic aldehyde with acetophenones in attendance of catalyst. (afpm.org.my)

An intrinsic sugar-assisted kinetic resolution mechanism between aldehyde and aminocatalyst was proposed and monitored in NMR studies. (miun.se)

Poly(benzoxazine-f-chitosan) films: The role of aldehyde neighboring groups on chemical interaction of benzoxazine precursors with chitosan. (case.edu)
Two hydrogel precursors (poly(acrylic acid) PAA/CaCl2 and Na2 CO3 ) diffuse from different locations and generate amorphous calcium carbonate (ACC) nanoparticles at the diffusional fronts, leading to the formation of hydrogel structures driven by electrostatic interactions between PAA and ACC nanoparticles. (bvsalud.org)

The tandem mass spectrometer ran in Multiple Reaction Monitoring (MRM) mode where the precursor ions fragmented with nitrogen gas in the collision cell at a defined electron voltage. (cdc.gov)

Preparation and characterization of carbon fiber reinforced polybenzoxazine and polybenzoxazole composites from the same precursor: Use of a smart, ortho-substituted and amide-co-imide functional matrix. (case.edu)

We show that short-chain genotoxic alkanals and also medium-chain alkanals are specifically enriched in EAC and associated tissues, on a genetic background of reduced aldehyde detoxification. (nature.com)

This precursor possesses an aldehyde handle which facilitates facile loading of the first amino acid onto the solid support by reductive amination. (purdue.edu)
However, many researchers have hypothesized that before the advent of cellular life, amino acids must have been generated from completely different precursors, aldehydes, rather than α-keto acids, since enzymes to carry out the conversion did not yet exist. (scitechdaily.com)
But that idea has led to debate about how and when the switch occurred from aldehydes to α-keto acids as the key ingredient for making amino acids. (scitechdaily.com)

Together, this suggests the esophagus is exposed to aldehyde stress, and that glandular esophageal cells may be vulnerable to this stress. (nature.com)
Pericytes of human skeletal muscle are myogenic precursors distinct from satellite cells. (medecinesciences.org)

Two aldehyde groups are significantly enriched in EAC biopsies and adjacent tissue: (i) short-chain alkanals, and (ii) medium-chain alkanals, including decanal. (nature.com)
After generation of these - usually charged - synthons they are converted into precursors by addition or removal of charged atoms or groups. (uni-erlangen.de)

There is present both 2,3-dimethoxy-4-(methylthio)benzaldehyde and 3,4-dimethoxy-2-(methylthio)benzaldehyde (the two desired precursors to 4-TIM and 2-TIM, respectively), but also present is 3,4-dimethoxybenzaldehyde from the veratrole contamination. (drugwiki.net)

Angiotensinogen is the sole precursor of angiotensin peptides and has a key role in the pathogenesis of hypertension. (cdc.gov)

Exhaled aldehydes have been consistently demonstrated to be enriched in EAC patients 5 , 6 , and could form the basis of a non-invasive, primary care-based, triage test for patients with non-specific upper gastrointestinal symptoms. (nature.com)

The formation of these precursors is still not entirely understood chemically. (ucdavis.edu)
Although efforts to separate this mixture were not effective, one of the aldehydes could be isolated in small yield by derivative formation. (drugwiki.net)

These results support EAC early diagnosis trials using exhaled aldehyde analysis. (nature.com)

It is a major precursor to lignin. (wikipedia.org)

The pure rotational spectral analysis of the low-lying torsional states of the simplest alpha-hydroxy aldehyde, glycolaldehyde, has also been completed. (caltech.edu)
The residue was distilled through a Vigreaux column under vacuum (0.1 mm/Hg) with the fraction boiling at 125-135 °C being richest in aldehydes, as determined by GC analysis. (drugwiki.net)

Anatomy19

Organisms10

Diseases4

Chemicals and Drugs98

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Psychiatry and Psychology1

Phenomena and Processes50

Disciplines and Occupations3

Technology, Industry, Agriculture2

Information Science3

Health Care1

Dehydrogenase11

Aromatic aldehydes2

Oxidation of fatty3

Ketones7

Enzyme3

Strecker1

Volatile4

Oxidoreductase1

Formaldehyde2

Pinonaldehyde1

Nucleotides1

Alkylation1

Fatty3

ALDH11

Synthesis4

Proteins2

Organic compound1

Reactive1

Pathway1

Glutathione3

Biosynthesis1

Compound2

Cyclisation2

Accumulation2

Interstellar2

Chiral2

Reactions1

Condensation1

Mechanism1

Poly2

Nitrogen1

Carbon1

Genetic1

Amino3

Cells2

Groups2

Present1

Role1

Form1

Formation2

Results1

Major1

Analysis2