Albicans. Medical search. Frequent questions

M. Montazeri and H. G. Hedrick, "Factors Affecting Spore Formation in a Candida albicans Strain," Applied and Environmental Microbiology, Vol. 47, No. 6, 1984, pp. 1341-1342. (scirp.org)

The fungus Candida albicans, a type of yeast, lives in the gut microbiota and plays a role in health and gastrointestinal disease. (eurekalert.org)
The fungus Candida albicans colonizes the oral mucosal surface of 30-70% of healthy individuals. (frontiersin.org)
As part of the human mycobiome the polymorphic fungus Candida albicans colonizes the oral mucosal surface of up to 70% of healthy individuals ( 4 ). (frontiersin.org)
Candida albicans is a species of yeast - a single-celled fungus, in fact - that lives naturally in the body. (thecandidadiet.com)
Abstract: Candida albicans, a dimorphic fungus and human opportunistic pathogen, undergoes hyphal development in response to many different environmental cues, including growth in contact with a semi-solid matrix. (tufts.edu)
Candida albicans is a commensal fungus that resides on the skin, mucosal surfaces, and in the gut of an estimated 80% of individuals. (tmc.edu)
Yeast infections are usually caused by Candida albicans , a fungus that many of us carry harmlessly on our skin and mucous membranes. (cdc.gov)

Tracking the pathogenicity of the yeast Candida albicans (April 2000) Candida albicans is the most frequent fungal pathogen for humans. (fraunhofer.de)
Candida albicans is the most frequent fungal pathogen for humans. (fraunhofer.de)
Candida albicans is an opportunistic fungal pathogen that is the principal cause of superficial and systemic candidiasis in human and animals. (scialert.net)
Candida albicans is an opportunistic fungal pathogen with a dimorphic phenotype, i.e., it can grow in either a yeast or hyphal form (Lass-Flörl et al. (researchsquare.com)
For this reason, it is imperative to understand the molecular mechanisms by which C. albicans shifts from commensal organism to deadly bloodstream pathogen in order to identify novel therapeutics. (tmc.edu)
The work 'Restriction digest screening facilitates efficient detection of site-directed mutations by CRISPR in Candida albicans' by Evans and colleagues describes a useful mutagenesis and screening strategy for the important fungal pathogen Candida albicans. (peerj.com)
The opportunistic human fungal pathogen Candida albicans relies on cell morphological transitions to develop biofilm and invade the host. (lu.se)
Candida albicans is an important opportunistic fungal pathogen capable of causing both mucosal and disseminated disease . (bvsalud.org)

The transition of C. albicans from unicellular yeast form to filamentous form i.e ., pseudohyphae and hyphae is referred to as morphogenesis. (scirp.org)
Three main morphological forms of C. albicans are unicellular yeast, pseudohyphae and hyphae. (scirp.org)
C. albicans forms hyphae that invade agar when cells are embedded in or grown on the surface of agar, and the integral membrane protein Dfi1p is required for this activity. (tufts.edu)
Candida albicans very efficiently adheres to these epithelia growing as hyphae. (fraunhofer.de)
These experiments were accomplished by disrupting pathways that allow C. albicans to form hyphae in response to hyphal-inducing stimuli (namely, pH and CO2) and determining if hyphal phenotypes were altered. (tmc.edu)
In the current study, we developed new regulatory molecules, which inhibit the morphological transition of C. albicans from yeast-form cells to cells forming hyphae. (lu.se)
These compounds, benzyl α-l-fucopyranoside and benzyl β-d-xylopyranoside, inhibit the hyphae formation and adhesion of C. albicans to a polystyrene surface, resulting in a reduced biofilm formation. (lu.se)
Invasion by the active penetration of C. albicans into host cells by involving hyphae. (microbenotes.com)
The Candida albicans and C. dubliniensis form true hyphae organisms are enclosed in an exopolysaccharide matrix (germ tubes) and thick-walled cells referred to as chlamy- occurring on any surface, particularly aquatic and industri- dospores, both of which are used by mycology diagnostic al water systems as well as medical devices. (cdc.gov)

Albicans (Latin, 'whitening') may refer to: Corpus albicans, the regressed form of the corpus luteum in ovaries Species with binomial names including albicans: see All pages with titles containing albicans Whitening (disambiguation) This disambiguation page lists articles associated with the title Albicans. (wikipedia.org)
Candida albicans is the most common species of yeast isolated from patients with oral candidiasis [ 2 ]. (hindawi.com)
Although the genus Candida consists of around 200 species, only 20 are reported as etiological agents of IC, being Candida albicans the most frequent causal agent. (intechopen.com)
The species isolated are less susceptible to FLU than most C albicans . (bmj.com)
Further, AMP-17 treatment resulted in an increase in reactive oxygen species (ROS) levels, depolarization of the mitochondrial membrane potential (MMP), and changes in the cell cycle, leading to the apoptosis and necrosis, which ultimately contributed to the death of C. albicans cells. (researchsquare.com)
Although C. composed of a population that developed from a single albicans is the predominant etiologic agent of candidiasis, species or a community derived from multiple microbial other Candida species that tend to be less susceptible to the species (14,17). (cdc.gov)
Over the past 10 years there have been fre- niques for differentiating between isolates quent reports describing "atypical" isolates of the 2 species, C. albicans and C. dublin- of Candida albicans [ 1-5 ]. (who.int)
If you look here at about 7,000 isolates that we have from our surveillance system within the Emerging Infectious Program here at CDC with state and academic partners, you can see that this pie chart represents the different species that we see and the blue is the classic species of Candida albicans . (cdc.gov)

Most of these commensal C. albicans cells proliferate as budding yeasts. (hindawi.com)
Thus, in the oral cavity B lymphocytes contribute to control commensal C. albicans carriage by secreting IgA at foci of colonization thereby preventing fungal dysbiosis. (frontiersin.org)
In fact, commensal fungi, such as C. albicans , are required for microbial community structure, metabolic function, and immune priming ( 6 - 8 ). (frontiersin.org)
Since the adaptive immunity plays a critical role in maintaining immune tolerance toward commensal organisms, such as commensal C. albicans , understanding its relationship with fungi is critical ( 14 ). (frontiersin.org)
However, as a commensal, C. albicans is in constant interaction with the host epithelium ( 17 ). (frontiersin.org)
Lower IL-12p70 production may avoid an unnecessary Th1 response in order to retain immune tolerance, which may be one of the mechanisms by which C. albicans achieves a successful commensal lifestyle without having a detrimental effect on the host's health. (nih.gov)
2021). When the immune system is functioning normally, C. albicans can be present on the skin, oral cavity, gastrointestinal tract, and genitourinary tract of an individual as a commensal, without causing infection (Wiederhold. (researchsquare.com)
Innate immune cells are the first line of defense against C. albicans , and a fully functioning innate immune system confines C. albicans to commensal niches. (tmc.edu)
We will argue that fungi in general and C. albicans specifically, should be regarded a keystone commensal in the oral cavity. (vu.nl)

Three C. albicans strains, two isolated from the oral cavities of HIV positive patients and an ATCC 90028 strain, were used in the study. (hindawi.com)
To broaden our understanding on the population structure and genetic diversity of C. albicans strains in birds, we analysed 30 isolates recovered from animal and human hosts and investigated whether the genotype distribution related to their different source. (springer.com)
C. albicans , 10 reference strains of C. albicans , 2 reference strains of C. dubliniensis and 102 fresh clinical isolates identified as C. albicans . (who.int)
Ten C. albicans reference strains were isolates of C. dubliniensis and C. albicans . (who.int)

Simpotentin, a new potentiator of amphotericin B activity against Candida albicans and Cryptococcus neoformans , was isolated from the culture broth of Simplicillium minatense FKI-4981 by Diaion HP-20 column chromatography, centrifugal partition chromatography, and preparative HPLC. (nature.com)

In an adaptive immunity OPC rechallenge model using a derivate of the pathogenic C. albicans strain SC5314, CD4 + Th17 cells protect from mucosal Candida infection but can be compensated by other IL-17-producing cells in CD4-deficient hosts ( 15 , 16 ). (frontiersin.org)
Finally, we show in Candida albicans -infected mice that CE is highly effective in clearing pathogenic fungal burden in the lungs, liver, and spleen, thus reducing overall mortality rates. (rcsb.org)
2017). When the immune system is impaired, such as in AIDS patients, patients using immunosuppressive agents for an organ transplant, and patients with microbial flora disorders, C. albicans can readily become pathogenic (Wubulikasimu et al. (researchsquare.com)

Therefore, we utilized C. albicans clinical isolates which are able to persist in the oral cavity without causing disease to analyze adaptive responses to oral fungal commensalism. (frontiersin.org)
In this study, multilocus sequence typing was used to characterise the genetic diversity and population structure of 24 avian origin C. albicans isolates collected from different birds with candidiasis and compared to human isolates. (springer.com)
C. albicans is predominantly diploid and displays high degree of genetic diversity across isolates, notably variations in the distribution of heterozygous polymorphisms along the genome. (springer.com)
A total of 30 C. albicans isolates (one isolate from each bird) were examined in this study. (springer.com)
Human isolates were randomly selected and preliminary identified as C. albicans by Matrix-assisted laser desorption/ionization time of flight mass spectrometer at the University of Debrecen. (springer.com)
Yeasts other than C albicans are common vaginal isolates even in a primary care population. (bmj.com)
The aim of the study was to evaluate the protein similarity degree among 15 C. albicans isolates with different virulence obtained from healthy and infected human and animals. (scialert.net)
2005). Different types of electrophoretic techniques have been used for the characterization or typing of C. albicans isolates including separation of chromosomes, DNA fragments, isoenzymes, cell wall glycoproteins and whole cell proteins (Asakura et al . (scialert.net)
In this study, we described the use of SDS-PAGE, along with PAGE techniques, to analyze the similarity of the protein profiles of the cytoplasmic extracts and cell walls of different C. albicans isolates obtained from different host conditions (human against animal isolates and patient against healthy subject isolates) with various virulence degrees. (scialert.net)
Seventeen fresh C. albicans , originated from infected human (7 isolates) and animals (10 isolates), were obtained from Fungal Collection of Mycology Research Center, University of Tehran between April and November, 2007. (scialert.net)

The aims of the present study were evaluate the antifungal action of Photodynamic Therapy (PDT) on Candida albicans planktonic cultures and biofilms formed in vitro and experimental candidosis model in mice, as well as its interference on C. albicans adherence on humans buccal epithelial cells in vitro. (unesp.br)
There was little overlap between AMB- or CAS-responsive genes in biofilms and those that have been identified as AMB, FLU, or CAS responsive in C. albicans planktonic cultures. (who.int)

Foi utilizada cepa padrão de C. albicans (ATCC 18804) para os ensaios. (unesp.br)
Standard strain of C. albicans (ATCC 18804) was used for assays. (unesp.br)
Enterococcus faecalis (ATCC 29212) e Candida albicans (ATCC antimicrobiana sobre os microrganismos estudados. (bvs.br)
ATCC 29212) e a Candida albicans (ATCC 10231). (bvs.br)

In this study, we demonstrate that heat-killed C. albicans (HKC) strongly suppressed LPS-induced IL-12p70 production in M2 macrophages. (nih.gov)
Candida albicans induced a high level of EBI3 expression in M2 macrophages, which served as a mechanism for IL-12p70 suppression by competitive binding of the common protein subunit (p35) of IL-35 and IL-12p70. (nih.gov)
Using more robust approaches, I demonstrated that the intracellular pH of C. albicans is controlled tightly near neutral during morphogenesis, both in vitro and within macrophages, contrary to what was reported previously. (tmc.edu)

M. S. A Khan, I. Ahmad, F. Aqil, M. Owais, M. Shahid and J. Musarrat, "Virulence and Pathogenicity of Fungal Pathogens with Special Reference to C. albicans," In: I. Ahmad, M. Owais, M. Shahid and F. Aqil, Eds. (scirp.org)
AMP-17, an antimicrobial peptide from Musca domestica , is known to be an effective inhibitor of many fungal pathogens, including C. albicans . (researchsquare.com)

The virulence factors of Candida albicans are germ tube and biofilm formation, adherence to host tissues, and production of hydrolytic enzymes. (hindawi.com)

Adhesion to mammalian epithelia is one of the prerequisites that are essential to accomplish pathogenesis of Candida albicans in the mammalian host. (fraunhofer.de)

Our results have indicated that C. albicans can suppress host inflammatory responses in mucosal skin by suppressing LPS-induced IL-12p70 production. (nih.gov)
Though generally harmless, C. albicans is capable of causing uncomfortable mucosal infections as well as deadly disseminated infections depending on the immune status of the host. (tmc.edu)

angustifolia extract on the germ tube and biofilm formation of C. albicans . (hindawi.com)
DVA extract has ability to reduce virulence of C. albicans by inhibiting germ tube and biofilm formation through damage to the cell wall. (hindawi.com)
The present study investigated the effect of subinhibitory concentration of crude extract of DVA on the germ tube and biofilm formation by C. albicans . (hindawi.com)
The effect of different growth media (Horse serum medium, RPMI-1640, MSGB), incubation temperatures (34°C, 37°C, 40°C) and pH values (5.4, 6.4, 7.4) on germ tube production by C. albicans was evaluated. (scirp.org)
The germ tube of C. albicans developed early in 1.5 hr at high temperature i.e ., 40°C. Incubation temperature of 37°C was associated with highest germ tube formation while 34°C shows low filamentation. (scirp.org)

This chapter summarizes the main molecular mechanisms to C. albicans antifungal drug resistance, besides offering an overview of new antifungal agents and new antifungal targets to combat fungal infections. (intechopen.com)
The molecular epidemiology of Candida albicans infections in animals has been rarely studied. (springer.com)
An intestinal Candida albicans infection is often associated with Candida infections elsewhere on the body. (thecandidadiet.com)
Further, C. albicans is the fourth most common cause of all bloodstream infections and continues to present as a major clinical issue with less than satisfactory treatment options. (tmc.edu)

Thus, oral fungal challenge with the commonly used laboratory C. albicans strain SC5314 generates an acute immune response in a naive host ( 13 ). (frontiersin.org)

Patients with asymptomatic candidiasis on one occasion were more likely to have Candida albicans again when sampled a year later than were women with no yeasts on the first occasion. (bmj.com)
Histatin 5 is a histidine-rich, intrinsically disordered, multifunctional saliva protein known to act as a first line of defense against oral candidiasis caused by Candida albicans. (lu.se)

Simpotentin was found to potentiate amphotericin B activity against C. albicans by the microdilution method. (nature.com)
In vitro susceptibility to amphotericin (AMB), fluconazole (FLU), itraconazole (ITZ), and voriconazole (VOR) was determined for approximately 40% of non- C albicans yeasts using a standardised microdilution method. (bmj.com)

C. albicans cells bearing germ tubes are more adherent to buccal epithelial cells (BEC) than yeast forms of C. albicans [ 5 ] due to the antigens found on germ tubes [ 6 ]. (hindawi.com)
Besides CD19 + CD138 − B cells, plasmablasts, and plasma cells were enriched in the tongue of mice colonized with C. albicans suggesting a potential role of B lymphocytes during oral fungal colonization. (frontiersin.org)
To study the response of C. albicans adhering to different surfaces on the transcriptional level we have established an in vitro adhesion assay exploiting confluent monolayers of the human colorectal carcinoma cell line Caco-2 or epidermoid vulvo-vaginal A-431 cells. (fraunhofer.de)
Using whole-genome DNA microarrays comprising probes for almost 7000 predicted ORFs we found that transcriptional profiles of C. albicans adhering to Caco-2 or to A-431 cells, although very similar, still significantly differ from those of Candida cells adhering to plastic surfaces. (fraunhofer.de)
Differences became even more obvious when comparing C. albicans cells either growing in an adherent manner or in suspension culture. (fraunhofer.de)
Transmission electron microscopy showed that, following AMP-17 treatment, the shape of C. albicans cells became irregular, and vacuoles could be seen in the cytoplasm. (researchsquare.com)
56 adults and males mice were immunosuppressed and inoculated with suspensions containing 108 cells/ mL of C. albicans. (unesp.br)
The yeasts recovered after PDT and control group were evaluated for interference of PDT on C. albicans adherence to humans buccal epithelial cells. (unesp.br)
PDT applied on C. albicans planktonic culture was concentrationdependent with significant reduction from minor concentration tested (0.39 μM) and 100% of cells death from 3.12 μM. (unesp.br)
In vivo, 0.73 log10 of C. albicans and 35% adherence on buccal epithelial cells were reduced, but there was not. (unesp.br)
Helps with the invasion of C. albicans into host epithelial and endothelial cells. (microbenotes.com)
C. parapsilosis -stimulated human peripheral blood mononuclear cells (PBMCs) produced similar quantities of tumor necrosis factor α and interleukin 6 and slightly lower amounts of interleukin 1β, compared with C. albicans-stimulated cells. (bath.ac.uk)
PBMCs stimulated with C. parapsilosis displayed a skewed T-helper cell response, producing more interleukin 10 and less interferon γ than cells stimulated with C. albicans . (bath.ac.uk)
Objective To evaluate the effect of photodynamic therapy in the inactivation of Candida albicans planktonic cells, using methylene blue, 150 mg/mL, as a photosensitizer. (bvsalud.org)
Mature C. albicans biofilms grown under continuous flow were exposed for as long as 2 h to concentrations of fluconazole (FLU), amphotericin B (AMB), and caspofungin (CAS) that, while lethal for planktonic cells, were not lethal for biofilms. (who.int)
In this regard, our study led us to observe that AMB physically bound C. albicans biofilms and beta-glucans, which have been proposed to be major constituents of the biofilm extracellular matrix and to prevent azoles from reaching biofilm cells. (who.int)

Specifically, it is currently unclear what triggers the morphological transition that allows C. albicans to escape the macrophage. (tmc.edu)
The purpose of my thesis research was to rigorously test specific molecular signals to determine their relevance in controlling the morphological switch after C. albicans is phagocytosed by a macrophage. (tmc.edu)
Together, these elements likely have a complex, indirect effect on the morphological state of C. albicans . (tmc.edu)

C. albicans biofilm formed in vitro was reduced 0.74 log10 by PDT with reduction of yeasts and hyphaes verified by SEM. (unesp.br)

We performed RNA sequencing to determine the transcriptional host response landscape during C. albicans colonization. (frontiersin.org)
In this context C. albicans is able to adhere to a plethora of different cell types providing different microenvironments for colonization. (fraunhofer.de)
Metabolic modeling predicts specific gut bacteria as key determinants for Candida albicans colonization levels. (umassmed.edu)

Several molecular mechanisms with antifungal agents have been reported for C. albicans where insertions, deletions, and point mutations in genes codifying target proteins are frequently related to the antifungal drug resistance. (intechopen.com)
Candida albicans can form biofilms that exhibit elevated intrinsic resistance to various antifungal agents, in particular azoles and polyenes. (who.int)
We have used transcript profiling to explore the early transcriptional responses of mature C. albicans biofilms exposed to various antifungal agents. (who.int)

Candida Albicans Infection of the Placenta and Fetus: Report. (lww.com)
S. P. Saville, A. L. Lazzell, C. Monteagudo and J. L. Lopez-Ribot, "Engineered Control of Cell Morphology in Vivo Reveals Distinct Roles for Yeast and Filamentous Forms of C. albicans during Infection," Eukaryotic Cell, Vol. 2, No. 5, 2003, pp. 1053-1060. (scirp.org)
Candida Albicans 6C is a homeopathic medicine that relieves symptoms of yeast infection. (vitaminlife.com)
It is usually a superficial infection of the moist areas of the body and is generally caused by CANDIDA ALBICANS. (lookformedical.com)

Serum containing the three subinhibitory concentrations of leaf extract was inoculated with C. albicans , incubated, and viewed under a light microscope. (hindawi.com)

As molecular tests are currently unsuitable for use in routine diagnostic laboratories, we compared a variety of phenotypic techniques for differentiating C. albicans and C. dubliniensis . (who.int)

2022). However, whether AMP-17 acts on intracellular targets in C. albicans remains unclear. (researchsquare.com)

Conclusion Photodynamic Therapy presented antifungal effect against Candida albicans and can be used as an adjunct to conventional treatment. (bvsalud.org)

A novel approach to therapy has been suggested by some researchers, where the virulence of C. albicans can be targeted instead of an antimicrobial property. (hindawi.com)

We investigated the spectrum of yeasts isolated, and compared the epidemiological and laboratory characteristics of women carrying vulvovaginal Candida albicans with those carrying yeasts other than C albicans . (bmj.com)
Of these, C albicans only was isolated from 1087 (89%) and yeasts other than C albicans from 129 (11%) women. (bmj.com)

Also, were the mutations homozygous or heterozygous, as C. albicans is an obligate diploid? (peerj.com)

ISO 18416:2015 gives general guidelines for the detection and identification of the specified microorganism Candida albicans in cosmetic products. (iso.org)

Pathway analysis revealed an upregulation of adaptive host responses due to C. albicans oral persistence, including the upregulation of the immune network for IgA production. (frontiersin.org)

Dfi1p Binding to Calmodulin Promotes Filamentation and Cek1p Activation in Candida albicans. (tufts.edu)

2020). Such patients with specific risk factors are generally susceptible to C. albicans , and almost all organs can be infected (Boniche et al. (researchsquare.com)

In this study, we compared the cytokine responses evoked by Candida albicans and C. parapsilosis . (bath.ac.uk)

Os objetivos do presente estudo foram avaliar a ação antifúngica da Terapia Fotodinâmica (TFD) em culturas planctônicas e biofilmes de Candida albicans formados in vitro e em modelo de candidose experimental em camundongos, bem como sua interferência na aderência de C. albicans às células epiteliais bucais humanas in vitro. (unesp.br)
56 camundongos machos e adultos foram imunossuprimidos e inoculados com suspensões contendo 108 células/mL de C. albicans. (unesp.br)
As leveduras recuperadas após a TFD e grupo controle foram avaliadas quanto a interferência da TFD na aderência de C. albicans às células do epitélio bucal humano. (unesp.br)

These results suggested that the resistance of C. albicans biofilms to azoles or polyenes was due not to the activation of specific mechanisms in response to exposure to these antifungals but rather to the intrinsic properties of the mature biofilms. (who.int)

This phenomenon may be unique to C. albicans as we did not detect activation of Kss1p in S. cerevisiae in response to increased intracellular calcium levels, even if Dfi1p is overexpressed. (tufts.edu)

C. albicans has the ability to respond to environmental conditions and accordingly changing its cell morphology. (scirp.org)
L. A. Merson-Davies and F. C. Odds, "A Morphology Index for Characterization of Cell Shape in C. albicans," Journal of General Microbiology, Vol. 135, No. 11, 1989, pp. 3143-3152. (scirp.org)

however, the mechanism of C. albicans-induced immune tolerance has not been investigated in detail. (nih.gov)
However, C. albicans is able to adapt to the hostile environment of the macrophage phagosome, and in many cases, escape and kill the immune cell by undergoing hyphal morphogenesis. (tmc.edu)

S. Nadeem, A. Shafiq, S. Hakim, Y. Anjum and S. U. Kazm, "Effect of Growth Media, pH and Temperature on Yeast to Hyphal Transition in Candida albicans ," Open Journal of Medical Microbiology , Vol. 3 No. 3, 2013, pp. 185-192. (scirp.org)

Decreased cytokine production after inhibition of dectin 1 revealed that this receptor plays a major role in the recognition of both C. albicans and C. parapsilosis . (bath.ac.uk)

Anatomy25

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SC53141

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