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SGPTAspartate aminotransferaseAminotransferase activityEnzymePyruvate and L-glutamateElevationsBiomarkersBiochemicalHepaticPrevalenceActivityAminotransferasesCatalyzesDiseasesProteinPatientsTestsIncreaseAminotransferaseNormal alanine transaminaseSerumAspartate transaminaseAlkaline phosphatasePyruvateLiver diseaseLevelGreater

SGPT4

• It is also called alanine aminotransferase (ALT or ALAT) and was formerly called serum glutamate-pyruvate transaminase or serum glutamic-pyruvic transaminase (SGPT) and was first characterized in the mid-1950s by Arthur Karmen and colleagues. (wikipedia.org)
• Alanine Transaminase (ALT), also known as Serum Glutamic-Pyruvic Transaminase (SGPT), is an enzyme found primarily in the liver. (prognohealth.com)
• Alanine aminotransferase (ALT) is also known as serum glutamic pyruvic transaminase (SGPT). (medicinenet.com)
• They include aspartate aminotransferase (AST or SGOT) and alanine aminotransferase (ALT or SGPT). (medicinenet.com)

Aspartate aminotransferase5

• In 2000, the American Association for Clinical Chemistry determined that the appropriate terminology for AST and ALT are aspartate aminotransferase and alanine aminotransferase. (wikipedia.org)
• In vivo , Pts treatment effectively protected against APAP-induced severe liver injury by decreasing the lethality rate, the serum alanine transaminase (ALT) and aspartate aminotransferase (AST) levels, liver histological injury, liver malondialdehyde (MDA) formation and myeloperoxidase (MPO) levels and by increasing liver glutathione (GSH) and superoxide dismutase (SOD) levels. (karger.com)
• The enzyme aspartate aminotransferase (AST) is also known as serum glutamic oxaloacetic transaminase (SGOT). (medicinenet.com)
• Moderate wine drinking showed a significant alanine transaminase (ALT)- and aspartate aminotransferase-lowering effect compared to that of the nondrinkers. (biomedcentral.com)
• Twenty percent of patients experienced an increase in either alanine aminotransferase (ALT) or aspartate aminotransferase (AST). (aol.com)

Aminotransferase activity1

• Most of the AGXT gene mutations decrease or eliminate alanine-glyoxylate aminotransferase activity, which impairs the conversion of glyoxylate to glycine. (medlineplus.gov)

Enzyme3

• Alanine transaminase (ALT) is a transaminase enzyme (EC 2.6.1.2). (wikipedia.org)
• An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (curehunter.com)
• The AGXT gene provides instructions for making an enzyme called alanine-glyoxylate aminotransferase. (medlineplus.gov)

Pyruvate and L-glutamate1

• ALT catalyzes the transfer of an amino group from L-alanine to α-ketoglutarate, the products of this reversible transamination reaction being pyruvate and L-glutamate. (wikipedia.org)

Elevations2

• JUXTAPID can cause elevations in transaminases ( 5.1 ). (drugs.com)
• In patients with transaminase elevations, monitor liver enzymes more frequently. (aol.com)

Biomarkers2

• Serum ALT level, serum AST (aspartate transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. (wikipedia.org)
• Control of hepatitis B virus (HBV) infection requires functional virus-specific T cells, yet clinical management of patients with chronic HBV infection (CHB) relies exclusively on the assessment of virological (HBV-DNA, HBsAg) and biochemical (alanine transaminase (ALT)) biomarkers. (bmj.com)

Biochemical1

• After 70 d, liver pathology, serum alanine aminotransferase (ALT), biochemical markers of oxidative stress, liver fatty acid composition, cytochrome P450 2E1 (CYP2E1) expression and activity and cytochrome P450 4A (CYP4A) expression were assessed. (nih.gov)

Hepatic2

• Elevated levels of the transaminases can indicate myocardial infarction, hepatic disease, muscular dystrophy, or organ damage. (cdc.gov)
• JUXTAPID increases hepatic fat (hepatic steatosis) with or without concomitant increases in transaminases ( 5.1 ). (drugs.com)

Prevalence1

• Conclusion： In summary, our study showed that the prevalence of HDV infection in patients with elevated transaminases is not low and the predominance of HDV genotype 2 infection in Shanghai. (researchsquare.com)

Activity2

• Detection and Quantification of Alanine Transaminase Activity. (bioworlde.com)
• We examined whether central adiposity and metabolic markers explain the association of body mass index (BMI as kg/m(2)) with abnormal serum alanine aminotransferase (ALT) activity in a national, population-based study. (nih.gov)

Aminotransferases2

• citation needed] L-alanine + α-ketoglutarate ⇌ pyruvate + L-glutamate ALT (and all aminotransferases) require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid. (wikipedia.org)
• Measure alanine and aspartate aminotransferases (ALT, AST), alkaline phosphatase, and total bilirubin before initiating treatment and then ALT and AST regularly as recommended ( 2.4 , 5.1 ). (drugs.com)

Catalyzes1

• It catalyzes the two parts of the alanine cycle. (wikipedia.org)

Diseases1

• Alanine aminotransferase measurements are used in the diagnosis and treatment of certain liver diseases (e.g., viral hepatitis and cirrhosis) and heart diseases. (cdc.gov)

Protein1

• In the peroxisome, alanine-glyoxylate aminotransferase converts a compound called glyoxylate to the protein building block (amino acid) glycine. (medlineplus.gov)

Patients1

• Out of the 225 HBsAg-positive serum samples with elevated transaminases, HDV-RNA was identified in 11 (4.9%) patients. (researchsquare.com)

Tests1

• Aspartate transaminase Liver function tests Karmen A, Wroblewski F, Ladue JS (January 1955). (wikipedia.org)

Increase1

• The UL-VWFM disappeared transiently on day 9, but reappeared on day 11, coinciding with a mild increase of transaminase. (wjgnet.com)

Aminotransferase7

• It is also called alanine aminotransferase (ALT or ALAT) and was formerly called serum glutamate-pyruvate transaminase or serum glutamic-pyruvic transaminase (SGPT) and was first characterized in the mid-1950s by Arthur Karmen and colleagues. (wikipedia.org)
• In 2000, the American Association for Clinical Chemistry determined that the appropriate terminology for AST and ALT are aspartate aminotransferase and alanine aminotransferase. (wikipedia.org)
• Serum triglyceride (TG), total-cholesterol (T-cho), glucose (Glu), alanine transaminase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), geranylgeranyltransferase (GGT) and albumin (Alb) levels were measured. (spandidos-publications.com)
• Alanine aminotransferase measurements are used in the diagnosis and treatment of certain liver diseases (e.g., viral hepatitis and cirrhosis) and heart diseases. (cdc.gov)
• First, look at liver enzymes: alanine transaminase (ALT) or aspartate aminotransferase (AST). (nih.gov)
• Another enzyme, alanine aminotransferase or ALT, is primarily found in the liver. (medscape.com)
• Plasma alanine aminotransferase levels, hepatic expression of tumor necrosis factor-α, interleukin-6, fatty acid synthesis-related genes, oxidative stress biomarker 8-hydroxydeoxyguanosine (8-OHdG), and apoptosis marker terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells in the liver were decreased in the HW and PGZ groups. (researchgate.net)

Normal alanine transaminase3

• Approximately 20-30% of patients chronically infected with hepatitis C virus (HCV) have persistently normal alanine transaminase (PNALT) levels. (medscape.com)
• Controversies about the histological features of chronic HCV patients with persistently normal alanine transaminase levels: what can be done about the present definition? (pasteur.fr)
• Improved Performance of Serum Alpha-Fetoprotein for Hepatocellular Carcinoma Diagnosis in HCV Cirrhosis with Normal Alanine Transaminase. (nih.gov)

Serum4

• Serum ALT level, serum AST (aspartate transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. (wikipedia.org)
• Is Serum Alanine Transaminase Level a Reliable Marker of Histological Disease in Chronic Hepatitis C Infection? (medscape.com)
• See Full Prescribing Information for serum transaminase and bilirubin monitoring recommendations. (nih.gov)
• AST formerly was called serum glutamic oxaloacetic transaminase (SGOT). (medscape.com)

Aspartate transaminase3

• Aspartate transaminase Liver function tests Karmen A, Wroblewski F, Ladue JS (January 1955). (wikipedia.org)
• For example, elevated alanine transaminase and aspartate transaminase disproportional to bilirubin and alkaline phosphatase levels often indicates liver disease. (healthline.com)
• Aspartate transaminase catalyzes the interconversion of aspartate and α-ketoglutarate to glutamate. (medscape.com)

Alkaline phosphatase1

• Liver glucose-6- phosphatase (G-6-Pase), liver alkaline-phosphatase (AP), tyrosine- transaminase (TT), plasma AP, and alanine-transaminase (AT) were determined in homogenized liver by undisclosed biochemical methods. (cdc.gov)

Pyruvate2

• ALT catalyzes the transfer of an amino group from L-alanine to α-ketoglutarate, the products of this reversible transamination reaction being pyruvate and L-glutamate. (wikipedia.org)
• citation needed] L-alanine + α-ketoglutarate ⇌ pyruvate + L-glutamate ALT (and all aminotransferases) require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an amino acid is converted into a keto acid. (wikipedia.org)

Liver disease1

• The term transaminase is outdated and no longer used in liver disease. (wikipedia.org)

Level3

• Alanine Transaminase Level: Reliable Marker of HCV Histological Disease? (medscape.com)
• An elevated alanine transaminase (ALT) level is indicative of hepatocellular necrosis and has been used as a surrogate marker of liver injury. (medscape.com)
• Liver function tests showed a depressed level of alanine transaminase and an abnormal HDL: LDL. (open.ac.uk)

Greater1

• This research is being done to determine if men with rising PSA after initial therapy for localized prostate cancer who display the Alanine/Alanine SOD2 genotype of MnSOD and supplement their diet with MPX have greater decrease in PSA slope following treatment compared to men that do not supplement with MPX. (dana-farber.org)