The only murine cells tested not detectably expressing gp71 determinants were BALB/3T3 lines. (duke.edu)
Fresh thymocytes from BALB/cJ (GIX-), C57BL/6J (GIX-), and 129/J (GIX+) mouse strains were also reactive with Friend gp71 antiserum, and this activity, as well as that of an antiserum prepared against purified AKR gp71, were also group specific. (duke.edu)
Several commonly used laboratory mouse strains such as BALB/c, SJL, AKR, CBA, C3H and A do not express the NK1.1 antigen. (thermofisher.com)
C57BL2
Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
Description: The PK136 monoclonal antibody reacts with mouse NK1.1, an antigen expressed by natural killer cells and a subset of T cells in the NK1.1 mouse strains including C57BL and NZB. (thermofisher.com)
Mice3
Different strains of mice may have different numbers of endogenous retroviruses, and new viruses may arise as the result of recombination of endogenous sequences. (wikipedia.org)
The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
MLVs include both exogenous and endogenous viruses. (wikipedia.org)
citation needed] The MLVs include both exogenous and endogenous viruses. (wikipedia.org)
The genomes of exogenous and endogenous murine leukemia viruses have been fully sequenced. (wikipedia.org)
Incidence1
L. C. Dunn breeds Strain 129, which later proves to have a high incidence of testicular cancer. (jax.org)
Spontaneous2
Quantitation of spontaneous virus expression. (jax.org)
Effect of host strain and H-2 type on spontaneous regression of murine leukemia. (jax.org)
Lung1
L. C. Strong breeds a Bagg albino with an albino from Little 's stock and starts the first of many tumor-prone strains, called the A strain, known for mammary and lung tumors. (jax.org)
Cells5
Among the latter MLVs are amphotropic viruses (Gr. amphos, "both") that can infect both mouse cells and cells of other animal species. (wikipedia.org)
Scholars@Duke publication: Immunofluorescent analysis of expression of the RNA tumor virus major glycoprotein, gp71, on the surfaces of normal murine cells. (duke.edu)
Although some Friend gp71 interspecies reactivity was discernible on normal murine cells, the principal reactivity was shown to be group specific. (duke.edu)
Process of growing viruses in live animals, plants, or cultured cells. (lookformedical.com)
For detection of NK cells in these strains the monoclonal antibody DX5 (Cat. (thermofisher.com)
Embryonic1
Using viable cell membrane immunofluorescence, most established and early passage normal murine cell lines were significantly reactive with the antiserum, irrespective of neoplastic transformation, strain genotype, or whether they were of embryonic or adult tissue origin. (duke.edu)
Viral1
As Type C retroviruses, replicating murine leukemia viruses produce a virion containing a spherical nucleocapsid (the viral genome in complex with viral proteins) surrounded by a lipid bilayer derived from the host cell membrane. (wikipedia.org)
Proteins2
The encoded proteins are trafficked to the plasma membrane, where they assemble into progeny virus particles. (wikipedia.org)
The expression of the major glycoprotein, gp71, of murine leukemia virus was studied on the surfaces of a variety of normal murine cell lines with a monospecific rabbit antiserum raised against purified Friend murine leukemia virus gp71. (duke.edu)
An activity discriminating GIX+ from GIX- thymocytes was not observed with either Friend or AKR gp71 antisera. (duke.edu)
Particles2
This cleavage is essential for the Env incorporation into virus particles. (wikipedia.org)
The murine leukemia viruses are group/type VI retroviruses belonging to the gammaretroviral genus of the Retroviridae family. (wikipedia.org)
Cell2
The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response. (lookformedical.com)