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  • viral
  • The AKR murine leukemia viruses do not contain acute transforming oncogenes ( 4 ) and are thought to transform cells as a result of activating cellular proto-oncogenes in the vicinity of viral integration into chromosomal DNA ( 5 ). (jimmunol.org)
  • Khoury G., May E. Regulation of early and late simian virus 40 transcription: overproduction of early viral RNA in the absence of a functional T-antigen. (medkursor.ru)
  • Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines. (asm.org)
  • A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication. (asm.org)
  • Gross, L. 1958 Viral etiology of "spontaneous" mouse leukemia: A review. (springer.com)
  • Integration of viral DNA into host DNA was first discerned for the prophage of the temperate bacteriophage lambda by Andre Lwoff in 1950 and for the simian DNA virus SV40 in cultured mammalian cells in 1968 [ 8 ]. (royalsocietypublishing.org)
  • For small DNA tumour viruses, the full replication cycle occurs via non-integrated circular viral genomes, whereas viral integration into host DNA usually leads to abortive infection and sometimes to cell transformation. (royalsocietypublishing.org)
  • This indicates that some human cells express a protein on their surface that acts as a receptor for MCF viruses and allows MCF viral entry. (umassmed.edu)
  • We have previously demonstrated recombinational rescue of primer binding site (PBS)-impaired Akv murine leukemia virus-based vectors involving initial priming on endogenous viral sequences and template switching during cDNA synthesis to obtain PBS complementarity in second-strand transfer of reverse transcription (Mikkelsen et al. (asm.org)
  • Endogenous viral RNAs found to be encapsidated in virus particles ( 13 , 32 , 43 , 49 ) may thus serve to provide the functional sequences required for repair of deleterious viral mutations. (asm.org)
  • Photochemical addition of the cross-linking reagent 4,5', 8-trimethylpsoralen (trioxaslen) to intracellular and viral simian virus 40 DNA-histone complexes. (asm.org)
  • Purification of virus-specific RNA from chicken cells infected with avian sarcoma virus: identification of genome-length and subgenome-leghth viral RNAs. (asm.org)
  • thymic
  • E710.2.3 is a murine thymic lymphoma cell line with an immature phenotype (CD4 − CD8 − ) that proliferates in response to thymocytes or PMA when cultured at low density and proliferates spontaneously when grown at high density. (jimmunol.org)
  • E710.2.3 is a cloned murine CD4 − CD8 − thymic T lymphoma cell line. (jimmunol.org)
  • It was isolated from a thymic tumor from an AKR/J mouse that was explanted and cultured in PMA-containing medium. (jimmunol.org)
  • endogenous virus
  • These data effectively exclude the interpretation of consanguinity of AKR and molossinus and support the notion of acquisition of the endogenous virus in AKR by horizontal infection of the molossinus virus. (nova.edu)
  • By use of the same forced recombination system, we have now found recombinant proviruses of different structures, suggesting that PBS knockout vectors may be rescued through initial priming on endogenous virus RNA, read-through of the mutated PBS during minus-strand synthesis, and subsequent second-strand transfer mediated by the R-U5 complementarity of the plus strand and the extended minus-strand DNA acceptor template. (asm.org)
  • Reverse transcription-mediated recombination may involve endogenous virus-like elements, as seen in studies of various replication-defective retroviral mutants ( 6 , 7 , 9 , 31 , 32 , 34 , 51 ). (asm.org)
  • encodes
  • The avian erythroblastosis virus erbA oncogene encodes a DNA-binding protein exhibiting distinct nuclear and cytoplasmic subcellular localizations. (asm.org)
  • In one example, the gag gene from Friend Leukemia Virus encodes an H-2D d -restricted CTL target on the leukemia cell line, FBL-3 [ 22 ]. (pubmedcentralcanada.ca)
  • Thirteen years later, it was shown that the oncogene transduced by this virus encodes a serine/threonine protein kinase (AKT) (also known as PKB), which harbors an N-terminal regulatory domain (now known as the PH domain) and exhibits a high degree of homology with the kinases PKC and PKA ( 2 - 5 ). (sciencemag.org)
  • molecule
  • X. Identification of an IgD-like molecule on the surface of murine splenocytes. (naver.com)
  • In agreement with the essential role of the PBS in initiation and completion of reverse transcription ( 35 , 47 , 62 ), we previously observed a strong restriction in transduction of Akv murine leukemia virus (MLV) vectors with PBSs having only partial (PBS-XXX) or no [PBS-UMU and PBS-Met(i)int] homology with the 3′ end of any known murine tRNA molecule ( 32 ). (asm.org)
  • Murine cells expressing a HLA molecule are specifically lysed by HLA restricted antiviral human T cells. (histrecmed.fr)
  • infection
  • The sexual descent model carries with it a prediction of relative consanguinity of the AKR strain and molossinus , whereas the horizontal infection model does not. (nova.edu)
  • Identification of a cellular cofactor required for infection by feline leukemia virus. (springer.com)
  • Normal DBA/2 mouse cells synthesize a glycoprotein which interferes with MCF virus infection. (springer.com)
  • Biegeleisen K., Rush M. G. Association of herpes simples virus type I DNA with host chromosomal DNA during productive infection. (medkursor.ru)
  • splenocytes
  • However, it was not detected on adult murine thymocytes, splenocytes, or bone marrow cells or on splenic LPS-activated B cells or Con A-activated T cells. (jimmunol.org)
  • simian
  • Lai Ching-Juh, Nathans D. The ВС gene of simian virus 40. (medkursor.ru)
  • The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts. (asm.org)
  • Measurements of the molecular size of the simian virus 40 large T antigen. (asm.org)
  • Bergholz С M., Wolfe L. G., Delnhardt F. Oncogenicity in marmosets of HL - 23/V, a type С oncornavirus isolated from human leukemic cells, and comparison with simian sarcoma virus type I (SSV - I/SSAV - I). - «J. nat. (medkursor.ru)
  • Beth E., Cikes M., Schloen L. Interspecies species- and type - specific determinants of human papovaviruses (JC and BK) and of simian virus 40. (medkursor.ru)
  • replication
  • Structures of herpes simplex virus type 1 genes required for replication of virus DNA. (asm.org)
  • The recognition of the importance of Rous's discovery after such a long delay was largely owing to the cell transformation assay in monolayer culture of chick embryo fibroblasts reported by Temin & Rubin [ 7 ] in 1958 which enabled quantitative experimental studies of virus replication and cell transformation. (royalsocietypublishing.org)
  • These ERVs affect retrovirus-induced disease in a number of ways, including manipulation of the immune response, inhibition or facilitation of entry or other steps of virus replication, or as participants in the generation of infectious pathogenic viruses. (springer.com)
  • To address this issue, primary and immortalized human cells were tested for their ability to be infected by MCF packaged defective vectors as well as replication competent MCF virus. (umassmed.edu)
  • The cellular tropism of MPAC-packaged retroviral vectors was the same as replication competent MCF viruses. (umassmed.edu)
  • In addition, I show that some human cells fully support MCF virus replication while others either partially or fully restrict MCF virus replication. (umassmed.edu)
  • A replication competent MCF virus containing a bacterial amber suppressor tRNA gene ( supF ) was used to investigate the changes in the enhancer region following injection of MCF containing one enhancer in the LTR. (umassmed.edu)
  • glycoproteins
  • Effect of tunicamycin on the synthesis of herpes simplex virus type 1 glycoproteins and their expression on the cell surface. (asm.org)
  • Polyoma Virus
  • Charge microheterogeneity of the major capsid protein of polyoma virus. (asm.org)
  • Characterization of a DNA-protein complex and capsomere subunits derived from polyoma virus by treatment with ethyleneglycol-bis-N,N'-tetraacetic acid and dithiothreitol. (asm.org)
  • genes
  • Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis. (asm.org)
  • Functional mapping of Autographa california nuclear polyhedrosis virus genes required for late gene expression. (asm.org)
  • Rous
  • Kawai S., Hanafusa H. Recombination between a temperature - sensitive mutant and a deletion mutant of Rous sarcoma virus. (medkursor.ru)
  • Kopecka H., Hillova J., Hilt M. Effect of restriction endonucleases on infectivity of Rous sarcoma virus DNA. (medkursor.ru)
  • I first came across an endogenous factor which functionally complemented env -defective Rous sarcoma virus (RSV) during my doctoral studies in 1966. (royalsocietypublishing.org)
  • That was the year that Peyton Rous was awarded the Nobel Prize for Medicine or Physiology for the isolation of his eponymous virus published in 1911, representing a record 55 year incubation period between reporting a discovery and the award [ 6 ]. (royalsocietypublishing.org)
  • Bandyopadhyay A. K. Partial purification and characterization of DNA polymerases from a Rous sarcoma virus - transformed rat cell line. (medkursor.ru)
  • polymerase
  • Genetic evidence for vaccinia virus-encoded DNA polymerase: isolation of phosphonoacetate-resistant enzyme from the cytoplasm of cells infected with mutant virus. (asm.org)
  • Lack of exodeoxyribonuc lease activity and error - correcting function in avian myeloblastosis virus DNA polymerase. (medkursor.ru)
  • Genetic
  • Kumar V., Eckner R. J., Bennett M. Mechanism of genetic resistance to immune suppression by friend leukemia virus: the role of marrow - dependent cells. (medkursor.ru)
  • Alizon M, Wain-Hobson S, Montagnier L, Sonigo P (1986) Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients. (springer.com)
  • Coffin JM (1986) Genetic variation in AIDS viruses. (springer.com)
  • Genetic diversity of enzootic isolates of vesicular stomatitis virus New Jersey. (asm.org)
  • influenza A vir
  • A highly buy generic cialis sensitive one-step immunocapture EIA for the detection of influenza A virus antigen directly in a clinical specimen was developed. (buymetformin.site)
  • Removal of carbohydrate from influenza A virus and its hemagglutinin and the effect on biological activities. (asm.org)
  • An influenza a virus specific and HLA DRw8 restricted T cell clone cross reacting with a transcomplementation product of the HLA DR2 and DR4 haplotypes. (histrecmed.fr)
  • sarcoma viruses
  • Hakomori S., Wyke J. A., Vogt P. K. Glycolipids of chick embryo fibroblasts infected with temperature - sensitive mutants of avian sarcoma viruses. (medkursor.ru)
  • 1976
  • It was only in 1976 that a virologist named Harald zur Hausen identified the human papillomavirus, one of the first viruses known to lead to human cancer. (smithsonianmag.com)
  • tumour
  • Kaschka-Dierich C, Adams A., Klein G. Intracellular forms of Epstein - Barr virus DNA in human tumour ceils in vivo. (medkursor.ru)
  • He postulated that RNA tumour viruses made DNA copies which then integrated into host chromosomal DNA, analogous to integration of prophage in bacteria. (royalsocietypublishing.org)
  • Barbacid M., Stephenson J. R., Aaronson S. A. Gag Gene of mammalian type - С RNA tumour viruses. (medkursor.ru)
  • restriction
  • Cloning of a new murine endogenous retrovirus, MuERV-L, with strong similarity to the human HERV-L element and with a gag coding sequence closely related to the Fv1 restriction gene. (springer.com)
  • protein
  • Mapping of functional and antigenic domains of the alpha 4 protein of herpes simplex virus 1. (asm.org)