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  • thymic
  • E710.2.3 is a murine thymic lymphoma cell line with an immature phenotype (CD4 − CD8 − ) that proliferates in response to thymocytes or PMA when cultured at low density and proliferates spontaneously when grown at high density. (jimmunol.org)
  • E710.2.3 is a cloned murine CD4 − CD8 − thymic T lymphoma cell line. (jimmunol.org)
  • It was isolated from a thymic tumor from an AKR/J mouse that was explanted and cultured in PMA-containing medium. (jimmunol.org)
  • encodes
  • The avian erythroblastosis virus erbA oncogene encodes a DNA-binding protein exhibiting distinct nuclear and cytoplasmic subcellular localizations. (asm.org)
  • In one example, the gag gene from Friend Leukemia Virus encodes an H-2D d -restricted CTL target on the leukemia cell line, FBL-3 [ 22 ]. (pubmedcentralcanada.ca)
  • Thirteen years later, it was shown that the oncogene transduced by this virus encodes a serine/threonine protein kinase (AKT) (also known as PKB), which harbors an N-terminal regulatory domain (now known as the PH domain) and exhibits a high degree of homology with the kinases PKC and PKA ( 2 - 5 ). (sciencemag.org)
  • endogenous virus
  • These data effectively exclude the interpretation of consanguinity of AKR and molossinus and support the notion of acquisition of the endogenous virus in AKR by horizontal infection of the molossinus virus. (nova.edu)
  • By use of the same forced recombination system, we have now found recombinant proviruses of different structures, suggesting that PBS knockout vectors may be rescued through initial priming on endogenous virus RNA, read-through of the mutated PBS during minus-strand synthesis, and subsequent second-strand transfer mediated by the R-U5 complementarity of the plus strand and the extended minus-strand DNA acceptor template. (asm.org)
  • Reverse transcription-mediated recombination may involve endogenous virus-like elements, as seen in studies of various replication-defective retroviral mutants ( 6 , 7 , 9 , 31 , 32 , 34 , 51 ). (asm.org)
  • viral
  • The AKR murine leukemia viruses do not contain acute transforming oncogenes ( 4 ) and are thought to transform cells as a result of activating cellular proto-oncogenes in the vicinity of viral integration into chromosomal DNA ( 5 ). (jimmunol.org)
  • Khoury G., May E. Regulation of early and late simian virus 40 transcription: overproduction of early viral RNA in the absence of a functional T-antigen. (medkursor.ru)
  • Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines. (asm.org)
  • A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication. (asm.org)
  • Integration of viral DNA into host DNA was first discerned for the prophage of the temperate bacteriophage lambda by Andre Lwoff in 1950 and for the simian DNA virus SV40 in cultured mammalian cells in 1968 [ 8 ]. (royalsocietypublishing.org)
  • For small DNA tumour viruses, the full replication cycle occurs via non-integrated circular viral genomes, whereas viral integration into host DNA usually leads to abortive infection and sometimes to cell transformation. (royalsocietypublishing.org)
  • Gross, L. 1958 Viral etiology of "spontaneous" mouse leukemia: A review. (springer.com)
  • This indicates that some human cells express a protein on their surface that acts as a receptor for MCF viruses and allows MCF viral entry. (umassmed.edu)
  • glycoproteins
  • Effect of tunicamycin on the synthesis of herpes simplex virus type 1 glycoproteins and their expression on the cell surface. (asm.org)
  • infection
  • Gallis B. M., Eisenman R. N., Dtggelmann H. Synthesis of the precursor to avian RNA tumor virus internal structural proteins early after infection. (medkursor.ru)
  • The sexual descent model carries with it a prediction of relative consanguinity of the AKR strain and molossinus , whereas the horizontal infection model does not. (nova.edu)
  • genes
  • Identification of herpes simplex virus type 1 genes required for origin-dependent DNA synthesis. (asm.org)
  • Structures of herpes simplex virus type 1 genes required for replication of virus DNA. (asm.org)
  • Functional mapping of Autographa california nuclear polyhedrosis virus genes required for late gene expression. (asm.org)
  • mink
  • Identification of a nonvirion protein of Aleutian disease virus: mink with Aleutian disease have antibody to both virion and nonvirion proteins. (asm.org)
  • Mink cell focus-inducing (MCF) viruses are polytropic MuLVs that by definition infect cells from a wide variety of species. (umassmed.edu)
  • replication
  • The recognition of the importance of Rous's discovery after such a long delay was largely owing to the cell transformation assay in monolayer culture of chick embryo fibroblasts reported by Temin & Rubin [ 7 ] in 1958 which enabled quantitative experimental studies of virus replication and cell transformation. (royalsocietypublishing.org)
  • To address this issue, primary and immortalized human cells were tested for their ability to be infected by MCF packaged defective vectors as well as replication competent MCF virus. (umassmed.edu)
  • The cellular tropism of MPAC-packaged retroviral vectors was the same as replication competent MCF viruses. (umassmed.edu)
  • In addition, I show that some human cells fully support MCF virus replication while others either partially or fully restrict MCF virus replication. (umassmed.edu)
  • A replication competent MCF virus containing a bacterial amber suppressor tRNA gene ( supF ) was used to investigate the changes in the enhancer region following injection of MCF containing one enhancer in the LTR. (umassmed.edu)
  • tRNA
  • In agreement with the essential role of the PBS in initiation and completion of reverse transcription ( 35 , 47 , 62 ), we previously observed a strong restriction in transduction of Akv murine leukemia virus (MLV) vectors with PBSs having only partial (PBS-XXX) or no [PBS-UMU and PBS-Met(i)int] homology with the 3′ end of any known murine tRNA molecule ( 32 ). (asm.org)
  • cells infected
  • Genetic evidence for vaccinia virus-encoded DNA polymerase: isolation of phosphonoacetate-resistant enzyme from the cytoplasm of cells infected with mutant virus. (asm.org)
  • 1976
  • It was only in 1976 that a virologist named Harald zur Hausen identified the human papillomavirus, one of the first viruses known to lead to human cancer. (smithsonianmag.com)
  • avian
  • Kurth R., Bosch V., Bolognesi D. P. Polypeptides of endogenous avian С - type viruses: their detection in the plasma membrane of normal and infected cells. (medkursor.ru)
  • Salden M. H. L., Bloemendal H. Transplantation of avian myeloblastosis virus RNA in a reticulocyte cell - free system. (medkursor.ru)
  • Hakomori S., Wyke J. A., Vogt P. K. Glycolipids of chick embryo fibroblasts infected with temperature - sensitive mutants of avian sarcoma viruses. (medkursor.ru)
  • simian
  • Lai Ching-Juh, Nathans D. The ВС gene of simian virus 40. (medkursor.ru)
  • The late spliced 19S and 16S RNAs of simian virus 40 can be synthesized from a common pool of transcripts. (asm.org)
  • Isolation
  • That was the year that Peyton Rous was awarded the Nobel Prize for Medicine or Physiology for the isolation of his eponymous virus published in 1911, representing a record 55 year incubation period between reporting a discovery and the award [ 6 ]. (royalsocietypublishing.org)
  • Genetic
  • Kumar V., Eckner R. J., Bennett M. Mechanism of genetic resistance to immune suppression by friend leukemia virus: the role of marrow - dependent cells. (medkursor.ru)
  • Alizon M, Wain-Hobson S, Montagnier L, Sonigo P (1986) Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients. (springer.com)
  • Coffin JM (1986) Genetic variation in AIDS viruses. (springer.com)
  • Genetic diversity of enzootic isolates of vesicular stomatitis virus New Jersey. (asm.org)
  • antigen
  • Evidence for two classes of chromatin-associated Epstein-Barr virus-determined nuclear antigen. (asm.org)
  • Padgett B. L., Hunt J. M., Walker D. L. Specificity of the tumor - specific transplantation antigen induced by JC virus, a human polyomavirus. (medkursor.ru)
  • cell
  • The DMF10 62.3 mAb stained a number of immortalized murine and human cell lines and, where tested, blocked their proliferation and caused death to varying extents by apoptosis. (jimmunol.org)
  • Kerr I M., Olshevsky U., Baltimore D. Translation of murine leukemia virus RNA in cell - free systems from animal cells. (medkursor.ru)
  • However, it has also illustrated the potential dangers involved, with 2 out of 10 patients developing T cell leukemia as a consequence of the treatment. (biomedcentral.com)
  • The first retro viruses were identified as cell free oncogenic factors in chickens. (biomedcentral.com)