AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
AKR murine leukemia virusLeukemia Virus, MurineMice, Inbred AKRMoloney murine leukemia virusFriend murine leukemia virusLeukemia, ExperimentalAbelson murine leukemia virusLeukemia Virus, FelineRauscher VirusRetroviridae InfectionsLeukemia Virus, BovineLeukemiaMink Cell Focus-Inducing VirusesRetroviridaeCell LineVirus ReplicationDNA, ViralGenes, ViralRNA-Directed DNA PolymeraseReceptors, VirusGammaretrovirusMice, Inbred StrainsMolecular Sequence DataProvirusesGene Products, gagBase SequenceTumor Virus InfectionsPreleukemiaLeukemia, Myeloid, AcuteVirus IntegrationLeukemia Virus, Gibbon ApeRNA, ViralViral ProteinsThymus Neoplasms3T3 CellsMinkLymphomaViral Envelope ProteinsDefective VirusesHuman T-lymphotropic virus 1Cell Transformation, ViralGene Products, envRetroviridae Proteins, OncogenicRepetitive Sequences, Nucleic AcidGenetic VectorsSarcoma Viruses, MurineHelper VirusesVirionVirus AssemblyAmino Acid SequenceRecombination, GeneticLeukemia, LymphoidAntigens, ViralRNA VirusesGenes, gagXenotropic murine leukemia virus-related virusGenes, envVirus CultivationLeukemia, Lymphocytic, Chronic, B-CellNucleic Acid HybridizationSpecies SpecificityThymomaMurine Acquired Immunodeficiency SyndromeOncogenic VirusesGene Products, taxRibonuclease HSpleenRetroviridae ProteinsRadiation Leukemia VirusTransfectionMice, Inbred BALB CCloning, MolecularTerminal Repeat SequencesGenes, polMuridaeGene Expression Regulation, ViralHylobates
Newborn miceJohn BittnerTumorsViralGAMMARETROVIRUSFemale miceSTRAINTumorGENESSpeciesPlantsTRANSMISSIONHUMANLiveResearchTermCellBodyCellsEndogenousEcotropicMammaryLymphocytesStrains1976ViralERYTHROLEUKEMIAAntigenRousSV40SendaiReplicationNormal miceIrradiationLaboratoryResistanceVitroLungFriend VirusProteinHumanTimeFound
Newborn mice1
  • Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice. (nih.gov)
John Bittner1
  • It took many decades before the seminal contributions of several virologists studying cancers were appreciated, such as Peyton Rous' 1911 discovery of the Rous sarcoma virus (which caused tumors in chickens), and discoveries of Richard Shope (rabbit fibroma) and John Bittner (mouse mammary carcinoma) in the 1930s. (cdc.gov)
Tumors7
  • In 1944, when Stewart requested support to study the link between animal tumors and viruses, the directors of the NIH Laboratory of Microbiology and the National Cancer Institute (NCI) refused on the grounds that the proposal seemed dubious and that she lacked appropriate qualifications. (cdc.gov)
  • in 1953, he reported parotid tumors in these mice. (cdc.gov)
  • So in 1956, when Stewart approached Eddy for assistance growing the agent causing parotid tumors in mice, Eddy readily agreed and the 2 women rapidly worked out the characteristics of the agent that was not referred to as a virus in their publications until 1959. (cdc.gov)
  • Together they showed that the virus produced 20 types of mouse tumors and could cause tumors in other small mammals. (cdc.gov)
  • At Eddy's suggestion, the virus was dubbed polyoma, which means many tumors, and they named it the SE (Stewart-Eddy) polyomavirus. (cdc.gov)
  • They also demonstrated that the virus causes cell necrosis and proliferation in cell culture, that it is highly antigenic, and that it leads to formation of specific antibodies in infected animals whether or not tumors develop. (cdc.gov)
  • Lathrop sends mice that developed tumors to Leo Loeb at the University of Pennsylvania , who publishes pioneering papers on cancer. (jax.org)
Viral2
  • This is a photograph of Sarah Elizabeth Stewart, PhD, MD (1905-1976), whose discoveries involving the murine polyomavirus with Bernice Eddy, PhD, propelled the then-reluctant field of oncology to pursue viral etiologies of cancer. (cdc.gov)
  • To understand Stewart's role in catalyzing viral oncology research, it is necessary to recognize that until the 1950s, scientists dismissed the idea that viruses could cause cancer. (cdc.gov)
GAMMARETROVIRUS1
Female mice2
  • First successful transplantations of ovaries between female mice are performed by William Russell at JAX. (jax.org)
  • In vivo experiments confirm epitope-selective cytolysis in xenograft models in female mice using engrafted IGLV3-21R110 expressing cell lines or primary CLL cells. (bvsalud.org)
STRAIN1
  • The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
Tumor1
  • The mechanism by which latent viruses, such as genetically transmitted tumor viruses ( PROVIRUSES ) or PROPHAGES of lysogenic bacteria, are induced to replicate and then released as infectious viruses. (lookformedical.com)
GENES1
  • 1939 International Committee on Standardized Nomenclature for Mice begins, bringing order to the naming of mice and their genes. (jax.org)
Species2
Plants1
  • Process of growing viruses in live animals, plants, or cultured cells. (lookformedical.com)
TRANSMISSION1
  • Virus shedding is an important means of vertical transmission (INFECTIOUS DISEASE TRANSMISSION, VERTICAL). (lookformedical.com)
HUMAN2
  • B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV). (cdc.gov)
  • We further demonstrate in two humanized mouse models lack of cytotoxicity towards human B cells. (bvsalud.org)
Live1
  • In 1954, Eddy had been sidelined for whistleblowing about the presence of live virus in Jonas Salk's inactivated polio vaccine (the infamous Cutter incident). (cdc.gov)
Research3
  • The results of their collaboration were picked up by a 1959 Time Magazine cover story, citing John Heller, then the NCI director, "the hottest thing in cancer research is research on viruses as possible causes of cancer. (cdc.gov)
  • The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
  • Initially sought as pets, the Granby mice become important in research. (jax.org)
Term1
Cell3
  • The ability of a pathogenic virus to lie dormant within a cell (latent infection). (lookformedical.com)
  • Specific molecular components of the cell capable of recognizing and interacting with a virus, and which, after binding it, are capable of generating some signal that initiates the chain of events leading to the biological response. (lookformedical.com)
  • We develop murine and humanized CAR constructs expressed in T cells from healthy donors and CLL patients that eradicate IGLV3-21R110 expressing cell lines and primary CLL cells, but neither cells expressing the non-pathogenic IGLV3-21G110 light chain nor polyclonal healthy B cells. (bvsalud.org)
Body1
Cells1
  • Here, we use a BCR light chain neoepitope defined by a characteristic point mutation (IGLV3-21R110) for selective targeting of a poor-risk subset of chronic lymphocytic leukemia (CLL) with chimeric antigen receptor (CAR) T cells. (bvsalud.org)
Endogenous4
  • Serological characterization of C-type retroviruses endogenous to the C57BL/6 mouse and isolated in tumours induced by radiation leukaemia virus (RadLV-Rs). (microbiologyresearch.org)
  • Different serotypes of B-tropic murine leukemia viruses and association with endogenous ecotropic viral loci. (microbiologyresearch.org)
  • Serological characterization of B-tropic viruses of C57BL mice: possible origin by recombination of endogenous N-tropic and xenotropic viruses. (microbiologyresearch.org)
  • Radiation-induced murine leukemias and endogenous retroviruses: the time course of viral expression. (microbiologyresearch.org)
Ecotropic1
  • MCF viruses are generated by recombination with ecotropic murine leukemia viruses including AKR, Friend, Moloney, and Rauscher, causing ERYTHROLEUKEMIA and severe anemia in mice. (nih.gov)
Mammary2
  • It took many decades before the seminal contributions of several virologists studying cancers were appreciated, such as Peyton Rous' 1911 discovery of the Rous sarcoma virus (which caused tumors in chickens), and discoveries of Richard Shope (rabbit fibroma) and John Bittner (mouse mammary carcinoma) in the 1930s. (cdc.gov)
  • different populations of wild mice (mus musculus domesticus) in los angeles and ventura counties were observed over their lifespan in captivity for expression of infectious murine leukemia virus (mulv) and murine mammary tumor virus (mmtv) and for the occurrence of cancer and other diseases. (liverpool.ac.uk)
Lymphocytes3
  • A higher proportion of normal mice and ts 1 survivors, both inoculated with CVB3(m), contained splenic cytotoxic T lymphocytes with higher reactivity against CVB3(m)-infected neonatal skin fibroblasts than against normal skin fibroblasts, as assessed by a (51)Cr release assay. (nih.gov)
  • However, ts 1 survivors and normal mice possessed the same proportions of splenic lymphocytes carrying either allele for Lyt 1 and Lyt 2 surface markers. (nih.gov)
  • phenotype and tcr gamma delta variable gene repertoire of intestinal intraepithelial lymphocytes in wild mice (mus musculus domesticus): abundance of v gamma 1 transcripts and extensive delta gene diversity. (liverpool.ac.uk)
Strains4
  • Strains of MURINE LEUKEMIA VIRUS discovered in 1976 by Hartley, Wolford, Old, and Rowe and so named because the viruses originally isolated had the capacity to transform cell foci in mink cell cultures. (nih.gov)
  • We were doing work on enteric viruses in water and sewage and, at that time, I was also collecting fecal specimens from Albert Sabin's polio vaccine experiments to determine what quantities of Poliovirus were in feces, and we were using his vaccine strains in his volunteers as some indication of what you could find in raw feces. (nih.gov)
  • southern blotting analysis using a cdna probe consisting of the central portion of the e12 coding region has revealed two distinct forms of e2a, one which is common to all inbred and wild mouse strains derived from mus musculus musculus and mus musculus domesticus, whereas the other is less common and has only been found in the wild mouse population of mus musculus domesticus. (liverpool.ac.uk)
  • tcrg gene polymorphism was investigated by southern blot analysis on a panel of laboratory and wild mouse strains using a set of probes which identify all known tcrg-v and -c genes. (liverpool.ac.uk)
19761
  • This is a photograph of Sarah Elizabeth Stewart, PhD, MD (1905-1976), whose discoveries involving the murine polyomavirus with Bernice Eddy, PhD, propelled the then-reluctant field of oncology to pursue viral etiologies of cancer. (cdc.gov)
Viral1
  • To understand Stewart's role in catalyzing viral oncology research, it is necessary to recognize that until the 1950s, scientists dismissed the idea that viruses could cause cancer. (cdc.gov)
ERYTHROLEUKEMIA2
  • Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene. (microbiologyresearch.org)
  • Antibody-induced loss of Friend virus leukemia cell surface antigens occurs during progression of erythroleukemia in F1 mice. (microbiologyresearch.org)
Antigen1
  • genetic analysis of liver tumorigenesis in sv40 t antigen transgenic mice implies a role for imprinted genes. (liverpool.ac.uk)
Rous1
  • Transformation by subgenomic fragments of Rous sarcoma virus DNA. (wikidata.org)
SV402
  • 23¥&# SV49Q transforemd human cells aren't even tumorigenic in nude mice, Efforts to force the SV40 system into a full analogy with Py have failed, to date, Of course, there is a candidate middle T (dubbed mah "phantom Ty by local talent) proposed o by Berg on the basis of a new splice his troops have found in a late version of early message (clear? (nih.gov)
  • liver tumors from interspecific hybrid, transgenic mice containing the sv40 early region linked to a mouse major urinary protein enhancer/promoter were analyzed for loss of heterozygosity to identify chromosomal regions which potentially contain genetic loci involved in multistep tumorigenesis. (liverpool.ac.uk)
Sendai4
  • PMID- 6299951 TI - Pneumotropism of Sendai virus in relation to protease-mediated activation in mouse lungs. (nih.gov)
  • AB - The pneumotropism of Sendai virus in mice was studied in relation to the activation and replication of the virus in the lung. (nih.gov)
  • Inactive Sendai virus grown in LLC-MK(2) cells, which possessed an uncleaved precursor glycoprotein, F, and was noninfectious to tissue culture cells, neither grew nor caused pathological changes in the lung of mice. (nih.gov)
  • The overall results suggest that some activating mechanism for the progeny virus of wild-type Sendai virus exists in the lung of mice and the principle (activator) responsible for this phenomenon has a character similar to trypsin. (nih.gov)
Replication4
  • When trypsin treatment was made which cleaved F into F(1) and F(2) subunits, the virus became activated so that it could initiate replication in the bronchial epithelium of the lung. (nih.gov)
  • In this case, the progeny virus was produced in the activated form and multiple-cycle replication occurred successively. (nih.gov)
  • A protease mutant, TR-2, which was able to be activated only by chymotrypsin but not by trypsin, could also initiate replication in the bronchial epithelium, when activated by chymotrypsin before inoculation into mice. (nih.gov)
  • The progeny virus, however, remained inactive, and the replication was limited to a single cycle, which resulted in the limited lung lesion. (nih.gov)
Normal mice2
  • Cell-mediated immunity in ts 1 survivors was compared with that of normal mice after challenge with CVB3(m). (nih.gov)
  • X-irradiation of C57BL/6 mice induces thymic lymphosarcomas which sometimes contain retroviruses which upon injection into normal mice mimic the effect of the irradiation. (microbiologyresearch.org)
Irradiation1
  • Stevenson: And I remember when I first moved to Washington, in '58, the following year I went to the AACR meeting in Atlantic City and Miriam Liebermann was talking about this agent that they had found in their mice after irradiation and so forth. (nih.gov)
Laboratory6
  • In 1944, when Stewart requested support to study the link between animal tumors and viruses, the directors of the NIH Laboratory of Microbiology and the National Cancer Institute (NCI) refused on the grounds that the proposal seemed dubious and that she lacked appropriate qualifications. (cdc.gov)
  • Stewart became medical director of the NCI Laboratory of Oncology and spent the remainder of her life researching several oncogenic viruses (e.g. (cdc.gov)
  • He was at the National Institute of Allergy and Infectious Diseases and had a Branch, or a Laboratory, consisting of a number of well known investigators, amongst which was Wally Rowe and, in his lab, Janet Hartley, who were pretty well known for work in some of the murine viruses. (nih.gov)
  • And up until I knew Bob from the Cancer Institute, I had been at the Public Health Service in Cincinnati and knew him more in terms of Adenoviruses and a variety of enteric viruses which his laboratory had been very instrumental in discovering, developing and, in fact, he supplied us with Adenovirus Type 3, which we used in disinfection studies and things like that. (nih.gov)
  • only three haplotypes are found in laboratory mice: ga, gb, and gc which are represented by balb/c, akr, and dba/2 prototypes respectively. (liverpool.ac.uk)
  • ga and gc haplotypes are the most frequent among laboratory mice whereas gb is poorly represented. (liverpool.ac.uk)
Resistance4
  • PMID- 6299950 TI - Temperature-sensitive mutant of coxsackievirus B3 establishes resistance in neonatal mice that protects them during adolescence against coxsackievirus B3 induced myocarditis. (nih.gov)
  • biochemical basis of warfarin and bromadiolone resistance in the house mouse, mus musculus domesticus. (liverpool.ac.uk)
  • danish mice (mus musculus domesticus) genetically resistant to the anticoagulant action of two 4-hydroxycoumarins, warfarin and bromadiolone, were examined to determine their mechanism of resistance. (liverpool.ac.uk)
  • In addition, this report outlines several special circumstances (e.g., delayed exposure report, unknown source person, pregnancy in the exposed person, resistance of the source virus to antiretroviral agents, or toxicity of the PEP regimen) when consultation with local experts and/or the National Clinicians' Post-Exposure Prophylaxis Hotline ([PEPline] 1-888-448-4911) is advised. (cdc.gov)
Vitro1
  • the hepatic vitamin k epoxide reductase in the bromadiolone-resistant mice and in one phenotype of warfarin-resistant mice was highly insensitive to in vitro inhibition by warfarin and bromadiolone. (liverpool.ac.uk)
Lung1
  • mouse la-4 lung adenoma cells treated with either spermine or the spermine analog, n1,n12-bis(ethyl)spermine, produced a 2.3 and 6.5-fold increase, respectively, in ssat mrna. (liverpool.ac.uk)
Friend Virus1
  • Huebner: Was that the Friend virus that she was talking about? (nih.gov)
Protein1
Human2
  • This report updates and consolidates all previous U.S. Public Health Service recommendations for the management of health-care personnel (HCP) who have occupational exposure to blood and other body fluids that might contain hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV). (cdc.gov)
  • Avoiding occupational blood exposures is the primary way to prevent transmission of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) in health-care settings ( 1 ). (cdc.gov)
Time5
  • The results of their collaboration were picked up by a 1959 Time Magazine cover story, citing John Heller, then the NCI director, "the hottest thing in cancer research is research on viruses as possible causes of cancer. (cdc.gov)
  • Stevenson: Before we get started on that, maybe we could go back in time and kind of pick up where Bob Huebner got started with virus cancer type investigations. (nih.gov)
  • Do you recall when Bob got interested in tumor viruses for the first time? (nih.gov)
  • They were ubiquitous and they hung around for a long time and they had qualities that some of the other DNA viruses he was aware of did not. (nih.gov)
  • Well, it was right about that time that Charlotte Friend came up with her virus. (nih.gov)
Found1
  • Virus was not detected in heart tissues of adolescent ts 1 survivors, but inoculation of these mice with CVB3(m) resulted in virus concentrations similar in titers to those found in CVB3(m)-inoculated normal adolescent mice. (nih.gov)