StrainsBALBC57BLRecombinant inbredSpontaneousGeneticStrain of mouseLeukemiaEcotropicAnnotationExperimentalGlomerularProteinsMeSHTransgenicLociCancersGenomes ProjectTumorsBiomedical researchSpeciesGenome DatabaseMMTVDataSusceptibilityTermsMutant miceResistantNeuronsGeneSequencesLaboratory mouseGeneticsSusceptible1977CellCellsBrainModelActivityDaysApproachModels
Strains17
- Species of GAMMARETROVIRUS , containing many well-defined strains, producing leukemia in mice. (lookformedical.com)
- There is mounting evidence suggesting that inbred mouse strains with different genetic backgrounds demonstrate variable susceptibility to a fibrotic injury. (biomedcentral.com)
- A total of 44 studies were included covering 21 mouse strains and focusing on fibrosis in the lung, liver, kidney, intestine and heart. (biomedcentral.com)
- Few studies have assessed the effect of the same injury stimulus in different organ systems using the same strains of mouse. (biomedcentral.com)
- Mice are also easy to breed with a short generation time and a short life span allowing direct study of disease development and can accurately eludicidate how genetic sequences may vary in different strains and result in susceptibility to fibrotic pathologies. (biomedcentral.com)
- Quantitative trait locus (QTL) analysis is a common genetic approach that has been used in the past two decades to identify loci involved in differences in fibrotic response between inbred strains of mice [ 9 ]. (biomedcentral.com)
- In this approach, two inbred strains that differ in fibrotic response are crossed and the F1 offspring are either mated together (intercross) or to one of the parental strains (backcross). (biomedcentral.com)
- Quantitative trait loci analysis can be time consuming and can only analyse two different mouse strains at a time. (biomedcentral.com)
- Pathobiology of aging mice and GEM: background strains and experimental design. (jax.org)
- HET3 mice used in this program are (F2) offspring of CByB6F1/J and C3D2F1/J (combining BALB/cBy, C57BL/6, C3H, and DBA/2) strains. (jax.org)
- Using two independent AKR/J-derived sets of recombinant inbred mouse strains, AKXL (AKR/J x C57L/J) and AKXD (AKR/J x DBA/2J), as well as the HP/EiTy strain (an Emv-13-carrying inbred strain partially related to AKR/J mice) (Taylor et al. (jax.org)
- Cell cultures derived from recombinant inbred strains that carry only Emv-13 failed to express detectable infectious virus, viral proteins, or cytoplasmic ecotropic virus-specific RNA even after treatment with 5-iodo-2-deoxyuridine or 5-azacytidine, an inhibitor of DNA methylation. (jax.org)
- One of the first INBRED MOUSE STRAINS to be sequenced. (uchicago.edu)
- Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains. (jefferson.edu)
- Using a pair of black mice from the Granby farm, Little develops the C57BL and C57BR strains. (jax.org)
- High quality reference genomes and annotation are available for seventeen inbred mouse strains. (mousegenomes.org)
- In 2018, we produced the first draft reference genomes for sixteen inbred strains (described in this paper ). (mousegenomes.org)
BALB2
- However, BALB/c mice are resistant to pulmonary fibrosis but susceptible to hepatic fibrosis. (biomedcentral.com)
- Halsey Bagg develops the BALB /c ( Bagg albino) mouse for behavioral experiments. (jax.org)
C57BL6
- For instance, C57BL/6J mice are resistant to hepatic, renal and cardiac fibrosis but susceptible to pulmonary and intestinal fibrosis. (biomedcentral.com)
- J:235854 lists J:27148 as the reference for these mice but then describes them as "B6C3F1" when the mice in the given reference were C57BL/6J mice fostered on C3Hf/Nctr mice. (jax.org)
- Mice, Inbred C57BL" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
- This graph shows the total number of publications written about "Mice, Inbred C57BL" by people in this website by year, and whether "Mice, Inbred C57BL" was a major or minor topic of these publications. (uchicago.edu)
- Below are the most recent publications written about "Mice, Inbred C57BL" by people in Profiles. (uchicago.edu)
- C57BL/6 lymph node cells were incubated simultaneously with FITC Mouse Anti-Mouse Vβ 5.1, 5.2 T-Cell Receptor (Cat. (bdbiosciences.com)
Recombinant inbred1
- The chromosomal location of Evi-1, a common site of ecotropic viral integration in AKXD murine myelogenous leukemias, was determined by recombinant inbred and conventional backcross analyses. (jax.org)
Spontaneous5
- AKT8 was isolated from a spontaneous thymoma cell line derived from AKR mice by cocultivation with an indicator mink cell line. (wikipedia.org)
- The origins of the Akt name date back to 1928, when J. Furth performed experimental studies on mice that developed spontaneous thymic lymphomas. (wikipedia.org)
- The use of induced and spontaneous mutant mice and genetically engineered mice (and combinations thereof) to study cancers and other aging phenotypes to advance improved functional human life spans will involve studies of aging mice. (jax.org)
- Bessa?h T, de Yebenes EG, Kirkland K, Higley MJ, Buono RJ, Ferraro TN, Contreras D. Quantitative trait locus on distal chromosome 1 regulates the occurrence of spontaneous spike-wave discharges in DBA/2 mice. (jefferson.edu)
- Pentylenetetrazole (PTZ)-kindled and spontaneous model of epilepsy (EL) mice were used as models of chemically induced and spontaneous epilepsy, respectively. (aspetjournals.org)
Genetic3
- Such mouse strain studies may prove useful in elucidating the genetic as well as epigenetic factors in humans that could help determine why some people are more susceptible to the development of certain organ specific fibrosis than others. (biomedcentral.com)
- This strain is commonly used as genetic background for transgenic mouse models. (uchicago.edu)
- Peter Gorer shows in mouse studies at JAX that transplant rejection is primarily governed by what he calls the H2 genetic locus, later described as the major histocompatibility complex, a key component of immunity. (jax.org)
Strain of mouse3
- Data were collected from studies that were deemed eligible for analysis based on set inclusion criteria, and findings were assessed in relation to strain of mouse, type of injury and organ of investigation. (biomedcentral.com)
- An inbred strain of mouse. (ouhsc.edu)
- An inbred strain of mouse that is widely used in BIOMEDICAL RESEARCH . (nih.gov)
Leukemia1
- Effective treatment of AKR leukemia with antibody to gp7 1 eliminates the neonatal burst of ecotropic AKR virus producing cells. (duke.edu)
Ecotropic4
- Emv-13 (Akv-3): a noninducible endogenous ecotropic provirus of AKR/J" by H G. Bedigian, N G. Copeland et al. (jax.org)
- Emv-13 (Akv-3): a noninducible endogenous ecotropic provirus of AKR/J mice. (jax.org)
- All AKR/J mice carry at least three endogenous ecotropic viral loci which have been designated Emv-11 (Akv-1), Emv-13 (Akv-3), and Emv-14 (Akv-4) (Jenkins et al. (jax.org)
- Bedigian HG, Copeland NG, Jenkins NA, Salvatore K, Rodick S. Emv-13 (Akv-3): a noninducible endogenous ecotropic provirus of AKR/J mice. (jax.org)
Annotation1
- Annotation of mouse strain AKR/J genome assembly provided by GENCODE consortium. (jax.org)
Experimental1
- Increased recognition of expected phenotypes, experimental variables that influence phenotypes and research outcomes, and experimental design options and rationales can maximize the utility of genetically engineered mice (GEM) models to translational research on aging. (jax.org)
Glomerular1
- Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. (ouhsc.edu)
Proteins1
- Quantitative targeted absolute proteomic analysis of 31 membrane proteins showed that P-glycoprotein (P-gp/mdr1a) protein expression levels were significantly increased in brain capillaries of PTZ (129%), EL (143%), and PHT mice (192%) compared with controls. (aspetjournals.org)
MeSH1
- Mice, Inbred DBA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ouhsc.edu)
Transgenic2
- Transgenic mouse lines are invaluable tools for neuroscience but, as with any technique, care must be taken to ensure that the tool itself does not unduly affect the system under study. (bvsalud.org)
- Here we report aberrant electrical activity, similar to interictal spikes, and accompanying fluorescence events in some genotypes of transgenic mice expressing GCaMP6 genetically encoded calcium sensors. (bvsalud.org)
Loci2
- The location of Evi-1 is distinct from these three loci and from all other proto-oncogenes, common sites of viral integration, or growth factor loci previously mapped in mouse chromosomes. (jax.org)
- These gene loci are deleted in mice having the a (e.g. (bdbiosciences.com)
Cancers1
- Mice from three different stocks were studied, and the stocks were designated A, R, and S. Stock A was noted to yield many cancers, and inbred families were subsequently designated by a second small letter (Aa, Ab, Ac, etc.), and thus came the Ak strain of mice. (wikipedia.org)
Genomes Project1
- J:259852 Mouse Genome Informatics and the WTSI Mouse Genomes Project, MGI Strain Genome Feature and Gene Model Load. (jax.org)
Tumors2
- Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice. (lookformedical.com)
- Lathrop sends mice that developed tumors to Leo Loeb at the University of Pennsylvania , who publishes pioneering papers on cancer. (jax.org)
Biomedical research1
- The Jackson Laboratory has made fundamental contributions to biomedical research, including cancer genetics and establishing the mouse as the premier research animal model. (jax.org)
Species1
- In parallel, multiple technologies and manual finishing were used to produce an 85-Mb reference genome assembly from the more readily available mouse parasite species T. muris (Online Methods and Supplementary Note ). (nature.com)
Genome Database1
- To date, the Mouse Genome Database through The Jackson Laboratory, lists 24 QTL in mice associated with fibrosis of which all but 3 are phenotypes in the lung. (biomedcentral.com)
MMTV2
Data3
- For individual strain files see the "Inbred Strain Exome Data" subdirectory. (jax.org)
- Using RNA sequencing data from whipworm-infected mice, we describe the regulated T helper 1 (T H 1)-like immune response of the chronically infected cecum in unprecedented detail. (nature.com)
- Gene expression data from mice with low-dose whipworm infection provide a detailed description of a regulated T H 1-like immune response to the infected cecum that is not limited to the immediate site of infection. (nature.com)
Susceptibility3
- There is evidence that mouse strain differences influence susceptibility to fibrosis and this appears to be organ specific. (biomedcentral.com)
- The majority of genomic studies used to identify susceptibility pathways involved in disease pathologies have been performed in the mouse. (biomedcentral.com)
- Analysis of a quantitative trait locus for seizure susceptibility in mice using bacterial artificial chromosome-mediated gene transfer. (jefferson.edu)
Terms1
- Pleural effusion CFC appeared to be adherent cells and resembled mouse peritoneal exudate colony forming cells in terms of growth requirement, having a long lag period before proliferation and sensitivity to ionizing irradiation. (wustl.edu)
Mutant mice2
- We tested whether their cortical expression was altered in mutant mice with known patterning defects (Emx2, Nr2f1, and Pax6), which enabled us to define a cortical regionalization TF network (CRTFN). (bvsalud.org)
- To map enhancers involved in regional patterning of cortical progenitors, we performed assays for epigenomic marks and DNA accessibility in VZ cells purified from wild-type and patterning mutant mice. (bvsalud.org)
Resistant1
- Mice lacking Akt1 are also resistant to cancer: They experience considerable delay in tumor growth initiated by the large T antigen or the Neu oncogene. (wikipedia.org)
Neurons2
- Methamphetamine self-administration in mice decreases GIRK channel-mediated currents in midbrain dopamine neurons. (ouhsc.edu)
- We demonstrate that TRPC6 deficiency in mice not only results in anxious and depressive behavior, but also reduces excitability of hippocampal CA1 pyramidal neurons and dentate gyrus granule cells. (afpm.org.my)
Gene1
- Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. (jefferson.edu)
Sequences2
- We report here the whole-genome sequences of the human-infective Trichuris trichiura and the mouse laboratory model Trichuris muris . (nature.com)
- Here we present high-quality genome sequences for T. trichiura and T. muris , the first duo of a major human STH and its mouse counterpart. (nature.com)
Laboratory mouse1
- T. muris is an established laboratory mouse model for human trichuriasis and shares with T. trichiura many aspects of its biology, including the specialized niche within the host. (nature.com)
Genetics2
- Mice provide a suitable model for the study of human genetics because more than 95% of the genome is identical. (biomedcentral.com)
- Systems genetics analysis of mouse chondrocyte differentiation. (jefferson.edu)
Susceptible1
- Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice. (jefferson.edu)
19771
- In 1977, a transforming retrovirus was isolated from the AKR mouse. (wikipedia.org)
Cell2
- Retinal ganglion cell protection by 17-beta-estradiol in a mouse model of inherited glaucoma. (ouhsc.edu)
- Single CAR-T cell treatment controls disseminated ovarian cancer in a syngeneic mouse model. (uchicago.edu)
Cells3
- A class of colony forming cells was induced in the pleural cavity of mice after a local injection of thioglycollate medium (TM). (wustl.edu)
- Foxe1 Deletion in the Adult Mouse Is Associated With Increased Thyroidal Mast Cells and Hypothyroidism. (uchicago.edu)
- The strain is now valued as a source of embryonic stem cells for making knockout mice. (jax.org)
Brain2
- Emphasis of the BICCN is on the whole mouse brain with demonstration of prototype feasibility for human and nonhuman primate (NHP) brains. (bvsalud.org)
- In all mice, reconstructed K p brain values agreed well with the observed values within a 1.21-fold range. (aspetjournals.org)
Model1
- A mouse model of antiepileptic drug treatment was prepared by consecutive 5-week administration of phenytoin (PHT). (aspetjournals.org)
Activity1
- We encourage researchers to be aware of these activity patterns while interpreting neuronal recordings from affected mouse lines and when considering which lines to study. (bvsalud.org)
Days1
- The plating efficiency was 2.2% (1.3 to 3.9%) in AKR mice 3 days after intrapleural injection of 0.5 ml TM. (wustl.edu)
Approach1
- This integrated approach has identified a CRTFN and VZ enhancers involved in cortical regional patterning in the mouse. (bvsalud.org)
Models1
- Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. (uchicago.edu)