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  • tomography
  • Computed tomography (CT) is today a remarkable tool to assess airway wall morphology in vivo since submillimetric acquisitions over the whole lung volume could be obtained allowing 3D evaluation. (hindawi.com)
  • Effects of Bronchodilation on Computed Tomography (CT) Parameters Reflecting Airways Remodelling, and Pulmonary Emphysema Extent. (webhealthnetwork.com)
  • Researchers also believe that a good non-invasive tool for measuring for airway thickness and remodeling is high resolution computed tomography, or high resolution cat scan ( a CT ). (blogspot.com)
  • cell proliferation
  • In addition, TGF-β1 activates EGFR phosphorylation and increases p21WAF1/CIP1 expression that implicates airway remodeling due to irregular cell proliferation and prolonged repair duration. (nih.gov)
  • infiltration
  • Unfortunately, the conventional assessments of asthma in mice often rely on invasive measures of pulmonary function, ex vivo characterization of pulmonary cellular infiltration and observation of anatomical changes, such as airway remodeling due to inflammation, an approach that, while used extensively and highly validated, preclude the possibility of repeated, longitudinal assessment of test animals. (biomedcentral.com)
  • fibroblasts
  • Conclusion: It is clear that airway mesenchymal cells, including fibroblasts/myofibroblasts, are more dynamic in terms of differentiation and origin than has previously been recognised. (lu.se)
  • genes
  • This study elucidated the expression changes of airway remodeling genes in human lung mucoepidermoid NCI-H292 cells exposed to bioaerosols from a composting plant. (nih.gov)
  • Real-time polymerase chain reaction was used to quantify the level of Aspergillus fumigatus and the profile of remodeling genes. (nih.gov)
  • A possible mechanism of airway remodeling genes in response to bioaersol exposure in the composting hall. (nih.gov)
  • This study observed that the expression of remodeling genes, including TGF-β, p21WAF1/CIP1 and EGFR was upregulated after exposure to field-sampled bioaerosols. (nih.gov)
  • The possible mechanism of airway remodeling response of genes to bioaerosols from the composting hall is illustrated in Figure 5. (nih.gov)
  • corticosteroids
  • Asthma treatment with inhaled corticosteroids does not fully prevent airway remodelling and thus have restricted influence on the natural course of the. (lu.se)
  • This is added evidence that asthma should be treated aggressively with inhaled corticosteroids early on in the course of the disease to prevent permanent airway damage and worsening asthma. (blogspot.com)
  • Inhaled corticosteroids seemed to be the ideal treatment although they suppress part of the whole remodeling process without reversing it. (pneumon.org)
  • cells
  • Objectives: This review highlights the role of different fibroblast phenotypes and potential origins of these cells in airway remodelling. (lu.se)
  • Considering that these cells are key players in the remodelling process, it is of utmost importance to characterise specific markers for the various fibroblast phenotypes and to explore factors that drive the differentiation to develop future diagnostic and therapeutic tools for asthma patients. (lu.se)
  • Consequently, both the atopy reaction and ligand induced activation of EGFR signaling cascade are to tend toward to guide cells healing or remodeling. (nih.gov)
  • This review mainly focuses upon the pivotal role of MMP-9 in airway remodeling, and also upon major cellular source of MMP-9 in asthma such as eosinophils, neutrophils, epithelial cells and alveolar macrophages. (eurekaselect.com)