• Conditions that block the airways, damage lung tissue, weaken the muscles that control breathing, or decrease the drive to breathe may cause respiratory failure. (msdmanuals.com)
  • Acute Respiratory Distress Syndrome (ARDS) Acute respiratory distress syndrome is a type of respiratory (lung) failure resulting from many different disorders that cause fluid to accumulate in the lungs and oxygen levels in the blood. (msdmanuals.com)
  • Almost any condition that affects breathing or the lungs can lead to respiratory failure. (msdmanuals.com)
  • Airway stents are used in patients with various respiratory disorders such as tracheobronchial strictures, tumors, and stenosis caused by external compression or inflammation. (acumenresearchandconsulting.com)
  • They are also used in patients with chronic obstructive pulmonary disease (COPD), lung cancer, and other respiratory conditions. (acumenresearchandconsulting.com)
  • There are standard recommendations from the European Respiratory Society (ERS) and the American Thoracic Society (ATS) 2 about lung function tests and how spirometry should be performed. (rcjournal.com)
  • Thus, the time points to perform a lung function test after respiratory physiotherapy are still unclear. (rcjournal.com)
  • This study shows that a respiratory viral infection aggravates the airway damage in rat lung allografts with chronic rejection. (rug.nl)
  • The lungs are the primary organs of the respiratory system in humans and most other animals, including some snails and a small number of fish. (wikipedia.org)
  • The lungs are part of the lower respiratory tract that begins at the trachea and branches into the bronchi and bronchioles, and which receive air breathed in via the conducting zone. (wikipedia.org)
  • The tissue of the lungs can be affected by a number of respiratory diseases, including pneumonia and lung cancer. (wikipedia.org)
  • The effects of airway pressure release ventilation on respiratory mechanics in extrapulmonary lung injury. (tcavnetwork.org)
  • In this article, we outline some of the key challenges faced by the respiratory community in the management of airways diseases, including early diagnosis, disease stratification and monitoring of therapeutic response. (ox.ac.uk)
  • These emerging techniques have the potential to enhance existing measures in the assessment of airways diseases, may be particularly valuable in early disease, and should facilitate the efforts to deliver precision respiratory medicine. (ox.ac.uk)
  • Clinical features of lung transplantation-related pathology can range from an absence of symptoms to signs and symptoms of respiratory distress and/or infection and are not detailed in this article. (medscape.com)
  • The severity of lung irritation and respiratory symptoms increases during winter and is also related to the number of working hours [ 6 ]. (biomedcentral.com)
  • Alveolar type II (ATII) epithelial cells synthesize, secrete and recycle all components of surfactant and dysfunction in surfactant metabolism can result in a variety of pediatric lung diseases including respiratory distress syndrome and interstitial lung disease 3 . (nature.com)
  • He found no inflammation in the airway, the trachea, like you would see with other respiratory viruses like influenza. (globaloncologyacademy.org)
  • Increasing evidence supports the united airway disease concept for the management of upper and lower respiratory tract diseases , particularly in patients with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). (bvsalud.org)
  • Airway difficulties may be encountered in numerous scenarios, including head and neck trauma, traumatic airway injury, morbid obesity with or without respiratory distress, thermal injury, upper-airway pathology (eg, Ludwig angina), and term pregnancy (to name only a few examples). (medscape.com)
  • Distal lung tissue is severely damaged in many lung diseases, causing respiratory insufficiency from loss of surface area available for gas exchange. (lu.se)
  • It is important for interpreting volume-dependent pulmonary mechanics such as airway resistance or forced expiratory flows, and for defining normal lung growth. (ersjournals.com)
  • Chronic Obstructive Pulmonary Disease (COPD) Chronic obstructive pulmonary disease is persistent narrowing (blocking, or obstruction) of the airways occurring with emphysema, chronic obstructive bronchitis, or both disorders. (msdmanuals.com)
  • Pulmonary Embolism (PE) Pulmonary embolism is the blocking of an artery of the lung (pulmonary artery) by a collection of solid material brought through the bloodstream (embolus)-usually a blood clot (thrombus) or. (msdmanuals.com)
  • BACKGROUND: The aim of this study was to evaluate the effects of single and chronic dosing with salmeterol on exercise capacity and lung function in patients with chronic obstructive pulmonary disease. (bmj.com)
  • In the general population, spirometric test results showing impaired pulmonary function can indicate lung disease and predict future lung ailments and mortality. (uw.edu)
  • Airway remodeling and destruction is a characteristic finding in chronic obstructive pulmonary disease and emphysema. (uw.edu)
  • The lungs have a unique blood supply, receiving deoxygenated blood from the heart in the pulmonary circulation for the purposes of receiving oxygen and releasing carbon dioxide, and a separate supply of oxygenated blood to the tissue of the lungs, in the bronchial circulation. (wikipedia.org)
  • Pulmonary exposure to NQ dose-dependently aggravated antigen-related airway inflammation, as characterised by infiltration of eosinophils and lymphocytes around the airways and an increase in goblet cells in the bronchial epithelium. (ersjournals.com)
  • DEP have been correlated to lung cancer, pulmonary fibrosis, chronic alveolitis 1 and oedematous changes 2 . (ersjournals.com)
  • Although rare, pulmonary embolism, infections, or neoplasms in the allograft may be diagnosed in this manner, which would affect the decision to use the donor lung. (medscape.com)
  • Recurrent exposure can lead to interstitial lung disease and pulmonary vascular pathologies. (medscape.com)
  • For reasons that are not entirely clear, patients with asthma develop deleterious immune responses to otherwise innocuous substances, like allergens, that result in tissue inflammation and airway hyperreactivity. (rochester.edu)
  • Scientists have identified diverse pathways associated with normal lung function, as well as with airflow obstruction and emphysema, by data-mining large-scale genetic information from over 50,000 subjects. (uw.edu)
  • The paper, "Integrated Pathway Genomics of Lung Function and Airflow Obstruction" is featured on the cover of the December issue of the journal. (uw.edu)
  • Cover image in Human Molecular Genetics for the paper, "Integrative Pathway Genomics of Lung Function and Airflow Obstruction. (uw.edu)
  • Lung function parameters are used as end points in most clinical and therapeutic trials in cystic fibrosis (CF) and to evaluate the effects of airway clearance techniques. (rcjournal.com)
  • Furthermore, a recent study has shown that organic chemicals in DEP, rather than their carbonaceous nuclei, are important contributors to the aggravating effects of airway inflammation. (ersjournals.com)
  • The forced air delivered by CPAP (continuous positive airway pressure) prevents episodes of airway collapse that block the breathing in people with obstructive sleep apnea and other breathing problems. (medlineplus.gov)
  • Continuous positive airway pressure (CPAP) provides a gentle and steady pressure of air in your airway to keep it open. (medlineplus.gov)
  • Surface activities after 5 min of adsorption were determined in the CBS and correlated to the perinatal data (e.g., gestational age, birth weight, gender), airway interventions (like CPAP, conventional ventilation) and surfactant treatment. (uni-luebeck.de)
  • Obstructive sleep apnea syndrome (OSAS) has been associated with increased morbidity and mortality, principally from cardiovascular disease, but the impact of nasal continuous positive airway pressure (CPAP) therapy is unclear. (medscape.com)
  • [ 3 ] Continuous positive airway pressure (CPAP) is an effective therapy and is the most widely used modality in patients with moderate-to-severe disease. (medscape.com)
  • Continuous positive airway pressure (CPAP) is being increasingly used clinically to transition preterm infants at birth. (edu.au)
  • Continuous positive airway pressure (CPAP) is being increasingly used clinically to transition preterm infants at birth.ObjectiveTo test if distending pressures will activate acute phase reactants and inflammatory changes in the airways of fetal, preterm lambs.MethodsThe head and chest of fetal lambs at 128 +/- 1 day GA were surgically exteriorized. (edu.au)
  • To determine work-of breathing with continuous positive airway pressure (CPAP) delivery systems, we used a lung model to simulate spontaneous breathing. (nih.gov)
  • Seven demand-flow CPAP delivery systems were compared with one continuous-flow, 5-L reservoir-bag system (flow of 60 L/min to maintain positive airway pressure). (nih.gov)
  • 4 Lower body weight at birth was shown to be associated with reduced forced expiratory volume and vital lung capacity, 5-7 with an increased risk for asthma, 8-13 as well as with increased death rates from chronic obstructive airways disease. (bmj.com)
  • 6 Only a few studies failed to find an association between birth weight and lung function 14 , 15 or asthma. (bmj.com)
  • Recent progress in multimodal molecular profiling of single cells has allowed discovAIR partners to draft the first cellular census of healthy human lung3, and to describe the alterations in molecular states and relative frequencies of cells in the airway wall in asthma. (oncoage.org)
  • Chronic airways diseases, including asthma, COPD and cystic fibrosis, cause significant morbidity and mortality and are associated with high healthcare expenditure, in the UK and worldwide. (ox.ac.uk)
  • In this systematic review , we focused on the role of biologics in the lung function and quality of life in patients with severe asthma and CRSwNP. (bvsalud.org)
  • Primary diagnosis was mostly asthma or CRSwNP, with only 15 studies, mainly observational, performed in populations with united airway disease . (bvsalud.org)
  • The use of biologics in patients with severe asthma and CRSwNP was overall associated with significant improvements in lung function and quality of life . (bvsalud.org)
  • Notwithstanding the need of larger studies, our results reinforce the joint management of asthma and CRSwNP as united airway disease in clinical practice. (bvsalud.org)
  • Chemical irritation of the airway can result in the development of new onset asthma or worsening of prior symptoms of asthma. (medscape.com)
  • In multiple organs, including the lungs, age-related tissue and organ dysfunction interferes with tissue regeneration, which requires functional stem cells. (karger.com)
  • Stem cells of all organs - including the lung, which harbors distinct stem cells for each separate tissue that makes up the lung as a whole - reside in niches described as a microenvironment that supports and maintains the 'stemness' of cells as a critical reservoir for maintaining tissue homeostasis and responding to injury [ 3 ]. (karger.com)
  • In the bronchioles and the large airways throughout the allogeneic lung transplants, inflammation with epithelial necrosis and formation of granulation tissue was present. (rug.nl)
  • Fetal lung fluid (FLF), bronchoalveolar lavage fluid (BAL), right mainstem bronchi and peripheral lung tissue were evaluated for inflammation. (edu.au)
  • mRNA expression of early response genes and pro-inflammatory cytokines did not increase in airway tissue or lung tissue at any pressure compared to controls. (edu.au)
  • Fetal lung fluid (FLF), bronchoalveolar lavage fluid (BAL), right mainstem bronchi and peripheral lung tissue were evaluated for inflammation.ResultsRecruitment volume increased from 0.4 +/- 0.04 mL/kg at 4 cmH(2)O to 2.4 +/- 0.3 mL/kg at 16 cmH(2)O. The lambs were surfactant deficient, and all pressures were below the opening inflection pressure on pressure-volume curve. (edu.au)
  • To achieve this, a detailed understanding is required of the cells that make up the lung, their fixed and variable features, their interactions and their organization into macroscopic tissue architecture in health and disease. (oncoage.org)
  • In particular, we need to map lung cells onto the tissue architecture, chart the local cellular neighbourhoods and their alterations in a wider range of diseases, and identify their molecular fingerprints. (oncoage.org)
  • DiscovAIR will move beyond the current state of the art by combining multimodal profiling of lung tissue cells with a detailed spatial mapping of the identified cell states, 3D reconstruction of lung tissue architecture from transcriptionally defined cell states, in-depth molecular phenotyping of local cellular neighbourhoods and development of novel computational approaches to integrate the multimodal data of the spatial and the cellular branches of discovAIR. (oncoage.org)
  • Molecular phenotypes of lung cells are determined by their role in maintaining physical and immunological barrier functions or facilitating gas exchange, as well as by their location within the tissue architecture. (oncoage.org)
  • Importantly, healthy lung tissue is available to a large number of research groups through bronchoscopy programs involving healthy volunteers and patients with lung disease, and from lung transplantation and resection programs. (oncoage.org)
  • This combination of a highly ordered tissue architecture - facilitating the implementation of a common coordinate framework - and good community-wide availability of tissue makes lung especially well-suited as a lead organ for the HCA to develop the infrastructure, workflows and platforms needed for a community-driven mapping effort as laid down in the vision of the Human Cell Atlas consortium5. (oncoage.org)
  • Included in this package are an additional soft airway, an additional replacement face tissue, a replacement set of teeth, and two additional replaceable tracheas. (simulab.com)
  • Bronchus-associated lymphoid tissue (BALT) in the lungs of rats exposed for 20 days contained germinal centers and mitotic cells suggesting activation. (biomedcentral.com)
  • Bioengineering lung tissue or bioengineering cells with biomaterials for transplantation is an exciting new approach to (re)generate tissue to close this large unmet clinical need. (lu.se)
  • Whether you are a patient living with lung disease or a caregiver, join the Patient & Caregiver Network for timely education, support and connection. (lung.org)
  • 20+ Years continually advancing lung disease research. (lung.org)
  • Your tax-deductible donation funds lung disease and lung cancer research, new treatments, lung health education, and more. (lung.org)
  • All were ventilator dependent with chronic lung disease. (nih.gov)
  • These results suggest that in infants with early and late chronic lung disease, bronchospasm can be partially alleviated by inhaled bronchodilators. (nih.gov)
  • BACKGROUND Associations have been found between a large head size at birth and atopy, and between low birth weight and obstructive airways disease. (bmj.com)
  • A study was undertaken of people born around the time of the Dutch famine in 1944-5 to determine the effects of maternal malnutrition during specific periods of gestation on the prevalence of obstructive airways disease and atopy. (bmj.com)
  • The prevalence of obstructive airways disease was increased in people exposed to famine in mid gestation (odds ratio adjusted for sex 1.7, 95% confidence interval (CI) 1.1 to 2.6) and tended to be higher in those exposed in early gestation (odds ratio 1.5, 95% CI 0.9 to 2.6). (bmj.com)
  • CONCLUSIONS The observed increase in the prevalence of obstructive airways disease in people exposed to famine in mid and early gestation was not parallelled by effects on IgE concentrations or lung function. (bmj.com)
  • The link between exposure to famine in mid and early gestation and obstructive airways disease in adulthood suggests that fetal lungs can be permanently affected by nutritional challenges during periods of rapid growth. (bmj.com)
  • A number of studies have shown associations between head size of newborn babies and atopy, and between birth weight and obstructive airways disease. (bmj.com)
  • It is therefore likely that increased concentrations of IgE and obstructive airways disease have origins in utero. (bmj.com)
  • Effects of regular salmeterol on lung function and exercise capacity in patients with chronic obstructive airways disease. (bmj.com)
  • Airway-centered idiopathic fibrosis (ACIF) is one of a few relatively recently described entities with combined features of airway fibrosis and chronic interstitial lung disease. (medscape.com)
  • Other conditions with features of bronchiolocentric interstitial lung disease that are histologic variants of idiopathic interstitial pneumonia include bronchiolocentric interstitial pneumonia, bronchiolitis interstitial pneumonia, and centrilobular fibrosis. (medscape.com)
  • A retrospective study (1995-2012) of 68 Brazilian patients with airway-centered idiopathic fibrosis found that hypersensitivity pneumonitis was the cause in 42.6% (n = 29) of patients, followed by gastroesophageal reflux disease in 25% (n = 17), collagen vascular disease in 5.9% (n = 4), a combination of these in 22% (n = 15), and idiopathic in 4.4% (n = 3). (medscape.com)
  • In recent years, the number of studies on rheumatoid arthritis-related interstitial lung disease (RA-ILD) has been increasing, which has led to many publications on this topic. (hindawi.com)
  • Interstitial lung disease (ILD) is an extra-articular manifestation of RA, which occurs frequently in up to 80% of patients with RA. (hindawi.com)
  • The retrieval steps and strategies were as follows: Title = rheumatoid arthritis AND Title = (interstitial lung disease OR interstitial pneumonia) AND Language = English AND Document type = (review OR article) AND Time span =1980 to 2021. (hindawi.com)
  • We will also examine how regenerative failure may contribute to development of aging-related, chronic lung disease. (karger.com)
  • People with inflammatory lung disease such as cystic fibrosis are particularly vulnerable to this condition. (nih.gov)
  • Dr. Olivier's experiences in evaluating and managing large patient cohorts enrolled in bronchiectasis and mycobacterial natural history protocols, as well as his efforts to foster research partnerships with industry, have allowed assessment of novel therapeutic approaches for treating refractory NTM lung disease, such aerosolized liposomal amikacin for inhalation. (nih.gov)
  • Lung disease is a leading cause of death worldwide1, with incidence increasing at an alarming rate while curative interventions are lacking. (oncoage.org)
  • Research into lung disease lags behind compared to cancer and cardiovascular disease, the other 2 major causes of death2. (oncoage.org)
  • Hence, there is an urgent need to grasp this complexity and propel basic, translational and clinical research in lung disease into a fast-track for the development of precision diagnostics and therapeutics. (oncoage.org)
  • DiscovAIR will establish the first draft of the Human Lung Cell Atlas, focusing on healthy lung, but including small disease cohorts, enabling accelerated translational and clinical research into lung disease. (oncoage.org)
  • The discovAIR results will facilitate progress in regenerative and precision medicine and identify novel candidates for precision diagnostics and curative interventions in lung disease for the diagnostic and pharmacological industry, thereby contributing to healthy ageing and active living in Europe. (oncoage.org)
  • We also chart a radically changed intercellular communication network in disease, revealing a wealth of novel interactions specific to the asthmatic airway wall, that need to be tested for diagnostic and therapeutic applications. (oncoage.org)
  • In this context, the identification and targeting of 'treatable traits' is an important priority in airways disease, both to ensure the appropriate use of existing treatments and to facilitate the development of new disease-modifying therapy. (ox.ac.uk)
  • This requires not only better understanding of airway pathophysiology but also an enhanced ability to make physiological measurements of disease activity and lung function and, if we are to impact on the natural history of these diseases, reliable measures in early disease. (ox.ac.uk)
  • The cut surface shows the characteristic findings of the disease for which lung transplantation was indicated. (medscape.com)
  • These findings suggest that a lethal lung disease can be targeted and corrected in a human lung organoid model in vitro . (nature.com)
  • This hypothesis "may provide a rationale for understanding why some individuals develop COVID-19 lung disease and others do not. (globaloncologyacademy.org)
  • The effect of biologics in lung function and quality of life of patients with united airways disease: A systematic review. (bvsalud.org)
  • COPD, also referred to as emphysema or chronic bronchitis, is a serious lung disease that makes it hard to breathe. (cdc.gov)
  • Lung transplantation remains the only potential curative option at end-stage disease but is severely limited by a lack of suitable donor lungs and low long-term survival. (lu.se)
  • Other studies of the general population have found that Latinos, and Mexican-Americans specifically, experienced reduced odds for obstructive lung disease (OLD) compared to whites [Diaz et al. (cdc.gov)
  • Occupational lung disease can result from inhalational exposure to minerals and dusts, microbes, animal and insect proteins, and chemicals and can have long-lasting effects even after the exposure ceases. (medscape.com)
  • Chemical worker's lung refer to the development of lung disease in the work environment from inhalational exposure to chemicals. (medscape.com)
  • The list of chemicals that has been associated with lung disease continues to increase. (medscape.com)
  • Determining the actual prevalence rate of chemical worker's lung is difficult because of low reporting, poor appreciation of symptoms and signs associated with substance exposure, and lack of proper understanding of and diagnostic guidelines for the disease. (medscape.com)
  • Histologically, it shows the presence of a bronchiolocentric pattern of lung injury resulting in centrilobular fibrosis and mild chronic inflammatory cell infiltrate, which extends into the adjacent interstitium. (medscape.com)
  • Fig. 3: Phagocytosis function of newly formed resident lung alveolar macrophages is altered locally by secondary inflammatory mediators released during infection. (nature.com)
  • Distending Pressure Did Not Activate Acute Phase or Inflammatory Responses in the Airways and Lungs of Fetal, Preterm Lambs. (edu.au)
  • To test if distending pressures will activate acute phase reactants and inflammatory changes in the airways of fetal, preterm lambs. (edu.au)
  • The current authors have recently shown that PQ induces recruitment of inflammatory cells, such as eosinophils and neutrophils, into the lung with the lung expression of pro-inflammatory molecules such as interleukin (IL)-5 and eotaxin in vivo 24 . (ersjournals.com)
  • NQ contributes to DEP toxicity through the reduction of superoxide dismutase activity in vitro 26 , which raises the possibility that NQ may facilitate airway inflammatory conditions in vivo . (ersjournals.com)
  • yet the mechanisms responsible for connecting the lung-bone inflammatory axis remain unclear. (cdc.gov)
  • IL-6 might be an important link in explaining the lung-bone inflammatory axis. (cdc.gov)
  • Overview of Pneumonia Pneumonia is an infection of the small air sacs of the lungs (alveoli) and the tissues around them. (msdmanuals.com)
  • Together, the lungs contain approximately 2,400 kilometres (1,500 miles) of airways and 300 to 500 million alveoli. (wikipedia.org)
  • Personalizing mechanical ventilation according to physiologic parameters to stabilize alveoli and minimize ventilator induced lung injury (VILI). (tcavnetwork.org)
  • Fine particulate matter, which is widespread both indoors and outdoors, damages the health of more people than any other air pollutant, through the deposition of particles in smaller airways and alveoli in the lungs and their penetration into the bloodstream. (who.int)
  • Overview of Pleural and Mediastinal Disorders The pleura is a thin, transparent, two-layered membrane that covers the lungs and also lines the inside of the chest wall. (merckmanuals.com)
  • Lung transplantation-related pathology encompasses a spectrum of disorders that include, but are not limited to, indications for lung transplantation (seen in explanted lungs), surgical complications (airway anastomotic and vascular complications), ischemia-reperfusion injury, rejection (acute and chronic), infections, and posttransplantation lymphoproliferative disorders (PTLDs). (medscape.com)
  • Before you can understand COPD, you need to know how your lungs work. (cdc.gov)
  • If you have any symptoms of COPD, your lungs may be trying to tell you something and the time to listen is now. (cdc.gov)
  • The CPR/Airway Management Torso is ideal for practicing intubation, ventilation, suctioning techniques, and CPR. (anatomywarehouse.com)
  • A difficult airway is one for which a preintubation examination identifies attributes that are likely to make laryngoscopy, intubation, bag-mask ventilation (BMV), the use of a supraglottic device, or surgical airway management more difficult than would be the case for a normal airway. (medscape.com)
  • A failed airway occurs when a provider has embarked on a certain course of airway management (eg, rapid sequence intubation/induction [RSI]) and has determined that intubation by that method will not succeed and that immediate initiation of a rescue sequence must be implemented. (medscape.com)
  • While much work has focused on the failure of epithelial cell populations as a key component of the aging process, additional studies have shown that aging, as a global phenomenon in the lung, also impacts resident endothelial, mesenchymal, and immune cell populations. (karger.com)
  • Here we show the differentiation of patient specific iPSCs derived from a patient with SFTPB deficiency into lung organoids with mesenchymal and epithelial cell populations from both the proximal and distal portions of the human lung. (nature.com)
  • Although many differentiation protocols in the literature have been successful in mimicking lung development from stem cells, there has not been an examination of how a specific mutation impacts the differentiation process including its effects on the early endoderm, as well as the proximal and distal lung epithelial cell populations in the lung organoids. (nature.com)
  • An airway stent, also known as a lung stent, is a medical device used to maintain the patency of the airways, including the trachea, bronchi, and bronchioles. (acumenresearchandconsulting.com)
  • The lungs stretch from close to the backbone in the rib cage to the front of the chest and downwards from the lower part of the trachea to the diaphragm. (wikipedia.org)
  • The medial surfaces of the lungs face towards the centre of the chest, and lie against the heart, great vessels, and the carina where the trachea divides into the two main bronchi. (wikipedia.org)
  • In the present study, we investigated whether viral infections could induce airway damage in rat lung transplants in the absence or presence of chronic rejection. (rug.nl)
  • Lower molecular weight antigens can induce airway sensititzation without the mediation of IgE. (medscape.com)
  • Thus, a comprehensive understanding of lung transplantation-related pathology is necessary for both tertiary care pathologists dealing with highly specialized lung transplantation teams and a much larger spectrum of healthcare providers who may be involved in the care of lung transplant recipients or candidates for lung transplantation. (medscape.com)
  • The etiology of lung transplantation-related pathology is almost always immune-mediated. (medscape.com)
  • ODE-induced airway neutrophil influx, cytokine/chemokine release, and lung pathology were not reduced in IL-6 KO animals compared to WT mice. (cdc.gov)
  • We now need to chart the cellular makeup of the lung at higher resolution, sampling more locations along the bronchial tree and in the parenchyma. (oncoage.org)
  • Sometimes most or all of the lung collapses, leading to severe shortness of breath. (msdmanuals.com)
  • The Laboratory of Chronic Airway Infection, led by Dr. Kenneth Olivier, focuses on bronchiectasis, a condition that damages the body's ability to clear mucus from the airways and increases risk of severe lung infections by nontuberculous mycobacteria (NTM), which commonly are found in wet environments such as streams, rivers, and marshes. (nih.gov)
  • Dr. Olivier's research focuses on bronchiectasis , a condition that damages the body's ability to clear mucus from the airways and increases risk of severe lung infections by nontuberculous mycobacteria (NTM), which commonly are found in wet environments such as streams, rivers, and marshes. (nih.gov)
  • In contrast, in the allogeneically transplanted lungs the viral infection caused severe and permanent damage of the airways. (rug.nl)
  • Some people with severe symptoms may need lung transplant surgery when other methods do not help. (denverhealth.org)
  • IU School of Medicine faculty are dedicated to preventing bronchopulmonary dysplasia (BPD), providing interdisciplinary inpatient and outpatient care for patients with severe BPD and caring for patients with airway issues requiring supplemental oxygen or procedures to be safely discharged from the hospital. (iu.edu)
  • Alveolar macrophages, or AMs, are the first line of cellular defense in the airways. (medium.com)
  • Surfactant is produced by alveolar type II cells which can be differentiated in vitro from patient specific induced pluripotent stem cell (iPSC)-derived lung organoids. (nature.com)
  • Lung development is a complicated process that involves the specialization of multiple bronchiolar and alveolar epithelial populations. (nature.com)
  • The current authors investigated the effects of naphthoquinone (NQ), one of the extractable chemical compounds of DEP, on antigen-related airway inflammation, local expression of cytokine proteins, and antigen-specific immunoglobulin (Ig) production in mice. (ersjournals.com)
  • The Global Airway Stent/Lung Stent Market Size accounted for USD 112.6 Million in 2022 and is projected to achieve a market size of USD 204.4 Million by 2032 growing at a CAGR of 6.3% from 2023 to 2032. (acumenresearchandconsulting.com)
  • Our proprietary Airways Clinical Research Centers (ACRC) Network is a jewel in the crown of the American Lung Association research program. (lung.org)
  • [ 3 ] In a case report, a patient had clinical, radiologic, and serologic evidence of hypersensitivity pneumonitis with a pattern of airway-centered idiopathic fibrosis on histology. (medscape.com)
  • This study aimed to determine surface activity from small volume aspirates of the upper airways of neonates by means of the CBS and to correlate the results with clinical data. (uni-luebeck.de)
  • The Registry of the International Society for Heart and Lung Transplantation (ISHLT) monitors and reports statistics on clinical lung transplantation. (medscape.com)
  • We conclude that multiple exposures to endotoxin-containing swine barn air induce AHR, increase in mucus-containing airway epithelial cells and lung inflammation. (biomedcentral.com)
  • The airways can also become swollen and mucus production might increase, making it even harder to get air in and out of the lungs. (cdc.gov)
  • A bony cage (commonly called the rib cage), which is formed by the sternum, ribs, and spine, protects the lungs and other organs in the chest. (merckmanuals.com)
  • In embryonic development, the lungs begin to develop as an outpouching of the foregut, a tube which goes on to form the upper part of the digestive system. (wikipedia.org)
  • Pneumonia in Immunocompromised People Pneumonia is infection of the lungs. (msdmanuals.com)
  • Airway-centered idiopathic fibrosis was initially described by Yousem et al in 2002 as "idiopathic bronchiolocentric interstitial pneumonia. (medscape.com)
  • Medical terms related to the lung often begin with pulmo-, from the Latin pulmonarius (of the lungs) as in pulmonology, or with pneumo- (from Greek πνεύμων "lung") as in pneumonia. (wikipedia.org)
  • In this review, we examine aging as a process dependent on specific changes in molecular pathways within multiple lung cell populations. (karger.com)
  • More recently, it has also been demonstrated that PQ aggravates antigen-related airway inflammation in mice, and that PQ also has adjuvant activity for antigen-specific Igs 25 . (ersjournals.com)
  • As part of their investigation, the team exposed mice to the influenza virus to determine the cellular and biochemical processes orchestrated by airway-hugging NAMs during infection. (medium.com)
  • The current authors have previously demonstrated that diesel exhaust particles (DEP) enhance antigen-related airway inflammation in mice. (ersjournals.com)
  • The current authors have recently demonstrated that extracted organic chemicals from DEP, rather than residual carbonaceous nuclei of DEP after extraction, predominantly enhance antigen-related airway inflammation in mice 17 . (ersjournals.com)
  • A. alternata filtrate applied to the airway in nonsensitized Balb/c mice induced a protease-dependent lung inflammation. (arizona.edu)
  • The risk of worsening airway injuries (eg, turning a partial tear of the larynx into a total one) through injudicious airway instrumentation must be avoided. (medscape.com)
  • This method has the further advantage that with suitable adaptations to the equipment, simultaneous measurements of airway resistance can also be obtained. (ersjournals.com)
  • The aim of this paper is to summarize what is currently seen to be good laboratory practice, and to provide recommendations for both users and manufacturers of infant lung function equipment and software with respect to plethysmographic measurements of lung volume and airway resistance in infants. (ersjournals.com)
  • Measurements of spirometric parameters, static lung volumes, and exercise capacity were made one and six hours after a single dose, and six hours after the final dose of salmeterol or placebo. (bmj.com)
  • Several spirometric measurements of the volume of exhaled air and lung capacity are inherited traits. (uw.edu)
  • The mediastinum isolates the left and right lung from each other so that they function as two separate chest cavities. (merckmanuals.com)
  • Lung function was measured in 733 and serum concentrations of total IgE and specific IgE against mite, pollen and cat were measured in 726. (bmj.com)
  • RESULTS Exposure to famine during gestation affected neither the concentrations of total or specific IgE nor lung function values. (bmj.com)
  • The researchers analyzed data from several genome-wide association studies of lung function by using pathway-based computational approaches. (uw.edu)
  • Their work identified a large repertoire of more than one hundred gene sets associated with spirometric measures of lung function. (uw.edu)
  • By grouping functionally similar pathways, the scientists were able to dissect biological processes linked to lung function, such as cell adhesion, movement, proliferation, and signaling, as well as those regulating immunity and development. (uw.edu)
  • Exposure to dust and smoke at the WTC collapse site has caused ongoing loss of lung function and reduced quality of life. (cdc.gov)
  • The effectiveness of medications in treating accelerated decline in lung function is unclear. (cdc.gov)
  • When the lungs are formed the fetus is held in the fluid-filled amniotic sac and so they do not function to breathe. (wikipedia.org)
  • Therefore, we tested a hypothesis in a rat model that multiple interrupted exposures to the barn air will cause chronic lung inflammation and decline in lung function. (biomedcentral.com)
  • In total, 18 studies reported data on quality of life (mostly 22-item Sino-Nasal Outcome Test score), 8 on lung function (mostly FEV1), and 22 on both outcomes. (bvsalud.org)
  • Humans have two lungs, one on the left and one on the right. (wikipedia.org)
  • Small upper airway aspirates from 159 neonates (gestational age 25-42 weeks) were withdrawn and concentrated 16.7-fold by ultracentrifugation and resuspension in saline. (uni-luebeck.de)
  • Workplace exposure to inhaled chemicals can lead to changes in the airway, lung parenchyma, blood vessels, and pleura or a combination of these structures in the lung. (medscape.com)
  • Healthy airways and air sacs in the lungs are elastic--they bounce back to their original shape after being filled with air and stretched, just the way a new rubber band or balloon does. (cdc.gov)
  • Background/Aims: Patients with chronic airway lung diseases often experience depression and anxiety, but little information is available regarding Koreans with these conditions. (ewha.ac.kr)
  • We thus assessed depression and anxiety in Korean patients with chronic airway lung diseases. (ewha.ac.kr)
  • p = 0.018) were independent risk factors for depression in patients with chronic airway lung diseases. (ewha.ac.kr)
  • Natural lung aging is marked by molecular changes that occur during development, maturation, and late-life decline. (karger.com)
  • American Journal of Physiology - Lung Cellular and Molecular Physiology , 300 (4), L605-L614. (arizona.edu)
  • American Journal of Physiology - Lung Cellular and Molecular Physiology , Vol. 300, No. 4, 01.04.2011, p. (arizona.edu)
  • NTM lung infection treatment currently requires multiple drugs taken for months or even years. (nih.gov)
  • After viral infection in these lungs, mild inflammation developed in the airways that was transient and completely resolved by day 56 after infection. (rug.nl)
  • These rats were killed for histological investigation 4, 7, 21, and 56 days after infection.In the lungs of the noninfected rats of the nontransplanted and syngeneically transplanted groups, airway changes were absent. (rug.nl)
  • from shock, infection of the corroded tissues, lung damage, or loss of measurable pulse. (cdc.gov)
  • Because of the underlying lung disorder, the symptoms and outcome are generally worse in secondary spontaneous pneumothorax. (msdmanuals.com)
  • Although the serum precipitins were negative in these patients, the lung biopsies demonstrated a histologic pattern similar to that of hypersensitivity pneumonitis but with more extensive fibrosis and less inflammation without any granulomas. (medscape.com)
  • Such abnormalities disrupt the usual ability of the lung tissues to take in oxygen from the air. (msdmanuals.com)
  • This disorder does not disrupt the usual ability of the lung tissues to take in oxygen, but without blood flowing to a portion of the lungs, oxygen is not properly extracted from the air. (msdmanuals.com)
  • A blood clot that goes from the nose down the airway and into the lungs. (snopes.com)
  • A photograph shows a large blood clot removed from a patient's lung. (snopes.com)
  • Finally, we highlight emerging technologies including imaging methods such as quantitative CT and hyperpolarised gas MRI as well as quantification of lung inhomogeneity using precise in-airway gas analysis and mathematical modelling. (ox.ac.uk)
  • However the mechanisms of lung dysfunction following repeated exposures to the barn air are still largely unknown. (biomedcentral.com)
  • These results provide the first experimental evidence that naphthoquinone can enhance antigen-related airway inflammation in vivo , and that naphthoquinone can, to some extent, partly play a role in the pathogenesis of diesel exhaust particle toxicity on the condition. (ersjournals.com)
  • DEP enhance the antigen-specific immunoglobulin (Ig)E response 5 , 6 and aggravate airway inflammation induced by repetitive intratracheal instillation of antigen in vivo 7 - 10 . (ersjournals.com)
  • We examined the impact of proteases from A. alternata on lung inflammation in vivo and on cleaving protease-activated receptor-2 (PAR 2 ) in vitro. (arizona.edu)
  • These data demonstrate that A. alternata proteases act through PAR2 to induce rapid increases in human airway epithelial [Ca 2+ ] i in vitro and cell recruitment in vivo. (arizona.edu)