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  • viral
  • Like other viral diseases, including small pox and polio, AlDS may disappear from the scene with the development of a vaccine. (latimes.com)
  • The May 30 issue of Science reports that Viral Technologies Inc., a Washington corporation, has managed to prevent the AIDS virus from invading human cells inside a test tube. (latimes.com)
  • According to a Yerkes study reported in the October 2002 edition of the Journal of Virology, levels of viral DNA in the monkeys have declined to the nearly undetectable levels characteristic of a small subset of HIV-infected people, termed long-term nonprogressors, who carry HIV but do not develop AIDS. (emory.edu)
  • A vaccine mimics the viral region where the antigens sit, and train the immune system to recognize and attack the virus in that vital spot when the real thing enters the blood stream. (thestar.com)
  • Drugmakers Merck and sanofi-aventis have each made versions of a T cell-stimulating vaccine by inserting HIV genes into a viral vector, or gene delivery system. (scientificamerican.com)
  • Antiretroviral drugs have made AIDS treatable for those who have access and adhere to it, and - by reducing viral load in blood - can reduce the risk of transmission to others. (iavi.org)
  • Over the last decade, we have created AIDS vaccines that generate T-cell populations that can combat HIV," explains lead author Norman Letvin, M.D., chief of the Division of Viral Pathogenesis at BIDMC, professor of Medicine at Harvard Medical School, and investigator at the NIAID VRC. (emaxhealth.com)
  • scientists
  • Teams of scientists from industry, academia and government collaborate to develop and test novel experimental HIV vaccine concepts in the laboratory and in animal models. (nih.gov)
  • Scientists say they may know within months how fast and well this new HIV target can be employed in a vaccine strategy. (thestar.com)
  • The [vaccine] regimen is sufficiently different from the Merck product to warrant further testing," linkurl:Eric Hunter,;http://www.vaccines.emory.edu/scientists/hunter.shtml Emory University vaccinologist and subcommittee chair, said at the panel's linkurl:meeting. (the-scientist.com)
  • Instead, Letvin and other scientists in this field have focused their work on developing a vaccine that confers cellular immunity, so that a group of T-cells induced by a vaccine recognizes the cells that have been infected by HIV and then destroys them so that the virus cannot continue replicating. (emaxhealth.com)
  • By measuring the levels of central memory cells in blood samples taken from participants in human clinical trials [to test the AIDS vaccine] scientists would be able to predict how well the vaccine would work over time. (emaxhealth.com)
  • clade
  • A California biotech company, ViCal, manufactured the priming components of the AIDS vaccine for the Phase I clinical trial from the DNA of clade B, the most common HIV subtype in North America and Western Europe. (emory.edu)
  • In late 2003, a Phase I clinical trial of a vaccine against clade AG, the most common HIV subtype found in West Africa, will be launched in the United States and then in Côte d'Ivoire (formerly the Ivory Coast). (emory.edu)
  • vectors
  • Here, we assessed the induction of HIV-1 trimer binding and neutralizing antibody (nAb) titres when BG505s trimers were also delivered by non-replicating simian (chimpanzee) adenovirus and non-replicating poxvirus modified vaccinia virus Ankara (MVA) vaccine vectors. (iavi.org)
  • Rabbits were immunized intramuscularly with these vaccine vectors and in some cases boosted with ISCOMATRIX™-adjuvanted BG505s protein trimer (P), using CCC, MMM, PPP, CPP, MPP and CMP vaccine regimens. (iavi.org)
  • These results demonstrate that ChAdOx1 and MVA vectors are useful delivery modalities for not only T-cell, but also antibody vaccine development. (iavi.org)
  • This new vaccine aims to overcome the problem of preexisting immunity to common vaccine vectors, which is thought to be a major problem in the developing world. (biologynews.net)
  • optimism
  • In formally announcing the decision, which was disclosed in news reports Monday, Federal health officials expressed hope and optimism about the new vaccine but said there was nothing about its development that suggested an imminent breakthrough in preventing the deadly disease, which cripples the immune system. (nytimes.com)
  • Africa
  • In central Africa, AIDS is endemic among young heterosexuals. (latimes.com)
  • By late 2004, the Vaccine Center hopes to begin a Phase I trial of a trivalent vaccine incorporating the DNA from clades B, AG, and C. Subtype C is the most prevalent form of HIV in India and southern Africa. (emory.edu)
  • Esparza said it is imperative to conduct more vaccine trials, especially in Africa. (sun-sentinel.com)
  • The NIH formed its own HIV vaccine trial network in 2000 to oversee clinical research sites in the U.S., Africa, Asia, the Caribbean and South America. (scientificamerican.com)
  • I cannot emphasise how badly we need to have a vaccine… to get rid of HIV in the next generation altogether," said Francois Venter of the University of the Witwatersrand Reproductive Health and HIV Institute in South Africa. (rawstory.com)
  • To establish clinical laboratory reference ranges among adults to determine relevant inclusion and exclusion criteria and to interpret safety data for HIV vaccine trials in the context of medical conditions present in an asymptomatic adult population at multiple sites in Africa. (iavi.org)
  • placebo
  • The participants were randomly given one of seven vaccine combinations or a placebo "dummy" alternative. (rawstory.com)
  • The $105 million Thailand study randomized 16,402 people to get either the two-step "prime-boost" vaccine or a placebo. (medpagetoday.com)
  • Then the volunteers were given booster injections -- at weeks 12 and 24 -- of a second vaccine, dubbed AIDSVAX B/E, or placebo. (medpagetoday.com)
  • But seven volunteers -- five in the vaccine arm and two in the placebo arm -- were found to have been HIV-positive at the start of the study and were excluded from the main analysis, of the "modified" intent-to-treat population. (medpagetoday.com)
  • In the modified intent-to-treat population, there were 51 infections in the vaccine arm and 74 in the placebo arm, a 31.2% reduction that was significant at P =0.04. (medpagetoday.com)
  • In the intent-to-treat population -- all those who got any study drug -- there were 56 HIV cases in the vaccine arm and 76 in the placebo arm. (medpagetoday.com)
  • Finally, in the smaller per-protocol population, there were 36 infections in the vaccine arm and 50 in the placebo arm. (medpagetoday.com)
  • research
  • To help reach this goal, the National Institute of Allergy and Infectious Diseases (NIAID), which spearheads federal funding for biomedical research on HIV/AIDS for the National Institutes of Health (NIH), has intensified its HIV vaccine research program. (nih.gov)
  • Throughout the fact sheet scientific terms common to vaccine research have been printed in boldface type and defined. (nih.gov)
  • NIAID's Division of AIDS (DAIDS) directs the HIV vaccine research program. (nih.gov)
  • Although traditional investigator-initiated research forms the foundation for HIV/AIDS vaccine research, NIAID supports several special initiatives to accomplish specific research objectives. (nih.gov)
  • AIDS Cooperative Adjuvant Groups conduct multidisciplinary research on the mechanisms of action of adjuvants, substances that can be combined with a vaccine to enhance immune responses. (nih.gov)
  • It's certainly the most exciting news in vaccine research in the last decade,' says Dr. Kelly MacDonald, director of the University of Toronto's HIV research program. (thestar.com)
  • Thus, to find infecting spike segments that are relatively permanent - or 'conserved' - across all HIV mutations has been the holy grail of AIDS vaccine research. (thestar.com)
  • This is the first demonstration of protection in humans and one of the most significant findings in HIV vaccine research in many years,' Esparza said. (sun-sentinel.com)
  • Global spending for HIV vaccine research increased from $186 million in 1997 to $759 million in 2005, according to the Joint United Nations Program on HIV/AIDS. (scientificamerican.com)
  • Jean-Daniel Lelievre of France's Vaccine Research Institute said the vaccine was likely not the "definitive" version, but may represent "a phenomenal advance. (rawstory.com)
  • CHICAGO, ILLINOIS-- The most surprising message from a major international AIDS meeting here last month is that vaccine research is heating up, although many obstacles remain. (sciencemag.org)
  • To characterize the effect splenomegaly may have on clinical laboratory reference ranges among adults to determine relevant inclusion and exclusion criteria and to interpret safety data for HIV vaccine trials at a research center where the prevalence of splenomegaly is high. (iavi.org)
  • This database lists social science research related to AIDS vaccine development conducted with IAVI's support. (iavi.org)
  • It has been proposed to initiate a HIV/AIDS trial in Kericho, as a collaborative work between Kenya Medical Research Institute (KEMRI) and Walter Reed Foundation within the next two months. (medindia.net)
  • The Kenya based research foundation seeks solution to medical problems, more specifically the AIDS pandemic, through active research that has been instrumental behind the partnership with Walter Reed Foundation. (medindia.net)
  • Late last week, the NIH's linkurl:AIDS Vaccine Research Subcommittee;http://www3.niaid.nih.gov/research/topics/HIV/vaccines/advisory/avrs/ voted 23-3 in favor of beginning the PAVE 100 HIV vaccine trial. (the-scientist.com)
  • The study would be conducted by the linkurl:Partnership for AIDS Vaccine Evaluation;http://www.hivpave.org/ (PAVE), which is a consortium of government agencies and government-funded organizations involved in HIV vaccine research, and is sponsored by NIAID. (the-scientist.com)
  • Volunteers
  • Pending final approval of the trial by institutional review boards, 30 human volunteers at three sites around the country will begin receiving the vaccine within the next several months. (emory.edu)
  • The trial will compare the effects of high and low dosages of the vaccine in two groups of (HIV negative) volunteers, who will receive two intramuscular injections. (emory.edu)
  • The AIDS vaccine is currently being tested for its safety and efficacy on over 200 human volunteers in America and Uganda. (medindia.net)
  • Small-scale human tests of other AIDS vaccines have already started in Zaire and France, but the new study, to be conducted with 81 volunteers who will be treated at the Clinical Center of the National Institutes of Health, in Bethesda, Md., is the first authorized in the United States. (nytimes.com)
  • Immunology
  • Most likely we will have to have a third trial to test the combined regimen of the DNA and booster portions of the vaccine," said Harriet Robinson, chief of the Yerkes Division of Microbiology and Immunology, who led the development of the vaccine. (emory.edu)
  • formulations
  • The groups also develop new adjuvant formulations and evaluate vaccine-adjuvant combinations in relevant animal models. (nih.gov)
  • cells
  • The protein in the vaccine is made in genetically engineered hamster ovary cells. (sun-sentinel.com)
  • A vaccine has proven elusive as the human immunodeficiency virus (HIV) mutates easily and can hide away in cells, evading the immune system, only to reemerge and spread years later. (rawstory.com)
  • First, we showed that approximately two-thirds and one-third of the trimers secreted from the ChAdOx1.BG505s (C) and MVA.BG505s (M) vaccine-infected cells, respectively, were cleaved and in a native-like conformation. (iavi.org)
  • These latest findings now provide us with an important new way of looking at subpopulations of CD4 helper T-cells and suggest how they may be used as a marker to gauge the efficacy of these vaccines. (emaxhealth.com)
  • test
  • As Dr. Lawrence K. Altman wondered earlier this year, who will test such a vaccine? (latimes.com)
  • Dr. Leon McKusick, a psychologist with the University of California at San Francisco, has surveyed 644 homosexual men about their willingness to participate in a test of an AIDS vaccine. (latimes.com)
  • The Emory Vaccine Center's Hope Clinic will serve as one of the clinical test sites for this trial. (emory.edu)
  • A spokesman for the F.D.A. said two other vaccine developers, Oncogen, a Seattle-based subsidiary of Bristol-Myers, and a team that includes the Institute for Immunologic Disorders in Houston, had also sought approval to test AIDS vaccines. (nytimes.com)
  • populations
  • With AIDS spreading among heterosexuals in other parts of the world, we cannot assume that it will remain limited to specialized populations here. (latimes.com)
  • infections
  • On the other hand, a new analysis of when infections took place hints that the vaccine was most protective shortly after vaccination and then waned, but Michael said that decrease in efficacy did not reach statistical significance. (medpagetoday.com)
  • AIDS remains one of the world's most devastating health problems, with an estimated 33.2 million people living with HIV/AIDS and 2.5 million new infections reported in 2007 alone. (biologynews.net)
  • individuals
  • Currently, more than 65,000 AIDS/HIV infected individuals are being provided anti-retroviral treatment, facilitated by financial support from the Kenyan Government. (medindia.net)
  • More than 30 million individuals - a majority in the world's developing nations - have died of AIDS since it was first identified 25 years ago. (emaxhealth.com)
  • It also suggests that the measurement of this cell in the blood of vaccinated individuals who subsequently become infected with HIV may provide an important predictor of vaccine efficacy. (emaxhealth.com)
  • trial
  • The Food and Drug Administration has approved the Emory Vaccine Center's application to begin a Phase I clinical trial of its multiprotein AIDS vaccine. (emory.edu)
  • Preliminary results from the Phase I trial of the DNA component of the vaccine should be available by the middle of next year. (emory.edu)
  • They conceded that the findings, though statistically significant, might change if the vaccine were tested among more members of minorities, who were only a small fraction of the people in the trial. (sun-sentinel.com)
  • Frahm was not part of the Thai study but presented data at the conference from the other recent large HIV vaccine study, the STEP trial. (medpagetoday.com)
  • widespread
  • There has been such widespread homophobia in the wake of the AIDS epidemic that it is important for the general population to appreciate that among a substantial number of homosexuals there is a strong sense of compassion and responsibility. (latimes.com)
  • design
  • The HIV Variation Project examines the rates and magnitudes of genetic and immunologic changes in HIV and related retroviruses and their consequences for vaccine design. (nih.gov)
  • vaccination
  • If virology ever gets to the point they can create a safe and reliable vaccine to treat virus' the world would be better served by a common cold vaccination. (newser.com)
  • Childhood vaccination has saved many lives, yet lots more has to be done to increase awareness and eliminate myths regarding vaccines. (medindia.net)