Ahsct hematopoietic autologous transplantation. Medical search. Frequent questions

There is great interest in the MS community around autologous haematopoietic stem cell transplantation or AHSCT. (msaustralia.org.au)
Comparative Effectiveness of Autologous Hematopoietic Stem Cell Transplant vs Fingolimod, Natalizumab, and Ocrelizumab in Highly Active Relapsing-Remitting Multiple Sclerosis. (msaustralia.org.au)
Autologous hematopoietic stem cell transplantation, or aHSCT for short, is usually used to treat blood cancers, and involves harvesting stem cells from the person's own bone marrow or blood followed by chemotherapy and antibody treatment. (news-medical.net)
A world-first trial is investigating if stem cell transplantation could be used in patients with aggressive multiple sclerosis (MS) as a first-line treatment. (sheffield.ac.uk)
It will be the first to compare how effectively autologous hematopoietic stem cell transplantation (AHSCT) is when compared with four other highly effective drug treatments which have shown great promise in clinical trials (alemtuzumab, ocrelizumab, ofatumumab and cladribine). (sheffield.ac.uk)
The trial will build on the results of the landmark MIST trial (explained below) which was the first in the world to show that stem cell transplantation could reverse disability in patients with MS. (sheffield.ac.uk)
Colette Beecher, 50, from Wickersley, Rotherham, was diagnosed with MS in January 2011, and has been relapse-free for three years after having the MS stem cell transplantation at Sheffield's Royal Hallamshire Hospital in April 2016. (sheffield.ac.uk)
The purpose of this trial is to compare the treatment strategy of Autologous Hematopoietic Stem Cell Transplantation (AHSCT) to the treatment strategy of Best Available Therapy (BAT) for treatment-resistant relapsing multiple sclerosis (MS). Participants will be randomized at a 1 to 1 (1:1) ratio. (mayo.edu)
Autologous haematopoietic stem cell transplantation and other cellular therapy in multiple sclerosis and immune-mediated neurological diseases: updated guidelines and recommendations from the EBMT Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of EBMT and ISCT (JACIE). (nih.gov)
Autologous hematopoietic stem cell transplantation (aHSCT) is a well-established treatment for hematologic malignancies such as multiple myeloma (MM) and non-Hodgkin lymphoma (NHL). (bloodline.net)
Various changes in the field over the past decade, including the frequent use of tandem aHSCT in MM, the advent of novel therapies for the treatment of MM and NHL, plus the addition of new stem cell mobilization techniques, have led to the need to reassess current stem cell mobilization strategies. (bloodline.net)
Autologous hematopoietic stem cell treatment (AHSCT) is considered an effective treatment option for patients with aggressive relapsing-remitting multiple sclerosis (RRMS). (ku.dk)
Background and ObjectivesUncontrolled evidence suggests that autologous hematopoietic stem cell transplantation (AHSCT) can be effective in people with active secondary progressive multiple sclerosis (SPMS). (mssm.edu)
0.001).DiscussionThe use of AHSCT in people with active SPMS is associated with a slowing of disability progression and a higher likelihood of disability improvement compared with standard immunotherapy.Classification of EvidenceThis study provides Class III evidence that autologous hematopoietic stem cell transplants prolonged the time to CDP compared with other DMTs. (mssm.edu)
Time to Add Autologous Stem Cell Transplant to Standard Care in RRMS? (medscape.com)
Three quarters of patients treated with autologous hematopoietic stem cell transplantation (aHSCT) for relapsing remitting multiple sclerosis (RRMS) were disease free 5 years after therapy and more than half reported improvement in disability, a new study shows. (medscape.com)
Open in a separate window Number 5 Reconstitution kinetics of memory space CD4+ and CD8+ T-cell subsets in type 1 diabetes individuals following autologous hematopoietic stem cell transplantation (AHSCT). (monossabios.com)
Rituximab maintenance had "significant benefits" for survival and disease control in older patients with mantle cell lymphoma (MCL) who did not receive autologous hematopoietic stem cell transplantation (AHSCT), according to a recent population-based real-world analysis. (bloodcancerstoday.com)
Long-acting disease-modifying therapies do not appear to increase the risk of complications following autologous hematopoietic stem cell transplantation (aHSCT), according to a retrospective study from Sweden (Kvistad et al. (neuro-sens.com)
The aim was to assess the cognitive dysfunction and physical disability after autologous hematopoietic stem cell transplantation (AHSCT), to explore the potential factors influencing disability regression after AHSCT and to estimate the safety of low-dose immunosuppressive therapy in highly active Multiple Sclerosis (MS) patients. (activemsers.org)
According to the risk classification, there are different therapeutic approaches for NB patients, such as observation, surgical tumor removal, chemo- and radiotherapy, autologous hematopoietic stem cell transplantation (AHSCT), differentiation therapy, and immunotherapy [ 7 ] . (encyclopedia.pub)
In second-line therapy for relapsed/refractory large B-cell lymphoma (LBCL), which patients would you consider eligible for chimeric antigen receptor (CAR) T-cell therapy that you would not consider eligible for autologous hematopoietic stem cell transplantation (AHSCT)? (bloodcancerstoday.com)
Autologous haematopoietic stem cell transplantation for multiple sclerosis: a position paper and registry outline. (inims.de)
These updated EBMT guidelines review the clinical evidence, registry activity and mechanisms of action of haematopoietic stem cell transplantation (HSCT) in multiple sclerosis (MS) and other immune-mediated neurological diseases and provide recommendations for patient selection, transplant technique, follow-up and future development. (ox.ac.uk)
In research presented in Bone Marrow Transplantation , investigators examined whether the time interval from ending induction therapy to receiving an autologous hematopoietic stem cell transplant (AHSCT) impacted outcomes in patients with multiple myeloma (MM). Lead author, Charalampos Charalampous, MD, noted that the last cycle of induction therapy is typically completed two to four weeks before transplantation. (bloodcancerstoday.com)
Published by Dr. Julio Voltarelli and colleagues from the University of Sao Paulo in Brazil, it reported the results from a small 15-patient trial that tested a method called autologous nonmyeloablative hematopoietic stem cell transplantation (AHSCT) for the treatment of new type 1 patients. (diatribe.org)
Autologous hematopoietic stem cell transplantation halted progression of Multiple Sclerosis for 5 years in 46% of patients. (worldhealth.net)
Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis. (worldhealth.net)
High risk of acute pulmonary toxicity with both myeloablative and non-myeloablative total body irradiation-based conditioning for allogeneic stem cell transplantation. (dukecancerinstitute.org)
The procedure is known as hematopoietic stem cell transplantation, but you may have heard of it as a bone marrow transplant. (allnewscart.com)
Stem cell transplantation can work really well, but it does have risks. (allnewscart.com)
Research shows that for more than 20 years, autologous hematopoietic stem cell transplant, or aHSCT, has been an effective treatment for those with highly active relapsing-remitting MS that doesn't respond well to medications. (allnewscart.com)
Stem cell transplantation can work very well, nevertheless it does have dangers. (healthgienic.com)
Analysis reveals that for greater than 20 years, autologous hematopoietic stem cell transplant, or aHSCT, has been an efficient therapy for these with extremely lively relapsing-remitting MS that doesn't reply nicely to medicines. (healthgienic.com)
Prospective phase II clinical trial of autologous haematopoietic stem cell transplant for treatment refractory multiple sclerosis. (unm.edu)
Background: Effectiveness of autologous haematopoietic stem-cell transplantation (AHSCT) in relapsing-remitting multiple sclerosis (MS) is well known, but in secondary-progressive (SP-) MS it is still controversial. (unifi.it)
Researchers from the College of Genoa discovered hematopoietic stem cell transplants assist delay incapacity longer in individuals with lively secondary progressive MS than some MS drugs. (getnom.net)
Now a staff of researchers from the College of Genoa in Italy discovered hematopoietic stem cell transplants utilizing an individual's wholesome blood stem cells assist delay incapacity longer in individuals with lively secondary progressive MS than some MS drugs. (getnom.net)
Hematopoietic stem cell transplantation (HSCT) is a therapy utilizing wholesome blood or bone marrow stem cells. (getnom.net)
For this research, Prof. Inglese and her staff examined the information of 79 individuals with lively secondary progressive MS who acquired autologous hematopoietic stem cell transplants (AHSCT). (getnom.net)
There's scientific proof that the transplantation of autologous hematopoietic stem cell transplantation after intense immune suppression can induce a resetting of the autoreactive blood white cells (lymphocytes) chargeable for the illness pathogenesis, that are changed by new and self-tolerant white cells. (getnom.net)
TUESDAY, Sept. 26, 2023 (HealthDay News) -- Autologous hematopoietic stem cell transplantation (aHSCT) for treatment of relapsing-remitting multiple sclerosis (RRMS) yields freedom from disease activity for most patients, according to a study published online Sept. (physiciansweekly.com)
The history of hematopoietic stem cell transplantation is marked by remarkable milestones. (revistadehematologia.org.mx)
This breakthrough, for which Dausset was awarded the Nobel Prize in Physiology or Medicine in 1980, opened the door to safer and more successful organ and stem cell transplantation. (revistadehematologia.org.mx)
This was the first report of a hematopoietic stem cell transplantation (HSCT) conducted in Mexico, only 4 years after the pioneer work by E. Donnall Thomas in Cooperstown, New York, USA (Ruiz-Argüelles et al. (revistadehematologia.org.mx)

The major focus is on autologous HSCT (aHSCT), used in MS for over two decades and currently the fastest growing indication for this treatment in Europe, with increasing evidence to support its use in highly active relapsing remitting MS failing to respond to disease modifying therapies. (ox.ac.uk)

The use of autologous transplant in Hodgkin's and non-Hodgkin's lymphoma has significantly improved the survivals of patients with relapsed disease. (bloodline.net)
Dr. Westin spoke with Blood Cancers Today to elaborate on his post: "The question is based largely on the fact that, for the past quarter century, the standard treatment for second-line therapy of patients with relapsed/refractory LBCL has been autologous transplant. (bloodcancerstoday.com)
Two recent randomized, phase III trials (ZUMA-7 and TRANSFORM) showed that CAR T-cell therapy was superior to autologous transplant. (bloodcancerstoday.com)
We have a new standard of care, but with the old standard of AHSCT, the historical dogma has been that half of patients are eligible for transplant and half are ineligible based on medical issues, age, comorbidities, and organ dysfunction. (bloodcancerstoday.com)
Recent research indicates that the transplant of autologous hematopoietic stem cells (AHSCT) is an excellent treatment for multiple sclerosis. (worldhealth.net)
Then you get a transplant of hematopoietic stem cells, which are found in bone marrow. (allnewscart.com)

In single-center prospective study patients who failed to conventional therapies for highly active relapsing MS underwent the AHSCT. (activemsers.org)
Twenty four patients [18 (72.0%) female] underwent AHSCT. (activemsers.org)
Researchers identified 1,055 patients diagnosed with MM from 2004 to 2018 who underwent AHSCT within a year of diagnosis. (bloodcancerstoday.com)
They pinpointed 281 patients who suffered from multiple sclerosis and underwent AHSCT from 1995 to 2006. (worldhealth.net)

This will help build a more complete picture of the outcomes of AHSCT. (msaustralia.org.au)
Several recent studies have indicated that there is still a role for AHSCT even in the CAR-T era and that outcomes with AHSCT might exceed or at the very least be equal to CAR-T in those who obtain at least a significant partial response to salvage therapy. (bloodcancerstoday.com)
Those of a younger age, minimal immunotherapies before AHSCT and a comparably lower EDSS score also displayed improved outcomes with AHSCT. (worldhealth.net)

Mesenchymal stromal cells (MSCs) are non-hematopoietic, multipotent cells that can be sourced from various tissues, including bone marrow, umbilical cord (UC), and adipose tissue. (biomedcentral.com)

The objective of this study was to examine the efficacy and safety of one repeated transplantation of allogeneic MSCs in individuals with T1D. (biomedcentral.com)
The wholesome stem cells both come from the individual (autologous) or one other individual (allogeneic). (getnom.net)

Conclusion: AHSCT of patients with aggressive RRMS was an effective and relatively safe treatment with few serious AEs and no mortality in Danish patients. (ku.dk)
Time to Add aHSCT to Standard Care in RRMS? (medsearchuk.com)
Multicentre retrospective cohort study of 174 patients with RRMS from the Swedish MS registry who were treated with aHSCT before January 1, 2020. (medscape.com)
Our findings demonstrate that aHSCT for RRMS is feasible within regular healthcare and can be performed without compromising safety," the authors write. (medscape.com)

One important question that is yet to be definitively answered is how AHSCT stacks up as a treatment against the new generation, highly efficacious therapies available for relapsing MS. However, to date there have been limited clinical trials comparing the success rate of AHSCT with more conventional treatments of relapsing remitting MS. (msaustralia.org.au)
The research team did not identify significant differences in the likelihood of disability worsening between AHSCT and the other therapies studied. (msaustralia.org.au)
They also intend to explore the characteristics of individuals that may influence how effective AHSCT is in comparison to other therapies. (msaustralia.org.au)
In this study, we compared the effect of AHSCT with that of other anti-inflammatory disease-modifying therapies (DMTs) on long-Term disability worsening in active SPMS.MethodsWe collected data from the Italian Bone Marrow Transplantation Study Group and the Italian Multiple Sclerosis Register. (mssm.edu)
The research question was whether cell-depleting therapies (rituximab, cladribine, alemtuzumab), which can produce prolonged cytopenias, increase the risk of infections or other complications when administered prior to aHSCT. (neuro-sens.com)

Following aHSCT, 19% showed evidence of disease activity at three years, including three patients with sustained disease progression (baseline 4.0-5.5 increasing 1-3 points). (neuro-sens.com)
The clinical variable that explained the disability regression at months 6 and 12 after AHSCT was the disability progression over 6 months before AHSCT. (activemsers.org)
Despite the suppression of relapses was observed in the AHSCT group only, AHSCT did not show advantages over Cy on disability, suggesting that in SP-MS disability progression becomes more based on non-inflammatory neurodegeneration than on inflammation. (unifi.it)

To examine the real-world effectiveness of rituximab maintenance, Dr. Di and colleagues limited the overall study population to those who received R-CHOP or bendamustine-rituximab as a first-line treatment and did not receive consolidative AHSCT. (bloodcancerstoday.com)
Conclusion: This study provides Class III evidence, in SP-MS, on the superior effectiveness of AHSCT compared to Cy on relapse activity, without differences on disability accrual. (unifi.it)

Dr. Muraro and his research team are quick to point out that additional trials are necessary to gauge the efficacy and safety of AHSCT. (worldhealth.net)
It is clear that additional studies are required to accurately gauge the efficacy and safety of AHSCT. (worldhealth.net)

AHSCT is an immunosuppressive chemotherapy treatment combined with reinfusion of blood stem cells to help re-build the immune system. (msaustralia.org.au)
Sustained CD4/CD8 Inversion after AHSCT Lymphopenia was observed following transplantation in both organizations, reflecting the immunosuppressive effect of the procedure (Numbers S6A,B in Supplementary Material). (monossabios.com)
In summary, memory space CTL comprehended most of T cells recognized on long-term follow-up of individuals after AHSCT, indicating that the immunosuppressive routine may not sufficiently target potentially autoreactive and pathogenic memory space T cells. (monossabios.com)

While it does appear to be an effective treatment, AHSCT it is also associated with greater short-term risks which have limited its use in MS. (msaustralia.org.au)
The published findings of the first randomised controlled trial in this field confirm the global impact of this treatment on patients with severe inflammatory MS. The MIST trial showed that AHSCT stabilised the disease and reduced the level of disability to levels never previously seen before in research trials investigating new and emerging treatments for MS. Sheffield Teaching Hospitals NHS Foundation Trust was the sole UK site involved in the trial. (sheffield.ac.uk)
Since having the AHSCT treatment at Sheffield Teaching Hospitals Louise has since gone on to have a healthy baby daughter called Joy. (sheffield.ac.uk)
Still there are few randomized and controlled studies of AHSCT to shed light on the safety and efficacy of the treatment, and therefore experiences from single centers are important. (ku.dk)
Type 1 diabetes individuals were divided in organizations relating to duration of insulin independence after treatment with AHSCT. (monossabios.com)
I think the approval of CAR-T in this setting will allow us to at least have a better treatment option for those with primary refractory disease or those who are early relapsed who we know don't tend to fare very well with chemotherapy as a second-line therapy and either don't make it to AHSCT or don't have a durable response with AHSCT. (bloodcancerstoday.com)
aHSCT may have a potential role in the treatment of the progressive forms of MS with a significant inflammatory component and other immune-mediated neurological diseases, including chronic inflammatory demyelinating polyneuropathy, neuromyelitis optica, myasthenia gravis and stiff person syndrome. (ox.ac.uk)
Therefore, AHSCT activity was evaluated in SP-MS using low-dose immunosuppression with cyclophosphamide (Cy) as a comparative treatment. (unifi.it)
1992). Since then, hematopoietic stem cells, with their unique ability to differentiate into various blood cell types, have proven to be a revolutionary tool in the treatment of numerous hematological disorders. (revistadehematologia.org.mx)

Development of fresh strategies of AHSCT is necessary to increase rate of recurrence and function of T and B regulatory cells and decrease efficiently autoreactive islet-specific T and B memory space cells in type 1 diabetes individuals undergoing transplantation. (monossabios.com)

AHSCT aims to stop the damage caused by MS to the brain and spinal cord by 'wiping out' the faulty immune system with a high dose of chemotherapy. (sheffield.ac.uk)
Given this, in my opinion, AHSCT would still be considered the preferred option for patients who continue to demonstrate chemotherapy sensitivity. (bloodcancerstoday.com)
Those with primary chemotherapy-refractory disease or those who have an early relapse (less than six months) would be expected to be resistant to salvage chemotherapy and, in my opinion, would not be appropriate for AHSCT. (bloodcancerstoday.com)
The study reviewed the duration and dosing of participants' induction regimens, the date of final chemotherapy, and any biochemical response achieved before transplantation. (bloodcancerstoday.com)
AHSCT makes use of aggressive chemotherapy that significantly weakens the immune system and spikes one's risk for infection. (worldhealth.net)

While older patients may not be candidates for AHSCT "due to comorbidities and frailty" rituximab maintenance following induction chemoimmunotherapy "is often considered," Dr. Di and colleagues wrote, noting a randomized clinical trial showed rituximab maintenance had a "clinical benefit" for patients with MCL who are older and not eligible for AHSCT. (bloodcancerstoday.com)
That gets into cases where patients may have been borderline candidates for AHSCT with frailty or mild organ dysfunction, but we think that CAR T-cell therapy should be safe enough and have greater efficacy to try and get them into remission. (bloodcancerstoday.com)

In the whole cohort, relapse-free survival (RFS) was 77% (95% CI: 64-94%), worsening-free survival (WFS) was 79% (95% CI: 66-96%), MRI event-free survival (MFS) was 93% (95% CI: 85-100%), and no evidence of disease (NEDA-3) was 69% (95% CI: 54-89%) at the end of year two post-AHSCT. (ku.dk)
Two patients of 13 had one relapse during the first year and three patients-during the second year after AHSCT. (activemsers.org)

Method: Nationwide retrospective single center study of patients with multiple sclerosis (MS) treated with AHSCT. (ku.dk)
Impact of the time interval between end of induction and autologous hematopoietic transplantation in newly diagnosed patients with multiple myeloma. (bloodcancerstoday.com)
Some patients also experienced minor improvements in their multiple sclerosis symptoms following AHSCT. (worldhealth.net)
The findings described above clearly show promise for the AHSCT use in individuals who suffer from multiple sclerosis. (worldhealth.net)
Since multiple sclerosis is not a disease that is immediately life-threatening, the risk of death posed by AHSCT must be weighed by all multiple sclerosis patients. (worldhealth.net)
Dr. Muraro is adamant that a follow-up study must be performed that includes a group of multiple sclerosis patients who have not received AHSCT. (worldhealth.net)

Multivariable logistic regression assay indicated that lower fasting C-peptide and higher dose of UC-MSC correlated with achievement of clinical remission after transplantation. (biomedcentral.com)

The question is, 'Which patients would you consider eligible for CAR-T that you would not have for AHSCT? (bloodcancerstoday.com)

Having a randomized control group is particularly important because newly diagnosed type 1 patients often have a 'honeymoon' period during which they can stay relatively insulin independent, and it will be important to distinguish between the effects of the honeymoon period and the effects of the AHSCT procedure. (diatribe.org)

Results: A total of 32 patients were treated with AHSCT from May 2011 to May 2021. (ku.dk)
6 months prior to undergoing aHSCT in the period 2011-2021. (neuro-sens.com)

In the first step, doctors collect a large number of hematopoietic stem cells (HSCs) from the patient's blood. (diatribe.org)
AHSCT involves the harvesting of a patient's own stem cells. (worldhealth.net)

The disability may be temporarily reversible after AHSCT in a significant proportion of highly active RMS patients if AHSCT is well-timed performed. (activemsers.org)

P-FS did not differ between the groups (at year 5: 70% in AHSCT and 81% in Cy, p=0.572), nor did NEDA-2 (p=0.379). (unifi.it)

An amazing 73 percent of these patients did not endure worsening of symptoms in the 5 years following AHSCT. (worldhealth.net)

Methods: Retrospective monocentric 1:2 matched study in SP-MS patients treated with BEAM-AHSCT (cases) or IV pulses of Cy (controls) at a single Academic centre in Florence. (unifi.it)

Aim: To describe the Danish experience with AHSCT regarding patient characteristics, safety, and efficacy. (ku.dk)

Memory space CTL comprehended most of T cells recognized on long-term follow-up of individuals after AHSCT. (monossabios.com)

The scores of information processing speed and verbal learning were significantly higher at month 12 after AHSCT. (activemsers.org)

B cells reconstituted to SMYD3-IN-1 baseline levels approximately 2C3?months post-AHSCT in both patient organizations (Number S6F in Supplementary Material). (monossabios.com)
Ideally, a massive randomized controlled trial of AHSCT will be performed in the coming months. (worldhealth.net)
Mean follow-up: 99 months in the AHSCT and 91 months in the Cy groups. (unifi.it)

The process of AHSCT itself may somehow reset the immune system to be more tolerant of the body's own beta cells. (diatribe.org)
In layman's terms, AHSCT is best understood as a "resetting" of the body's immune system. (worldhealth.net)
1957). This pioneering work laid the foundation for the exploration of hematopoietic stem cells and their role in treating diseases of the blood and immune system. (revistadehematologia.org.mx)

At the time they performed the first transplants surprisingly little was known about hematopoietic stem cells, immune responses to transplants or the complex human leucocyte antigen system. (revistadehematologia.org.mx)

European Society for Blood and Marrow Transplantation (EBMT) Autoimmune Diseases Working Party (ADWP) and the Joint Accreditation Committee of the International Society for Cellular Therapy (ISCT) and EBMT (JACIE). (nih.gov)
Their objective is to research the efficacy of autologous transplantation of hematopoietic stem cells in opposition to the most effective accessible high-efficacy therapy in sufferers with very lively relapsing-remitting MS. (getnom.net)

The research team would like to make it perfectly clear that some patients died in the 100 days following AHSCT. (worldhealth.net)

In an accompanying editorial to the Voltarelli paper, noted Miami endocrinologist Dr. Jay Skyler points out that while the goal of AHSCT is to eliminate autoimmune white cells and replace them with new, healthy white blood cells, this may not be the whole story. (diatribe.org)
1987). Umbilical cord blood was recognized as an alternative source of hematopoietic stem cells (Gluckman et al. (revistadehematologia.org.mx)
1989). Hematopoietic stem cells could be harvested easier from peripheral blood after mobilization with G-CSF (Sheridan et al. (revistadehematologia.org.mx)

In addition, they will investigate the role of AHSCT in treating progressive forms of MS in more detail. (msaustralia.org.au)

Results: 93 SP-MS were included: 31 AHSCT, 62 Cy. (unifi.it)

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