Agranulocytosis granulocytes from patients. Medical search. Frequent questions

Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous lowered white blood cell count (leukopenia, most commonly of neutrophils) and thus causing neutropenia in the circulating blood. (wikipedia.org)
In agranulocytosis, the concentration of granulocytes (a major class of white blood cells that includes neutrophils, basophils, and eosinophils) drops below 200 cells/mm3 of blood. (wikipedia.org)
Neutropenia indicates a deficiency of neutrophils (the most common granulocyte cell) only. (wikipedia.org)
Vulnerability to infection is extremely high in patients with agranulocytosis, which is the virtual absence of neutrophils in peripheral blood, with ANC typically lower than 100/μL. (medscape.com)
Granulocytes include basophils, eosinophils, and neutrophils. (cancerhealthcenter.com)
Granulocytopenia is a generic term that refers to all granulocytes, including neutrophils, monocytes, eosinophils, and basophils. (arrhythmia.center)
It is usually caused by an increase in the number of granulocytes (especially neutrophils ), some of which may be immature (myelocytes). (britannica.com)

for these reasons, granulocytopenia is a more etymologically consistent term, and as such, is sometimes preferred to "agranulocytosis" (which can be misinterpreted as "agranulocyt-osis", meaning proliferation of agranulocytes (i.e. lymphocytes and monocytes). (wikipedia.org)
citation needed] The terms agranulocytosis, granulocytopenia and neutropenia are sometimes used interchangeably. (wikipedia.org)
Agranulocytosis implies a more severe deficiency than granulocytopenia. (wikipedia.org)
A Case of Transient Granulocytopenia during Treatment of a Patient with Graves' Disease and Type 1 Diabetes Mellitus - Differential Diagnosis from Agranulocytosis by a Single Injection of G-CSF. (e-enm.org)
Granulocytopenia, which can be seen in patients with Graves' disease during treatment with antithyroid agents, could be a self resolving transient episode or can imply the beginning of life threatening agranulocytosis requiring a change in treatment modality. (e-enm.org)
Therefore, differentiation of agranulocytosis and transient granulocytopenia, is important, but is not practically easy. (e-enm.org)
We introduce a case of transient granulocytopenia, which was detected in a patient with Graves'Disease, accompanied by underlying type 1 diabetes mellitus, during treatment with PTU. (e-enm.org)
Diagnosis of transient granulocytopenia was made by a normal granulocyte count following a single injection of G-SCF, and the patient was treated with conservative therapy. (e-enm.org)
This case confirms a diagnostic tool for differentiating transient granulocytopenia and PTU-induced agranulocytosis. (e-enm.org)
19 Schuld A, Kraus T, Hinze-Selch D, Haack M, Pollmächer T. Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia. (thieme-connect.de)

Authenticated cases of agranulocytosis associated with the drug have occurred in man, fatal reactions, although rare, have been reported in dogs after long-term therapy. (powerhorsevet.com)

Use acetaminophen/pamabrom/pyrilamine with caution in patients with G6PD enzyme deficiency, a genetic disorder . (medicinenet.com)

Concurrent anemia, thrombocytopenia, and/or an abnormal result on a peripheral blood smear from a patient with neutropenia suggest an underlying hematologic disorder. (medscape.com)

Due to the high incidence of SIgMD observed in schizophrenic patients treated with clozapine, clinicians should pay particular attention to not only granulocyte counts but also patterns of IgM decline to prevent drug iatrogenesis. (psychiatrist.com)
The repeated dose dependent inhibition of yeast cell growth by clozapine, in the presence of H2O2, indicates that yeast cells can indeed serve as a model for understanding agranulocytosis in the population of patients treated with clozapine. (wpi.edu)
M]ental health clinicians should be vigilant for signs and symptoms of hematological malignancy in patients treated with clozapine. (psychnews.org)

Acquired agranulocytosis is a rare, drug-induced blood disorder that is characterized by a severe reduction in the number of white blood cells (granulocytes) in the circulating blood. (cancerhealthcenter.com)
Because of the risks of severe neutropenia and of seizure associated with its use, FAZACLO should be used only in patients who have failed to respond adequately to standard antipsychotic treatment. (pillintrip.com)
In immunocompromised populations, such as patients with AIDS and recipients of solid organ and hematopoietic stem cell transplants, BK polyomavirus (BKPyV) can reactivate and cause several diseases, which can lead to death in their severe forms. (biomedcentral.com)
Both patients eventually died of systemic multi-organ failure caused by severe pneumonia. (biomedcentral.com)
Clozapine is relatively contraindicated in patients with severe cardiac or renal disorders, or a history of neutropenia, bone-marrow disorders, paralytic ileus, acute substance-induced psychosis or intoxication, circulatory collapse or epilepsy. (bpac.org.nz)
Patients with AIDS can develop severe and even fatal herpesvirus infections. (britannica.com)
Treatment with granulocyte colony-stimulating factor is used to stimulate neutrophil production and prevent bacterial infections after cancer chemotherapy and with severe chronic neutropenia. (msdmanuals.com)
We report a case of clopidogrel-induced bone marrow toxicity manifesting with severe neutropenia in a patient treated with multiple coronary stents and provide suggestions for an alternative treatment. (hindawi.com)
The CAPRIE trial, which included 9.599 patients treated with clopidogrel, showed a low annual incidence (0.05%) of severe neutropenia, considered as neutrophil count below 0.45 × 10 9 /L [ 4 ]. (hindawi.com)

Certain types of infection are characterized from the beginning by an increase in the number of small lymphocytes unaccompanied by increases in monocytes or granulocytes. (britannica.com)

Ritodrine therapy was immediately stopped, and she was given an intravenous injection of antibiotics and granulocyte colony-stimulating factor. (hindawi.com)
We started an intravenous injection of an antibiotic (cefazolin (CEZ) 2 g/day) and intramuscular injection of 75 μ g/body of granulocyte colony-stimulating factor (G-CSF). (hindawi.com)
Other drugs that interfere with, or inhibit, granulocyte colony formation may induce agranulocytosis. (orthopedicshealth.com)
She received four doses of filgrastim (Granulocyte-colony stimulating factor) which maintained the neutrophil count within a reasonable level while she continued to receive carbimazole to prepare her for surgery. (edu.pl)
4] F. Joseph, N. Younis and D. Bowen Jones: "Treatment of carbimazole-induced agranulocytosis and sepsis with granulocyte colony stimulating factor", Int. J. Clin. (edu.pl)
9 Pollmächer T, Fenzel T, Mullington J, Hinze-Selch D. The influence of clozapine treatment on plasma granulocyte colony stimulating (G-CSF) levels. (thieme-connect.de)

In rare cases of acute acquired agranulocytosis, destructive action of certain white blood cell antibodies (leukocyte isoantibodies) may be induced by certain drugs such as phenylbutazone, gold salts, sulfapyridine, aminopyrine, meralluride, and dipyrine. (orthopedicshealth.com)
21 Croarkin P, Rayner T. Acute neutropenia in a patient treated with quetiapine. (thieme-connect.de)
Leukopenia, which develops acutely, is often caused by drugs with the development of agranulocytosis, acute infections or acute leukemia. (arrhythmia.center)
Patients present with acute febrile illness, neutrophilia, and tender skin lesions. (medindiajournal.com)
A9 - Torlontano G, FIORITONI G, Pontano O, Iacone A, Bonanni G: Normal granulocyte transfusion therapy in the management of acute leukemias.Current Studies on Standardization Problems in Clinical Patholology, Haematology and Radiotherapy in Hodgkin's Disease.Eds: G. Astaldi, C. Biagini. (giuseppefioritoni.it)

To be precise, neutropenia is the term normally used to describe absolute neutrophil counts (ANCs) of less than 500 cells per microlitre, whereas agranulocytosis is reserved for cases with ANCs of less than 100 cells per microlitre. (wikipedia.org)
Patients initiating and continuing treatment with clozapine must have a baseline blood absolute neutrophil count (ANC) measured before treatment initiation and regular ANC monitoring during treatment ( 2.1 , 5.1 ). (nih.gov)
As neutrophil levels decrease, the susceptibility of patients with acquired agranulocytosis to bacterial infections becomes even greater. (orthopedicshealth.com)
Since the level of the neutrophil-mediated component of the inflammatory response are typically attenuated in neutropenic patients 1, physical findings of exudate, fluctuation, ulceration or fissure, local heat, swelling, and regional adenopathy are all less prevalent in the neutropenic patient1. (ukessays.com)

Although the reaction is generally idiosyncratic rather than proportional, experts recommend that patients using these drugs be told about the symptoms of agranulocytosis-related infection, such as a sore throat and a fever. (wikipedia.org)
Discontinue treatment if the patient develops such symptoms. (medicinenet.com)
The symptoms of this disorder come about as the result of interference in the production of granulocytes in the bone marrow. (orthopedicshealth.com)
The first symptoms of acquired agranulocytosis are usually those associated with a bacterial infection such as general weakness, chills, fever, and/or extreme exhaustion. (orthopedicshealth.com)
In particular, patients should not necessarily be relied on to report symptoms of adverse effects. (bpac.org.nz)
Patients taking clozapine should be monitored for symptoms and signs of cardiac toxicity and neutropenia. (bpac.org.nz)
3 Early treatment with clozapine is beneficial, i.e. six to 12 months after diagnosis, as disability typically develops in patients with unresolved symptoms 3 . (bpac.org.nz)
The clinical presentation of patients with aplastic anemia includes symptoms related to the decrease in bone marrow production of hematopoietic cells (see the image below). (medscape.com)

6 Gerson S L. G-CSF and the management of clozapine-induced agranulocytosis. (thieme-connect.de)
13 Claas F H, Abbott P A, Witvliet M D, D'Amaro J, Barnes P M, Krupp P. No direct clinical relevance of the human leucocyte antigen (HLA) system in clozapine-induced agranulocytosis. (thieme-connect.de)
14 Amar A, Segman R H, Shtrussberg S, Sherman L, Safirman C, Lerer B, Brautbar C. An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201. (thieme-connect.de)
16 Guest I, Sokoluk B, MacCrimmon J, Utrecht J. Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis. (thieme-connect.de)
All health professionals caring for patients taking clozapine should be aware that clozapine-induced constipation is highly prevalent, often difficult to detect and potentially fatal. (bpac.org.nz)

With myelotoxic agranulocytosis, the number of not only granulocytes in the blood decreases, but also platelets, reticulocytes, lymphocytes, therefore this condition is called cytotoxic disease An Older Post Example. (forumcapitalpartners.com)

Any chemical or drug that depresses the activity of the bone marrow may cause agranulocytosis. (orthopedicshealth.com)
A variety of drugs can cause acquired agranulocytosis and neutropenia by destroying special cells in the bone marrow that later mature and become granulocytes (precursors). (orthopedicshealth.com)
Allopurinol agranulocytosis occurs as a result of disruption of the process of myelopoiesis in the bone marrow and associated with the suppression of the production of buy allopurinol 300mg progenitor cells. (forumcapitalpartners.com)

People with acquired agranulocytosis are susceptible to a variety of bacterial infections, usually caused by otherwise benign bacteria found in the body. (orthopedicshealth.com)

Levamisole is an anthelmintic medication currently only licensed in the United States and Canada for use in veterinary medicine, due to reports of adverse events including agranulocytosis (severely decreased white blood cell count), facial retiform purpura and serological abnormalities in humans. (dermnetnz.org)
The white blood cell and granulocyte count nadirs were 1,660/ μ l and 438/ μ l. (hindawi.com)
Blood examination findings at the onset of agranulocytosis. (hindawi.com)
Agranulocytosis is a rare but serious condition that occurs when there is an extremely low number of white blood cells called granulocytes. (psychnews.org)
1%) side effect with PTU or MMI treatment is agranulocytosis, which involves having an extremely low number of granulocytes in the blood. (babiesafter35.com)
The complete absence of one of the other granulocyte rows is also abnormal and may affect innate immunity, but rarely causes a decrease in the total number of leukocytes in the blood. (arrhythmia.center)
On October 29, 2019, the patient underwent allogeneic peripheral blood stem cell transplantation from a full match (6/6) unrelated donor (man, blood type O, aged 37) (Fig. 1 a) at Nanfang Hospital, Southern Medical University. (biomedcentral.com)
After transplantation, the patient tested positive for recurrent blood cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infections, and on March 31, 2020, he underwent lung lavage because of bilateral pneumonia. (biomedcentral.com)
3 However, due to the risk of serious adverse effects, e.g. significant constipation, blood dyscrasias, metabolic and cardiac toxicity, clozapine is limited to treatment-resistant patients and the initiating prescriber needs to ensure that careful monitoring occurs. (bpac.org.nz)
a blood test used to measure the degree of anticoagulation in a patient taking warfarin. (ashp.org)

FAZACLO is indicated for the treatment of severely ill patients with schizophrenia who fail to respond adequately to standard antipsychotic treatment. (pillintrip.com)

We report a case of ritodrine hydrochloride-induced agranulocytosis accompanied by bacteremia due to catheter infection. (hindawi.com)
Many patients present with profound cytopenia and a notable risk for infection. (medscape.com)
Cancer patients, who receive cytotoxic antineoplastic therapy sufficient to harmfully affect myelopoiesis and the developmental integrity of the gastrointestinal mucosa, are at high risk for invasive infection due to the translocation of colonizing bacteria and/or fungi across intestinal mucosal surfaces. (ukessays.com)
With the increasing use of myelo-suppressive agents in the treatment of neoplastic and nonneoplastic diseases, the increased rate of infection in patients with neutropenia has been clearly established 3. (ukessays.com)
The definition of fever as an indicator of infection in patients with neutropenia has varied. (ukessays.com)
6 , 7 In each of these situations, the ANC is not actually low and these patients are not at increased risk of infection. (oncohemakey.com)

5 Alvir J MJ, Lieberman J A. Agranulocytosis: Incidence and risk factors. (thieme-connect.de)
Older patients may see an increase in the incidence of side-effects with this medicine. (tabletwise.net)

Clozapine dosing ideally starts low and is slowly titrated upwards over three weeks to minimise adverse effects, usually to a daily maintenance dose of 300-450 mg. 7 Some patients may require higher doses, with a maximum daily dose of 900 mg. 7 A therapeutic response may take some time to develop, therefore 12 months of continuous treatment is recommended before deciding on the efficacy of clozapine. (bpac.org.nz)
Patients with prolonged neutropenia after hematopoietic stem cell transplantation or chemotherapy and patients receiving broad-spectrum antibiotics and high doses of corticosteroids are predisposed to fungal infections. (msdmanuals.com)

Do not use in patients with known hypersensitivity to acetaminophen, pamabrom, pyrilamine, or any of the components in the formulation. (medicinenet.com)

In the absence of an iron chelating agent, patients with beta-thalassemia on regular transfusions present complications of transfusion-related iron overload. (scielo.br)
Consequently, agranulocytosis is sometimes described as "no granulocytes", but a total absence is not required for diagnosis. (wikipedia.org)
Agranulocytosis, the complete absence of granulocytes, belongs to a specific subgroup of neutropenia, which has a unique differential diagnosis. (arrhythmia.center)

Transfusion-dependent patients with thalassemia major(TM) develop iron overload which leads to damage of the liver, heart, and endocrine organs and related morbidity and mortality ( 1 1. (scielo.br)
Survival and complications in patients with thalassemia major treated with transfusion and deferoxamine. (scielo.br)
Although available in many countries, one third of the patients developed signs of iron overload, such as delayed or absent puberty, growth disorders, hypothyroidism, hypogonadism, bone abnormalities, cirrhosis and heart disease (main cause of death in transfusion dependent patients with TM). (scielo.br)

The onset of the abnormal movements should occur either while the patient is receiving an antipsychotic agent or within a few weeks of discontinuing the offending agent. (brainkart.com)

Any significant fall in the total white count, black or tarry stools or relative decrease in granulocytes should be regarded as a signal for immediate cessation of therapy and institution of appropriate countermeasures. (powerhorsevet.com)

This topic also provides a general approach to the management of neutropenic fever syndromes in cancer patients at high and low risk for complications, and the prophylaxis of infections in such patients. (ukessays.com)
Immunocompromised patients must actively manage their primary lung infections, pay close attention to pulmonary signs and imaging changes. (biomedcentral.com)
The integrity of the skin and mucous membranes, the vascular supply to tissue, and the nutritional status of the patient also influence the risk of infections. (msdmanuals.com)

Chronic acquired agranulocytosis generally progresses more slowly than acquired agranulocytosis. (orthopedicshealth.com)
FAZACLO is indicated for reducing the risk of recurrent suicidal behavior in patients with schizophrenia or schizoaffective disorder who are judged to be at chronic risk for reexperiencing suicidal behavior, based on history and recent clinical state. (pillintrip.com)

For pediatric patients with refractory cytopenia, certain cytogenetic abnormalities, or malignant transformation, hematopoietic stem cell transplantation (HSCT) from a matched related or unrelated donor early in the course of the disease is the treatment of choice. (medscape.com)
C linicians are often encouraged to conduct studies that provide insight into the pathogenesis, diagnosis, prognosis, and treatment of different subsets of patients with schizophrenia and patients with psychotic disorders. (psychiatrist.com)
Clozapine is an atypical antipsychotic medication that possesses immunomodulatory properties and is indicated for patients who fail standard antipsychotic treatment. (psychiatrist.com)
Casey (1999), how-ever, suggested that second-generation antipsychotics should be used as first-line treatment for patients who have TD or are at risk for TD. (brainkart.com)
However, among the drugs to which a patient may be sensitive are several used in the treatment of cancer (cancer chemotherapeutic agents) and others used as antipsychotic medications (e.g., clozapine). (orthopedicshealth.com)
A complicating factor is that several commonly used anti-cancer drugs are prone to cause agranulocytosis, thus interfering with treatment. (orthopedicshealth.com)
and it has become a standard treatment for acquired agranulocytosis. (orthopedicshealth.com)
The treatment of acquired agranulocytosis includes the identification and elimination of drugs or other agents that induce this disorder. (orthopedicshealth.com)
Different treatment strategies using less glucocorticoids in the presence of dyslipidemia and more common use of bDMARDs in patients with cardiovascular comorbidities suggest that rheumatologists are aware of the potential influence of the DMARDs in the risk of cardiovascular event. (bvsalud.org)
The patient declined radio-iodine treatment because she had a little child and wished to have thyroid surgery. (edu.pl)
Treatment of pregnant persons with subclinical hyperthyroidism is not recommended because there is no benefit to the patient or fetus. (babiesafter35.com)
The effectiveness of clozapine in treatment-resistant schizophrenia was demonstrated in a 6-week, randomized, double-blind, active-controlled study comparing clozapine and chlorpromazine in patients who had failed other antipsychotics. (pillintrip.com)
Clozapine is often effective for patients with treatment-resistant schizophrenia, however, proactive and co-ordinated management is required, which is the primary responsibility of the initiating prescriber. (bpac.org.nz)
2 Since then, clozapine has been shown to be the only medicine to reduce suicidal behaviour in patients with schizophrenia and it is now the medicine of choice for treatment-resistant schizophrenia. (bpac.org.nz)
The Company is dedicated to delivering effective and high-quality products to patients for better treatment. (wollsmilabs.com)
Dual antiplatelet therapy with aspirin plus thienopyridines has become the standard treatment of patients undergoing coronary stenting. (hindawi.com)
If the red cells are smaller or larger than normal, or if there's a lot of variation in the size of the red cells, this data can help guide the direction of further testing and expedite the diagnostic process so patients can get the treatment they need quickly. (wikidoc.org)

Agranulocytosis may be asymptomatic, or may clinically present with sudden fever, rigors and sore throat. (wikipedia.org)

The name granulocyte refers to grain-like bodies within the cell. (cancerhealthcenter.com)
Suicidal behavior refers to actions by a patient that put him/herself at risk for death. (pillintrip.com)

Reducing suicidal behavior in patients with schizophrenia or schizoaffective disorder. (nih.gov)
these patients were matched with 3,734 patients with schizophrenia who did not have a cancer diagnosis. (psychnews.org)
1 The medicine was reintroduced following a landmark study in 1988 demonstrating that patients with schizophrenia who were unresponsive to other medicines often found clozapine beneficial. (bpac.org.nz)

hence, it is important to consider SS in patients presenting with rash, even in this subgroup of patients. (medindiajournal.com)

This group was compared with 92 (27 + 65 ) patients without SIgMD matched to cases on age, sex, weight, mental health unit, diagnosis, and psychiatric medication. (psychiatrist.com)

Drug-induced agranulocytosis by ritodrine was diagnosed. (hindawi.com)

citation needed] The Centers for Disease Control and Prevention traced outbreaks of agranulocytosis among cocaine users, in the US and Canada between March 2008 and November 2009, to the presence of levamisole in the drug supply. (wikipedia.org)

Use with caution in patients with history of seizure or risk factors for seizure. (nih.gov)
Use with caution in patients who have a history of drug allergy. (powerhorsevet.com)
Oxokool Plus is used with caution in patients with disorders of the liver and kidneys, with benign hyperbilirubinemia, as well as in elderly patients. (sdrugs.com)

Although the severity of cytopenia does not help determine its cause, patients with leukocyte counts of less than 800 / μl should be considered immunodeficient. (arrhythmia.center)

It is also crucial to assess the risk of serious complications in patients with febrile neutropenia, since this assessment will dictate the approach to therapy, including the need for inpatient admission, IV antibiotics, and prolonged hospitalization 2. (ukessays.com)
The risk assessment and the diagnostic approach to patients presenting with febrile neutropenia are also discussed. (ukessays.com)
Here, we discuss a patient with febrile neutropenia, presenting with SS. (medindiajournal.com)

Patients carrying the major histocompatibility complex (MHC) class 1 human leukocyte antigen ( HLA )-B27 are at risk of developing levamisole related agranulocytosis [5]. (dermnetnz.org)
Monitor glucose regularly in patients with diabetes or at risk for diabetes. (nih.gov)
This study aims to analyze cardiovascular risk comorbidities in patients with RA and the correlation with the use of anti-rheumatic drugs. (bvsalud.org)
Conclusions: The presence of cardiovascular risk comorbidities was confirmed to be higher in RA patients. (bvsalud.org)
Since this time, a number of fatalities, along with new research, has reiterated the need for close monitoring of patients treated with this high-risk medicine. (bpac.org.nz)
The patient was free from previous cardiovascular events, with untreated hypertension and smoker status as risk factors. (hindawi.com)

Our working hypothesis is that clozapine reacts with H2O2 within granulocytes, generating a toxic product. (wpi.edu)

METHODS: The REAL study included RA patients from Brazilian public health centers. (bvsalud.org)

Iron chelation therapy with desferrioxamine (DFO), available since the late 1960s and the most widely used iron chelator, decreased iron overload-related complications and mortality rate of patients with TM ( 4 4. (scielo.br)
Increased Mortality in Elderly Patients with Dementia-Related Psychosis: Clozapine is not approved for this condition. (nih.gov)
Long-term clozapine use has a higher effect on mortality due to lymphoma and leukemia than due to agranulocytosis," Tiihonen and colleagues wrote. (psychnews.org)

If you have issues with the health of your liver, a low dose will usually be prescribed to elderly patients. (tabletwise.net)

At 24 weeks of gestation, a female patient presented due to threatened premature labor and was administered continuous intravenous infusion of ritodrine hydrochloride. (hindawi.com)
We, herein, report a case of agranulocytosis due to continuous infusion therapy with ritodrine and summarize ritodrine-induced agranulocytosis. (hindawi.com)
Currently there are three iron chelating agents available for continuous use in patients with thalassemia on regular transfusions (desferrioxamine, deferiprone, and deferasirox) providing good results in reducing cardiac, hepatic and endocrine toxicity. (scielo.br)

Clinicians do not understand why some people are susceptible to agranulocytosis and others are not. (orthopedicshealth.com)
Clinicians must stress the need for patient compliance with therapy. (medscape.com)

It typically presents in patients with pirexya, neutrophilia, painful tender erytomatous papules, nodules and plaques often distributed asymmetrically. (actasdermo.org)

The study of 247 patients with community-acquired UTI comprised 72% females and 28% males, illustrating an increased prevalence of UTIs among females. (ijp-online.com)
Common side effects include agranulocytosis among females, and agranulocytosis among males. (ehealthme.com)

Efficacy of deferoxamine in preventing complications of iron overload in patients with thalassemia major. (scielo.br)
A male patient born in November 2014 was diagnosed with thalassemia major (βCD41-42 homozygote) on January 3, 2015. (biomedcentral.com)

For the hepatic effects, a yellow discoloration of the skin and sclerae was observed in 5 patients, but the icteric index was normal in each case. (europa.eu)

In the case of gold, or anti-thyroid drugs, or quinidine, among others, antibodies are created that appear to break the granulocytes down. (orthopedicshealth.com)
Because of the persistence of maternal antibodies, the possibility of fetal thyrotoxicosis should be considered in all patients with a history of Graves disease. (babiesafter35.com)

Anatomy4

Diseases14

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes1

Anthropology, Education, Sociology and Social Phenomena1

Information Science1

Health Care2

Geographicals1

Neutrophils7

Granulocytopenia10

Cases of agranulocytosis1

Deficiency1

Thrombocytopenia1

Treated with clozapine3

Severe9

Monocytes1

Colony6

Acute5

Neutrophil4

Symptoms8

Clozapine-induced5

Lymphocytes1

Bone marrow3

Bacterial infections1

Blood10

Severely1

Infection6

Incidence2

Doses2

Hypersensitivity1

Absence3

Transfusion3

Onset1

Decrease1

Infections3

Chronic2

Treatment17

Asymptomatic1

Refers2

Schizophrenia3

Subgroup1

Diagnosis1

Drug-induced1

Cocaine1

Caution in patients3

Counts1

Febrile3

Risk6

Toxic1

Centers1

Mortality3

Elderly patients1

Continuous3

Clinicians2

Typically1

Females2

Thalassemia major2

Normal1

Antibodies2