• Rats received ten quinpirole injections in the test environment (Group Paired) or in the home cage (Group Unpaired), and saline in the alternate environment. (nih.gov)
  • At least one study has found that quinpirole induces compulsive behavior symptomatic of obsessive compulsive disorder in rats. (wikipedia.org)
  • Another study in rats show that quinpirole produces significant THC-like effects when metabolic degradation of anandamide is inhibited, supporting the hypothesis that these effects of quinpirole are mediated by cannabinoid CB1 receptors. (wikipedia.org)
  • The ability of bromocriptine (BRC), a selective dopamine D-2 receptor agonist, to induce yawning responses was studied in rats pretreated with reserpine and alpha-methyl-p-tyrosine (alpha-MPT). (baillement.com)
  • The neurochemical effects of partial D2-like agonists (i.e., terguride) to alter striatal DOPA accumulation under high and low dopaminergic tone was examined in preweanling rats. (csusb.edu)
  • Yoshida, Shelly Taeko, "Actions of a partial D2-like agonist during low or high dopaminergic tone: A neurochemical study using preweanling rats" (2005). (csusb.edu)
  • An increased sensitivity to quinpirole (a selective D2/3 agonist) in prior aripiprazole-treated rats was also found in the quinpirole-induced hyperlocomotion test BMS-777607 suggesting an enhanced D2/3-mediated function. (researchensemble.com)
  • 2003). A growing literature supports the notion that the sensitized behavioral responses to D2/D3 agonists, such as quinpirole, observed in foodrestricted rats result from an enhancement of the functional coupling of Gi G-proteins to D2 receptors, and not an increase in D2 receptor expression (Pothos et al. (baillement.com)
  • For example, previous studies suggest that the enhancement of quinpirole-induced locomotor activity observed in food-restricted rats results from an enhanced functional activity of the D2 receptor (Carr et al. (baillement.com)
  • Mechanisms of Kappa Opioid Receptor Potentiation of Dopamine D2 Receptor Function in Quinpirole-Induced Locomotor Sensitization in Rats. (neurobiologia.cl)
  • Reduced dopamine and glutamate neurotransmission in the nucleus accumbens of quinpirole-sensitized rats hints at inhibitory D2 autoreceptor function. (neurobiologia.cl)
  • Subjects received quinpirole on the 11th injection as a test for locomotor sensitization, and saline on the next injection as a test for conditioned activity. (nih.gov)
  • Regardless of the strength of discriminative stimuli, both Paired and Unpaired groups showed locomotor sensitization to 0.5 mg/kg quinpirole compared with the Acute group. (nih.gov)
  • With a lower sensitizing dose of quinpirole (0.1 mg/kg) used in one experiment, only the Paired group showed locomotor sensitization. (nih.gov)
  • It is suggested that with moderate doses of quinpirole, expression of locomotor sensitization does not require drug-signalling cues though such signals may have a modulatory influence. (nih.gov)
  • Repeated treatment with the kappa opioid receptor agonist U69593 reverses enhanced K+ induced dopamine release in the nucleus accumbens, but not the expression of locomotor sensitization in amphetamine-sensitized rats. (neurobiologia.cl)
  • In the striatum, the dopamine D1 receptor agonist SKF38393 and the dopamine D1 receptor antagonist SCH23390 were without effect. (aspetjournals.org)
  • In the nucleus accumbens, the agonist SKF38393 increased the DAT half-life, whereas the antagonist SCH23390 decreased the half-life. (aspetjournals.org)
  • 1983). Biochemical studies have demonstrated that BRC has both agonist and antagonist properties at preand postsynaptic dopaminergic neurons, and that it decreases synaptosomal tyrosine hydroxylase activity (Goldstein et al. (baillement.com)
  • The results indicate that terguride has agonist-like (quinpirole-like) effects under a low dopaminergic tone and antagonist-like (haloperidol-like) effects under a high dopaminergic tone during the preweanling period. (csusb.edu)
  • Aripiprazole shows high affinity for dopamine D2 receptors but as a partial agonist rather POLD4 than a full antagonist at these receptors (Aihara et al. (researchensemble.com)
  • 2003 As a result it acts as a D2 receptor agonist at receptor sites where dopaminergic transmission is significantly decreased while acting as an antagonist at other dopaminergic sites with normal or increased transmission functioning BMS-777607 as a dopamine activity stabilizer. (researchensemble.com)
  • In previous experiments we found that when given alone, the D1 agonist SKF 38393 increased vacuous chewing and the D1 antagonist SCH 23390 decreased it, while both the D2 agonist LY 171555 (quinpirole) and the D2 antagonist sulpiride decreased vacuous chewing. (duke.edu)
  • Surprisingly, the actions of D2 agonist and antagonist were affected in opposite ways. (duke.edu)
  • Utilizing a technique for measuring the kinetics (synthesis, degradation, and half-life) of the dopamine transporter (DAT) protein in the rat striatum and nucleus accumbens, we have investigated the effects of systemic administration of dopamine receptor agonists and antagonists upon DAT kinetics in these brain regions. (aspetjournals.org)
  • However, the dopamine D2 receptor agonists R -(−)-propylnorapomorphine hydrochloride (NPA) and quinpirole decreased the half-life of DAT. (aspetjournals.org)
  • Bromocriptine and the other dopaminergic agonists mentioned act over DA 2 receptors of the tuberoinfundibular system, inhibiting prolactin release and decreasing hyperprolactinemia and tumor size. (biopsychiatry.com)
  • Food restriction has also been shown to alter a variety of behavioral and pharmacological responses to dopaminergic agonists including an increased sensitivity to the locomotor stimulatory effects of direct- and indirect-dopamine agonists, elevated extracellular dopamine levels in responses to psychostimulants, as well as suppression of agonist-induced yawning. (baillement.com)
  • The effects of a number of dopaminergic agonists and antagonists upon the soma of a prothoracic inhibitory motoneurone of the cockroach (Periplaneta americana) have been recorded under voltage-clamp conditions. (silverchair.com)
  • The dopaminergic agonists apomorphine, bromocryptine, ergometrine and A-6,7-DTN mimic the action of dopamine on this neurone, all having a similar voltage-dependence to that of dopamine. (silverchair.com)
  • Quinpirole is a psychoactive drug and research chemical which acts as a selective D2 and D3 receptor agonist. (wikipedia.org)
  • SKF38393), a D2/3 agonist (quinpirole), or a selective D2R agonist (sumanirole). (archive.org)
  • A selective D1 dopamine receptor agonist used primarily as a research tool. (lookformedical.com)
  • A low dose of the selective D-1 dopamine receptor agonist SK&F38393 did not induce yawning but enhanced the BRC-induced response. (baillement.com)
  • The selective D-l receptor agonist SK&F 82526 and the D-2 agonist LY171555, however, were both inactive on the preparation. (silverchair.com)
  • It has been widely established that dopamine and its agonists play an important role in cardiovascular, renal, hormonal, and central nervous system regulation through stimulation of alpha and beta adrenergic and dopaminergic receptors. (biopsychiatry.com)
  • From a therapeutic point of view, the above-mentioned agonists are used for treating Parkinson's disease, acting over DA 2 dopaminergic receptors of the nigrostriatal system. (biopsychiatry.com)
  • VTA inactivation also hindered OR LTM, and even though this effect was unaffected by co-infusion of the dopamine D1/D5 receptor agonist SKF38393 in HIP, mPFC or AMY alone, it was reversed by simultaneous activation of D1/D5 receptors in the last two regions. (ufrn.br)
  • These results suggest that BRC-induced yawning may be mediated via presynaptic dopaminergic neuron activity and that BRC, in addition to the stimulation of dopamine 4J-2 receptors, appears to require endogenous dopamine or receptor activation by another dopamine agonist (D-1 agonist) for the induction of yawning, stereotypy and upright lighting responses. (baillement.com)
  • To determine which D 2 -like receptors possess morphogenic potentials, a clonal mesencephalic cell line (MN9D) was transfected with D 2 , D 3 , or D 4 receptor subtypes and treated with quinpirole, an agonist of D 2 - like receptors, and changes in morphological characteristics were quantitated. (wustl.edu)
  • In contrast, glutamate-mediated spontaneous excitatory postsynaptic currents (EPSCs) were significantly inhibited by quinpirole only when the total number of D2 receptor sites, normally composed by both D2L and D2S receptors in a ratio favoring the D2L isoform, was modified to express only the D2S isoform at higher than normal levels. (unipv.it)
  • 1987). While post-synaptic D2/D3 receptors within the mesolimbic dopaminergic pathway are thought to mediate the locomotor effects of D2-like agonists (Levant, 1997), the induction of yawning and PE by D2-like agonists is thought to be mediated by postsynaptic D2-like receptors on oxytocinergic neurons in the paraventricular nucleus (Argiolas and Melis, 1998). (baillement.com)
  • We applied dopamine agonists (Apomorphine, Quinpirole, SKF-38393) and antagonists (Haloperidol, Eticlopride, SCH-23390) to Lphn3.1 morpholino-injected or control-injected animals. (hal.science)
  • BRC cannot be considered a directly acting agonist like apomorphine, since reserpine and -MPT inhibit or completely abolish most of the behavioral effects induced by BRC (Johnson et al. (baillement.com)
  • Jenkins and Jackson (1985) reported that BRC, in behavioral terms, has no effect per se at the postsynaptic dopamine receptor and that BRC requires either endogenous dopamine or the administration of an exogenous agonist such as apomorphine for the expression of its effects. (baillement.com)
  • A pairing paradigm was employed to explore the contribution of associational mechanisms to the expression of sensitization to the dopamine agonist quinpirole. (nih.gov)
  • With lower quinpirole doses, however, quinpirole sensitization is context-dependent. (nih.gov)
  • However, U69593 cotreatment with a presynaptic dose of QNP changed a different set of measures of sensitization than did cotreatment with a postsynaptic dose of the dopamine agonist. (eurekamag.com)
  • Detrimental effect of clomipramine on hippocampus-dependent learning in an animal model of obsessive-compulsive disorder induced by sensitization with d2/d3 agonist quinpirole. (cas.cz)
  • Repeated bromocriptine in the test box but not in the home cage caused progressive increases in sensitivity to the locomotor-stimulating effects of bromocriptine and increases in the subsequent sensitivity to quinpirole but caused only trivial signs of cross-sensitization to cocaine or heroin. (eurekamag.com)
  • Lack of significant cross-sensitization between bromocriptine and either cocaine or heroin and lack of permanence of the cross-sensitization between bromocriptine and quinpirole raise questions as to the biological basis of psychomotor stimulant sensitization. (eurekamag.com)
  • In striatal neurons in primary culture, both the CB1 receptor agonist [3-(1,1-dimethylheptyl)-11-hydroxy-Δ 8 tetrahydrocannabinol] (HU210) and the D2 receptor agonist quinpirole inhibited forskolin-stimulated cAMP accumulation when applied separately. (jneurosci.org)
  • n=28), while the D2/3 receptor agonist quinpirole (10 microM) had no effect. (nih.gov)
  • A similar effect was observed after the application of SKF 38393 (1 microM), while quinpirole (10 microM) had no significant effect. (nih.gov)
  • Accordingly, the inhibitory effects of the DA D2 receptor agonist quinpirole (10 microM) on GABA(A)-mediated spontaneous inhibitory postsynaptic currents (IPSCs)correlate with the total number of D2 receptor sites in the striatum, irrespective of the specific receptor isoform expressed. (unipv.it)
  • In addition to their effects on locomotor activity, D2/D3 agonists are known to possess a variety of other behavioral effects including the induction of yawning (Yamada et al. (baillement.com)
  • Further, the co-administration of sub-maximum doses of SKF 38393 and quinpirole caused additive increases in ACTH in serum. (duke.edu)
  • This group also found no difference in the quinpirole-mediated inhibition of dopamine release between alcohol and control male cynomolgus macaques [24]. (onurtugman.com)
  • Quinpirole has been shown to increase locomotion and sniffing behavior in mice treated with it. (wikipedia.org)
  • Low incidence of spontaneous SIB increased significantly after repeated injections of dopamine-2/3 receptor (D2/D3R) agonist quinpirole (QNP). (elsevierpure.com)
  • responsiveness to quinpirole decreased with further quinpirole injections. (eurekamag.com)
  • We set out to compare patterns of dyskinetic behaviours induced by the systemic administration of L-DOPA and D1 or D2 receptor (D1R, D2R) agonists in mice with unilateral 6-hydroxydopamine lesions. (archive.org)
  • Dystonia ratings revealed that these agonists elicited marked dystonic features in trunk/neck, forelimbs, and hindlimbs, which were overall most severe in sumanirole-treated mice. (archive.org)
  • The response of ACTH to intraperitoneal injection of quinpirole was blocked by pretreatment with sulpiride and attenuated slightly by pretreatment with SCH 23390. (duke.edu)
  • 2003). However, this effect could also be explained by a tolerance, or down-regulation of the D3 receptor as the inhibition of locomotor activity by D2/D3 agonists has been hypothesized to be mediated by the D3 receptor (Svensson et al. (baillement.com)
  • Furthermore, BRC acts like a dopamine D-2 agonist and inhibits dopamine-stimulated synthesis of cyclic adenosine 3',S'-monophosphate (cyclic AMP) (Trabucchi et al. (baillement.com)
  • Activator of protein kinase A (cyclic AMP agonist). (biolog.de)
  • Experiments in flies found quinpirole may have neuroprotective effects against Parkinson's disease-like pathology. (wikipedia.org)
  • To investigate the relationship between dopamine (DA) and acetylcholine (ACh) systems in the control of oral movement, we studied the effects of specific D1 and D2 drugs on vacuous chewing movements induced by the muscarinic ACh agonist, pilocarpine. (duke.edu)
  • In contrast to the striatum, NPA and quinpirole increased the DAT half-life, which was blocked by eticlopride and by itself had no effect on DAT kinetics. (aspetjournals.org)
  • In contrast, HU210 and quinpirole in combination augmented cAMP accumulation. (jneurosci.org)
  • By contrast, both of the D2-class agonists (quinpirole, sumanirole) induced predominantly axial AIMs. (archive.org)
  • The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity. (uchicago.edu)
  • Quinpirole may also reduce relapse in adolescent rat models of cocaine addiction. (wikipedia.org)
  • The animals were then tested in the photocell boxes for their locomotor response to cocaine (10.0 mg/kg IP), heroin (0.5 mg/kg IP), or quinpirole (0.1 mg/kg IP). (eurekamag.com)
  • Similar results were found for primary mesencephalic cultures stimulated with quinpirole. (wustl.edu)
  • The dopamine D2 receptor agonist quinpirole had no effect on retention. (ufrn.br)
  • The intraperitoneal administration of either the D1 agonist, SKF 383393 (1-phenyl-2,3,4,5 tetrahydro-(iH)-benzazepine-7,8diol HCl, 5-20 mg/kg) or the D2 agonist quinpirole (0.05-1 mg/kg) dose-dependently elevated both adrenocorticotropic hormone (ACTH) and corticosterone (CS) in serum. (duke.edu)
  • Similarly, administration of either SKF 38393 or quinpirole (1-100 micrograms) into the third ventricle dose-dependently elevated ACTH in serum. (duke.edu)
  • The ability of dopamine agonists to induce these behaviors seems to depend apon the potency and ratio of D-2 versus D-1 receptor activity. (baillement.com)