Agonist effects. Medical search. Frequent questions

Rabbits pretreated with bacterial lipopolysaccharide (LPS) (25 micrograms/kg) and anesthetized 5 h later exhibit acute and transient hypotension in response to intra-arterial boluses of B1 receptor agonists. (aspetjournals.org)
Glucagon-like peptide 1 receptor agonists (GLP1-RA) have been associated with an increased risk of pancreatitis and pancreatic cancer. (nih.gov)
Presently available data confirm the safety of GLP-1 receptor agonists for pancreatitis. (nih.gov)
Inhibition of LPS-induced neutrophil ROS production by various adenosine receptor agonists. (avma.org)
Concentration of cAMP in equine neutrophils induced by 5 adenosine A 2A receptor agonists (A) and effects of ZM241385 and MRS1706 on ATL313-induced accumulation of cAMP (B). Each point represents the mean ± SEM of 3 replicates. (avma.org)
The major antiparkinson drugs are levodopa , dopamine - receptor agonists, amantadine , and the so-called COMT (catechol- O -methyltransferase) inhibitors, MAO-B (monoamine oxidase B) inhibitors, and muscarinic receptor antagonists . (britannica.com)
The proposed studies represent a new research direction for the treatment of levodopa-induced dyskinesias using nicotine or nicotinic receptor agonists. (michaeljfox.org)
Adenosine A2 Receptor Agonists" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Adenosine A2 Receptor Agonists" by people in Harvard Catalyst Profiles by year, and whether "Adenosine A2 Receptor Agonists" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Adenosine A2 Receptor Agonists" by people in Profiles. (harvard.edu)
Opioid receptor agonists. (medlineplus.gov)
Our results reveal that the dyskinetic effects of D1 and D2 receptor agonists are associated with distinct patterns of cortico-basal ganglia oscillations, suggesting a recruitment of partially distinct networks. (lu.se)

1 In addition, the United Kingdom guidelines recommend that treatment with levodopa should be delayed for as long as possible providing alternative drugs, such as dopamine agonists, can achieve adequate symptom control. (bmj.com)
Dopamine agonists exert their antiparkinsonian effects by acting directly on dopamine receptors and mimicking the endogenous neurotransmitter. (bmj.com)
11 There are two subclasses of dopamine agonists: ergoline and non-ergoline agonists. (bmj.com)
The ergoline dopamine agonists include bromocriptine, pergolide, lisuride, and cabergoline, whereas ropinirole and pramipexole are non-ergoline agonists. (bmj.com)
Apomorphine, one of the first dopamine agonists shown to improve parkinsonian symptoms, is a combined D 1 and D 2 agonist but has to be administered subcutaneously. (bmj.com)
Dopamine agonists have proved antiparkinsonian activity. (bmj.com)
Dopamine agonists have also been successfully used as monotherapy in de novo patients with the intention of delaying treatment with levodopa and consequently deferring the onset of complications. (bmj.com)
Dopamine agonists are not metabolised by oxidative pathways and so do not lead to the cytotoxic free radical formation that may be associated with metabolism of dopamine. (bmj.com)
The reason why motor complications are less often encountered with dopamine agonists than with levodopa is not fully understood. (bmj.com)
The cumulative body of empirical evidence shows that dopamine agonists and antagonists (e.g. (bvsalud.org)
However, patients with LID receive combination therapies that often include dopamine agonists. (lu.se)

The data show that tirzepatide stimulates islet hormone secretion from human islets through agonist effects at both incretin receptors (GIP and GLP-1). (medscape.com)
5. This increase in end-organ sensitivity might explain why LD 3098 appears as an α-adrenoreceptor agonist with preferential affinity for postsynaptic receptors when end-organ responses to nerve stimulation are measured and yet it is a preferential presynaptic agonist in 3 H-labelled transmitter-release studies. (portlandpress.com)
Effects of agonist efficacy on desensitization of phosphoinositide hydrolysis mediated by m1 and m3 muscarinic receptors expressed in Chinese hamster ovary cells. (aspetjournals.org)
Hypotensive effects of Lys-des-Arg9-bradykinin and metabolically protected agonists of B1 receptors for kinins. (aspetjournals.org)
The influence of γ-aminobutyric type-A (GABA A ) receptors agonist (muscimol hydrobromide, 0.1 µg/0.5 µl) injections into the right or left basolateral amygdala (BLA) on the behavior of high-an- xiety (HA) and low-anxiety (LA) rats subjected to the elevated plus-maze (EPM) test was investigated. (scirp.org)
This is a first-generation antihistamine with anticholinergic effects that binds to H1 receptors in the CNS and the body. (medscape.com)
Opioid full agonists are drugs that bind to and activate opioid receptors in the body . (osmosis.org)
Mixed agonist-antagonists bind to and activate opioid receptors to a certain extent, but also have the ability to block or inhibit the effects of other opioids . (osmosis.org)
Selectively blocks beta1-adrenergic receptors with little or no effect on beta2-receptors. (medscape.com)
We set out to examine the pattern of cortico-basal ganglia oscillations induced by selective agonists of D1 and D2 receptors in a rat model of LID. (lu.se)
Blocks beta 1- and beta 2-receptors and has mild intrinsic sympathomimetic effects. (medscape.com)
Selectively blocks beta 1-adrenergic receptors with little or no effect on beta 2-receptors. (medscape.com)

ABT-594 [5-2R-azetidinylmethoxy-2-chloropyridine], a novel neuronal nicotinic acetylcholine receptor agonist, produced significant antinociceptive effects in mice against both acute noxious thermal stimulation--the hot-plate and cold-plate tests--and persistent visceral irritation--the abdominal constriction writhing assay maximally-effective dose in each test 0.62 micromol/kg, i.p. (erowid.org)
The antinociceptive effect of ABT-594 was prevented, but not reversed, by the noncompetitive neuronal nicotinic acetylcholine receptor antagonist mecamylamine 5 micromol/kg, i.p. (erowid.org)
In contrast, the antinociceptive effect of ABT-594 was not prevented by hexamethonium 10 micromol/kg, i.p., a neuronal nicotinic acetylcholine receptor antagonist that does not readily enter the central nervous system, nor by naltrexone 0.8 micromol/kg, an opioid receptor antagonist. (erowid.org)
These data indicate that ABT-594 is a centrally acting neuronal nicotinic acetylcholine receptor agonist with potent antinociceptive and anxiolytic-like effects in mice. (erowid.org)
Alpha 7 nicotinic acetylcholine receptor (α7nAChR) agonists have been developed to treat schizophrenia but failed in clinical trials due to rapid desensitization. (bvsalud.org)

Pharmacologically, indacaterol is a nearly full β 2 -agonist with a high intrinsic efficacy and, unlike partial agonists, it does not exhibit antagonistic behaviour in the presence of isoprenaline 6 . (ersjournals.com)

1. Previous studies have shown that LD 3098 (cirazoline), a potent directly acting α-adrenoreceptor agonist, failed to antagonize heart rate increases induced by ansa subclavia stimulation in anaesthetized dogs. (portlandpress.com)
The naturally occurring B1 agonist Lys-des-Arg9-BK was more potent than des-Arg9-BK in the in vivo model, but the effect of either natural sequence was brief. (aspetjournals.org)
However, isoflurane, while a potent bronchodilator, does not add to the effect of fenoterol. (druglib.com)
Nine alkaloids constitute the active ingredients of betel nut ( Reference Farnworth Farnworth, 1976 ), the most abundant of which is arecoline - a potent muscarinic agonist that rapidly crosses the blood-brain barrier and induces a range of parasympathetic effects ( Reference Asthana, Greig and Holloway Asthana et al , 1996 ). (cambridge.org)
Levonogestrel, norethisterone and etonogestrel activate all the androgen receptor in fish at very low concentrations, whereas, for example, drosperionone is a much less potent androgen receptor agonist. (janusinfo.se)

With the well-documented effect diabetes mellitus has on the cardiovascular system, current cardiovascular pharmacology places special emphasis on the use of agents developed specifically for its treatment. (escardio.org)
The present study describes the preclinical pharmacology of a highly selective 5-HT 1D receptor agonist PNU-142633. (uky.edu)

No effect was observed upon administration of muscimol to LA rats. (scirp.org)
OBJECTIVE: Using 6-hydroxydopamine-lesioned rats as a model, we aimed to establish whether an adjunct treatment with the D2/3 agonist ropinirole impacts on patterns of LID-related neuroplasticity and drug responses. (lu.se)
Antidyskinetic effects of different drug categories were investigated in parallel groups of rats receiving either L-dopa monotreatment or L-dopa combined with ropinirole. (lu.se)
The aim of this research was to study the effect of non pulsatile GnRH agonist administration on the ovaries of immature rats. (celljournal.org)
Effects Of Nonpulsatile GnRH Agonist Administration On Ovaries Of Immature Rats', Cell Journal (Yakhteh) , 6(3), pp. 124-131. (celljournal.org)
In separate rats, we measured the effects of salvA on activation of extracellular signal regulated kinase (ERK), cyclic adenosine monophosphate (cAMP) response element binding protein, and c-Fos within the NAc. (erowid.org)
Attenuation of adverse effects of noise induced hearing loss on adult neurogenesis and memory in rats by intervention with Adenosine A2A receptor agonist. (harvard.edu)
The present study used pharmacological magnetic resonance imaging (phMRI) to evaluate the dose -dependent effect of GAT107 on brain activity in awake male rats . (bvsalud.org)

Selective FP prostanoid receptor agonist believed to reduce IOP by increasing uveoscleral outflow. (medscape.com)
In particular, compounds modulating D1 receptor signaling had a stronger effect in the L-dopa-only group, whereas both amantadine and the selective NMDA antagonist MK801 produced a markedly larger antidyskinetic effect in L-dopa-ropinirole cotreated animals. (lu.se)
The results will allow for the development of selective nicotinic drugs against levodopa-induced dyskinesias with optimal therapeutic efficacy and a minimum of adverse effects. (michaeljfox.org)
A relatively selective alpha-adrenergic agonist that does not have significant local anesthetic activity. (medscape.com)

Medications used to decrease aqueous production include beta-blockers (topical), carbonic anhydrase inhibitors (topical and/or oral), and alpha 2-agonists. (medscape.com)

The pharmacodynamics of ALT-801, a GLP-1/glucagon receptor dual agonist optimized for NASH and weight loss, were compared to semaglutide (GLP-1 receptor agonist) and elafibranor (peroxisome proliferator-activated receptor, PPAR-α/δ, agonist) in a biopsy-confirmed, diet-induced obese (DIO) mouse model of NASH (DIO-NASH). (researchsquare.com)
Moreover, naturally-occurring and synthetic PPARγ agonists promote growth inhibition and apoptosis. (eurekaselect.com)
Thiazolidinediones (TZDs) are synthetic agonists of PPARγ that were developed to treat type II diabetes. (eurekaselect.com)
These compounds also display anticancer effects which appear mainly to be independent of their PPARγ agonist activity. (eurekaselect.com)
PPARγ agonists have been shown to induce differentiation in solid tumors such as thyroid differentiated/ anaplastic cancers and sarcomas. (eurekaselect.com)
The exploration of newer PPARγ agonists can help in unveiling the underlying mechanisms of these drugs, providing new molecules that are able to treat cancer, without increasing the cardiovascular risk of neoplastic patients. (eurekaselect.com)

Potential adverse effects of these medications are similar to latanoprost (eg, eyelash growth, increased iris pigmentation). (medscape.com)
These agents are considered by some glaucoma specialists as first-line agents for glaucoma, mainly because of the lack of systemic adverse effects. (medscape.com)

It will also help determine whether nicotine and/or nicotinic agonists are of benefit in the treatment of dyskinesias that occur with levodopa treatment for Parkinson's disease. (michaeljfox.org)

The KOR antagonist nor-binaltorphimine (20 mg/kg) blocked the immediate and delayed effects of salvA and prolonged the duration of cocaine effects in ICSS. (erowid.org)

Our Codeine sulfate Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
How Do I Manage Medication Side Effects? (additudemag.com)
Common side effects of ADHD medication include sleeplessness, loss of appetite, and tics - problems that no child should have to tolerate. (additudemag.com)
Some people (including more than a few doctors) seem to assume that ADHD medication side effects are merely the price to pay for taking a prescription. (additudemag.com)
In this article, I'll explain the strategies that I've found particularly effective at controlling ADHD medication side effects in children - which, by the way, also work for adults with ADHD . (additudemag.com)
What Are the ADHD Medication Side Effects for Stimulants? (additudemag.com)
Methylphenidate ( Ritalin ), dextro-amphetamine ( Dexedrine, Evekeo ), and dextro-amphetamine/levo-amphetamine (Adderall, Adzenys) have similar side-effect profiles, and the strategies that curb side effects for one medication generally work for the other two, as well. (additudemag.com)
For some kids, difficulty falling asleep is truly a side effect of stimulant medication. (additudemag.com)

This effect may decrease aqueous humor secretion, reducing IOP. (medscape.com)
This effect decreases aqueous humor secretion, reducing IOP. (medscape.com)

The antinociceptive effects of morphine and ABT-594 in the mouse hot-plate test appeared to be additive, but ABT-594 did not potentiate the respiratory depression produced by morphine when the two compounds were coadministered. (erowid.org)
Examples of opioid agonists include morphine , codeine , and oxycodone . (osmosis.org)
Dissolving or dividing of the tablets wil damage the prolonged-release system, leading to a rapid release of morphine which may cause substantial side effects. (who.int)

We queried MEDLINE, Embase, and BIOSIS to identify all animal studies testing the efficacy of pregabalin published before January 2018 and recorded experimental design elements addressing threats to validity and all necessary data for calculating effect sizes, expressed as the percentage of maximum possible effect. (iasp-pain.org)

15-17 Addition of agonists to these patients' regimes allows around a 20%-30% reduction in the dose of levodopa in practice and leads to improvement in the disabling complications. (bmj.com)
As a result, greater amounts of levodopa are able to reach the brain, enabling the administration of lower doses of the drug and thereby reducing the risk for severe side effects. (britannica.com)
The primary side effect associated with large doses of levodopa is an increased risk for schizophrenia -like episodes, presumably because of excess formation of dopamine. (britannica.com)
Dr. Quik found that the targeted nAChR agonist varenicline resulted in significant declines in levodopa-induced AIMs at a relatively low dose of the agonist, with no worsening of parkinsonism. (michaeljfox.org)

3. LD 3098 was a full agonist in isolated dog saphenous veins and in low concentrations (0·01 μmol/l) shifted the concentration-response curves to noradrenaline, potasium (K + ) and prostaglandin F 2α (PGF 2α ) to the left without changing the maximum response. (portlandpress.com)

The present study used the generalized matching law (Baum, 1974) to assess effects of these drugs on the motor system and the organism's motivation for food reinforcers. (bvsalud.org)
The alternative demanding the higher motor requirement showed a decrement in the number of responses, suggesting effects of the drugs in the organism's motor system. (bvsalud.org)
However, because acetylcholine is involved in memory, learning and thinking, anticholinergic drugs can bring about cognitive side effects including confusion or dementia. (michaeljfox.org)
Meyler's Side Effects of Drugs. (medlineplus.gov)

Choosing The Right GLP-1 Agonist: Tirzepatide Or Semaglutide? (momfilter.com)
Semaglutide, marketed under brand names like Ozempic and Rybelsus, is an established and widely used GLP-1 agonist developed by Novo Nordisk. (momfilter.com)
Tirzepatide and semaglutide are both powerful GLP-1 agonists that offer effective solutions for managing type 2 diabetes. (momfilter.com)

However, we were unable to show any clear relationships between preclinical design characteristics and effect sizes. (iasp-pain.org)

More recently the clinical use of GLP-1R agonist based therapeutics at high doses for the treatment of obesity and diabetes has resulted in weight loss in the 9-16% range over 26-68 weeks depending on diabetes status and the degree of lifestyle intervention 7,8 . (researchsquare.com)
That decision in effect meant that CMS would not pay for the drug any longer when people who need it get it administered in a clinical setting. (medpagetoday.com)
Tirzepatide is a relatively new GLP-1 agonist that has gained attention for its impressive clinical trial results. (momfilter.com)

Here, we speculate that SIRT1 might mediate the effect of the GLP-1 receptor agonist exenatide (exendin-4) on ameliorating hepatic steatosis. (diabetesjournals.org)
Our data demonstrate that SIRT1 mediates the effect of exenatide on ameliorating hepatic steatosis, suggesting the GLP-1 receptor agonist could serve as a potential drug for nonalcoholic fatty liver disease (NAFLD), especially in type 2 diabetes combined with NAFLD, and SIRT1 could be a therapeutic target of NAFLD. (diabetesjournals.org)

What Are Side Effects of Codeine Sulfate? (rxlist.com)
The use of codeine sulfate by some nursing mothers may lead to life-threatening side effects in the baby. (rxlist.com)

Indacaterol is a β 2 -agonist bronchodilator in development for the treatment of asthma and chronic obstructive pulmonary disease (COPD). (ersjournals.com)

Objective To determine whether treatment with agonists of glucagon-like peptide-1 receptor (GLP-1R) result in weight loss in overweight or obese patients with or without type 2 diabetes mellitus. (bmj.com)
Conclusions The present review provides evidence that treatment with GLP-1R agonists leads to weight loss in overweight or obese patients with or without type 2 diabetes mellitus. (bmj.com)
This has implications for how we view the effects of acute hyperglycaemia found in patients with diabetes mellitus as well as other conditions. (gla.ac.uk)
11 weeks, enrolling patients with type 2 diabetes and comparing a GLP-1 receptor agonist with placebo or any other non-GLP-1 receptor agonist drug. (nih.gov)
While the use of glucagon-like peptide1 (GLP-1) analogs in the control of diabetes has been associated with appetite suppression and reduced food intake, substantial numbers of patients exhibit gastrointestinal side effects (nausea, emesis) and average weight loss has ranged from 1-7% in studies leading to approval 6 . (researchsquare.com)
In the realm of diabetes management, the development of GLP-1 agonists has been a game-changer, offering effective solutions for individuals with type 2 diabetes. (momfilter.com)
Diabetes mellitus (DM) is a widespread disorder that effects patients from different age groups and sexes, and is a complex disease that involves both genetic and environmental factors. (who.int)
Diabetes has a huge effect on the lives of patients, because of constant constraints including dieting, exercising and regular monitoring of blood sugar levels, in addition to complications that affect HRQoL. (who.int)

GLP-1R agonists were associated with nausea, diarrhoea, and vomiting, but not with hypoglycaemia. (bmj.com)
Common side effects include gastrointestinal issues, such as nausea and diarrhea. (momfilter.com)

MacKenzie, A. , Cooper, E.J. and Dowell, F.J. (2008) Differential effects of glucose on agonist-induced relaxations in human mesenteric and subcutaneous arteries. (gla.ac.uk)

Conclusions and implications: Short periods of high glucose exert a variable influence on endothelial function in human isolated blood vessels that is dependent on factors of time, agonist-used and vessel studied. (gla.ac.uk)
Our principal hypothesis is that the muscarinic action of betel nut may exert a beneficial effect on the symptoms of people with schizophrenia. (cambridge.org)

CONCLUSIONS: Repeated salvA might trigger opponent processes such that "withdrawal" from the dysphoric effects of KOR activation is rewarding and decreases the net rewarding valence of cocaine. (erowid.org)
In addition, administration of DCs treated ex vivo with an A2AR agonist protected the kidneys of WT mice from IRI by suppressing NKT production of IFN-γ and by regulating DC costimulatory molecules that are important for NKT cell activation. (jci.org)
GAT107 presented with an inverted-U dose response curve with the 3 mg/kg dose having the greatest effect on the positive BOLD volume of activation. (bvsalud.org)

Beta-adrenergic blocker that has little or no intrinsic sympathomimetic effects and membrane-stabilizing activity. (medscape.com)

Issues for future research include the effects of the newer long-acting beta-agonists, large versus small airway effects, and combination effects with other inhaled therapeutic agents (eg, steroids and ion-channel blockers). (nih.gov)
Beyond the GLP-1 receptor (GLP-1R) agonists, unimolecular peptide dual agonists activating both GLP-1R and the glucagon receptor (GCGR) have been developed with the aim to achieve superior therapeutic benefits versus single agonist peptides 12 , 13 . (researchsquare.com)

The pancreatic effects of the "twincretin" tirzepatide (Mounjaro) appear to depend at least as much on the drug's agonist activity on the glucose-dependent insulinotropic polypeptide (GIP) receptor as on its glucagon-like peptide-1 (GLP-1) receptor activity. (medscape.com)
In addition, Lys-des-Arg9-BK is hydrolyzed in vitro by aminopeptidase M. Therefore, we tested the hypotensive effects of Lys-des-Arg9-BK analogs selectively protected against ACE activity (Lys-[D-Phe8]des-Arg9-BK) or against both ACE and aminopeptidase M (Sar-[D-Phe8]des-Arg9-BK). (aspetjournals.org)
Structure-activity relationship studies on the immune stimulatory effects of base-modified CpG toll-like receptor 9 agonists. (umassmed.edu)
Jurk M, Kritzler A, Debelak H, Vollmer J, Krieg AM, Uhlmann E. Structure-activity relationship studies on the immune stimulatory effects of base-modified CpG toll-like receptor 9 agonists. (umassmed.edu)
Abnormal involuntary movements were elicited by the D1 agonist SKF82958 or the D2 agonist sumanirole, while overall motor activity was quantified using video analysis (DeepLabCut). (lu.se)

Background and purpose: Acute periods of hyperglycaemia are strongly associated with vascular disorder, yet the specific effects of high glucose on human blood vessel function are not fully understood. (gla.ac.uk)
In this study we (1) characterized the endothelial-dependent relaxation of two similarly sized but anatomically distinct human arteries to two different agonists and (2) determined how these responses are modified by acute exposure to high glucose. (gla.ac.uk)
Opioid agonists are medications used mainly to control acute or chronic pain in particular situations. (osmosis.org)
While mainly central nervous system excitation has been noted following acute and chronic exposure, the effects observed in animals (body weight changes, hepatic, neurological, reproductive, and developmental effects) are toxicities that can occur in humans. (cdc.gov)
Aldrin: acute oral MRL is based on a LOAEL of 2 mg/kg/day for neurobehavioral effects (increased electroconvulsive shock threshold, the study did not identify a NOAEL) in offspring of maternal mice administered aldrin by gavage during the third trimester of pregnancy (Al-Hachim 1971). (cdc.gov)

All doses were well tolerated with a good safety profile and were not associated with consistent or clinically relevant effects on systemic β-agonist mediated events 7 - 10 . (ersjournals.com)

Cite this: Tirzepatide's Benefits Go Beyond GLP-1 Agonist Effects - Medscape - Jun 09, 2023. (medscape.com)

Although millions of people with schizophrenia live in betel chewing regions, the effects of betel chewing on their symptoms are unknown. (cambridge.org)

Limited data on the in vivo dose-response relationships of these mucociliary clearance effects suggest that larger doses are required for enhancement of mucociliary clearance than are needed for bronchodilatation. (nih.gov)

Effects of neonatal cocaine treatment and gender on opioid agonist-stimulated [(35)S]GTP gamma S binding in the striatum and nucleus accumbens. (umassmed.edu)
The D1 agonist induced prominent narrowband oscillations in the high gamma range (70-110 Hz) in all recorded structures except for the nigra reticulata. (lu.se)
Following treatment with the D2 agonist, narrowband gamma oscillations were detected only in forelimb motor cortex and dorsolateral striatum, while prominent oscillations in the theta band occurred in the globus pallidus and nigra reticulata. (lu.se)

The Global Initiative for Asthma guidelines recognise the role of long-acting β 2 -agonists (LABAs) for the optimal treatment of moderate-to-severe persistent asthma 1 . (ersjournals.com)
The availability of a once-daily β 2 -agonist could be expected to improve the treatment of asthma by providing patients with greater convenience and sustained bronchodilation. (ersjournals.com)
Health-related QoL (HRQoL) evaluates how a person perceives the effect of a disease and its treatment on the quality of their life (2). (who.int)

Do you agree with those effects known to occur in humans as reported in the text? (cdc.gov)
Are the effects only observed in animals likely to be of concern to humans? (cdc.gov)
I agree that the effects noted in animals are likely to be of concern to exposed humans. (cdc.gov)

This effect was not stereoselective since the S-enantiomer, A-98593 [5-2S-azetidinylmethoxy-2-chloropyridine], produced similar antinociceptive effects in this dose range. (erowid.org)
Participants completed an 11-item SCRA withdrawal symptom checklist and compared SCRAs and high-potency herbal cannabis on their onset and duration of effects, speed of the development of tolerance, severity of withdrawal, and difficulty with dose titration. (bath.ac.uk)
High dose stimulates the maturation of primary follicles but suppresses maturation of graffian follicles and low dose administration dose not have any effect on maturation of follicles. (celljournal.org)
The correct dose for every patient is a dose that is sufficient to control pain with no or tolerable side effects for 12 hours. (who.int)

But ADHD medications can also make things worse and cause severe side effects, including headaches, sleep problems, and a blunted appetite. (additudemag.com)
GLP-1 (Glucagon-Like Peptide-1) agonists are a class of medications designed to mimic the effects of a naturally occurring hormone in the body. (momfilter.com)
Side effects may vary, but both medications generally have a similar safety profile. (momfilter.com)
This could change the effects and side effects of these medications. (webmd.com)
Some medications also have this effect. (webmd.com)

SalvA had biphasic effects on reward: an immediate effect was to decrease the rewarding impact of ICSS, whereas a delayed effect was to increase the rewarding impact of ICSS. (erowid.org)
Repeated salvA produced a net decrease in the reward-potentiating effects of cocaine. (erowid.org)

Has minimal cardiovascular effects. (medscape.com)

Dr. Quik is currently doing further work to identify the optimal agonists for reducing dyskinesias. (michaeljfox.org)

Suprachiasmatic nucleus (SCN) and cortical astrocytes showed striking differences in sensitivity to glutamate and to mGluR agonists, even after several weeks in culture. (jneurosci.org)
We used intracranial self-stimulation (ICSS), a method that provides a behavioral index of reward sensitivity, to measure the effects of repeated administration of the KOR agonist salvinorin A (salvA) (2 mg/kg) on the reward-potentiating effects of cocaine (5.0 mg/kg). (erowid.org)
The temporal effects of salvA on ERK signaling suggest KOR-mediated engagement of distinct signaling pathways within the NAc that might contribute to biphasic effects on reward sensitivity. (erowid.org)

Short-acting beta-adrenergic agonists have been shown to enhance mucociliary clearance rates to varying degrees in patients with various lung diseases (eg, asthma, chronic bronchitis, and cystic fibrosis), although the enhancement is generally less than that seen in the normal lung. (nih.gov)
Little is known about chronic effects, but studies with dosing for up to a week also suggest an enhancement of mucociliary clearance, primarily by agonists that are lipophilic. (nih.gov)

Unlike the mGluR-kainate interaction, which required a pretreatment with an mGluR agonist and was insensitive to pertussis toxin (PTx), the mGluR modulation of 5HT actions was rapid and was blocked by PTx. (jneurosci.org)

Anatomy9

Organisms8

Diseases1

Chemicals and Drugs208

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Psychiatry and Psychology2

Phenomena and Processes20

Disciplines and Occupations1

Information Science2

Receptor agonists12

Dopamine agonists11

Receptors12

Nicotinic acetylch5

Partial agonists1

Potent5

Pharmacology2

Rats8

Selective4

Inhibitors1

PPAR6

Adverse2

Parkinson's1

Antagonist1

Medication8

Secretion2

Morphine3

Efficacy1

Levodopa4

Prostaglandin1

Drugs4

Semaglutide3

Preclinical1

Clinical3

Exenatide2

Codeine2

Bronchodilator1

Diabetes8

Nausea2

Differential1

Exert2

Activation3

Intrinsic1

Therapeutic2

Activity5

Acute5

Systemic1

20231

Symptoms1

Vivo1

Gamma3

Treatment3

Humans3

Dose4

Medications5

Decrease2

Cardiovascular effects1

Optimal1

Sensitivity3

Chronic2

Unlike1