• Leuprorelin , one of the most widely used GnRH agonists. (wikipedia.org)
  • GnRH agonists are given by injections into fat , as implants placed into fat , and as nasal sprays . (wikipedia.org)
  • Side effects of GnRH agonists are related to sex hormone deficiency and include symptoms of low testosterone levels and low estrogen levels such as hot flashes , sexual dysfunction , vaginal atrophy , osteoporosis , infertility , and diminished sex-specific physical characteristics . (wikipedia.org)
  • They are agonists of the GnRH receptor and work by increasing or decreasing the release of gonadotropins and the production of sex hormones by the gonads . (wikipedia.org)
  • When used to suppress gonadotropin release, GnRH agonists can lower sex hormone levels by 95% in both sexes. (wikipedia.org)
  • Typically, after GnRH agonists have induced a state of hypoestrogenism, exogenous FSH is given to stimulate ovarian follicle, followed by human chorionic gonadotropins (hCG) to trigger oocyte release . (wikipedia.org)
  • Women with menorrhagia , endometriosis , adenomyosis , or uterine fibroids may receive GnRH agonists to suppress ovarian activity and induce a hypoestrogenic state. (wikipedia.org)
  • Women of reproductive age who undergo cytotoxic chemotherapy have been pretreated with GnRH agonists to reduce the risk of oocyte loss during such therapy and preserve ovarian function. (wikipedia.org)
  • GnRH agonists that have been marketed and are available for medical use include buserelin , gonadorelin , goserelin , histrelin , leuprorelin , nafarelin , and triptorelin . (wikipedia.org)
  • GnRH agonists that are used mostly or exclusively in veterinary medicine include deslorelin and fertirelin . (wikipedia.org)
  • GnRH agonists can be administered by injection , by implant , or intranasally as a nasal spray . (wikipedia.org)
  • With the exception of gonadorelin, which is used as a progonadotropin , all approved GnRH agonists are used as antigonadotropins . (wikipedia.org)
  • In an attempt to increase the predictability of FET cycles, many programs have experimented with using a GnRH agonist (e.g. (inciid.org)
  • Lupron) in their protocol, as patients using a GnRH agonist are far less likely to experience a spontaneous LH surge. (inciid.org)
  • The cost and additional effort required by adding a GnRH agonist, as well as several studies questioning its necessity, however, have raise the question of whether it is possible to increase the predictability of a medicated FET cycle without using a GnRH agonist. (inciid.org)
  • Based on these results, the authors concluded that, among patients with functioning ovaries, an FET protocol that does not use a GnRH agonist may be appropriate and effective. (inciid.org)
  • GnRH agonists have not been shown to cause major side effects in humans so far. (sart.org)
  • GnRH agonists have been taken inadvertently by more than 300 women in pregnancy. (sart.org)
  • The G-protein receptor can affect the function of adenylate cyclase or phospholipase C , an agonist of the receptor will upregulate the effects on the downstream pathway (it will not necessarily upregulate the pathway itself). (rug.nl)
  • Agonists of each class of receptor elicit these downstream responses. (rug.nl)
  • Potency is the amount of agonist needed to elicit a desired response. (wikipedia.org)
  • The EC50 can be measured for a given agonist by determining the concentration of agonist needed to elicit half of the maximum biological response of the agonist. (wikipedia.org)
  • The smaller the EC50 value, the greater the potency of the agonist, the lower the concentration of drug that is required to elicit the maximum biological response. (wikipedia.org)
  • Dopamine agonists can induce sleepiness as well as sleep attacks (falling asleep without warning) and must be used with great caution in those patients who are driving. (apdaparkinson.org)
  • Intrahippocampal injection of galnon also shortened the duration of self-sustaining status epilepticus in rats, confirming its agonist properties in vivo. (nih.gov)
  • A low molecular weight galanin receptor agonist, 7-((9-fluorenylmethoxycarbonyl)cyclohexylalanyllysyl)amino-4-methylcoumarin (galnon) was found to displace (125)I-galanin with micromolar affinity at Bowes cellular and rat hippocampal membranes. (nih.gov)