• The relationship between age of onset and APOE genotype was examined using linear regression analysis. (ox.ac.uk)
  • CONCLUSIONS: Substantial familial influence on age of onset, depression and agitation suggests that genotype does influence phenotype in Alzheimer's disease. (ox.ac.uk)
  • It should be "considered" during follow-up and for many other applications, including the evaluation of "genotype-positive but phenotype-negative relatives," she added. (medscape.com)
  • This laboratory-based activity is designed to supplement data from existing clinical notification schemes by adding information on the phenotype (the serogroup, the serotype and subserotype), on occasion the genotype, and the antibiotic susceptibility of invasive isolates to clinical data. (health.gov.au)
  • Adjustment for lifetime smoking, age, and NATI genotype did not alter the findings. (cdc.gov)
  • Participants responded to survey items and provided blood samples for evaluation of phenotype and genotype of CYP2A6 and CYP2B6 enzymes involved in nicotine and bupropion metabolism. (who.int)
  • CONCLUSION: KIS-III is the first study designed to examine both nicotine and bupropion metabolism, evaluating CYP2A6 and CYP2B6 phenotype and genotype in conjunction with psychosocial factors, in the context of treatment of African American light smokers. (who.int)
  • We corrected for sex, age, genotype-derived principal components and surrogate variables. (cdc.gov)
  • Senescence-associated secretory phenotype (SASP) is a phenotype associated with senescent cells wherein those cells secrete high levels of inflammatory cytokines, immune modulators, growth factors, and proteases. (wikipedia.org)
  • Senescent cells are highly metabolically active, producing large amounts of SASP, which is why senescent cells consisting of only 2% or 3% of tissue cells can be a major cause of aging-associated diseases. (wikipedia.org)
  • Because senescent cells accumulate with aging and contribute to multiple co-morbidities, the non-skeletal actions of zoledronate could be due to senolytic (killing of senescent cells) or senomorphic (inhibition of the secretion of the senescence-associated secretory phenotype [SASP]) actions. (sens.org)
  • 2017. Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism. . (oregonstate.edu)
  • Familial influence on variation in age of onset and behavioural phenotype in Alzheimer's disease. (ox.ac.uk)
  • AIMS: To determine the familial (genotypic) influence on phenomenology (phenotype) in Alzheimer's disease. (ox.ac.uk)
  • Neuronal hyperexcitability in Alzheimer's disease: what are the drivers behind this aberrant phenotype? (nature.com)
  • Atrophy patterns in early clinical stages across distinct phenotypes of Alzheimer's disease. (sens.org)
  • RESULTS: Significant familial effects on age of onset (intraclass correlation 0.41) and mood state (intraclass correlation 0.26), and a relatively high pairwise concordance for agitation (excess concordance 0.1) were found. (ox.ac.uk)
  • The APOE locus was found to account for 4% of the variance in age of onset. (ox.ac.uk)
  • Overall, our findings encourage further investigation on the role of col4a1 and col25a1 in the biology of the vertebrate brain as well as the onset of aging and neurodegenerative diseases. (unina.it)
  • Young onset Parkinson's disease (YOPD) is the Parkinson's disease (PD) diagnosed between ages of 21 and 40 years 1 . (biorxiv.org)
  • For example, mutations in TTN gene may present with a wide range of phenotypes ranging from congenital myopathy to late-onset distal myopathy. (medscape.com)
  • The higher the number of CAG repeats, the earlier the age of onset and the greater the severity of the disease. (medicalnewstoday.com)
  • 3,4 As such, lowering the risk of the onset of frailty with low-cost interventions, such as medical nutrition solutions and increased exercise, could transform the lives of many older adults at risk of developing this age-related condition. (dsm.com)
  • Mean age at onset was 5.3 years. (neurology.org)
  • Age of onset and clinical manifestations may vary widely among patients with a given lysosomal storage disease, and significant phenotypic heterogeneity between family members carrying identical mutations has been reported. (medscape.com)
  • Does the frailty phenotype at the age of 66 to 71 predict death? (smw.ch)
  • This longitudinal study aimed to evaluate the significance of fulfilling at least one criterion of the frailty phenotype in the late sixties as a predictor of short- and long-term mortality in males and females. (smw.ch)
  • After baseline assessment of the five criteria of Fried's frailty phenotype (shrinking, exhaustion, muscular weakness, motor slowness and low physical activity) in 2005 (age 66-71 years), deaths were recorded over 14 years. (smw.ch)
  • CONCLUSIONS: The significantly higher mortality of individuals presenting 1+ frailty criteria supports the appropriateness of a systematic assessment of the frailty phenotype at the age of 66-71 years. (smw.ch)
  • Frailty in older adults: evidence for a phenotype. (smw.ch)
  • Frailty phenotype in heart failure: A condition that transcends age. (bvsalud.org)
  • There is an overall lack of differentiation between younger and older HF patients with the frailty phenotype . (bvsalud.org)
  • Therefore, frailty phenotype should be assessed in all patients , regardless of age. (bvsalud.org)
  • As the global aging population increases, so does the age-related medical syndrome known as frailty. (dsm.com)
  • The term "frailty" or "being frail" refers to a clinically recognizable state of increased vulnerability resulting from an age-associated decline in physical function, such that the ability to cope with every day activity is compromised. (dsm.com)
  • Today, around 10% of people aged over 65 live with frailty - and this rises to 25-50% for those aged over 85. (dsm.com)
  • Over the course of the trial, frailty status was assessed at baseline and annually according to the five features of the physical frailty phenotype - weakness, fatigue, involuntary weight loss, low gait speed and low activity level. (dsm.com)
  • Noteworthy, we report that both col4a1 and col25a1 are expressed in cells with a neuronal phenotype, unlike what has already been documented in mammalian brain, in which only col25a1 is considered a neuronal marker, whereas col4a1 seems to be expressed only in endothelial cells. (unina.it)
  • Longitudinal multi-omics measurements are highly valuable in studying heterogeneity in health and disease phenotypes. (nature.com)
  • Reproducible quantifiable imaging features of GBM heterogeneity that explicitly examine links between the imaging findings and the underlying GBM phenotypes characteristics are identified. (hindawi.com)
  • Introduced quantitative histogram features can discriminate phenotype heterogeneity from MRI images and thereby strengthen personalized medicine in GBM [ 12 ]. (hindawi.com)
  • The distinction in significant genes between total lifetime CAPS score and the anxious arousal symptom dimension of PTSD highlights a potential biological difference in the mechanism underlying the heterogeneity of the PTSD phenotype. (cdc.gov)
  • We sought to characterize them as "biomarker phenotypes" and to conclude differences in their overall characteristics. (karger.com)
  • To characterize the clinical phenotype of LGMD2C in gypsies. (neurology.org)
  • Taking tolcapone in mid-gestation barely caused embryo lethality, however, the mice developed preeclampsia-like phenotypes, including maternal hypertension, proteinuria and fetal growth restriction. (biorxiv.org)
  • In conclusion, tolcapone causes embryo lethality and growth restriction in early gestation, while in mid-gestation tolcapone causes preeclampsia-like phenotypes in mice with defective trophoblast invasion. (biorxiv.org)
  • Aging phenotype(s) in kidneys of diabetic mice are p66ShcA dependent. (hofstra.edu)
  • Natural aging of wild-type mice is marked by decreased expression of BubR1 in multiple tissues, including testis and ovary. (elsevierpure.com)
  • Next, in aged mice treated with zoledronate or vehicle for 8 weeks, zoledronate significantly reduced circulating SASP factors, including CCL7, IL-1β, TNFRSF1A, and TGFβ1 and improved grip strength. (sens.org)
  • We used loss- and gain-of-function approaches including genetic manipulation of the lipolytic enzyme Pnpla2 , change in environmental temperature, and lifestyle interventions to comprehensively test the premise that a thermogenic-like BAT phenotype is coupled with enhanced glucose tolerance in female mice. (diabetesjournals.org)
  • 9 The study utilized data from the DO-HEALTH trial, a three-year, double-blind, randomized controlled clinical trial comprising 2,157 participants aged 70 and over. (dsm.com)
  • We established a well-phenotyped sample of 371 WTC responders, recruited from a longitudinal WTC responder cohort using stratified random sampling, by obtaining blood, self-reported and clinical interview data. (cdc.gov)
  • The relationship between the phenotype and mortality was investigated graphically using Kaplan-Meier survival curves and quantified in Cox models. (smw.ch)
  • Physical activity phenotypes and mortality in older adults: a novel distributional data analysis of accelerometry in the NHANES. (harvard.edu)
  • We hypothesized the existence of distinct phenotype-based groups within the very heterogeneous population of patients of heart failure with preserved ejection fraction (HFpEF) and using an unsupervised hierarchical clustering applied to plasma concentration of various biomarkers. (karger.com)
  • Here, we test the hypothesis that aging phenotype(s) commonly associated with broad category of chronic kidney disease are accelerated in diabetic kidneys and linked to the p66ShcA locus. (hofstra.edu)
  • Thus, our results and other published data led us to the current hypothesis: an intestinal glucose hyper-absorptive phenotype in obese patients may be a predictor for successful outcome of BS. (mayo.edu)
  • According to the United Nations, the proportion of people aged over 65 now outnumber children younger than 5. (fightaging.org)
  • Microglia may be divided into four main states or phenotypes. (frontiersin.org)
  • After the inflammation fades away, microglia shift into the alternative activated M2 phenotypes that play a role in neuroprotection. (frontiersin.org)
  • The presence of neurotransmitter receptors in microglia illustrates their functional connection to neurons and this receptor activation could cause microglial cells to perform different activation phenotypes ( Pocock and Kettenmann, 2007 ). (frontiersin.org)
  • Digital phenotyping refers to the in-situ quantification of the human phenotype using data from personal digital devices. (bvsalud.org)
  • Multivariable analyses incrementally controlled age, socioeconomic and health characteristics. (smw.ch)
  • However, it is still unknown what proportion of genetic and environmental variability is shared between these anthropometric characteristics and the bone phenotypes. (nih.gov)
  • Associations between participants' characteristics and age were calculated using binary logistic regression . (bvsalud.org)
  • Our aim was to establish whether or not major repeaters are a distinctive suicidal phenotype, taking into account a wide range of potential competing risks including sociodemographic characteristics, personal and familial history, psychiatric diagnoses, and personality traits. (psychiatrist.com)
  • Homozygous mutation at the p66 locus delays or prevents aging phenotype(s) in the kidney that may be precursors to diabetic nephropathy. (hofstra.edu)
  • Notably, LGMD subtypes are phenotypically highly variable, limb-girdle weakness may not be the predominant presentation, and mutation in genes assigned to LGMD subtypes may cause allelic conditions with a different phenotype. (medscape.com)
  • LGMD2C in gypsy patients with C283Y mutation presents a rather homogeneous phenotype, characterized by an initial Duchenne-like progressive course followed by a more prolonged survival rate possibly due to the absence of early respiratory impairment and cardiac failure. (neurology.org)
  • Chronic inflammation associated with aging has been termed inflammaging, although SASP may be only one of the possible causes of this condition. (wikipedia.org)
  • Significant upregulation of major intestinal sugar transporters, including SGLT1, GLU2 and GLUT5 was responsible for hyper-absorptive phenotype and their pharmacologic inhibition significantly decreased glucose absorption. (mayo.edu)
  • Reactive oxygen species (ROS) metabolism was substantially increased in Wild Type (WT)-MSCs in HG media in association with increased cell death by apoptosis and acquisition of the senescent phenotype. (hofstra.edu)
  • Moreover, when a candidate gene or genomic region is responsible for the variation of both bone phenotypes and anthropometric indices, its true genetic effect on the bone phenotypes may be lost after one has adjusted the phenotypic values with weight and height as random environmental factors. (nih.gov)
  • Future studies should be clear about methods used to analyze PTSD status, as phenotypes based on PTSD symptom dimensions may yield different gene sets than combined CAPS score analysis. (cdc.gov)
  • This phenotype has recently attracted interest in other medical specialties for risk assessment before stressful interventions in older adults. (smw.ch)
  • Although many older adults strive to remain safely in their homes, often termed "safe aging in place" (SAIP), this goal often becomes less feasible over time and may necessitate assistance to remain living at home safely. (springer.com)
  • The alarming rate of falls among older adults, in combination with reports that 38% of these falls will require medical treatment, warrants proactive measures to reduce falls and fall risk in the aging population [ 6 ]. (springer.com)
  • It may have implications for population studies of candidate genes that underlie the complex bone phenotypes and for the development of strategies for therapeutic application. (nih.gov)
  • From my point of view, the key innovations include a diagnostic workup that starts with a detailed phenotypic description, including the new phenotype of nondilated left ventricular cardiomyopathy, that then triggers a multiparametric, systematic evaluation," said Kaski, co-chair of the task force. (medscape.com)
  • Collagens play an important and multifaceted role in the development and functioning of the nervous system and undergo structural remodeling and quantitative modifications during aging. (unina.it)
  • The genetic and environmental correlations between the bone phenotypes and anthropometric indices in Chinese subjects were studied by bivariate quantitative genetic analysis on a sample of 931 healthy subjects from 292 Chinese nuclear families aged from 19 to 79 years. (nih.gov)
  • This study demonstrated the ability of statistical features to provide a quantitative, individualized measurement of glioblastoma patient and assess the phenotype progression. (hindawi.com)
  • We showed that col4a1 and col25a1 are relatively well conserved during vertebrate evolution, and their expression significantly increases in the brain of N. furzeri upon aging. (unina.it)
  • Hand grip strength seems to be a good predictor for older age and more studies are needed to define age-specific hand grip strength cut-offs for HF populations . (bvsalud.org)
  • Height and weight are often used in population studies to adjust the bone phenotypes. (nih.gov)
  • Growth from birth to adulthood and bone phenotype in early old age: a British birth cohort study. (ox.ac.uk)
  • At the organ level, tissue stem cells antagonize senescent phenotypes, by replacing old dysfunctional cells. (hofstra.edu)
  • Apocrine metaplasia is a reversible transformation of cells to an apocrine phenotype . (wikipedia.org)
  • We are delighted to announce the fifth Ending Age-Related Diseases conference on August 11-14, 2022! (fightaging.org)
  • The enormous growth in the elderly population is posing a socioeconomic challenge to societies worldwide, and necessitates new sweeping interventions for age-associated diseases. (fightaging.org)
  • It aims to prevent and reverse diseases of aging by addressing their common root cause, the aging process itself. (fightaging.org)
  • Various physical, medical, psychological, and psychosocial factors may individually or cumulatively impact an older adult's ability to safely age in place. (springer.com)
  • To augment an older adult's ability and resources to safely age in place, key physical, medical, and social determinants of health must be addressed. (springer.com)
  • Age was associated with hand grip strength (OR=0.90), gait speed (OR=0.01) and diabetes (OR=4.95). (bvsalud.org)
  • Age ≥ 18 years. (mayo.edu)
  • It is seen in women mostly over the age of 50 years. (wikipedia.org)
  • Patients in the study, who were aged 2 months to 15 years, were assessed after 15 and 30 days, with a statistically significant improvement seen in the AR-GG27® patients compared with those on placebo. (medscape.com)
  • At two years' age, Beckwith-Wiedemann Syndrome (BWS) stigmata emerged, and at five years a liver tumour with focal nodular hyperplasia and an. (lu.se)
  • Historically, shigellosis has predominantly affected young children (age 1-4 years) in the United States. (cdc.gov)
  • The median age of patients was 42 years (range 1-83 years). (cdc.gov)
  • Participants had a mean age of 46.5 years and 66.1% were women. (who.int)
  • Here we collected the blood samples from 18 healthy donors (HD) and 38 COVID-19 patients to analyze changes in the adaptive immune cell populations and phenotypes. (medrxiv.org)
  • Obesity , muscle mass or heart failure functional classes were not associated with age categories. (bvsalud.org)
  • Rejuvenation therapies aim to reverse or repair age-related cellular changes such as molecular waste, calcification , tissue stiffening , loss of stem cell function , genetic alterations, and impaired energy production . (fightaging.org)
  • In light of recent research indicating hyperexcitability could be a predictive marker of cognitive dysfunction, we further argue that the hyperexcitability phenotype could be leveraged to improve the diagnosis and treatment of AD, and present potential targets for future AD treatment development. (nature.com)
  • Rowe and Kahn defined successful aging to include a low level of disability, having high cognitive and functional capacity, and actively engaging in life events [ 9 ]. (springer.com)
  • They also emphasize the value of cardiovascular magnetic resonance (CMR) imaging in the "diagnosis, screening, monitoring, and prognostication" for patients of all ages, according to Kaski. (medscape.com)
  • However, the parameters in COVD-19 patients remained unchanged across various age groups. (medrxiv.org)
  • All patients of childbearing age undergo history as well as urine pregnancy test as a standard of care prior to undergoing endoscopy as the procedure is performed under anesthesia. (mayo.edu)
  • Police who react to a random black male behaving suspiciously who might be in the critical age range as though he is an near-imminent lethal threat, are being rational , not racist. (ibiblio.org)
  • Although PCP can occur at any age, among children it is most commonly diagnosed between 3- 6 months of age (Figure 1). (cdc.gov)
  • Additionally, sugar transporters responsible for hyper-absorptive phenotype represent potential targets for future drugs that could provide an alternative approach to BS. (mayo.edu)
  • Identification of Asthma Phenotypes in the Spanish MEGA Cohort Study Using Cluster Analysis. (harvard.edu)
  • however, animal and cell models have provided insights into some of the factors involved in this phenotype. (nature.com)
  • This year we have an incredibly exciting program with global thought-leaders sharing their latest insights into aging and how we target aging process ensuring everyone lives a healthier and longer life. (fightaging.org)
  • Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. (mayo.edu)
  • There is need for new and/or innovative approaches to promoting health as individuals' age, and for public health programs to be a proactive blessing and not an archaic status quo 'eat your vegetables' mandate. (springer.com)
  • If you restrict to males in the age range that concentrates criminal behavior, the numbers work out to a black suspect being a a more likely homicidal threat to cops and public safety by at least 26:1. (ibiblio.org)