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  • abnormal
  • The diagnosis of CLL is based on the demonstration of an abnormal population of B lymphocytes in the blood, bone marrow, or tissues that display an unusual but characteristic pattern of molecules on the cell surface. (wikipedia.org)
  • tissues
  • Leukemias and lymphomas both belong to a broader group of tumors that affect the blood, bone marrow, and lymphoid system, known as tumors of the hematopoietic and lymphoid tissues. (wikipedia.org)
  • Clonal hypereosinophilia, also termed Primary hypereosinophelia or clonal eosinophilia, is a grouping of hematological disorder characterized by the development and growth of a pre-malignant or malignant population of eosinophils, a type of white blood cell, in the bone marrow, blood, and/or other tissues. (wikipedia.org)
  • The expanding population of eosinophils, initially formed in the bone marrow may spread to the blood and then enter into and injure various tissues and organs. (wikipedia.org)
  • Some hematological malignancies exhibit increased numbers of circulating blood eosinophils, increased numbers of bone marrow eosinophils, and/or eosinophil infiltrations into otherwise normal tissues. (wikipedia.org)
  • lymphoma
  • Therapy for aggressive non-Hodgkin lymphoma (NHL) has evolved significantly in the last 30 years. (medscape.com)
  • You will learn about the different treatments doctors use for people with this type of lymphoma. (cancer.net)
  • Human T-cell lymphotropic virus type 1 or human T-lymphotropic virus type 1 (HTLV-I), also called the adult T-cell lymphoma virus type 1, is a retrovirus of the human T-lymphotropic virus (HTLV) family that has been implicated in several kinds of diseases including very aggressive adult T-cell lymphoma (ATL), HTLV-I-associated myelopathy, uveitis, Strongyloides stercoralis hyper-infection and some other diseases. (wikipedia.org)
  • eosinophils
  • These aberrant lymphocytes function abnormally by stimulating the proliferation and maturation of bone marrow eosinophil-precursor cells termed colony forming unit-Eosinophils or CFU-Eos. (wikipedia.org)
  • anemia
  • In some individuals, the disease comes to light only after the cancerous cells overwhelm the bone marrow resulting in anemia producing tiredness or weakness. (wikipedia.org)
  • Some types of anemia are named for the factors causing them: poor diet ( nutritional anemia ), excessive blood loss ( hemorrhagic anemia ), congenital defects of hemoglobin ( hypochromic anemia ), exposure to industrial poisons, diseases of the bone marrow ( aplastic anemia and hypoplastic anemia ), or any other disorder that upsets the balance between blood loss through bleeding or destruction of blood cells and production of blood cells. (thefreedictionary.com)
  • Infiltration of the bone marrow may cause pallor from anemia. (wikipedia.org)
  • therapy
  • The treatment is subsequently tailored according to stage or bulk of disease and response to therapy. (medscape.com)
  • Most recently Dr Moore has been studying the cancer stem cell in lung cancer and ovarian cancer and has developed some novel methods for growing human cancer stem cells in vitro allowing extensive molecular analysis and identification of targets for therapy designed to eliminate this rare cell population that is responsible for aggressive tumor growth and relapse. (wikipedia.org)
  • Mertelsmann is known for his scientific works in the fields of hematology, oncology, gene therapy and stem cell transplantation. (wikipedia.org)
  • diseases
  • Parvovirus B19 inhibits erythropoiesis by lytically infecting RBC precursors in the bone marrow and is associated with a number of different diseases ranging from benign to severe. (wikipedia.org)
  • cells
  • 89 Zr-labeled bone marrow cells (2 × 10 7 cells, 16.6 kBq/10 6 cells) were transferred intravenously, and serial microPET images were obtained ( n = 5). (aacrjournals.org)
  • Transferred bone marrow cells rapidly migrated to the bone marrow, spleen, and liver ( n = 5). (aacrjournals.org)
  • Mobilization of approximately 0.64% of pretransplanted bone marrow cells induced a 3.8-fold increase of circulating bone marrow cells. (aacrjournals.org)
  • 89 Zr-oxine complex ex vivo cell labeling combined with PET imaging has shown promise as a sensitive method of tracking transferred bone marrow cells. (aacrjournals.org)
  • A: The three major types of blood cells are produced in the bone marrow and include red blood cells (RBCs) that carry oxygen, white blood cells (WBCs) that fight infection and platelets that help the blood clot to prevent excessive bleeding. (tauntongazette.com)
  • The crowding that results from such cells makes the bone marrow unable to produce healthy blood cells. (wikipedia.org)
  • In myeloid or myelogenous leukemias, the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (wikipedia.org)
  • Bone marrow suppression also known as myelotoxicity or myelosuppression, is the decrease in production of cells responsible for providing immunity (leukocytes), carrying oxygen (erythrocytes), and/or those responsible for normal blood clotting (thrombocytes). (wikipedia.org)
  • Instead, the drugs affect new blood cells that are being made by the bone marrow. (wikipedia.org)
  • Because the bone marrow is the manufacturing center of blood cells, the suppression of bone marrow activity causes a deficiency of blood cells. (wikipedia.org)
  • These predictive in-vitro assays reveal effects the administered compounds have on the bone marrow progenitor cells that produce the various mature cells in the blood and can be used to test the effects of single drugs or the effects of drugs administered in combination with others. (wikipedia.org)
  • Such stem cell transplants give a faster recovery of white blood cells, platelets and red cells than seen with conventional bone marrow transplantation. (wikipedia.org)
  • Duplicated segments of the LMO1 gene within neuroblastoma tumor cells have been shown to increase the risk of developing an aggressive form of the cancer. (wikipedia.org)
  • doses
  • Clinical trials can test a new drug, a new combination of standard treatments, or new doses of standard drugs or other treatments. (cancer.net)
  • Early research in bone marrow transplantation by E. Donnall Thomas and colleagues demonstrated that this process of splitting TBI into multiple smaller doses resulted in lower toxicity and better outcomes than delivering a single, large dose. (wikipedia.org)
  • diagnosis
  • Although there have been many advances in the treatment of Hodgkin's disease, diagnosis of the disease still rests on the identification of the Reed-Sternberg cell. (cancernetwork.com)
  • HealthTap does not provide medical advice, diagnosis, or treatment. (healthtap.com)
  • Although molecular markers and genetic rearrangements can be used to aid in diagnosis, histology alone can be insufficient and clinical course is often used to determine diagnosis and treatment [ 3 , 4 ]. (hindawi.com)
  • It tends to be aggressive, difficult to treat, and is often metastatic at the time of diagnosis. (wikipedia.org)
  • tumor
  • Rare but characteristic presentations include transverse myelopathy (tumor spinal cord compression, 5% of cases), treatment-resistant diarrhea (tumor vasoactive intestinal peptide secretion, 4% of cases), Horner's syndrome (cervical tumor, 2.4% of cases), opsoclonus myoclonus syndrome and ataxia (suspected paraneoplastic cause, 1.3% of cases), and hypertension (catecholamine secretion or renal artery compression, 1.3% of cases). (wikipedia.org)
  • genetic
  • However, many of the clonal hypereosinophilias are distinguished from these other hematological malignancies by the genetic mutations which underlie their development and, more importantly, by their susceptibility to specific treatment regiments. (wikipedia.org)
  • vitro
  • The effect of 89 Zr-oxine labeling on bone marrow cell viability and differentiation was evaluated in vitro . (aacrjournals.org)
  • In-vitro colony forming cell (CFC) assays using normal human bone marrow grown in appropriate semi-solid media such as ColonyGEL have been shown to be useful in predicting the level of clinical myelotoxicity a certain compound might cause if administered to humans. (wikipedia.org)
  • In 1980-82 his group first identified (and provided an in vitro assay for) the human mesenchymal stem cell - the precursor of bone, cartilage, adipose tissue and smooth muscle. (wikipedia.org)
  • Cancer Research
  • 2011: Lifetime Achievement Award, Cancer Research and Treatment Fund 2013: The C. Chester Stock Award, (Memorial Sloan-Kettering Cancer Center) Dr Moore received his Bachelor of Medicine degree in 1963 and his Doctor of Philosophy degree in 1967 from the University of Oxford. (wikipedia.org)
  • procedure
  • Oocyte cryopreservation use to be a procedure saving the fertility of women suffering the side effects of cancer treatment. (conceivingconcepts.com)
  • Neither the owners or employees of ConceivingConcepts.com nor the author(s) of site content take responsibility for any possible consequences from any treatment, procedure, exercise, dietary modification, action or application of medication which results from reading this site. (conceivingconcepts.com)
  • prognosis
  • Early studies suggesting that mediastinal large-cell lymphomas were unusually aggressive, with a poorer prognosis than other large-cell lymphomas, 2-4 have been contradicted by more recent reports. (bloodjournal.org)
  • Biopsy
  • Rare missense and other loss of function mutations in ETV6 cause thrombocytopenia 5, an autosomal dominant familial disease characterized by variable thrombocytopenia (blood platelet counts from 5% to 90% of normal), mild to modest bleeding tendencies, and bone marrow biopsy findings of abnormal appearing megakaryocytes (i.e. nuclei with fewer than the normal number of lobulations) and red cell macrocytosis. (wikipedia.org)
  • tumor cells
  • At experiment termination, several distinct endpoints can be measured, such as size and molecular characterization of the primary tumor, the presence and quantification of circulating tumor cells in the blood and bone marrow, and formation of metastasis to the lung. (jove.com)
  • systemic
  • Systemic therapy is often used in conjunction with other modalities that constitute local therapy (i.e. treatments whose efficacy is confined to the anatomic area where they are applied) for cancer such as radiation therapy, surgery or hyperthermia therapy. (wikipedia.org)
  • corticosteroids
  • Long term treatment with corticosteroids lowers blood eosinophil levels as well as suppresses and prevents complications of the disease in >80% of cases. (wikipedia.org)
  • Current treatment focuses on general wound healing and administering corticosteroids, which has not demonstrated a high success rate. (wikipedia.org)
  • disease
  • Treatment continues in the absence of disease progression or unacceptable toxicity. (clinicaltrials.gov)
  • There are an array of clinical variants of the disease, ranging from the asymptomatic monoclonal gammopathy of undetermined significance (MGUS) and smouldering MM, to the more aggressive active MM and plasma cell leukaemia. (biomedcentral.com)
  • Treatment repeats every 21 days for up to 2 years in the absence of disease progression or unacceptable toxicity. (knowcancer.com)
  • Disease spread has been linked to land use,landscaping and agricultural practices as the aggressive use of land for various purposes is extending the reach of infectious agents,allowing colonization in new areas thus increasing spread of infection. (blogspot.com)
  • Stem cell transplantation may be used if the disease recurs following standard treatment. (wikipedia.org)
  • cell
  • However, studies suggest that Leydig cell dysfunction may be observed following treatment with alkylator-based regiments. (euroformhealthcare.biz)
  • Other genetic manipulation studies in mice indicate that the gene is required for the development and maintenance of bone marrow-based blood cell formation and the vascular network. (wikipedia.org)
  • It is the terminal stage and most aggressive form of these dyscrasias, constituting 2% to 4% of all cases of plasma cell malignancies. (wikipedia.org)
  • At Freiburg University Medical Center he became the director of the Department for Medicine I, Oncology, Hematology and Stem Cell Transplantation. (wikipedia.org)
  • In 1980-82 his group first identified (and provided an in vitro assay for) the human mesenchymal stem cell - the precursor of bone, cartilage, adipose tissue and smooth muscle. (wikipedia.org)
  • cancer treatment
  • In 1965, the NCI created an intramural program in the Division of Cancer Treatment (DCT) located at the U.S. Public Health Service (USPHS) Hospital in Baltimore. (wikipedia.org)
  • Radiation
  • UM Radiation oncology physicists developed direct aperture optimization (DAO), an IMRT planning technique that dramatically reduces treatment time. (wikipedia.org)