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  • coagulation
  • When endothelial injury occurs, the endothelial cells stop secretion of coagulation and aggregation inhibitors and instead secrete von Willebrand factor which initiate the maintenance of hemostasis after injury. (wikipedia.org)
  • induce
  • In RISTOlow, the ristocetin concentration is just 0,2 mg/ml, and at a level that does not normally induce a strong aggregation response. (wikipedia.org)
  • promote further aggregation
  • these metabolites act as autocrines by feeding back to promote further aggregation of their cells of origin and as paracrines by recruiting nearby platlets into the response as well as exerting effects on other nearby tissues such as contracting blood vessels. (wikipedia.org)
  • contraction
  • Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves activation of Ca2+ entry and Ca2+sensitization: Rho-associated kinase-mediated phosphorylation of MYPT1 at Thr-855 but not Thr-697" (PDF). (wikipedia.org)
  • Eicosanoids
  • Thromboxane is a member of the family of lipids known as eicosanoids. (hmdb.ca)
  • These E,Z,E PUFA are 20- to 100-fold stronger in inhibiting human platelet aggregation than two mono-hydroxyl-containing eicosanoids, 5-HETE and 12-HETE, which contain an E,Z conjugated double bond configuration. (wikipedia.org)