• It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (wikidoc.org)
  • Also known as phytoestrogens, these compounds are structurally similar to the hormone estrogen, and they interact with estrogen receptors in the body. (ucdavis.edu)
  • Phytosterols (PS) are bioactive compounds widely distributed in nature and are similar to cholesterol in structure and function. (researchgate.net)
  • Increasing regulatory restrictions and consumer negative response to chemical compounds and to the use of antibiotics in agriculture have contributed to the pressure for the development of alternative compounds for use as antimicrobial agents [ 6 ]. (hindawi.com)
  • MER-25, a simple triphenylethanol derivative, is closely related structurally to the triphenylethylene (TPE) group of SERMs, which includes clomifene and tamoxifen. (wikipedia.org)
  • Lovastatin is structurally similar to the HMG, a substituent of the endogenous substrate of HMG-CoA reductase. (pharmfair.com)
  • Lovastatin is a cholesterol-lowering agent that belongs to the class of medications called statins. (pharmfair.com)
  • Like mevastatin, lovastatin is structurally similar to hydroxymethylglutarate (HMG), a substituent of HMG-Coenzyme A (HMG-CoA), a substrate of the cholesterol biosynthesis pathway via the mevalonic acid pathway. (pharmfair.com)
  • Lovastatin differs structurally from mevastatin by a single methyl group at the 6' position. (pharmfair.com)
  • However, the receptor is structurally similar to other enzymes within the CDK family, therefore increasing the likelihood of off-target effects. (technologynetworks.com)
  • As enzymes are specific biological catalysts, they should make the most desirable therapeutic agents for the treatment of metabolic diseases. (infinitabiotech.com)
  • A majority of enzymes are used as therapeutic agents. (infinitabiotech.com)
  • Using X-ray crystallography to view Anf3's structure at an atomic resolution, the team saw that it was similar to a family of oxygen-reducing enzymes. (asbmb.org)
  • This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. (wikidoc.org)
  • However, fluvastatin is structurally distinct and has a different biopharmaceutical profile (eg, no active metabolites, extensive protein binding, minimal CSF penetration). (medscape.com)
  • however, consumption of soy protein-rich foods may indirectly reduce heart disease risk if it serves as a substitute for animal protein, which contains saturated fat and cholesterol while soy does not (5). (ucdavis.edu)
  • Lp(a) is structurally similar to plasminogen , the protein that dissolves blood clots, and so it acts as competitive inhibitor against fibrinolysis. (medscape.com)
  • In a study in the Journal of Biological Chemistry , researchers in the U.K. biochemically and structurally characterized a protein that might protect nitrogenases from oxygen inactivation. (asbmb.org)
  • Winstrol also carries a few traits similar to many Muscle Building Supplements in its ability to promote protein synthesis, nitrogen retention, increases red blood cell count and reducing glucocorticoid hormones in the body. (dynamicsportsnutrition.com)
  • Treatment for isolated low HDL cholesterol levels is reserved mostly for individuals with established coronary heart disease (CHD) and for patients with risk factors for CHD. (medscape.com)
  • For example, the pro-drug compactin is catalysed by cytochrome oxidase to form pravastatin, which is a treatment of cholesterol-related diseases. (infinitabiotech.com)
  • Bouic 2001 In the 1950s, it was noted that these sterols lower serum cholesterol concentrations by reducing the absorption of cholesterol from the gut. (drugs.com)
  • These oxylipins have been previously described in an array of plant-based foods with similar concentrations as phenolics in some fruits and vegetables. (researchgate.net)
  • However, when no statin use was reported, 42.4% of the samples had detectable levels of statins, with a similar range of concentrations as the samples from the self-reported statin users. (cdc.gov)
  • This review paper will focus on the plant-derived products as antimicrobial agents for use in food preservation and to control foodborne pathogens in foods. (hindawi.com)
  • Antimicrobial agents have been predominantly isolated from bacteria and fungi and either produced through fermentation or produced chemically [ 1 ]. (hindawi.com)
  • a plant biomimetic active compound, structurally similar to cholesterol, which offers a soothing effect on the skin (anti-inflammatory tested in vitro). (lakshmi.it)
  • as an anti-estrogen, an HDL (good) cholesterol-supporting drug, and as a testosterone-stimulating compound. (professionalmuscle.com)
  • Although it is not a synthetic compound, turkesterone is structurally similar to steroid hormones, which may contribute to its powerful effects. (zshare.net)
  • Fibric acid antilipemic agent that lowers LDL cholesterol more effectively than do older fibrates (ie, clofibrate, gemfibrozil). (medscape.com)
  • This agent increases plasma catabolism and the clearance of TG-rich particles by lipoprotein lipase induction and the suppression of the hepatic production of apo C-III through the activation of PPARs. (medscape.com)
  • All the phytoceramides ("Phyto" means plants) improved the recovery rate of the damaged stratum corneum and enhanced hydration as they have a similar lipid structure to the ceramides found in our skin. (keyaseth.in)
  • They are structurally related and specifically classified as selective estrogen receptor modulators (SERMs) with mixed agonistic and antagonistic properties. (professionalmuscle.com)
  • According to NCEP ATP III guidelines, the primary goal of therapy is to lower low-density lipoprotein (LDL) cholesterol levels. (medscape.com)
  • These medications usually lower low-density lipoprotein (LDL) cholesterol levels. (medscape.com)
  • In addition, they sometimes lower triglyceride (TG) levels and may modestly elevate high-density lipoprotein (HDL) cholesterol levels. (medscape.com)
  • Beta-sitosterol has been used to lower low-density lipoprotein (LDL) cholesterol and improve symptoms in mild to moderate benign prostatic hypertrophy (BPH). (drugs.com)
  • The classic pathway is the predominant pathway, with the first and rate-limiting reaction catalyzed by a cytochrome P450 enzyme, cholesterol 7 α -hydroxylase (CYP7A1). (aspetjournals.org)
  • Outside of performance enhancement, Winstrol has enjoyed a high level of success as a therapeutic agent. (dynamicsportsnutrition.com)
  • Biased agonists might represent a novel and uniquely effective type of therapeutic agent with reduced side-effects. (cas.cz)
  • PT-141 is structurally similar to the biosynthetic peptide hormone Melanotan II, but has shown to be a potent binding agent of MC3 and MC4 only, showing no affinity for MC1. (extremepeptides.com)
  • Most contraceptive drugs in preclinical development target the sex hormone testosterone, which can lead to adverse side effects including depression, weight gain and increased cholesterol levels. (technologynetworks.com)
  • Directly, this is a structurally altered form of the DHT hormone possessing two specific structural changes. (dynamicsportsnutrition.com)
  • Polypharmacology (one drug with multiple molecular targets) is viewed as an attractive strategy for identifying novel mechanisms of a drug and then rationally designing more-effective next-generation therapeutic agents. (oncotarget.com)
  • Plant sterols are potentially atherogenic, like cholesterol, but atherogenesis does not occur because very little of the plant sterol is absorbed (approximately 5% of beta-sitosterol). (drugs.com)
  • Lp(a) is similar to its more well-known atherogenic cousin LDL. (medscape.com)
  • Another meta-analysis that included patients with established cardiovascular disease showed similar results. (medscape.com)
  • They contribute to the decrease of cardiovascular diseases, which are associated with high‐cholesterol consumption. (researchgate.net)
  • Melanotan II and Melatonan I, both synthetic analogues of α-MSH, produce similar effects in terms of skin tanning by binding the MC1 receptor 9 , though Melanotan II is unique in this family of agents in that it stimulates an aphrodisiac effect (MC3 and MC4), improving libido significantly in test subjects. (extremepeptides.com)
  • The agent, also known as mevinolin, was isolated from the fungi Aspergillus terreus . (pharmfair.com)
  • They are morphologically similar to fungi but have no close phylogenetic relationship to them. (lookformedical.com)
  • Law 2000 Because of this structural similarity, beta-sitosterol can replace cholesterol in the human body. (drugs.com)
  • The hydrolyzed lactone ring mimics the tetrahedral intermediate produced by the reductase allowing the agent to bind to HMG-CoA reductase with 20,000 times greater affinity than its natural substrate. (pharmfair.com)
  • We recommend, in conjunction with lifestyle and dietary changes, taking 2-3 tablets daily of plant sterols if you wish to lower cholesterol, and assessing effectiveness over 2-3months. (naturesbest.co.uk)
  • A 1-year study in healthy patients consuming 1.6 g/day of plant sterols contained in a dietary spread demonstrated cholesterol-lowering effects as well as general tolerability with long-term consumption. (drugs.com)
  • It can be separated from the yolk for cooking or to avoid the high fat and high cholesterol content of the yolk. (w8mdspa.com)
  • Transplantation tolerance could eliminate many of the adverse events associated with immunosuppressive agents. (medscape.com)
  • Organisms, biological agents, or biologically-derived agents used strategically for their positive or adverse effect on the physiology and/or reproductive health of other organisms. (lookformedical.com)
  • The distribution of lead appears similar across routes of exposure. (cdc.gov)
  • The effects of lead are similar across inhalation and oral routes of exposure. (cdc.gov)
  • The goal of this minireview is to provide an update on the regulation of bile acid (BA) homeostasis by the nuclear receptor Farnesoid X receptor (FXR) and the effects on this regulation by exposure to environmental or therapeutic agents. (aspetjournals.org)
  • Exposure to foreign antigens, such as an infectious (bacterial or viral) or toxic agent, may be the instigating event. (msdmanuals.com)
  • Fortified margarines used for lowering cholesterol contain 2 g of plant sterols per daily portion. (drugs.com)
  • Davidson 2001 Beta-sitosterol is the most common plant sterol and is structurally similar to cholesterol. (drugs.com)
  • Plant oils and plant extracts have been utilized for thousands of years, serving many purposes, such as food preservatives and medical therapeutic agents [ 2 ]. (hindawi.com)
  • We found that sorafenib may act as a histone deacetylase (HDAC) inhibitor based on similar gene expression profiles. (oncotarget.com)
  • Cholesterol has been found to co-crystallize with a number of GPCRs. (cas.cz)
  • Melanotan II has demonstrated great efficacy in reducing caloric intake, while eliminating cholesterol and fat stores in obese mice through its targeted metabolic action 8 . (extremepeptides.com)
  • As long as the gene in question doesn't have any pleiotropic effects, (ie, it doesn't also affect an important confounder, such as blood pressure or diabetes risk), people with allele A or allele B should be similar in every other respect. (medscape.com)
  • Up to now, many kinds of antidiabetic medicines have been developed for the patients and most of them are chemical or biochemical agents aiming at controlling or/and lowering blood glucose to a normal level. (gotomydoctor.com)
  • But it might help lower cholesterol and control blood sugar. (medlineplus.gov)
  • A few years later, von Euler of Sweden independently discovered similar effects of human seminal fluid on smooth muscle tissue. (medscape.com)
  • Stimulant drugs whose effects are very similar to cocaine. (w8mdspa.com)
  • Limonene has a strong, citrusy aroma and is used in a wide range of products from cleaning agents to cosmetics. (celignis.com)
  • Ceramide ingredients function primarily as skin & hair conditioning agents miscellaneous in cosmetics. (keyaseth.in)
  • Unlike other agents that have an effect on erectile response, Melanotan II performs no action on the vascular system, but rather induces arousal and heightens sexual desire via the nervous system - binding important receptors in the brain 10 . (extremepeptides.com)
  • The heart rate immediately before and 1, 2, 3, 6 and 24 h after 10 versus 40 g / kg granisetron administration were to each other Similar and has entered within the normal range for age, granisetron 40 g / kg Born, a statistically significant decrease in mean heart rate after 1 h after infusion, then returned to baseline. (cd177signaling.com)
  • Evidence suggests that COX-1 and COX-2 are similar in structure and function but that they exist as 2 distinct enzymatic entities. (medscape.com)
  • Isoflavones have been associated with lowering total and LDL cholesterol, and increasing HDL cholesterol, reducing LDL oxidation, and improving vascular function, possibly reducing the risk of coronary artery disease (3-5). (ucdavis.edu)
  • In addition to its promotion of skin tanning, Melanotan II has been shown to be a lipolytic (fat cell-destroying) agent 5 , a suppressant of appetite 6 , and a stimulant of libido in animal test subjects 7 . (extremepeptides.com)
  • Especially, trehalose synthase only reacts with maltose and converts it to trehalose, which is used as a food additive and biological agent. (infinitabiotech.com)
  • Our current experiments show that membrane cholesterol specifically binds to a muscarinic receptor and slows down their activation. (cas.cz)
  • They are also used by many cultures as flavoring agents and as natural preservatives in food. (hindawi.com)
  • Extensive research has been carried out to understand breast carcinogenesis, and to develop new-targeted therapeutic agents and biomarkers to improve patient outcomes. (biomedcentral.com)
  • The structure of clomifene is similar to that of its predecessor, MER-25. (wikipedia.org)
  • Activity of opioid receptor (OR) is among others modulates by monovalent cations especially by sodium (Na+) and lithium (Li+) which atomic radius is very similar to those of sodium. (cas.cz)
  • Due to the common use of calcium sulfate as the curdling agent, tofu can also be a good source of calcium. (ucdavis.edu)
  • and traditional paradigms, such as HDL-C being the "good" cholesterol , have not survived rigorous testing. (medscape.com)
  • The drug, a derivative of the cholesterol-lowering agent triparanol (MER-29) (which itself was derived from the estrogen chlorotrianisene (also known as TACE)), was originally being studied in animals at Merrell Dow as a treatment for coronary artery disease. (wikipedia.org)
  • Their current application in oncology has revolutionized cancer treatment by improving the antitumor activity of several chemotherapeutic agents. (mdpi.com)
  • Astaxanthin Structurally similar to beta-carotene, 3 astaxanthin has tremendous antioxidant activity. (photonuriacastilla.com)
  • This cluster includes a pseudogene, CYP3A5P1 , which is very similar to CYP3A5 . (wikidoc.org)
  • histopathology is similar in humans and animals and includes intranuclear inclusion bodies, swollen mitochondria, and tubular damage. (cdc.gov)
  • And for cholesterol, well, most bodybuilders unfortunately pay little attention to this important issue, so by way of disinterest, another easy opinion to discuss. (professionalmuscle.com)