Profound blockiEffectsAntimicrobial agentsAnti-inflammatoryDownstreamBiologicalMechanismsSelectiveAnticancer agentImmune systemMechanismEffectAntifungalAntipsychoticInfectious agentsTherapeutic agentColorlessActivityMoodDerivativeMicrobialHumansSodiumPotentialControlChemOrganSlowlyChronicInfluence uponClinicalAntibioticsChemicalContaminationPeopleSignificantlyPropertiesHumanHighlyAgricultureCellsDoseAIDSTreatmentDirectSymptomsDiseasesMainMakesTreatHelpsSkinNormal

Profound blocki1

• Antocholinergic agents in particular exert a profound blocking effect on this extract. (cdc.gov)

Effects14

• Antihypertensive agents may, even within the same class, exert variable effects on arterial stiffness variables. (nih.gov)
• Aliskiren exerts similar effects on markers of arterial stiffness as quinapril. (nih.gov)
• In this study, we use cutting edge technologies to understand the mechanisms by which punicalagin exerts its biological effects. (usda.gov)
• Rutin exerts antitumor effects on nude mice bearing SW480 tumor. (rain-tree.com)
• The effects of mediator modifying drugs, as well as an angiotensin converting enzyme inhibitor (captopril), a calcium channel blocking agent (TMB8) and capsaicin were tested. (cdc.gov)
• In addition to direct antimicrobial activity, macrolides also exert immune modifying effects 2 , 3 . (ersjournals.com)
• Flucytosine (25 mg/kg PO q6h) exerts its fungicidal effects on susceptible Candida and Cryptococcus species by interfering with DNA synthesis. (unboundmedicine.com)
• Glycerin also has the ability to easily diffuse into the surface layer of the skin, which allows it to easily exert its beneficial effects. (cetaphil.com)
• These data indicate that AST may be an effective chemotherapeutic agent in colon cancer treatment, and may also be used as an adjuvant in combination with other orthodox chemotherapeutic drugs to reduce the side-effects of the latter compounds. (spandidos-publications.com)
• Emotions, experienced in higher brain centers, may exert downstream effects on the PMC, which is why some people can experience incontinence with excitment or fear. (medscape.com)
• This agent exerts antisecretory and antimicrobial effects. (medscape.com)
• Nonetheless, the precise mechanisms through which APOE4 exerts its deleterious effects are yet to be determined. (lu.se)
• The selective serotonin/noradrenaline reuptake inhibitors and g abapentinoid agents may exert beneficial effects on vasomotor symptoms and quality of life, and numerous nonhormonal therapeutics are also available for osteoporosis. (medscape.com)
• Contact allergen-induced innate immunity contrast to irritant contact dermatitis (ICD), which evolves emollients may help reduce irritancy and stabilize the barrier as a consequence of direct toxic effects of physical or chemi- function of the skin avoiding the penetration of contact aller- cal agents resulting in keratinocyte damage and local inflam- gens. (cdc.gov)

Antimicrobial agents2

• The wide and increasing use of antimicrobial agents in humans and animals, and in agriculture, has exerted intense pressure for microorganisms to develop resistance which is rapidly becoming a leading cause of concern for public health. (who.int)
• It is used in combination with other antimicrobial agents. (medscape.com)

Anti-inflammatory1

• Novel triterpenoids and glycosides from durian exert pronounced anti-inflammatory activities. (nutraingredients.com)

Downstream1

• A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)

Biological1

• Facile synthesis and biological evaluation of novel symmetrical biphenyls as antitumor agents. (rain-tree.com)

Mechanisms1

• 2021). Consequently, there is a critical need to develop effective antifungal agents with unique structures and mechanisms of action targeting this pathogen. (researchsquare.com)

Selective3

• For these autoimmune disorders, the switch could be activated by specific infectious agents that trigger immune responses that are mediated by selective immunological pathways," he said. (scienceblog.com)
• Infections cause a lot of adaptation within the immune system, and could be exerting selective pressure in driving genomes to evolve, where the resulting disease risk or protection is more of a bystander," Hakonarson added. (scienceblog.com)
• Another approach is tissue selective estrogen complex (TSEC) agents. (medscape.com)

Anticancer agent2

• Linking glucose and anticancer agent presents an approach that exploits the Warburg effect. (oncotarget.com)
• A natural anticancer agent taspine targets human topoisomerase IB. (rain-tree.com)

Immune system1

• 2017). When the immune system is impaired, such as in AIDS patients, patients using immunosuppressive agents for an organ transplant, and patients with microbial flora disorders, C. albicans can readily become pathogenic (Wubulikasimu et al. (researchsquare.com)

Mechanism1

• The mechanism of this effect is complex and capable of being modulated by many mediator modifying agents. (cdc.gov)

Effect5

• There are some examples of coumarin natural products that exert antidiabetic effect [ 1 , 3 ]. (hindawi.com)
• In depressed individuals, amoxapine exerts a positive effect on mood. (genelabs.com)
• However, 5‑Aza‑CdR exerted no effect on p53 expression. (spandidos-publications.com)
• We conclude that WGE exerts a non-immunologic constrictor effect on guinea pig tracheal muscle. (cdc.gov)
• miRNAs are thought to exert a profound effect on almost every aspect of liver biology and pathology. (wjgnet.com)

Antifungal1

• Terbinafine (250 mg PO q24h for 6-12 wk) is an allylamine antifungal agent that kills fungi by inhibiting ergosterol synthesis. (unboundmedicine.com)

Antipsychotic1

• Amoxapine, the N -demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). (genelabs.com)

Infectious agents1

• Multiple studies have revealed that early-life exposure to environmental factors, pollutants or infectious agents impact AD development [3]. (lu.se)

Therapeutic agent4

• Our findings will be conducive to the optimization of the use of punicalagin as a therapeutic agent in the treatment and management of various disorders. (usda.gov)
• Our findings should facilitate the exploitation of dual applications of PA as a bioactive food ingredient and a therapeutic agent. (usda.gov)
• To the best of our knowledge, the present study is the first to report that the demethylation reagent 5‑Aza‑CdR may serve as a therapeutic agent in MM by upregulating MEG3 expression. (spandidos-publications.com)
• a process which can be reversed by 5-Aza-2'-deoxycytidine (5-Aza-CdR), suggesting a potential therapeutic agent for MM. The maternally expressed 3 (MEG3) imprinted gene is located on chromosome 14q32, which produces a non-coding RNA transcript ( 11 ). (spandidos-publications.com)

Colorless2

• G-type nerve agents (GA, GB, and GD) are clear, colorless liquids that are volatile at ambient temperatures. (cdc.gov)
• G-type agents are clear,colorless, and tasteless liquids that are miscible in water and most organic solvents. (cdc.gov)

Activity1

• In addition, autophagy interpheres with cell cycle progression, de facto exerting a cytostatic activity. (nature.com)

Mood1

• Carboxylic acid commonly used as antiepileptic drug, mood stabilizer in mania, and prophylactic agent for migraine. (medscape.com)

Derivative1

• Osthole, a coumarin derivative, reported as antidiabetic agent, alleviates hyperglycemia in db / db mice [ 3 ]. (hindawi.com)

Microbial1

• Microbial agents are thought to gain access to the lymph nodes via the intestinal lymphatics. (medscape.com)

Humans1

• The agents documented and list- ed that carcinogens commonly show tween tumour sites in humans and ed as carcinogenic to humans one or more of 10 key characteristics experimental animals. (who.int)

Sodium1

• An antiarrhythmic agent which exerts a potential- and frequency-dependent block of sodium channels. (harvard.edu)

Potential3

• Medicinal plants from Peru: a review of plants as potential agents against cancer. (rain-tree.com)
• Further large prospective and long-term studies are required in order to identify potential benefit and harm before these agents can be recommended routinely for these conditions. (ersjournals.com)
• In addition to the potential benefit, use of these agents also has the potential for harm. (ersjournals.com)

Control3

• no such people exerted control over us. (wikipedia.org)
• Cognitive control of micturition is achieved by communication from a number of brain structures to the periaqueductal gray matter, which then exerts control over the pontine micturition center to suppress or trigger a voiding reflex. (medscape.com)
• Thus, carcinogens nogenic are polycyclic aromatic hy- to induce DNA damage, it can be may act not only by producing DNA drocarbons and benzene, which by cal ed a genotoxicant or a genotox- damage directly but also by altering themselves are relatively inert chem- in, and if it is shown that the agent the processes that control normal ical y. (who.int)

Chem1

• Anticancer Agents Med, Chem. (rain-tree.com)

Organ1

• Itseems to have an especial affinity for the uterus, exerting a powerful tonicand alterative influence upon this organ, and has hence been found highlybeneficial in many uterine derangements, as in amenorrhoea some forms of dysmenorrhoea , menorrhagia , chronic congestion of the uterus,enfeebled uterine nervous system, etc. (healthy.net)

Slowly1

• The gospel influence in a culture works the same way: Christians within a culture act as agents of change, slowly transforming that culture from within. (gotquestions.org)

Chronic1

• 1] This process may be acute or chronic, depending on the causative agent, and it causes a clinical presentation that is often difficult to differentiate from acute appendicitis,[1, 2, 3] particularly in children. (medscape.com)

Influence upon1

• Binding to target proteins in plasma and peripheral tissues exerts a major influence upon broadening linagliptin distribution. (nih.gov)

Clinical1

• The field of synthesis and evaluation of sugar-conjugated anticancer agents has grown significantly in recent years, with certain compounds in advanced clinical trials [ 1 ]. (oncotarget.com)

Antibiotics1

• Macrolide antibiotics are used as first-line agents in the treatment of acute bacterial infections, such as community-acquired pneumonia 1 . (ersjournals.com)

Chemical4

• A Totally-Encapsulating Chemical Protective (TECP) suit that provides protection against CBRN agents. (cdc.gov)
• A hooded chemical-resistant suit that provides protection against CBRN agents. (cdc.gov)
• Nerve agents are the most toxic of the known chemical warfare agents. (cdc.gov)
• The classic examples of necessarily be processed by the cel replication fidelity can confer strong chemical agents that require met- into a mutation (see Chapter 12, by mutator phenotypes that result in ge- abolic activation to become carci- DeMarini). (who.int)

Contamination1

• This group exert big it influences in the family ambit, could act as agents multipliers and avoiding the child's precocious contamination. (bvsalud.org)

People1

• Government gathers information about people in a variety of ways, through a variety of agents. (encyclopedia.com)

Significantly1

• Peripheral and central systolic and diastolic BP, peripheral PP, and PWV were significantly and similarly reduced by all agents. (nih.gov)

Properties2

• Table 1 lists selected physical properties for each of the nerve agents. (cdc.gov)
• It also exerts cardioprotective properties by scavenging free radicals and reducing vascular oxidative stress. (purebulk.com)

Human1

• Rapid advances in synthetic biology are driving the development of genetically engineered microbes as therapeutic agents for a multitude of human diseases, including cancer. (nature.com)

Highly1

• and it exerts a highly favorableinfluence over spermatorrhea. (healthy.net)

Agriculture1

• Although related organophosphate chemicals are used in medicine, pharmacology, and agriculture, these are not as toxic as the nerve agents. (cdc.gov)

Cells1

• Conjugation of glucose with metabolic agents to selectively target cancer cells was inspired by the widespread use of radiolabeled glucose analog to visualize tumors and their metastases. (oncotarget.com)

Dose1

• Accordingly, the number of clinically significant drug-drug interactions associated with these agents is minimal, with only saxagliptin necessitating dose adjustment if administered concurrently with medications that strongly inhibit CYP3A4. (nih.gov)

AIDS1

• Glycerin is easily absorbed into the skin, which also aids its effectiveness as a moisturizing agent. (cetaphil.com)

Treatment2

• The standard of care for the treatment of GBM consists in maximal resection followed by radiotherapy and concomitant chemotherapy with the alkylating agent temozolomide (TMZ) 3 . (nature.com)
• This agent should not be used as monotherapy, apart from treatment of fluconazole-resistant Candida cystitis, because of risk for rapid emergence of resistance. (unboundmedicine.com)

Direct2

• Persons whose skin or clothing is contaminated with nerve agent can contaminate rescuers by direct contact or through off-gassing vapor. (cdc.gov)
• Examples of direct-acting elec- all have an impact on the outcome trophilic carcinogens are formalde- The term "genotoxic" refers to an of this proces s (Arana and Kunkel, hyde, sulfur mustard, and ethylene agent that induces DNA damage, 2010) . (who.int)

Symptoms1

• Pharmacologic agents are also available to treat women with severe symptoms," explained Dr Santen. (medscape.com)

Diseases1

• Author affi liations: National Institute of Public Health and the En- infectious diseases caused by bacterial pathogens. (cdc.gov)

Main1

• Around main agent for attacking insects. (who.int)

Makes1

• This property makes glycerin an excellent moisturizing agent, particularly in colder environments where skin dries more easily. (cetaphil.com)

Treat1

• The dried root of Astragalus membranaceus ( Radix Astragali ) has a long history of medicinal use in traditional Chinese medicine as an immunomodulating agent in mixed herbal decoctions to treat the common cold, diarrhea, fatigue and anorexia ( 4 ). (spandidos-publications.com)

Helps1

• Resveratrol helps to preserve the agents responsible for vasorelaxation, such as acetylcholine and nitric oxide. (purebulk.com)

Skin1

• Nerve agent liquids are readily absorbed from the skin and eyes. (cdc.gov)

Normal1

• In the medical setting a resistant organism is one which is not inhibited or killed by concentrations of an antimicrobial agent in normal doses. (who.int)