Age related diseases. Medical search. Frequent questions

What is Alzheimer's Disease? (cdc.gov)
Alzheimer's disease is the most common form of a group of brain diseases called dementias. (cdc.gov)
Alzheimer's disease accounts for 60% to 80% of dementia cases. (cdc.gov)
Alzheimer's disease, like all dementias, gets worse over time and there is no known cure. (cdc.gov)
Nearly 6 million Americans are living with Alzheimer's disease. (cdc.gov)
Alzheimer's disease destroys brain cells causing problems with memory, thinking, and behavior that can be severe enough to affect work, lifelong hobbies, and social life. (cdc.gov)
What is known about caregiving for a person with Alzheimer's disease or another form of dementia? (cdc.gov)
People with Alzheimer's disease and related dementias are usually cared for by family members or friends. (cdc.gov)
The majority (80%) of people with Alzheimer's disease and related dementias are receiving care in their homes. (cdc.gov)
Each year, more than 16 million Americans provide more than 17 billion hours of unpaid care for family and friends with Alzheimer's disease and related dementias. (cdc.gov)
Her insights, which predated the advent of precision medicine, formed the basis for research programs that are critical to personalized therapeutic care for Alzheimer's disease. (bio5.org)
Scientists continue to make great strides in identifying potential new ways to diagnose , treat , and even prevent Alzheimer's disease and related dementias. (nih.gov)
Nearly two dozen experimental therapies targeting the immune system are in clinical trials for Alzheimer's disease, a reflection of the growing recognition that immune processes play a key role in driving the brain damage that leads to confusion, memory loss and other debilitating symptoms. (worldhealth.net)
The findings, published on March 8 in the journal Nature , suggest that targeting T cells is an alternative route to preventing neurodegeneration and treating Alzheimer's disease and related diseases involving tau, collectively known as tauopathies. (worldhealth.net)
This could really change the way we think about developing treatments for Alzheimer's disease and related conditions," said senior author David M. Holtzman, MD, the Barbara Burton and Reuben M. Morriss III Distinguished Professor of Neurology. (worldhealth.net)
Before this study, we knew that T cells were increased in the brains of people with Alzheimer's disease and other tauopathies, but we didn't know for sure that they caused neurodegeneration. (worldhealth.net)
It's likely that some drugs that act on T cells could be moved into clinical trials for Alzheimer's disease and other tauopathies if these drugs are protective in animal models. (worldhealth.net)
She analyzed immune cells in the brains of mice genetically engineered to mimic different aspects of Alzheimer's disease in people, looking for changes to the immune cell population that occur over the course of the disease. (worldhealth.net)
T cells were similarly abundant at sites of tau aggregation and neurodegeneration in the brains of people who had died with Alzheimer's disease. (worldhealth.net)
Previously I have written about the roles of glia and microglia in Alzheimer's disease and in spinal cord injury. (anti-agingfirewalls.com)
This blog entry reports on recent research which documents the importance of glial pathology as a general underlying factor in essentially all age related neurodegenerative diseases including Alzheimer's Disease, Parkinson's Disease, advanced spinal degeneration, ALS, multiple sclerosis, and several retinal diseases. (anti-agingfirewalls.com)
In my February 2010 blog entry New views of Alzheimer's disease and new approaches to treating it , I cited evidence for the hypothesis that microglial cell senescence is probably a fundamental cause for AD, a cause upstream of beta amyloid plaque production and the setting in of tau tangles. (anti-agingfirewalls.com)
In the March 2011 blog entry Alzheimer's Disease Update I included a discussion on this hypothesis and on how with aging microglia lose their capability to get rid of beta amyloid via phagocytosis. (anti-agingfirewalls.com)
Recent findings associate AGEs with familial, early-onset and sporadic forms of Parkinson's disease, and with proteins linked to Alzheimer's disease. (northbayleadership.org)
It's also a timely question to ask, because in the past year, many promising Alzheimer's disease trials ended in failure. (drugtargetreview.com)

Radical-induced oxidative stress and inflammation can be modulated by Tempol (TP)-based nitroxide drugs to prevent or treat vascular, ocular, and other pathological conditions and aging associated disease. (frontiersin.org)
A transplant drug with anti-aging properties can regenerate bone and decrease gum inflammation, promising new treatments for common dental problems in aging patients, according to researchers at the University of Washington School of Dentistry . (dentistrytoday.com)
But until now, nobody has ever explored the effect of rapamycin in the aging mouth, where people also commonly experience age-related decline and diseases such as bone loss and gum inflammation leading to periodontal disease. (dentistrytoday.com)
A high ratio of omega-6 to omega-3 is associated with an increased risk of various health issues , including increased heart disease risk factors, metabolic syndrome, obesity and inflammation. (naturalnews.com)
Moreover, given the role gut microbiota plays in the induction and the maintenance of inflammaging (the inflammation associated with aging), microbiome variations could predispose to the development of several age-related diseases, such as osteoporosis, diabetes, cardiovascular diseases, dementia, and cancer. (bioinst.com)
Dis)Trust your gut: the gut microbiome in age-related inflammation, health, and disease. (bioinst.com)
Inflammation, Epigenetics, Aging, Epidemiology The population is aging worldwide not only due to gains in early-life survival but also due to progress with declining late-life mortality (1). (deepdyve.com)
This review also illustrates the potential role that mitochondrial health and inflammation play in the progression of age-related pathology. (nova.edu)
The AGEs cause chronic inflammation, make proteins lose their shape, and send our metabolism into a sugar burning state, making it hard to lose weight. (northbayleadership.org)
Our objectives were to characterise the microbiota in cystic fibrosis (CF) bronchoalveolar lavage fluid (BALF), and determine its relationship to inflammation and disease status. (ersjournals.com)
Progressive lung disease secondary to chronic airway infection and inflammation is the leading cause of morbidity and mortality in cystic fibrosis (CF) [ 1 ]. (ersjournals.com)
A molecular 'switch' that controls the immune machinery responsible for chronic inflammation has been identified which could help treat or even reverse the development of age-related conditions like Alzheimer's, Parkinson's, cancer and diabetes. (drugtargetreview.com)
Mice that were bred with a genetic mutation that prevented them from producing SIRT2 showed more signs of inflammation at old age than their normal counterparts. (drugtargetreview.com)

Canberra, Philadelphia and Manchester, Feb 20 2017 (IPS) - Old age is often characterised by poor health due to isolation, morbidities and disabilities in carrying out activities of daily living (DADLs) leading to depression. (ipsnews.net)

A new study found that cholesterol drugs and diabetes drugs may lessen the risk of age-related macular degeneration (AMD). (medicalnewstoday.com)
Age-related macular degeneration (AMD) is an eye condition characterized by deterioration of the central field of vision. (medicalnewstoday.com)
Nitroxide small molecule agents are in development as preventative or therapeutic pharmaceutical drugs for age-related macular degeneration (AMD) and cardiovascular disease, which are two major diseases of aging. (frontiersin.org)
For example, chronic exposure to cigarette tobacco smoke can cause and accelerate microvascular dysfunction in cardiovascular disease (CVD) and age-related macular degeneration (AMD). (frontiersin.org)
On the other hand, the disturbances in the proper HO-1 level are associated with the pathogenesis of some age-dependent disorders, including neurodegeneration, cancer or macular degeneration. (springer.com)
This review focuses on the effects of oxidative stress and the role of a particular antioxidant system-the Keap1-Nrf2-ARE pathway-on ocular diseases, specifically age-related macular degeneration, cataracts, diabetic retinopathy, and glaucoma. (hindawi.com)
Progression from a baseline status of no or mild lens opacity to at least moderate severity was analyzed and cumulative incidence estimated rates were calculated for each lens opacity type and cataract surgery stratified by age, sex, race, age-related macular degeneration category, multivitamin (Centrum) use and history of diabetes. (emmes.com)
What is age-related macular degeneration? (msdmanuals.com)
Age-related macular degeneration (AMD) is an eye disease that causes the macula to lose its normal structure (called degeneration). (msdmanuals.com)

Approximately two-thirds of dementia caregivers are women, about one in three caregivers (34%) is age 65 or older, and approximately one-quarter of dementia caregivers are "sandwich generation" caregivers, meaning that they care not only for an aging parent, but also for children under age 18. (cdc.gov)
June 30, 2022 Senescent cells -- those that have lost the ability to divide -- accumulate with age and are key drivers of age-related diseases, such as cancer, dementia and cardiovascular disease. (sciencedaily.com)
These criteria might include age, stage of dementia, gender, genetic profile, and whether or not you have a study partner who can accompany you. (nih.gov)
Alzheimer s disease (AD) is the most common form of dementia in the elderly and the number of patients with AD is estimated to double over the next 20 years. (neurodegenerationresearch.eu)
Patients with motor neuron disease (MND) are generally free of cognitive impairment, but evidence is growing to support an association between MND and frontal lobe or frontotemporal dementia (FTD). (medscape.com)
For patient education information, see the Brain and Nervous System Center , as well as Dementia Overview , Dementia Medication Overview , and Dementia in Amyotrophic Lateral Sclerosis (Lou Gehrig's Disease) . (medscape.com)
Worldwide, frontotemporal lobe dementia with motor neuron disease (FTD/MND) is a sporadic condition with an unknown etiology. (medscape.com)
Protein aggregation has been specifically implicated in a wide variety of aging-linked diseases, including Alzheimer's, Parkinson's, frontotemporal dementia, Huntington's disease and ALS (amyotrophic lateral sclerosis). (azolifesciences.com)

A new study in Science Translational Medicine suggests an FMD could have significant benefits for ageing-related diseases, reducing the risk of diabetes, cancer and heart disease. (cosmosmagazine.com)
Wei, Brandhorst and colleagues wanted to test the potential of the diet to affect factors associated with metabolic syndrome, a condition that often leads to heart disease and shortened life span. (cosmosmagazine.com)
The risk of developing age-related diseases, such as multiple sclerosis, heart disease and cancer, has been linked with faster 'biological' aging in an international study led by researchers at the University of Leicester. (medindia.net)
Professor Nilesh Samani, British Heart Foundation Professor of Cardiology at the University of Leicester and Director of the National Institute for Health Research (NIHR) Leicester Cardiovascular Biomedical Research Unit, who led the project said: "Although heart disease and cancers are more common as one gets older, not everyone gets them - and some people get them at an earlier age. (medindia.net)
When exposed to 'detrimental ' environments for telomeres - like smoking, obesity, or lack of exercise - they are likely to become even biologically older and consequently be more at risk of age-related diseases like heart disease and cancer. (medindia.net)
Studies show that these fatty acids can help prevent heart disease, heart attack and cancer, and help treat mood disorders like depression. (naturalnews.com)
In a 2019 review, researchers found that people who took omega-3 fish oil supplements had a lower risk of heart attack, death from coronary heart disease and other cardiovascular events than those who took a placebo. (naturalnews.com)
DNA methylation age predicts mortality independent of chronologic age and other risk factors (11,12) and is associated with some age-related conditions such as brain aging (13), but not with coronary heart disease (14). (deepdyve.com)
During the first half of the 20th century, the concept of beriberi heart disease (ie, thiamine deficiency) was present throughout the medical literature, and the idea that alcohol had any direct effect on the myocardium was doubted. (medscape.com)
Older patients have more pronounced anatomical changes and more severe functional impairment, and they are more likely to have additional health conditions not related to heart disease," said Damluji. (worldhealth.net)
This increased risk due to age is even higher than that seen in heart disease, stroke, cancer, and other leading causes of death. (agingresearch.org)
A fundamental habit for optimal health, longevity, and freedom from heart disease is regular physical activity. (worldhealth.net)
If women have other risk factors for heart disease, such as obesity, diabetes, autoimmune disorders, [or] pregnancy complications, or if they have parents with high blood pressure, their blood pressure should be measured every 1-2 years. (medicalnewstoday.com)
Depression is more common in people who also have other illnesses (such as heart disease or cancer) or whose function becomes limited. (cdc.gov)

Aging is the main risk factor for late-onset AD and several other neurodegenerative diseases, but it remains a mystery why AD largely strikes older adults. (neurodegenerationresearch.eu)
That same blog entry also cites publications arguing that, t o a considerable extent, aging-related neurodegenerative diseases appear to depend on the same underlying mechanisms. (anti-agingfirewalls.com)

Most interestingly, the authors found that in aggregate the seven variants also associated with risk of coronary artery disease which can lead to heart attacks. (medindia.net)
We had previous evidence that shorter telomere lengths are associated with increased risk of coronary artery disease but were not sure whether this association was causal or not. (medindia.net)
This research strongly suggests that biological ageing plays an important role in causing coronary artery disease, the commonest cause of death in the world. (medindia.net)

We are uniquely poised to conduct both basic and clinical research on the biology of aging and age- related brain diseases such as Alzheimer's, Parkinson's, and other neurological conditions. (bio5.org)
While there is a long way to go before any clinical application, there are data in experimental models where lengthening telomere length has been shown to retard and in some situations reverse age-related changes in several organs. (medindia.net)
Methods In Framingham Offspring participants at Exams 7 (1998-2001, mean age 62 ± 10) and 8 (2005-2008, mean age 67 ± 9), we used the Klemera-Doubal method to estimate clinical BA and inflammatory BA and computed the difference (∆age) between BA and CA. Clinical ∆age was computed at Exam 2 (1979-1983, mean age 45 ± 10). (deepdyve.com)
Given the complexity of the aging process, different measures of biologic aging (BA) and of successful aging have been constructed to better reflect an individual's rate of aging by combining clinical biomarkers representative of different physiologic systems (4-7). (deepdyve.com)
We had the opportunity to examine a measure of clinical BA over several time points in the adult life course in addition to inflammatory and DNA methylation age constructed in later adulthood in a large community-based sample under continuous surveillance. (deepdyve.com)
We hypothesized that different types of BA measures (clinical, inflammatory, and genomic) make unique contributions to age-related disease risk and all-cause mortality. (deepdyve.com)
Over the past decade it has become clear that AD is a multi-factorial disease and that changes take place in the brain many years before the first clinical symptoms. (neurodegenerationresearch.eu)
Ultimately, AC is a clinical diagnosis made in a patient presenting with a constellation of findings that includes a history of excessive alcohol intake, possible physical signs of alcohol abuse (eg, parotid disease, telangiectasia or spider angiomata, mental status changes, cirrhosis), heart failure, and supportive evidence consistent with DC . (medscape.com)
This may provide a basis for clinical characterization of memory deficits of ALS, which may be distinct from those of Alzheimer disease. (medscape.com)
The primary objective of this scoping review is to identify and summarize the clinical relevance of UA supplementation in the prevention of age-related pathology and diseases. (nova.edu)
Identifying the clinical relevance of UA supplementation in the prevention of age-related pathology and diseases will help further the focus of research on treatments that may improve the longevity and quality of life in patients at risk for these comorbidities. (nova.edu)
Kapahi says interest in the then red-hot field flagged when a drug designed to clear AGEs in diabetic kidney disease failed in clinical trials in 1998. (northbayleadership.org)
Distinguishing pathogenic bacteria that contribute to airway disease from commensal microbiota in sputum has proved challenging and remains an obstacle to clinical application of sequencing results [ 13 , 14 ]. (ersjournals.com)
Therefore, we retrospectively analyzed disease characteristics and clinical outcomes in 120 patients ≤ 45 years and 84 patients ≥ 65 years at diagnosis. (northwestern.edu)
Long-term incidence rates of type-specific cataract can be useful in designing clinical studies of age-related cataract. (emmes.com)
Common clinical sequelae of aging. (medlineplus.gov)
Heterozygotes usually do not manifest clinical features of the disease. (medscape.com)

Senescent cells accumulate with age and at sites of multiple chronic conditions, such as in fat tissue in diabetes, the lungs in chronic pulmonary diseases, the aorta in vascular disease, or the joints in osteoarthritis," says James Kirkland, M.D., Ph.D., director of the Robert and Arlene Kogod Center on Aging. (sciencedaily.com)
As people age, they tend to develop diseases such as heart failure, kidney failure, diabetes, and obesity, and the presence of any one disease increases the risk of developing others. (technologynetworks.com)
Scientists have recently begun to connect a wide variety of diseases, including diabetes and Parkinson's, among many others, to changes in the microbiota, but they do not yet know exactly what healthy microbiota look like. (technologynetworks.com)
They've long been implicated in insulin-resistant type 2 diabetes (which affects more than 29 million people in the U.S.) and are linked to its complications - diabetic nerve pain, retinopathy, cardiomyopathy, and kidney disease. (northbayleadership.org)
This, they say, could lead to new ways to halt or even reverse age-related conditions such as Alzheimer's, Parkinson's, cancer and diabetes. (drugtargetreview.com)
ABSTRACT This study aimed to evaluate the health-related quality of life (HRQOL) of Emirati people with diabetes and to explore the sociodemographic and disease-related variables affecting it. (who.int)
This study therefore aimed Data collection to fill the gap in knowledge about HR- To ensure a rigorous research process, Diabetes is a chronic disease and is a QOL of people with diabetes in the 5 trained research staff conducted face- public health concern worldwide. (who.int)

Centers for Disease Control and Prevention. (cdc.gov)
The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
The conclusions, findings, and opinions expressed by authors contributing to this journal do not necessarily reflect the official position of the U.S. Department of Health and Human Services, the Public Health Service, the Centers for Disease Control and Prevention, or the authors' affiliated institutions. (cdc.gov)

The Wolfson Centre for Age-Related Diseases (CARD) is based at the Guy's Hospital campus of King's College London, England. (wikipedia.org)
Professor Tim Spector from King's College London, who co-led the project added: "Our research over the last five years suggests that some people are genetically programmed to age at a faster rate. (medindia.net)

Nuclear factor erythroid-2-related factor 2 (Nrf2) is a transcription factor that is upregulated in times of oxidative stress. (hindawi.com)

The team says larger studies among patients with diagnosed diseases, or at particularly high-risk, will help confirm the benefits of FMDs on disease prevention and treatment. (cosmosmagazine.com)
Pharmaceutical nitroxide drug candidates for treatment and/or prevention of aging-related and smoking-related diseases are in various different stages of development. (frontiersin.org)
Urolithin A as a Potential Agent for Prevention of Age-Related Disease" by Breanne Kothe, Sarah Klein et al. (nova.edu)
Urolithin A as a Potential Agent for Prevention of Age-Related Disease: A Scoping Review. (nova.edu)
The work under this strategic objective focuses on prevention, early detection, diagnosis, treatment, control, elimination and eradication measures to combat communicable diseases that disproportionately affect poor and marginalized populations. (who.int)

The scientists found that the variants were indeed linked to risk of several types of cancers including colorectal cancer as well as diseases like multiple sclerosis and celiac disease. (medindia.net)
Other studies also support taking omega-3 fatty acids to prevent cardiovascular disease and cancer. (naturalnews.com)
However, if you notice a lump, make an appointment with your health care provider, because breast cancer risk increases with age. (medlineplus.gov)

To see the data online and access volumes on other chronic diseases of aging, visit www.silverbook.org . (agingresearch.org)
I think this finding has very important implications in treating major human chronic diseases," Chen continued. (drugtargetreview.com)

Researchers have uncovered three new agents to add to the emerging repertoire of drugs that aim to delay the onset of aging by targeting senescent cells - cells that contribute to frailty and other age-related conditions. (sciencedaily.com)
Cycles of a five-day FMD are safe, feasible, and effective in reducing risk factors for ageing and age-related diseases," the researchers write. (cosmosmagazine.com)
Also, even though the drug is approved for use in humans, the researchers must determine the optimum dosage for bone regeneration or microbiome de-aging, as well as the best mode of application. (dentistrytoday.com)
So how to get researchers excited about understanding and exploiting the biology of AGEs? (northbayleadership.org)
The researchers investigated possible links between mildly elevated blood pressure in middle age and acute coronary syndromes in 6,381 women and 5,948 men participating in Norway's Hordaland Health Studies . (medicalnewstoday.com)
In new research published Jan. 19 in Nature , researchers at Stanford University have traced this problem to age-dependent impairment of the machinery that produces new proteins. (azolifesciences.com)
To root out this issue, researchers in the lab of Judith Frydman, the Donald Kennedy Chair in the School of Humanities and Sciences at Stanford, focused on how age affects the functioning of ribosomes - the cellular machinery responsible for converting messenger RNA into proteins. (azolifesciences.com)
Amassing data from all the genes translated in young and aged Caenorhabditis elegans roundworms and yeast, the researchers noticed that in older cells ribosomes periodically moved more slowly and were more likely to stall and bump into each other. (azolifesciences.com)
As one might expect, the researchers saw that decreases in proper ribosome performance aligned with increases in the aging-dependent aggregation of misfolded proteins. (azolifesciences.com)
In follow-up experiments in worms, the researchers found that even if the overall fraction of newly made proteins with altered translation during aging is low (~10%), this small effect can still be enough to overwhelm the quality control system and trigger significant aggregation that can disrupt many different cellular components or processes. (azolifesciences.com)
Quality Of Life (OHRQOL) to serve as adjuncts for Researchers have defined an oral mucosal lesion measuring outcomes associated with (OML) as any abnormal alteration in colour, surface diseases/conditions. (who.int)

We have a long-standing interest in modeling Parkinson's disease (PD) using human iPSC and ESC-derived dopamine neurons. (mskcc.org)
We are particularly focused on improving the iPSC-based tools for modeling late-onset disorders such as Parkinson's disease using state-of-the-art genetic tools for gene repair, cell purification, and manipulation of cell maturation and age. (mskcc.org)
Background: Although housing accessibility is associated with important health outcomes in other populations, few studies have addressed this in a Parkinson's disease population. (lu.se)
Aim: To determine the most severe environmental barriers in terms of housing accessibility problems and how these evolved over 3 years among people with Parkinson's disease. (lu.se)
Conclusions and Significance: The new knowledge about how accessibility problems evolve over time could be used by occupational therapists to recommend more effective housing adaptations taking the progressive nature of Parkinson's disease into account. (lu.se)

In this webinar brought to you by The Scientist and Tecan, Cammie Lesser and Andrew Koh will discuss how they plan to manage disease by manipulating the microbiome. (the-scientist.com)

Fingolomid, for example, is commonly used to treat multiple sclerosis, which is an autoimmune disease of the brain and spinal cord. (worldhealth.net)

Well over half (57%) of family caregivers of people with Alzheimer's and related dementias provide care for four years or more. (cdc.gov)
Family caregivers of people with Alzheimer's and related dementias are at greater risk for anxiety, depression, and poorer quality of life than caregivers of people with other conditions. (cdc.gov)
Why participate in Alzheimer's and related dementias research? (nih.gov)
There are many reasons you might choose to participate in Alzheimer's and related dementias research. (nih.gov)

At the start of the study, when the average age of the participants was 41 years, 25% of the women and 35% of the men had stage 1 hypertension. (medicalnewstoday.com)
Baseline and annual lens photographs of participants, aged 55-80 years, were graded centrally for nuclear, cortical, and posterior subcapsular (PSC) lens opacities using the AREDS System for Classifying Cataracts. (emmes.com)

Microbiome composition is a good indicator of age . (bioinst.com)
The human microbiome is an intricate system, and its role in health and disease is currently under intense investigation. (the-scientist.com)
Altering the microbiome with beneficial organisms and editing the species that are already established holds promise for treating a variety of diseases. (the-scientist.com)

Several of the measures have been related to risk for mortality (4,6,7) and physical and cognitive decline (5-7). (deepdyve.com)
Age-onset decline is very tightly linked to changes within the community of gut microbes," said David Walker, a UCLA professor of integrative biology and physiology, and senior author of the research. (technologynetworks.com)
Sensory decline due to aging may also alter hearing, vision and pain sensations. (worldhealth.net)
Aging leads to a decline in cellular fitness and loss of optimal protein function. (azolifesciences.com)

Prevalence of Oral Mucosal Lesions and Oral Health Related Quality of Life among Adolescents in a Rural Nigerian Population. (who.int)
They affect al age groups to varying degrees and METHODOLOGY sociodemographic factors are wel known to STUDY DESIGN AND LOCATION contribute to the prevalence of diseases. (who.int)

Understanding the structure and dynamics of the muscle sarcomere, the small molecular machines that power heart and skeletal muscles, at unprecedented detail will boost our understanding of fundamental muscle biology and allow analysing processes like ageing and muscle diseases with previously unknown insight. (kcl.ac.uk)
One of the big questions in the biology of aging relates to the large variation in how we age and how long we live," said Walker, who added that scientific interest in intestinal microbes has exploded in the last five years. (technologynetworks.com)
It's the best way to get at the genetics and the biology behind AGEs. (northbayleadership.org)
Getting down to the basic-biology of these diseases, and understanding what mechanisms cause them, can help us make better decisions about what therapies could be effective before we test them. (azolifesciences.com)

Understanding the biologic processes of aging and how these processes confer susceptibility to chronic disease may lead to successful interventions that delay aging and improve health span (3). (deepdyve.com)

Nitroxide drugs preventing aging-, smoking-, high sugar or high fat diet-, or radiation- and other environmental-induced pathophysiological conditions in aging disease are reviewed. (frontiersin.org)
Certain age- and environmental-related pathophysiological changes, degenerative conditions, and diseases are driven and accelerated by radical- (i.e. (frontiersin.org)
Heart function in mice with heart failure improved by 58 percent when they were given sTGFβR2 alone or in combination with either of the other two genes, showing that a combined therapeutic treatment of FGF21 and sTGFβR2 could successfully treat all four age-related conditions, therefore improving health and survival. (technologynetworks.com)
The companion dog has recently been identified as a promising model for exploring these complex conditions, as like humans they are phenotypically diverse, experience many of the same health problems in old age and share similar environments. (rvc.ac.uk)
This study, conducted using VetCompass data, aimed to describe how aging influences the accumulation of concurrent disease conditions across various breeds of dog. (rvc.ac.uk)
Age-related gut microbiota variations are associated with several conditions, such as enteric nervous system degeneration, intestinal motility alteration, intestinal barrier defense function reduction, and decrease in capability to ferment carbohydrates. (bioinst.com)
Indeed, pervasive stigma and discrimination contributes to the imbalance between the burden of disease due to mental disorders, and the attention these conditions receive. (ipsnews.net)
Changes in the cardiovascular system associated with normal aging and non-heart-related medical conditions that become more common with age should be considered when planning heart attack treatment and follow-up. (worldhealth.net)
Overactivation of the NLRP3 inflammasome has been linked to a variety of chronic conditions and these results, the scientists have said, suggest that drugs targeted toward deacetylating, or switching off, this NLRP3 inflammasome might help prevent or treat such conditions and possibly age-related degeneration in general. (drugtargetreview.com)
So, I think it's more urgent than ever to understand the reversibility of ageing-related conditions and use that knowledge to aid a drug development for ageing-related diseases. (drugtargetreview.com)
The first objective of the new IDSR strategy is to strengthen national capacity for early detection, complete recording, timely reporting, regular analysis and prompt feedback of IDSR priority diseases, events and conditions at all levels. (who.int)
The second objective is to strengthen national and supranational laboratory capacity to confirm IDSR priority diseases, events and conditions. (who.int)

What makes this so exciting is that we could potentially be supplementing fundamental ideas of oral health, where by targeting the biological aging processes we may be able to provide a unique approach toward prognostics, diagnostics, and even the treatment of age-related dysfunction in our mouths," said An. (dentistrytoday.com)
Recent work from the Wyss-Coray lab has shown that the aged systemic milieu can modify brain processes and impair cognitive function. (neurodegenerationresearch.eu)
Based on this research and the fact that old age is the greatest risk factor for late-onset AD I propose to study the contribution of age-related circulatory factors on processes that are known to be affected in AD. (neurodegenerationresearch.eu)
To answer these questions I will use a mouse model of AD and study the effect of old circulatory factors on brain processes that occur at a young age when disease characteristics just become noticeable. (neurodegenerationresearch.eu)

For nearly 150 years, alcohol consumption has been associated with a variety of cardiovascular diseases. (medscape.com)

According to the National Eye Institute , AMD is the leading cause of blindness in older adults and typically affects those ages 55 and older. (medicalnewstoday.com)
The Alliance for Aging Research supports safe, effective vaccinations that help older adults maintain their best health and support longer life. (agingresearch.org)

Microglial dysfunction worsens neurodegeneration and accelerates the course of the disease. (worldhealth.net)
Growing scientific evidence points to mitochondrial dysfunction as a key contributor in the aging process and subsequent development of age-related pathologies. (nova.edu)

states Simon Cauchemez, co-senior author of the study and head of the Mathematical Modelling of Infectious Diseases Unit at the Institut Pasteur. (pasteur.fr)
Seniors are more susceptible to developing a significant illness from these common infectious diseases, which too often lead to hospitalization, severe complications, and death. (agingresearch.org)
Every year, between 50,000 and 90,000 adults in the U.S. die from vaccine-preventable infectious diseases or their complications. (agingresearch.org)
The Lancet Infectious Diseases article was selected for the Elsevier Atlas award, given to a single article every month from the thousands of papers published across Elsevier's 1,800 journals. (brighton.ac.uk)
A 2019 WHO evaluation of disease trends indicates that the risk of emerging infectious diseases has risen.2 This is largely attributed to the growth of cross-border and international travel, increasing human population density and the growth of informal settlements. (who.int)

The targeted diseases include but are not limited to: vaccine-preventable, tropical, zoonotic and epidemic-prone diseases, excluding HIV/AIDS, tuberculosis and malaria. (who.int)

While additional studies are needed to determine the safety and efficacy, we hope that they will be able to extend health span and delay the onset of multiple age-related diseases and disabilities. (sciencedaily.com)
The structure of entire sarcomeres is unknown, yet a precise molecular understanding of how the entire sarcomere machine forms and functions are required to fully understand its role in health, disease and ageing. (kcl.ac.uk)
The group will solve the structure of the sarcomere at near-atomic resolution, unravel the fundamentals of its force-driven assembly and turnover in health and ageing, and develop the foundations for future basic and translational research including the design and development of new agents to mitigate muscle disease and ageing. (kcl.ac.uk)
With more individuals living longer, the aging Arizona population brings unique challenges and opportunities to health care. (bio5.org)
With our health and community partners, we have the expertise and support to translate basic studies into effective treatments and life-enhancing strategies for humankind, ultimately reducing costs and increasing the odds for a long, healthy, productive, and disease-free life. (bio5.org)
We've been asking ourselves now: What's happening in the mouth as a function of age, and can we target these biological changes with interventions to extend the oral health span? (dentistrytoday.com)
In the Wyss study, a single administration of an adeno-associated virus (AAV)-based gene therapy, which delivered combinations of three longevity-associated genes to mice, dramatically improved or completely reversed multiple age-related diseases, suggesting that a systems-level approach to treating such diseases could improve overall health and lifespan. (technologynetworks.com)
They hypothesized that providing extra copies of those genes to nonengineered mice via gene therapy would similarly combat age-related diseases and bring health benefits. (technologynetworks.com)
Achieving these results in nontransgenic mice is a major step toward being able to develop this treatment into a therapy, and co-administering multiple disease-addressing genes could help alleviate the immune issues that could arise from the alternative of delivering multiple, separate gene therapies for each disease," said Church, who is also a professor of genetics at HMS and professor of health sciences and technology at Harvard and MIT. (technologynetworks.com)
Aging in humans is highly variable with wide differences in health at a given chronologic age. (deepdyve.com)
Specifically, the study suggests that analyzing intestinal bacteria could be a promising way to predict health outcomes as we age. (technologynetworks.com)
The health of the intestine - in particular the maintenance of the barrier protecting the rest of the body from the contents of the gut - is very important and might break down with aging," said Rebecca Clark, the study's lead author. (technologynetworks.com)
70% and no available treatment or vaccines, Nipah virus was identified by the World Health Organization as an emerging infectious disease that may cause major epidemics if the pathogen evolves to become more transmissible, leading the organization to prioritize it for research to prevent future health emergencies. (pasteur.fr)
Health services research and value-based care that addresses disaster-related injury and illness for chronic disease. (cdc.gov)
Health-Related Quality caries and other oral diseases. (who.int)
INTRODUCTION focus on diseases only (such as caries, periodontitis, Oral health is important to the quality of life of al gingivitis et cetera. (who.int)
The original instrument was developed rise to epidemic proportions with the Data were collected from 5 main cities: to provide a quick assessment tool for adoption of modern lifestyles and an Abu Dhabi (the capital), Dubai, Shar- HRQOL which refers to health-related increase in lifespan [2]. (who.int)
This section focuses on topics related to human or animal health, and medicine. (curlie.org)

Dr. Krauss added that AMD has a significant metabolic component to the disease. (medicalnewstoday.com)
AGEs contribute to obesity and metabolic syndrome. (northbayleadership.org)
Those who were given the 'off' version of the inflammasome had improved insulin resistance after six weeks which, the scientists say, indicates that switching off this immune machinery might reverse the course of metabolic disease. (drugtargetreview.com)

Infections in humans result in severe respiratory and neurological disease with a high case fatality. (pasteur.fr)

The study used fruit flies in part because although their typical life span is just eight weeks, some live to the age equivalent of humans' 80s and 90s, while others age and die much younger. (technologynetworks.com)
But it's nearly impossible to study the biological development of AGEs and their implications in humans because they take decades to accumulate and there are obvious ethical concerns in encouraging the development of the toxic molecules in test subjects. (northbayleadership.org)

It has been suspected that the occurrence of these diseases may in part be related to some people "biologically" ageing more quickly than others. (medindia.net)
From there, the disease quickly worsens: The brain shrinks, nerve cells die, neurodegeneration spreads, and people start having difficulty thinking and remembering. (worldhealth.net)
Mirroring the early phase of the disease in people, two of the mouse strains build up extensive amyloid deposits but do not develop brain atrophy. (worldhealth.net)
Why do some people remain healthy into their 80s and beyond, while others age faster and suffer serious diseases decades earlier? (technologynetworks.com)
A new American Heart Association scientific statement provides updated information about how aging influences the diagnosis and treatment of heart attacks in people ages 75 and older. (worldhealth.net)
According to the statement, 30-40% of people hospitalized with ACS are age 75 or older. (worldhealth.net)
Kidney function also declines with age, with more than one-third of people ages 65 and older having chronic kidney disease. (worldhealth.net)
However, troponin levels may already be higher in older people, especially those with kidney disease and a stiffened heart muscle. (worldhealth.net)
In fact, the death rate from pneumonia and influenza combined is close to 130 times higher in people age 85 and older, compared to people ages 45 to 54. (agingresearch.org)
Housing Matters for People with Parkinson´s disease. (lu.se)

With the human population rapidly aging, the study of age-related disorders has become an important area of research. (rvc.ac.uk)
The authors found that across all dogs, the number of disorders increased significantly with age, but not with size. (rvc.ac.uk)
There is wide agreement that excessive microglial activation is a key process in nervous system disorders involving release of strong pro-inflammatory cytokines, cytokines which can trigger worsening of multiple disease states. (anti-agingfirewalls.com)
Other iPSC-based models affecting neural crest lineages include Schwann cell and melanocyte-related disorders, including our effort to model human melanoma in pluripotent stem cells. (mskcc.org)

We have demonstrated that iPSC technology represents an excellent model of the disease in a dish to study mechanism of disease and to identify and validate promising therapeutic compounds for use in FD patients. (mskcc.org)
Current studies are aimed at understanding variability in disease manifestation among patients and the identification of compounds in our iPSC model to treat later stages of the disease. (mskcc.org)
Having developed iPSC lines to many genetic forms of PD, we are interested in shared and distinct mechanisms of disease and whether those mechanisms apply to sporadic disease. (mskcc.org)
The ability to induce age-like features in PD-iPSC-derived dopamine nerve cells has yielded late-stage disease phenotypes not commonly observed in standard PD-iPSC models. (mskcc.org)

The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)

La présence de complications était la variable la plus puissante ayant des répercussions sur les quatre domaines du questionnaire, en particulier le domaine physique. (who.int)

In addition, recent work from myself and others in the Wyss-Coray lab has shown that rejuvenating the systemic milieu by treating mice with young blood plasma can improve brain circuits and cognition both in normal aged mice and in a mouse model for AD. (neurodegenerationresearch.eu)
The aging of an organism is hallmarked by systemic loss of functional tissue, resulting in increased fragility and eventual development of age-related neurodegenerative, musculoskeletal, cardiovascular, and neoplastic diseases. (nova.edu)
Quality of life was negatively impacted by the presence of Teaching Hospital, Idi-Araba, Mushin Local systemic diseases as wel as cheek biting habit. (who.int)

Dr Jones recently featured in the media for his groundbreaking research showing how bacteriophage - viruses that kill bacteria and one of the alternatives recognised in the review - may be used to combat common infections related to the use of medical devices such as catheters. (brighton.ac.uk)

Findings appear online in Aging . (sciencedaily.com)
Conclusions Our findings suggest BA measures may be complementary in predicting risk for mortality and age-related disease. (deepdyve.com)

Approved by the US Food and Drug Administration, rapamycin prevents organ transplant rejection and has slowed aging and increased lifespan in a variety of species, including worms, mice, and dogs, in preclinical studies. (dentistrytoday.com)

Telomeres are cap- like structures at chromosome ends that play an important role in ageing and in the initiation and progression of various diseases. (medindia.net)
Despite considerable research effort over the past decades, there is still no effective therapy that can prevent, halt or reverse disease progression. (neurodegenerationresearch.eu)
Analysis of the 15 identified publications demonstrated that UA holds potential as a dietary intervention for slowing the progression of aging and preventing the development of age-related disease. (nova.edu)

Everyone wants to stay as healthy as possible for as long as possible, and this study is a first step toward reducing the suffering caused by debilitating diseases. (technologynetworks.com)
The study was conducted in the lab of Wyss core faculty member George Church as part of Davidsohn's postdoctoral research into the genetics of aging. (technologynetworks.com)
Methods Study Sample The Framingham Heart Study (FHS) is a community-based longitudinal cohort study initiated in 1948 to study determinants of cardiovascular disease (CVD) and its risk factors. (deepdyve.com)
the study found that the antibiotics prevented the age-related increase in bacteria levels and improved intestinal function during aging. (technologynetworks.com)
Pankaj Kapahi thinks the research community has neglected the importance of AGEs because they are challenging to study. (northbayleadership.org)
In one study, plaques extracted (post-mortem) from brains of patients with Alzheimer's show a 3-fold increase in AGEs content compared to age-matched individuals who died from other causes. (northbayleadership.org)
Is this regarding a Rare Disease study? (emmes.com)
Select "Yes" if this is regarding a Rare Disease study. (emmes.com)
Ten-year incidence rates of age-related cataract in the Age-Related Eye Disease Study (AREDS): AREDS report no. 33. (emmes.com)
To investigate the long-term incidence of age-related cataract and cataract surgery in the Age-Related Eye Disease Study (AREDS) cohort. (emmes.com)
in the study and who met the study wide are suffering from the disease [1]. (who.int)

In some countries, the number of young and middle-aged women hospitalized with acute coronary syndromes has actually increased. (medicalnewstoday.com)

Human Skin, Oral, and Gut Microbiomes Predict Chronological Age. (bioinst.com)
It is not clear if each of these different measures of BA captures unique information or adds complementary information over and above chronological age (CA) to predict disease risk and life span. (deepdyve.com)

These senolytic agents alleviated a range of age- and disease-related problems in mice. (sciencedaily.com)
Young AD mice and wildtype controls will be injected with plasma from old wildtype mice (containing age-related circulatory factors) or PBS as a control. (neurodegenerationresearch.eu)

We don't yet know how cholesterol or diabetic drugs might lower AMD risk, but we can hypothesize based on our current understanding of the disease. (medicalnewstoday.com)
They stuck to the diet for three months while the scientists recorded effects on risk factors for ageing-related diseases. (cosmosmagazine.com)
Positive effects were more pronounced among those with a high risk of age-related disease. (cosmosmagazine.com)
They then asked the question whether these genetic variants also affected risk of various diseases. (medindia.net)
This provides a novel way of looking at the disease and at least partly explains why some patients develop it early and others don't develop it at all even if they carry other risk factors. (medindia.net)
As our patients grow older, we as dentists see clinically firsthand the underlying consequences of aging in the mouth, such as increased risk for periodontal disease, root cavities, or low saliva," said An. (dentistrytoday.com)
Conversely, omega-3 deficiency can expose you to a greater risk of these age-related diseases. (naturalnews.com)
The risk of transmission of Nipah virus depends on the characteristics of the case, like the age or the type of symptoms. (pasteur.fr)
Several studies have documented that women with hypertension are more prone to develop blood pressure-associated organ damage and that hypertension is a stronger risk factor for cardiovascular disease [CVD] in women than men," she replied. (medicalnewstoday.com)
Durhing's Disease Or Dermatitis Herpetiformis Who Is At Risk? (healthstatus.com)

Some adults become frail in early old age, whereas others remain fit in their 90s and beyond (2). (deepdyve.com)

More recently, genomic data have been used to develop age predictors including transcriptomic and DNA methylation molecular signatures (8-10). (deepdyve.com)

Our research is key to understanding the complex genetic jigsaw of a whole variety of human age-related diseases. (medindia.net)
The results we saw were stunning and suggest that holistically addressing aging via gene therapy could be more effective than the piecemeal approach that currently exists," said first author Noah Davidsohn, a former research scientist at the Wyss Institute and HMS who is now chief technology officer of Rejuvenate Bio. (technologynetworks.com)
Research on how normal aging of the brain occurs, is shedding light on this question. (neurodegenerationresearch.eu)
In the 1950s, evidence began to emerge that supported the idea of a direct toxic myocardial effect of alcohol, and research during the last 35 years has been particularly productive in characterizing the disease entity of alcoholic cardiomyopathy (AC). (medscape.com)
A computer-assisted literature review was performed using PubMed and EMBASE for primary source research articles examining UA supplementation and aging-related pathologies. (nova.edu)
Home / News Posts / The Buck Institute for Research on Aging Sites AGEs as Drivers of Age-Related. (northbayleadership.org)
Kapahi is determined to give AGEs their rightful place in research on aging. (northbayleadership.org)
Previous research focused on addressing AGEs outside of the cell, in the blood and in serum. (northbayleadership.org)
Strategic objectives 2, 3, 4, 6 and 9: in relation to integrated disease control, surveillance and harmonized research initiatives. (who.int)

AGEs affect nearly every cell type and our bodies have inherent defense mechanisms that can clear them. (northbayleadership.org)
The goal of these studies is to further define cellular mechanisms of disease and to model other forms of HSE. (mskcc.org)
Yet, the mechanisms underlying how aging causes proteins to aggregate has largely remained a black box. (azolifesciences.com)

BALF from paediatric and adult CF patients and paediatric disease controls undergoing clinically indicated bronchoscopy was analysed for total bacterial load and for microbiota by 16S rDNA sequencing. (ersjournals.com)
Streptococcus , Prevotella and Veillonella ) constituted ∼50% of the microbiota, whereas in CF patients aged ≥6 years, traditional CF taxa ( e.g . (ersjournals.com)
Microbiota communities were distinct in CF compared with disease controls, but did not differ based on pulmonary exacerbation status in CF. (ersjournals.com)
The CF microbiota detected in BALF differs with age. (ersjournals.com)

Anatomy5

Organisms1

Diseases26

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment15

Psychiatry and Psychology1

Phenomena and Processes12

Disciplines and Occupations1

Information Science3

Health Care10

Alzheimer's Disease25

Inflammation13

20171

Macular9

Dementia8

Heart disease14

Neurodegenerative diseases2

Coronary artery3

Clinical17

Diabetes7

Centers3

King's Colleg2

Oxidative stress1

Prevention5

Cancer3

Chronic diseases2

Researchers11

Parkinson's Disease5

Webinar1

Multiple sclerosis1

Dementias4

Participants2

Microbiome3

Decline4

Prevalence2

Biology4

Susceptibility1

Conditions12

Processes4

Cardiovascular diseases1

Older adults2

Dysfunction2

Infectious Diseases5

Vaccine-preventable1

Health18

Metabolic3

Respiratory1

Humans2

People10

Disorders4

IPSC4

Nrf22

Complications1

Systemic3

Infections1

Findings2

Lifespan1

Progression3

Study11

Middle-aged1

Chronological Age2

Mice2

Risk10

Adults1

Genomic1

Research9

Mechanisms3

Microbiota4