• Subjects with early-onset BDD (age 17 or younger) were compared to those with late-onset BDD. (nih.gov)
  • Those with early-onset BDD were more likely to report a gradual onset of BDD than those with late-onset in both samples. (nih.gov)
  • In the present investigation, the effect of late-onset short-term intermittent fasting dietary restriction (IF-DR) regimen was studied on motor coordination and cognitive ability of ageing male rats. (springer.com)
  • These animals were further used to estimate protein carbonyl content and mitochondrial complex I-IV activity in different regions of brain and peripheral organs, and the degree of age-related impairment and reversion by late-onset short-term IF-DR was compared with their levels in 3-month-old young rats. (springer.com)
  • These results suggest that even late-onset short-term IF-DR regimen have the potential to retard age-associated detrimental effects, such as cognitive and motor performance as well as oxidative molecular damage to proteins. (springer.com)
  • The researchers found that people with familial AD started showing signs of cognitive decline at an average age of 46.2 years, as compared to the average of 68 years for late-onset AD. (alzforum.org)
  • In contrast with late-onset AD, these patients often have greater difficulties with executive function (planning, multitasking, organization), language or visual perception than with memory, and they may be diagnosed with syndromes such as posterior cortical atrophy (PCA), with primarily visuospatial symptoms or logopenic variant primary progressive aphasia (lvPPA), a form of primary progressive aphasia with specific language problems. (ucsf.edu)
  • Only late onset diagnosis patients had an extrapyramidal syndrome, with frequent difficulty to walk: 3/4 PA and 1/4 MMA required assistance to walk. (nih.gov)
  • In Part 1 of our examination of Anti-NMDA Receptor Encephalitis, I presented a late-onset case of autism. (ageofautism.com)
  • For some analyses, symptomatic patients were divided into those presenting with first symptoms during (i.e. early onset, EO) or after the newborn period (i.e. late onset, LO). (uzh.ch)
  • A founder mutation in the C1QTNF5 short-chain collagen gene results in late-onset retinal macular degeneration (L-ORMD), which resembles age-related macular degeneration (AMD). (arvojournals.org)
  • It occurs in three major isoforms in humans known as ApoE2, ApoE3 and ApoE4, with ApoE3 being the most frequent allele (~77% homozygosity ) followed by ApoE4 (~15-20% allele frequency) which is present in more than 50% of late onset Alzheimer's disease patients. (fightaging.org)
  • Panel A shows the ancestry of each study, panel B distinguishes early-onset from late-onset studies and panel C identifies studies ascertained with a positive family history of coronary artery disease. (figshare.com)
  • Panel D is a composite plot showing the degree of genetic enrichment among the studies in the meta-analysis, which ranged from non-enriched (late-onset studies without a positive family history of coronary artery disease) to doubly enriched (early-onset studies with a positive family history of coronary artery disease). (figshare.com)
  • Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late-onset, progressive, neurological disorder that affects a large subgroup of older male and, less frequently, older female carriers of premutation CGG repeat expansions (55-200 CGG repeats) of the FMR1 gene [review: Hagerman and Hagerman, (docme.ru)
  • Middle-aged and older adults are still at the highest risk for developing type 2 diabetes. (healthline.com)
  • Type 2 diabetes used to be prevalent only in adults and was once called "adult-onset" diabetes. (healthline.com)
  • According to the SEARCH for Diabetes in Youth Study, 5,300 people from ages 10 to 19 were diagnosed with type 2 diabetes between 2011 and 2012. (healthline.com)
  • The study found that, at current rates, the number of people under the age of 20 with type 2 diabetes could increase by up to 49 percent by 2050. (healthline.com)
  • This guideline covers the care and management of type 2 diabetes in adults (aged 18 and over). (amazonaws.com)
  • The landmark Search for Diabetes in Youth (SEARCH) and Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) studies, among others, have contributed to an understanding that type 2 diabetes presenting at a young age is of a particularly aggressive nature and have highlighted the challenges in the management of this patient group ( 1 , 2 ). (diabetesjournals.org)
  • Young people with type 2 diabetes are likely to be obese, with a clustering of unfavorable cardiometabolic risk factors all present at a very early age ( 3 , 4 ). (diabetesjournals.org)
  • In adolescents with type 2 diabetes, a 10-30% prevalence of hypertension and an 18-54% prevalence of dyslipidemia have been found, much greater than would be expected in a population of comparable age ( 4 ). (diabetesjournals.org)
  • In another study of patients with type 2 diabetes younger than 20 years of age, aortic pulse wave velocity was already higher than that of age-matched control subjects, indicating an increased degree of arterial stiffness ( 5 ). (diabetesjournals.org)
  • Our goal now is to identify a marker in the blood that will enable us to distinguish diabetes associated with pancreatic cancer from the far more common type 2 diabetes," said Dr. Chari, "so we are able to screen patients with new-onset diabetes to detect pancreatic cancer before it spreads. (rxpgnews.com)
  • It is now used as a synonym for dominantly inherited, monogenic defects of insulin secretion occurring at any age, and no longer includes any forms of type 2 diabetes. (wikipedia.org)
  • RESEARCH DESIGN AND METHODS The EarlyBird Diabetes study is a longitudinal prospective cohort study of healthy children aged 5-14 years. (diabetesjournals.org)
  • Methods: Female twins ages 18-60 years (N=950) from the University of Washington Twin Registry completed a survey in 2006. (washington.edu)
  • Conclusion: Among adult female twins, an earlier age at dieting onset was associated with an increased BMI, and greater use of dieting behaviors including restraint, risky dieting methods, and weight cycling in overall, cross-sectional analyses. (washington.edu)
  • They also identified strong evidence for an age at onset gene for Parkinson's disease on chromosome 1. (eurekalert.org)
  • This study emphasizes the similarity between the two diseases by highlighting a single gene that influences their age of onset. (innovations-report.com)
  • In this study, we examined a G-to-A single nucleotide polymorphism of the ATM gene, to determine if it influences HNPCC age of onset. (aacrjournals.org)
  • However, the mutated gene was an even stronger predictor of onset age. (alzforum.org)
  • The families also met one of two other criteria: either one individual in the family developed Parkinson's disease before age 54 years, or two affected siblings had identical versions of the parkin gene. (bio-medicine.org)
  • The fact that even heterozygotes developed Parkinson's disease at an earlier age than those with two normal copies indicates that the gene's effect may be stronger than previously recognized, and that screening for mutations in the gene may help identify those at risk of developing the condition. (bio-medicine.org)
  • The age of onset of Huntington's disease (HD) is inversely correlated with the CAG length in the HD gene. (biomedsearch.com)
  • Targeted candidate gene studies and a genome scan have suggested some loci as potential modifiers of the age of onset of HD. (biomedsearch.com)
  • Glutaredoxin 2 ( Grx2 ) Gene Deletion Induces Early Onset of Age-" by Hongli Wu, Yibo Yu et al. (unl.edu)
  • In this study, we investigated whether Grx2 gene deletion could induce faster age-related cataract formation and elucidated the biochemical changes effected by Grx2 gene deletion that may contribute to lens opacity. (unl.edu)
  • Background: Prader-Willi syndrome (PWS) results from loss of paternally imprinted gene(s) from the 15q 11-13 region and is characterised by weight faltering during early childhood due to hypotonia, followed by obesity due to onset of the hyperphagic phase. (endocrine-abstracts.org)
  • Maturity onset diabetes of the young" (MODY) refers to any of several hereditary forms of diabetes mellitus caused by mutations in an autosomal dominant gene disrupting insulin production. (wikipedia.org)
  • Researchers also found evidence for age at onset linkage to chromosomes 4 and 8, however, the linkage was not as statistically significant. (eurekalert.org)
  • The experiment uncovered four genes, including GSTO1, located in the region of the genome earlier linked to age at onset, the researchers report. (innovations-report.com)
  • Researchers at Mayo Clinic believe there is a link between these modifiable lifestyle factors and the biological processes of aging. (eurekalert.org)
  • In a recent study, researchers demonstrated that a poor diet and lack of exercise accelerated the onset of cellular senescence and, in turn, age-related conditions in mice. (eurekalert.org)
  • Researchers from the Mayo Clinic Robert and Arlene Kogod Center on Aging found that exercise prevents premature senescent cell accumulation and protects against the damaging effects of an unhealthy diet, including deficiencies in physical, heart, and metabolic function, equivalent to diabetes. (eurekalert.org)
  • The researchers set the solar radiation at a constant level in the climate models, and Miller said the Little Ice Age likely would have occurred without decreased summer solar radiation at the time. (colorado.edu)
  • Improving the ability to predict a given person's age at onset would help researchers select candidates for AD prevention studies who are most likely to show a benefit within the study's duration. (alzforum.org)
  • By Mayo Clinic, ROCHESTER, Minn. -- In a groundbreaking population-based study, researchers in Mayo Clinic Cancer Center found that new onset of hyperglycemic diabetes in adults age 50 or older may be a signal of underlying pancreatic cancer. (rxpgnews.com)
  • In the largest study of brain development in preschoolers with autism to date, a study by UC Davis MIND Institute researchers has found that 3-year-old boys with regressive autism, but not early onset autism, have larger brains than their healthy counterparts. (ucdavis.edu)
  • The researchers collected magnetic resonance imaging (MRI) scans on 180 participants at age 3. (ucdavis.edu)
  • In the new work, the researchers used this short-lived fish to test the effects of resveratrol on aging-related physiological decay. (bio-medicine.org)
  • The researchers added resveratrol to daily fish food and found that this treatment increased longevity and also retarded the onset of aging-related decays in memory and muscular performance. (bio-medicine.org)
  • Participants met researchers' criteria for CSA if they endorsed having experienced rape, sexual molestation, and/or forced sexual contact before age 16, or sexual contact by someone five or more years older before they reached age 16. (basisonline.org)
  • Two researchers independently scrutinised the chart for each patient and to estimate or identify the age at which an inappropriate rise in BMI began. (endocrine-abstracts.org)
  • This type isn't caused by genetics, and experts don't know why these people get the disease at a younger age than others do. (mayoclinic.org)
  • The age at onset varies widely depending on the disease. (hindawi.com)
  • Logopenic progressive aphasia and posterior cortical atrophy showed largely overlapping anatomic and biologic features with early age at onset of Alzheimer disease, suggesting that these clinical syndromes represent the spectrum of clinical manifestation of the nontypical form of Alzheimer disease that presents at an early age. (nih.gov)
  • Age at onset of disease can also be genetically influenced. (eurekalert.org)
  • For instance, the general age of onset for the spinal disease scoliosis is "10-15 years old," meaning that most people develop scoliosis when they are of an age between ten and fifteen years. (wikipedia.org)
  • Albers DS, Beal MF (2000) Mitochondrial dysfunction and oxidative stress in aging and neurodegenerative disease. (springer.com)
  • While most people who carry one of these mutations develop AD earlier than do people with the more common sporadic form of the disease, the variation in age at onset in FAD is large. (alzforum.org)
  • 2 months before disease onset, already harbor pathogenic T-cells in equal numbers to overtly diabetic animals. (diabetesjournals.org)
  • In NOD mice, rupture of self-tolerance is first evidenced at 3-4 weeks of age when the initial wave of mononuclear cells infiltrates pancreatic islets that is ∼3-4 months before the first signs of overt disease, as assessed by glycosuria and hyperglycemia ( 1 , 6 , 7 ). (diabetesjournals.org)
  • No longer just a disorder of mature age, there is now a well-recognized trend toward younger people presenting with this disease, particularly for some ethnic groups. (diabetesjournals.org)
  • Only a few studies have looked at the question of complications according to age of disease onset. (diabetesjournals.org)
  • The length of the CAG repeat tract is the major determinant of age of onset (AO) of Huntington's Disease (HD) However, there remains a significant variance in AO when the expanded repeat size is ruled out. (intechopen.com)
  • Genomewide linkage scan reveals novel loci modifying age of onset of Huntington's disease in the Venezuelan HD kindreds. (biomedsearch.com)
  • and Department of Pathology and Laboratory Medicine, Center for Neurodegenerative Disease Research and Institute on Aging (J.Q.T.), University of Pennsylvania, Philadelphia. (neurology.org)
  • Data are also given for the risk of developing Huntington's disease over varying finite periods in relation to age. (bmj.com)
  • Although the variation in age at onset (AO) is partly explained by the lengths of the expanded repeat, the unexplained variation in AO is heritable, emphasising the role of modifier genes on disease expression. (bmj.com)
  • The mean age of the onset of disease in 1 group was 27, in 2 37, in 3 51 years old. (endocrine-abstracts.org)
  • The effect of ApoE4 on amyloid-β (Aβ) accumulation through impaired Aβ turnover, increased aggregation, and thus plaque formation is allele dosage-dependent and this can partly explain its effect on the earlier age of disease onset. (fightaging.org)
  • Further study is needed to determine if and how the onset of type 1 diabetes shortly before or during puberty affects brain function and how better control of the disease at that important time could yield changes in brain function later in life. (psypost.org)
  • ever-smoking associated with older onset disease. (whiterose.ac.uk)
  • While the U.S. is experiencing a longevity revolution, at the same time our aging nation is triggering a Silver Tsunami of chronic age-related disease that bring with it increased national health care spending, high rates of morbidity and mortality, and declines in quality of life. (silverbook.org)
  • As many as 11.6 million Americans in the U.S. have heart valve disease (HVD), and more than 1 in 10 adults ages 75 and older have HVD. (silverbook.org)
  • Now, a meta-analysis that drew both from several large cohorts and from the literature on such families reports that the two best prognosticators of onset are parental age at onset, and the type of mutation. (alzforum.org)
  • Chromosome 2p25 (logarithm of the odds ratio (LOD)=4.29) and 2q35 (LOD=3.39) may contain genes that modify age of onset. (biomedsearch.com)
  • Furthermore, we examined risk for progression to diabetes in cotwins in relation to age at onset of the first affected twin (index twin) and the discordance time among concordant twin pairs. (diabetesjournals.org)
  • In the Grx2 null mice, the lens nuclear opacity began at 5 months, 3 months sooner than that of the control mice, and the progression of cataracts was also much faster than the age-matched controls. (unl.edu)
  • It is very possible that older age may amplify the progression of brain abnormalities and possibly lead to a faster cognitive decline than what would be observed because of age alone. (psypost.org)
  • The authors measured speed of progression to AD by measuring age at first drink and age at onset of AD. (basisonline.org)
  • MODY should not be confused with latent autoimmune diabetes of adults (LADA) - a form of type 1 DM, with slower progression to insulin dependence than child-onset type 1 DM, and which occurs later in life. (wikipedia.org)
  • Carter SC, Leeuwenburgh C, Daniels M, Foster CT (2009) Influence of calorie restriction on measures of age related cognitive decline: role of increased physical activity. (springer.com)
  • ACE scores were not related to age, current disability, or current level of cognitive impairment measured by the Symbol Digit Modalities Test (SDMT). (frontiersin.org)
  • Therefore, as a consequence of aging and hearing loss, all listening becomes effortful and cognitive load is constantly high, reducing the amount of available cognitive resources. (frontiersin.org)
  • Is there a relation between onset age of bilingualism and enhancement of cognitive control? (harvard.edu)
  • Other studies have shown an association between earlier onset type 1 diabetes and cognitive difficulties, so we expected to find that people with earlier age of onset would have weaker connections between brain regions," said John Ryan, Ph.D., assistant professor of psychiatry at Pitt. (healthcanal.com)
  • CONCLUSIONS: Uncontrolled seizures impair cognitive function with effects being most severe in infancy and lessening with increasing age at onset. (luriechildrens.org)
  • In addition, across a number of psychiatric disorders, early age at disorder onset is associated with greater illness severity and greater comorbidity with other disorders. (nih.gov)
  • More specifically, those with early-onset BDD were more likely to have a lifetime eating disorder (anorexia nervosa or bulimia nervosa) in both samples, a lifetime substance use disorder (both alcohol and non-alcohol) and borderline personality disorder in sample 1, and a lifetime anxiety disorder and social phobia in sample 2. (nih.gov)
  • Children conceived by older men may be at greater risk for early-onset schizophrenia , a more severe form of the disorder, according to a new study published in the journal Biological Psychiatry . (psychcentral.com)
  • Treatment algorithms for children of different ages with bipolar disorder are still being developed. (bipolarnews.org)
  • CONCLUSIONS The negative effect of diabetes on morbidity and mortality is greatest for those diagnosed at a young age compared with T2DM of usual onset. (diabetesjournals.org)
  • Adjustment for adaptive behavior measured near onset did not alter the conclusions. (luriechildrens.org)
  • Conclusions- Lower per capita gross domestic product adjusted for purchasing power parity and total health expenditures per capita at purchasing power parity were associated with higher incident risk of stroke, higher case-fatality, a greater proportion of hemorrhagic strokes, and lower age at stroke onset. (ahajournals.org)
  • How Does Age at Onset Influence the Outcome of Autoimmune Diseases? (hindawi.com)
  • The team s earlier work identified a broad chromosomal region linked to the age at onset of Alzheimer s and Parkinson s diseases. (innovations-report.com)
  • Senescent cells are cells that contribute to diseases and conditions associated with age. (eurekalert.org)
  • So that doesn't mean that we need to be marathon runners, but we need to find ways to increase our habitual activity levels to stay healthy and prevent processes that drive aging and aging-related diseases. (eurekalert.org)
  • Lifelong dietary restriction (DR) is known to have many potential beneficial effects on brain function as well as delaying the onset of neurological diseases. (springer.com)
  • The development of drugs able to retard the onset of aging-related diseases and improve quality of life in the elderly is a growing focus of aging research and public health in modern society. (bio-medicine.org)
  • But the successful development of drugs aimed at aging-related diseases needs to face the challenge posed by the lifespan of the available animal models--mammalian models for aging are relatively long-lived and aren't as easily studied as shorter-lived species. (bio-medicine.org)
  • Resveratrol appears to be the first molecul e to consistently cause life extension across very different animal groups such as worms, insects, and fish, and it could become the starting molecule for the design drugs for the prevention of human aging-related diseases. (bio-medicine.org)
  • Earlier age at onset of pubic hair development was unrelated to the presence of depression in girls and boys. (aappublications.org)
  • Revealing such associations in MMR mutation carriers may improve risk estimates and help to identify individuals who are genetically susceptible to developing HNPCC at an earlier age. (aacrjournals.org)
  • Having a close friend that smoked and a smoker at home correlated significantly with both initiation of smoking and smoking at an earlier age. (mdpi.com)
  • Students who reported smoking by parents or siblings were significantly more likely to start smoking at an earlier age, compared to other students living in a non-smoking home environment. (mdpi.com)
  • These studies are also inconclusive because an earlier age of first drink is associated with later AD regardless of CSA status (DeWit, 2000). (basisonline.org)
  • RESULTS After matching for duration, despite their younger age, T2DM 15-30 had more severe albuminuria ( P = 0.004) and neuropathy scores ( P = 0.003). (diabetesjournals.org)
  • SMR plots adjusting for duration show that for those with T2DM 15-30 , SMR is the highest at any chronological age, with a peak SMR of more than 6 in early midlife. (diabetesjournals.org)
  • Bivariate logistic regression analysis modeled the relationship between age at disability onset (based on self-report of duration of disability) and fair/poor self-perceived health status, adjusting for confounding variables. (oregonstate.edu)
  • The Effect of Hypertension Duration and the Age of Onset on CV Risk Factors Expression in Perimenopausal Women. (medworm.com)
  • Age at Onset, Duration, and Severity. (aim-digest.com)
  • Initiating appropriate treatment is extremely important, since the duration of the untreated interval (that is, the time from illness onset to first treatment) is directly related to worse outcomes in adulthood. (bipolarnews.org)
  • These detoxification pathways may represent important protective mechanisms against reactive intermediates modifying the susceptibility and onset of PD. (diva-portal.org)
  • Consequently, the age of children at OCD onset was a focus of this study. (umich.edu)
  • A 2012 study published in the ADA Journal Diabetes Care considered the potential future number of diabetes cases in people under the age of 20. (healthline.com)
  • The youngest reported mean age was 9.2 ± 1.3 years in a repeated measures study by Goran and Gower ( 9 ). (diabetesjournals.org)
  • The method used to detect pubertal onset is important for a study of pubertal IR, but the issue is not straightforward. (diabetesjournals.org)
  • This study examined whether delaying regular smoking until after age 21 had additional health benefits beyond those associated with delaying regular smoking until after age 18. (cdc.gov)
  • We think at both a biological level and a clinical level, poor nutrition choices and inactive lifestyles do accelerate aging," says Nathan LeBrasseur, Ph.D., director of the Center on Aging's Healthy and Independent Living Program and senior author of the study. (eurekalert.org)
  • The mean age of onset of type 1 diabetes was 26 in our study. (thefreedictionary.com)
  • Gifford Miller collects dead plant samples from melting ice for a study on the Little Ice Age. (colorado.edu)
  • Now, a new study led by INSTAAR Fellow and Geological Sciences Professor Gifford Miller indicates that the Little Ice Age began abruptly between A.D. 1275 and 1300, triggered by repeated, explosive volcanism and sustained by a self-perpetuating sea ice-ocean feedback system in the North Atlantic Ocean. (colorado.edu)
  • The new study, funded by the National Science Foundation and the Icelandic Science Foundation, suggests that the onset of the Little Ice Age was caused by an unusual, 50-year-long episode of four massive tropical volcanic eruptions. (colorado.edu)
  • A new study led by INSTAAR Fellow Gifford Miller appears to answer contentious questions about the onset and. (colorado.edu)
  • The study also revealed that age at onset still varies even after controlling for these two parameters, and that ApoE genotype accounted for only a small part of this variability. (alzforum.org)
  • A recent study showed that Finland's record type 1 diabetes incidence increased predominantly in younger age-groups ( 1 , 2 ). (diabetesjournals.org)
  • This study involves four days of testing at the UCSF Memory and Aging Center in San Francisco, California . (ucsf.edu)
  • Dr. Chari and his team's study shows that new-onset diabetes defines a high-risk group for pancreatic cancer. (rxpgnews.com)
  • Conclusion: This cross-sectional study provides population-level, generalizable evidence of increased fair or poor health in people with later onset disability compared to those with disability onset prior to the age of 21 years. (oregonstate.edu)
  • For the study, the authors enrolled a total of 180 children between age 2 and 4. (ucdavis.edu)
  • The Bambuí Health and Aging Study assessed 1,041 adults living in a small town in Minas Gerais. (scielo.br)
  • Sixty-six middle-aged adults (ages 32 to 58) who were diagnosed with type 1 diabetes as children participated in the study. (healthcanal.com)
  • The aim of our study was to analyze the association of per-capita gross domestic product (GDP), total health expenditures, and unemployment rate with incident risk of stroke, 30-day case-fatality, proportion of primary intracerebral hemorrhages, and age at stroke onset in population-based studies. (ahajournals.org)
  • We found that fish intake attenuated the strong association of smoking for RA diagnosed ≤55 years of age, but this requires further study. (springer.com)
  • In conclusion, the results of this first of its kind study show that soy intake does not affect the age at which girls begin menstruation. (thesoyfoodscouncil.com)
  • Half the study participants had onset of type 1 diabetes before age 8 and were matched with participants of the same sex and age who were diagnosed after age 8, but before age 17. (psypost.org)
  • Aim of study: To determine the presence of an age zone during which excessive weight gain is particularly likely, in order to target counselling and dietary input. (endocrine-abstracts.org)
  • ethods: Between 2003 and 2005, 499 boys 8-9 years of age were enrolled in a longitudinal study in Chapaevsk, Russia. (elsevier.com)
  • Moreover, across the whole sample of bilinguals, onset age of active bilingualism was negatively correlated with English proficiency and positively correlated with the flanker effect. (harvard.edu)
  • The age of onset was negatively associated with daily smoking count ( r =-0.210) and total smoking count ( r =-0.146). (dovepress.com)
  • These trends in pubertal development raise concerns because early onset of puberty may negatively influence the future health of adolescent girls. (thesoyfoodscouncil.com)
  • In 2015, adults aged 45 to 64 were the most diagnosed age group for diabetes. (healthline.com)
  • Data from a survey of 43,000 U.S. adults published in the July issue of Archives of Pediatrics & Adolescent Medicine.suggests those who began drinking in their early teens are at greater risk of developing alcohol dependence at some point in their lives, of developing dependence more quickly and at younger ages, and of developing chronic, relapsing dependence. (aim-digest.com)
  • Among all respondents who developed alcoholism at some point, 47% met the diagnostic criteria for alcohol dependence (alcoholism) by age 21. (aim-digest.com)
  • While one quarter of all drinkers in the survey started drinking by age 16, 46% of drinkers who developed alcohol dependence began drinking at age 16 or younger. (aim-digest.com)
  • Age at Drinking Onset and Alcohol Dependence. (aim-digest.com)
  • however, both twins having AD was the best predictor of rapid onset of AD after their first drink, suggesting genetics and environment are greater risk factors for this effect than CSA. (basisonline.org)
  • Age at onset is an important clinical feature of all disorders. (nih.gov)
  • Participants with early-onset BDD had a greater number of lifetime comorbid disorders on both Axis I and Axis II in sample 1 but not in sample 2. (nih.gov)
  • The age of onset of mental health disorders have been found to be harder to define than physical illnesses. (wikipedia.org)
  • Similarly the earliest mean age of onset of the anxiety disorders is in preschool, for specific phobia. (thefreedictionary.com)
  • Early age-of-onset for phobic and impulse-control disorders and later age-of-onset for mood disorders were observed. (scielo.br)
  • Age at first use: a risk factor for the development of alcohol use disorders. (basisonline.org)
  • In many countries throughout the world, the age at which puberty occurs among girls-manifested as breast development, appearance of pubic hair, and onset of menarche-has been commencing earlier. (thesoyfoodscouncil.com)
  • Because both factors are related to health status and the influence of the age at disability onset on health status is unclear, we examined the relationship between disability onset and health status. (oregonstate.edu)
  • We studied the influence of this DNMT3b polymorphism on HNPCC age of onset. (aacrjournals.org)
  • Does sex influence age at onset in cranial-cervical and upper limb dystonia? (bmj.com)
  • Midgard and colleagues have confirmed that several clinical features identifiable at or shortly after onset of MS influence survival. (acpjc.org)
  • Thus, genetics and the family environment may influence both the age at dieting onset and BMI, as well as the adoption of risky eating behaviors. (washington.edu)
  • Previous research examined these outcomes with relation to initiation before age 17 (6,7). (cdc.gov)
  • This communication presents the survival experience of a group of 586 individuals with acute leukemia in relation to their blood groups, sex, and age at symptomatic onset. (annals.org)
  • Future research relating to global health status and disability should consider incorporating age at disability onset. (oregonstate.edu)
  • Anxiety and self-esteem of 105 wheelchair-bound persons, distributed over four age-of-disability-onset groups, were assessed by the State-Trait Anxiety Inventory and the Self-Esteem Inventory. (ovid.com)
  • Significantly higher levels of trait anxiety and lower levels of self-esteem were found in the earliest disability-onset group. (ovid.com)
  • We sought to establish from longitudinal data its relationship to pubertal onset, and interactions with age, sex, adiposity, and IGF-1. (diabetesjournals.org)
  • Pubertal onset was adduced from Tanner stage (TS) and from the age at which luteinizing hormone (LH) first became serially detectable (≥0.2 international units/L). (diabetesjournals.org)
  • 0.001) over the 3 years preceding pubertal onset. (diabetesjournals.org)
  • Its emergence relates more to the age of the child than to pubertal onset. (diabetesjournals.org)
  • bjectives: We investigated the association of dioxins, furans, PCBs, and corresponding toxic equivalent (TEQ) concentrations with pubertal onset among boys in a dioxin-contaminated region. (elsevier.com)
  • We used Cox proportional hazards models to assess age at pubertal onset as a function of exposure adjusted for potential confounders. (elsevier.com)
  • We conducted sensitivity analyses excluding boys with pubertal onset at enrollment. (elsevier.com)
  • Higher dioxin TEQs were associated with later pubertal onset by TV (hazard ratio = 0.68, 95% confidence interval, 0.49-0.95 for the highest compared with the lowest quartile). (elsevier.com)
  • In the UK alone, 6.4 million (60%) of those over 65 years of age have some hearing loss ( Action-on-Hearing-Loss, 2011 )-when compared to 25 year-olds, 70 year-olds have average hearing thresholds that are raised 10 dB at lower frequencies (250-1000 Hz), and 20-60 dB at higher frequencies (2-8 kHz). (frontiersin.org)
  • 20 years of age. (neurology.org)
  • We tested the association between the ATM genotypes and HNPCC age of onset by survival analysis. (aacrjournals.org)
  • We tested the association between age of onset and the DNMT3b genotypes by comparing Kaplan-Meier survival curves, evaluating the homogeneity of the curves using the log-rank test and Wilcoxon's test, and estimating the association using the Cox proportional hazards regression model to adjust for potential demographic confounding factors. (aacrjournals.org)
  • Stroke outcome is determined by a complex interplay, where age and stroke severity are predominant predictors. (lu.se)
  • Ahn SH, Son BH, Kim SW, Kim SI, Jeong J, Ko SS, Han W (2007) Poor outcome of hormone receptor-positive breast cancer at very young age is due to tamoxifen resistance: nationwide survival data in Korea-a report from the Korean Breast Cancer Society. (springer.com)
  • Intrafamilial, age-related, phenotypic heterogeneity was noted in 14 PTD families. (neurology.org)
  • Individuals with early-onset BDD were more likely to have attempted suicide in both samples and to have attempted suicide due to BDD in sample 2. (nih.gov)
  • If so, individuals with early-onset OCD might respond differently to treatments. (umich.edu)
  • Of the individuals who began drinking before age 14, 47% experienced dependence at some point, vs. 9% of those who began drinking at age 21 or older. (aim-digest.com)