• Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene. (wikipedia.org)
  • TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). (wikipedia.org)
  • TrkC is the high affinity catalytic receptor for the neurotrophin-3 (also known as NTF3 or NT-3). (wikipedia.org)
  • On the other hand, the binding of NT-3 to the non-catalytic TrkC isoform induces neuronal differentiation, but nor neuronal proliferation Tropomyosin receptor kinases, also known as neurotrophic tyrosine kinase receptors (Trk) play an essential role in the biology of neurons by mediating Neurotrophin-activated signaling. (wikipedia.org)
  • BDNF binds with high affinity to the tropomyosin receptor kinase B (TrkB), and activates AKT and ERK pathways (Mattson et al. (stemcell.com)
  • TrkA (tropomyosin receptor kinase A) encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. (thermofisher.com)
  • In the hypothalamus, BDNF and its receptor, tropomyosin-related kinase B (TrkB), are extensively expressed in areas associated with feeding and metabolism. (hyperthermicwellness.com)
  • Mature BDNF is considered the biologically active form, which has a high affinity for the tropomyosin-related kinase B (TrkB) receptor ( 130 ). (hyperthermicwellness.com)
  • NGF binding experiments suggest two types of receptors, low affinity and high affinity, with the low affinity receptor being identified as p75 (or p75NTR). (fujifilm.com)
  • This molecule binds to all neurotrophins with a low affinity (Kd=10 -9 M), belongs to the tumor necrosis factor receptor family, is involved in apoptosis, and is again attracting attention as a receptor on which pro-neurotrophins act. (fujifilm.com)
  • In 1991, a high-affinity (Kd=10 -11 M) receptor was identified. (fujifilm.com)
  • It was tropomyosin receptor kinase (Trk), which was originally identified as a gene product of the trk protooncogene found in cancer, but its ligand remains unknown. (fujifilm.com)
  • TrkA (gene name: NTRK1) is a specific high-affinity receptor for NGF, TrkB (NTRK2) for BDNF and NT-4, and TrkC (NTRK3) for NT-3. (fujifilm.com)
  • Tropomyosin receptor kinase B is the high affinity catalytic receptor for several 'neurotrophins', which are small protein growth factors that induce the survival and differentiation of distinct cell populations. (assaysolution.com)
  • The intraepidermal nerve fibers and subepidermal nerve plexus were identified by immunohistochemistry of protein gene product 9.5 (PGP 9.5) and tropomyosin-receptor kinase (Trk) A, the high affinity nerve growth factor receptor. (transhumanist.ru)
  • Brain-derived neurotrophic factor (BDNF) is a nerve growth factor that binds two receptors, the low-affinity nerve growth factor receptor (LNGFR) and the tropomyosin receptor kinase B (TrkB), to support neuron growth and survival. (customscience.co.nz)
  • BDNF binds to two receptors of distinct classes: tropomyosin-related kinase receptor type B (TRKB), which is a tyrosine kinase receptor of the tropomyosin-related kinase (TRK) family, and the p75 receptor, which is a member of the tumour necrosis factor (TNF) receptor family. (jaycampbell.com)
  • TRKB is the key receptor for BDNF in the adult brain, owing to its wide pattern of expression and a higher binding affinity for BDNF than p75. (jaycampbell.com)
  • Unlike the TGFβ type II receptor, which has a high affinity for TGF-β1, BMPR2 does not have a high affinity for BMP-2, BMP-7 and BMP-4, unless it is co-expressed with a type I BMP receptor. (wikidoc.org)
  • [1] The low affinity for ligands suggests that BMPR2 may differ from other type II TGF beta receptors in that the ligand may bind the type I receptor first. (wikidoc.org)
  • The promising anticancer drug milciclib potently inhibits cyclin-dependent kinase (CDK) 2 and tropomyosin receptor kinase (TRK) A, and is currently in phase II clinical studies. (srcinhibitors.com)
  • It potently inhibits the complex formed between cyclin-dependent kinase (CDK) 2 and cyclin A, and the tropomyosin receptor kinase (TRK) A, with a half-maximal inhibitory concentration (IC50) of 45 and 53 nM, respectively (Brasca et al. (srcinhibitors.com)
  • Synthesis, release and action of BDNF is regulated by neuronal activity and BDNF in turn leads to trophic effects such as formation, stabilization and potentiation of synapses through its high-affinity TrkB receptors. (jaycampbell.com)
  • Tropomyosin, together with the troponin complex, regulates muscle contraction and, along with tropomodulin and leiomodin, controls the uniform thin-filament lengths crucial for normal sarcomere structure and function. (nih.gov)
  • We used Förster resonance energy transfer to study effects of the tropomyosin mutations on the structure and kinetics of the cardiac troponin core domain associated with the Ca 2+ -dependent regulation of cardiac thin filaments. (nih.gov)
  • NM is caused by mutations in at least nine genes: Nebulin ( NEB ), α-actin ( ACTA1 ), α-tropomyosin ( TPM3 ), β-tropomyosin ( TPM2 ), troponin T ( TNNT1 ), cofilin-2 ( CFL2 ), Kelch repeat and BTB (POZ) domain-containing 13 ( KBTBD13 ), and Kelch-like family members 40 and 41 ( KLHL40 and KLHL41 ). (biomedcentral.com)
  • At saturating calcium, all mutants decreased ATPase rates relative to wild-type actin-tropomyosin-troponin. (ecu.edu)
  • Changes in Ca21 affinity also support the idea that the equilibrium between states of actin-tropomyosin-troponin was shifted to the inactive state by mutations that mimic troponin I phosphorylation. (ecu.edu)
  • Cooperative mechanism 1 is based on the theory that cross bridge formation between actin and myosin increases the affinity of troponin for Ca 2+ . (physiomeproject.org)
  • Cooperative mechanism 2 simulates end-to-end interactions between adjacent troponin and tropomyosin. (physiomeproject.org)
  • All the models are similar in that they are structured around a functional unit of troponin, tropomyosin and actin. (physiomeproject.org)
  • Mutations in five different loci cause FHC and 3 disease genes have been identified: beta cardiac myosin heavy chain, alpha tropomyosin and cardiac troponin T. Because these genes encode contractile proteins, other FHC loci are predicted also to encode sarcomere components. (ox.ac.uk)
  • Missense mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), respectively. (nih.gov)
  • We also used the GST pull-down assay to test the affinity of WT nebulin super repeats for WT α- and β-tropomyosin, and for β-tropomyosin with six patient mutations: p.Lys7del, p.Glu41Lys, p.Lys49del, p.Glu117Lys, p.Glu139del and p.Gln147Pro. (biomedcentral.com)
  • Of the tropomyosin mutations, only p.Glu41Lys showed weaker affinity for nebulin (super repeat 18). (biomedcentral.com)
  • We demonstrate for the first time the existence of direct tropomyosin-nebulin interactions in vitro , and show that nebulin interactions with actin and tropomyosin are altered by disease-causing mutations in nebulin and tropomyosin. (biomedcentral.com)
  • Pathogenesis of most myopathies including inherited hypertrophic (HCM) and dilated (DCM) cardiomyopathies is based on modification of structural state of contractile proteins induced by point mutations, such as mutations in alpha-tropomyosin (TM). (ox.ac.uk)
  • Analysis of the data suggested that the point mutations in alpha-TM associated with hypertrophic or dilated cardiomyopathy caused abnormal changes in the affinity ofTM to actin and in the position of this protein on the thin filaments in the ATPase cycle. (ox.ac.uk)
  • Mutations in alpha-TM associated with HCM caused a shift of TM strands to the center of the thin filament and increased a range of tropomyosin motion and affinity of this protein to actin in the ATPase cycle. (ox.ac.uk)
  • In contrast, mutations in alpha-TM associated with DCM shifted the protein to the periphery of the thin filament, reduced the amplitude of the TM movement and its affinity for actin. (ox.ac.uk)
  • Both mutations are predicted to disrupt the high affinity, C-terminal, myosin-binding domain of cardiac MyBP-C. These findings define cardiac MyBP-C mutations as the cause of FHC on chromosome 11p and reaffirm that FHC is a disease of the sarcomere. (ox.ac.uk)
  • TrkA is required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). (biosensis.com)
  • Our in vitro assays show that the R21H mutation causes a twofold decrease in tropomyosin's affinity for F-actin and affects leiomodin's function. (nih.gov)
  • Background: Tropomyosin 1 alpha chain (Tm1) is an actin-binding protein that regulates the endothelial cell response to oxidative stress following its phosphorylation at Serine 283 (S283). (scirp.org)
  • Gunning, P., O'Neill, G. and Hardeman, E. (2008) Tropomyosin-Based Regulation of the Actin Cytoskeleton in Time and Space. (scirp.org)
  • Around 90% of the primary structure of nebulin is composed of approximately 35-residue α-helical domains, which form super repeats that bind actin with high affinity. (biomedcentral.com)
  • We performed F-actin and tropomyosin-binding experiments for the nebulin super repeats, using co-sedimentation and GST (glutathione-S-transferase) pull-down assays. (biomedcentral.com)
  • WT nebulin was shown to interact with actin and tropomyosin. (biomedcentral.com)
  • Both the nebulin super repeats containing the p.Glu2431Lys mutation and nebulin super repeats lacking exon 55 (p.Arg2478_Asp2512del) showed weak affinity for F-actin compared with WT fragments. (biomedcentral.com)
  • Super repeats containing the p.Ser6366Ile mutation showed strong affinity for actin. (biomedcentral.com)
  • Super repeats containing the deletion p.Val3924_Asn3929del showed similar affinity for actin and tropomyosin as that seen with WT super repeats. (biomedcentral.com)
  • Calponin is a calmodulin, F-actin and tropomyosin binding protein which is thought to be involved in the regulation of smooth muscle contraction. (enzolifesciences.com)
  • Tropomyosin can exist in four states, two permissive or two non-permissive (referring to whether or not the actin sites are available for binding to myosin and hence cross bridge formation). (physiomeproject.org)
  • Ran-GTP has higher affinity (binding strength) to nuclear import receptors than cargo proteins (that contain a nuclear localization sequence, NLS). (oneclass.com)
  • Protein A affinity purified. (enzolifesciences.com)
  • Most allergy to crustacea seems to involve a muscles protein called tropomyosin, which is very similar in a wide range of crustacean foods. (manchester.ac.uk)
  • Unlike immunofluorescence microscopy approaches, which provide correlative information about proteins sharing cellular space, co-IP can confirm direct often high-affinity physical interactions between two proteins or protein complexes of equal or better affinity. (aacrjournals.org)
  • SUBUNIT: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. (biosensis.com)
  • Asymmetric distribution of sites with high affinity for antithrombin III in rat skin heparin proteoglycans. (mcmaster.ca)
  • Abnormal tropomyosin function in ATPase cycle in hypertrophic and dilated cardiomyopathies]. (ox.ac.uk)
  • Zerradi, M. , Houle, F. and Huot, J. (2015) Regulation of Breast Cancer Progression by Phosphorylation of the Tumor Suppressor Tropomyosin-1 Alpha. (scirp.org)
  • Simoneau, B., Houle, F. and Huot, J. (2012) Regulation of Endothelial Permeability and Transendothelial Migration of Cancer Cells by Tropomyosin-1 Phosphorylation. (scirp.org)
  • Houle, F., Poirier, A., Dumaresq, J. and Huot, J. (2007) DAP Kinase Mediates the Phosphorylation of Tropomyosin-1 Downstream of the ERK Pathway, Which Regulates the Formation of Stress Fibers in Response to Oxidative Stress. (scirp.org)
  • The optimal Ig concentration for an application varies by species and antibody affinity. (uiowa.edu)
  • The antibody is from purified rabbit serum by affinity purification via sequential chromatography on phospho-peptide and non-phospho-peptide affinity columns. (affbiotech.com)
  • In general, rabbit antibodies demonstrate greater affinity and are used at a magnitude lower Ig concentration for initial testing. (uiowa.edu)
  • If you are pumping the polar adjustment disease of this package, you can back a limited Web liver by examining the advised Web affinity often into your blood Dialysis. (siriuspixels.com)
  • Perry, S.V. (2001) Vertebrate Tropomyosin: Distribution, Properties and Function. (scirp.org)
  • Tropomyosin receptor kinase C (TrkC), also known as NT-3 growth factor receptor, neurotrophic tyrosine kinase receptor type 3, or TrkC tyrosine kinase is a protein that in humans is encoded by the NTRK3 gene. (wikipedia.org)
  • On the other hand, the binding of NT-3 to the non-catalytic TrkC isoform induces neuronal differentiation, but nor neuronal proliferation Tropomyosin receptor kinases, also known as neurotrophic tyrosine kinase receptors (Trk) play an essential role in the biology of neurons by mediating Neurotrophin-activated signaling. (wikipedia.org)
  • Neurotrophic tyrosine kinase ( NTRK) is the name of the family of three genes encoding tropmomyosin receptor kinases ( Trk) A, B, and C. Tropomyosin receptor kinases belong to a larger group of receptor tyrosine kinases. (firebaseapp.com)
  • The syntax in most common usage The NTRK NGS Fusion Panel is an RNA-based next-generation sequencing panel that detects translocations and fusions of the Neurotrophic Tropomyosin-Related Kinase (NTRK) genes NTRK1, NTRK2, and NTRK3 with known and novel fusion partners. (firebaseapp.com)
  • Entrectinib is an inhibitor of tropomyosin receptor tyrosine kinases (TRKs) TRKA, TRKB, and TRKC (encoded by the neurotrophic tyrosine receptor kinase [NTRK] genes NTRK1 , NTRK2 , and NTRK3 , respectively), proto-oncogene tyrosine-protein kinase ROS1 ( ROS1 ), and anaplastic lymphoma kinase (ALK). (medscape.com)
  • The activation of tropomyosin-related kinase A (TRKA) receptor signaling by the nerve growth factor (NGF) or the neurosteroid dehydroepiandrosterone (DHEA) may combat neurodegeneration and regulate microglial function. (euroneurotrophin.eu)
  • Protein kinase affinity probe 1 is a novel protein kinase affinity probe for the functional identification of protein kinases (PKs) . (medchemexpress.com)
  • Protein kinase affinity probe 1 is a modified Purvalanol B (HY-18299) probe with 50% beads loading (Compound S3). (medchemexpress.com)
  • OTS964 hydrochloride is an orally active, high affinity and selective TOPK (T-lymphokine-activated killer cell-originated protein kinase ) inhibitor with an IC 50 of 28 nM. (medchemexpress.com)
  • Mutations in thin-filament regulatory proteins can cause DCM and have been shown in vitro to reduce contractility and myofilament Ca2+-affinity. (ox.ac.uk)
  • This is rather surprising, for the Ca ion, in general, is not known to have an affinity for hydrophilous proteins. (nih.gov)
  • TrkC is the high affinity catalytic receptor for the neurotrophin NT-3 (neurotrophin-3). (wikipedia.org)
  • TrkC is the high affinity catalytic receptor for the neurotrophin-3 (also known as NTF3 or NT-3). (wikipedia.org)
  • Tropomyosin is the major regulator of the thin filament. (nih.gov)
  • By increasing the affinity of Hb for oxygen, voxelotor demonstrates dose-dependent inhibition of HbS polymerization. (medscape.com)
  • Glycation by saccharides of different molecular sizes affected the allergenicity of shrimp tropomyosin via epitope loss and the generation of advanced glycation end products. (diagrade.com)
  • Tropomyosin is essentially the most potent allergen of shrimp that may trigger extreme meals allergy. (diagrade.com)
  • Pener (2014) has reviewed allergy to locusts and acridid grasshoppers and described cross-reactivity to tropomyosin from shrimp, lobster, HDM, and cockroach (Pener, 2014). (researchgate.net)
  • Multiple isoforms exist, with three striated muscle isoforms: α-tropomyosin fast ( TPM1 ), β-tropomyosin ( TPM2 ), and α-tropomyosin slow ( TPM3 ). (medscape.com)
  • Such an affinity could, however, be expected in colloids having numerous negative groups like SO3, POs, or COOH. (nih.gov)
  • In muscle, the heterodimers α-tropomyosin slow -β-tropomyosin (slow twitch) and α-tropomyosin fast -β-tropomyosin (fast twitch) are most common. (medscape.com)