These proteins are related to MHC class 1 molecules but have a high affinity for the lipidic moieties of antigens. (wikipedia.org)
Synthesis of pentasaccharides, which are the minimal structure required for high-affinity binding to the protein antithrombin III (ATIII). (bioglyco.com)
Lipids1
The understanding of the main types of lipids provides a solid foundation for advancing in biochemistry and other related studies. (hellovaia.com)
Compounds1
Heparin mimetics are synthetic and semi-synthetic compounds that are highly sulfated, structurally distinct analogs of glycosaminoglycans. (bioglyco.com)
Studies2
Animal models are based either on studies of human viruses in animals, often requiring the use of immunocompromised hosts and/or host-adapted viruses, or the use of related viruses in their natural hosts. (basicmedicalkey.com)
Alternatively, many studies have been carried out using related caliciviruses as HuNoV surrogate models. (basicmedicalkey.com)
GT1b1
Open VEGFC in another window Figure 1 Anti-GM1 IgG immunostaining patterns of individual sera.An assortment of GA1, GM1, GD1a, GD1b and GT1b gangliosides was separated on thin-layer chromatogram plates and immunostained with a 1/200 dilution of sera as described in Strategies. (antiviralbiologic.com)
GD1b2
Nearly half (13) of the sera stained just GM1 (Fig. 1B), whereas the others also demonstrated cross-reactivity with GA1 (Fig. 1C), GD1b (Fig. 1D) or with both glycolipids (Fig. 1Electronic). (antiviralbiologic.com)
Representative types of sera displaying reactivity solely with GM1 (B), or sera displaying yet another reactivity with GA1 (C), GD1b (D) or with both gangliosides (Electronic) are proven. (antiviralbiologic.com)
Membrane6
Here, we show that gangliosides in the HIV-1 membrane are the key molecules for mDC uptake. (plos.org)
Here we show that gangliosides, basic components of the host cell's plasma membrane, have an important role in this process. (plos.org)
Gangliosides are known to be incorporated into the viral envelope membrane during the process of viral particle budding and here we show that they serve as viral attachment factors: they are recognized and enable HIV-1 uptake by mDCs. (plos.org)
Thus, in addition to the well-known function of gangliosides as host cell receptors that mediate virus (e.g., polyoma and SV40) attachment and transport from the plasma membrane to the ER, we now demonstrate that they can also act as determinants for capture by mDCs. (plos.org)
Furthermore, we identify a moiety composed of sialyllactose on HIV-1 membrane gangliosides as the specific domain recognized by mDCs. (plos.org)
GM3 was used as another ganglioside on the membrane. (bvsalud.org)
Molecule2
Natural killer T (NKT) cells are a similar population with affinity to CD1d (the only group 2 CD1 molecule). (wikipedia.org)
Furthermore, the sialyllactose molecule present in specific gangliosides was identified as the determinant moiety for mDC HIV-1 uptake. (plos.org)
Viral1
Hence, these results demonstrate that gangliosides can act as viral attachment factors, in addition to their well known function as cellular receptors for certain viruses. (plos.org)
Attachment1
The sialic acid in the ganglioside headgroup is responsible for virus attachment and entry into host cells. (bvsalud.org)
Type2
In the early phase, the ganglioside type and concentration influence the adsorption kinetics of vesicles and their residence/lifetime on the surface before rupturing. (bvsalud.org)
The propagation of patch edges catalyzes the process and depends on the ganglioside type. (bvsalud.org)
The present disclosure concerns methods and compositions related to cell therapies for any purpose, including at least for treatment of cancer of any kind. (justia.com)
Show1
Here, using GM1, GM3, and GD3 ganglioside micelles as models, we show that the sugar distributions and cationic amino acids within Aß N-terminal region modulate oligomerization of Aß temporally, and dictate the stability and maturation of oligomers. (bvsalud.org)
Class1
CD1 proteins are structurally similar to MHC class 1 proteins, containing 3 domains and non-covalently bound β2 microglobulin. (wikipedia.org)
Function1
Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
Our pH-dependent experiments confirm that the polar/charged head groups of the gangliosides have a critical role in these steps and phases of SLB formation kinetics. (bvsalud.org)
Critical1
We propose that this novel recognition moiety might be crucial for inducing immune responses, but also critical to disseminate HIV-1 and other ganglioside-containing viruses. (plos.org)
Entry1
You can also upload a video entry or images related to this topic. (encyclopedia.pub)
Cells1
The methods and compositions relate to modulation of expression of multiple genes whose products are involved in suppression of the cells, in particular aspects. (justia.com)
Domains1
From a physicochemical standpoint, this is related to their ability to self-organize into nanoscopic domains, even at molar concentrations of one per 1000 lipid molecules. (bvsalud.org)