Cancer immunotherapy by chimeric antigen receptor-modified T (CAR-T) cells has shown exhilarative clinical efficacy for hematological malignancies. (ijbs.com)
Adoptive T-cell therapy with anti-CD19 chimeric antigen receptor (CAR)-expressing T cells is a new approach for treating advanced B-cell malignancies. (ashpublications.org)
Tumor associated2
These tumor proteins, when first defined, were referred to as tumor associated antigens. (jcancer.org)
Depletion of B cells in melanoma patients by anti-CD20 immunotherapy decreases tumor associated inflammation and CD8+ T cell numbers. (regenerativemedicine.net)
CD192
We used T cells that were retrovirally transduced with this CAR to treat mice bearing a syngeneic lymphoma that naturally expressed the self-antigen murine CD19. (ashpublications.org)
12 , 13 Clinical trials in which patients with advanced B-cell malignancies receive T cells expressing anti-CD19 CARs are in early stages, and it is not known whether adoptive transfer of T cells targeting this self-antigen will be an effective therapy for B-cell malignancies. (ashpublications.org)
Protein5
High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene. (wikipedia.org)
A major histocompatibility complex class I-like protein that contains an IMMUNOGLOBULIN C1-SET DOMAIN. (edu.au)
[5] TACI binds worst since its affinity is higher for a protein similar to BAFF, called a proliferation-inducing ligand (APRIL). (wikidoc.org)
All these ligands act as homotrimers (i.e. three of the same molecule) interacting with homotrimeric receptors, [6] although BAFF has been known to be active as either a hetero- or homotrimer (can aggregate into 60-mer depending on the primary structure of the protein). (wikidoc.org)
Streptavidin is a tetrameric protein providing 4 high-affinity biotin binding sites. (acrobiosystems.com)
Lymphocytes1
These receptors are expressed mainly on mature B lymphocytes and their expression varies in dependence of B cell maturation (TACI is also found on a subset of T-cells and BCMA on plasma cells ). (wikidoc.org)
Binds1
This Antibody was verified by Relative expression to ensure that the antibody binds to the antigen stated. (thermofisher.com)
Ligand3
Prostaglandin E1 (Alprostadil) is a prostanoid receptor ligand, with K i s of 1.1 nM, 2.1 nM, 10 nM, 33 nM and 36 nM for mouse EP3 , EP4 , EP2 , IP and EP1 , respectively. (medchemexpress.com)
This cytokine is a ligand for receptors TNFRSF13B /TACI, TNFRSF17 /BCMA, and TNFRSF13C /BAFF-R. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. (wikidoc.org)
[4] BAFF is the natural ligand of three unusual tumor necrosis factor receptors named BAFF-R (BR3), TACI (transmembrane activator and calcium modulator and cyclophilin ligand interactor), and BCMA (B-cell maturation antigen), all of which have differing binding affinities for it. (wikidoc.org)
Proteins2
Monoclonal antibodies developed against immunogenic proteins (Tumor Specific Antigens/TSA's) that are expressed in human cancers, display a unique behavioral pattern. (jcancer.org)
Explore our comprehensive collection of recombinant Fc receptor proteins! (acrobiosystems.com)
Antibody2
Description: The OKT3 monoclonal antibody reacts with an epitope on the epsilon-subunit within the human CD3 complex. (thermofisher.com)
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
Antibodies1
Donor-specific antibodies bind with high affinity to the vascular endothelium of graft and activate complement . (wikidoc.org)
Gene1
This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. (wikipedia.org)
Gamma1
The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. (wikipedia.org)
Cancer1
Adoptive T-cell therapy with T cells expressing chimeric antigen receptors (CARs) is an active area of cancer research. (ashpublications.org)
Cells4
However, due to intricacies of solid tumors and their locations in the human body, treatment of solid tumors with CAR-T cells is facing multiple obstacles, such as the hostile tumor microenvironment, on-tumor/off-tumor toxicities, and undesired antigen specificity [ 2 ]. (ijbs.com)
Most CARs that are being evaluated in current clinical and preclinical studies recognize self-antigens that are expressed by normal tissues as well as malignant cells. (ashpublications.org)
BAFF steady-state concentrations depend on B cells and also on the expression of BAFF-binding receptors. (wikidoc.org)
Inadequate level of BAFF will fail to activate B cells to produce enough immunoglobulin and will lead to immunodeficiency. (wikidoc.org)
Cell1
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. (wikipedia.org)
Complex1
This includes the amount of shed antigen in the serum at the time of treatment that could initiate immune complex formation as well as the shedding of inhibitory material into the serum possibly effecting an immune response. (jcancer.org)
Antibody3
This anti-CD3 is a polyclonal antibody directed against the epsilon chain of human CD3 molecule. (thermofisher.com)
Here, we report the crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) receptor binding domain (RBD) in complex with MAb WRAIR-2063, a moderate-potency neutralizing antibody with exceptional sarbecovirus breadth, that targets the highly conserved cryptic class V epitope. (bvsalud.org)
The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
Viral2
Protection in these models is mediated by Ly49H + NK cells, which upon recognition of m157 viral antigen (Ly49H ligand) proliferate and persist in lymphoid and nonlymphoid organs. (hindawi.com)
Instead of developing your own assays, explore our kits and services to quickly quantify viral antigens! (acrobiosystems.com)
Genes2
These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. (thermofisher.com)
The genes encoding the CD3 epsilon, gamma and delta polypeptides are located on chromosome 11. (thermofisher.com)
Differentiation2
in such context, memory NK cells have been initially identified in healthy HCMV-seropositive individuals, mainly on the basis of high expression levels of CD94/NKG2C activating receptor and CD57 terminal differentiation marker [ 17 - 21 ]. (hindawi.com)
The presence of a functional BCR is necessary during antigen-dependent differentiation and for continued survival in the peripheral immune system. (wikidoc.org)
Subunits1
T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta. (thermofisher.com)
Molecules3
antibodies, bispecific antigen-binding molecules that bind Fc?R1? (justia.com)
The bispecific antigen-binding molecules of the invention are useful for the treatment of diseases and disorders in which an upregulated or induced Fc epsilon-R1 alpha-targeted immune response is desired and/or therapeutically beneficial. (justia.com)
CD94/NKG2A and killer immunoglobulin-like receptors (KIR)) that recognize MHC class I molecules. (hindawi.com)
Murine1
The first demonstration of antigen-specific recall responses by NK cells was in the setting of hapten-induced contact hypersensitivity, where CXCR6 + liver-derived murine NK cells could mediate antigen-specific contact hypersensitivity independently from B and T cells [ 13 , 14 ]. (hindawi.com)
Mast1
The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. (wikipedia.org)
Involves1
The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. (wikipedia.org)
Encounter1
NK cell functional response to tumor cells encounter is triggered by a variety of activating receptors, some of which (e.g. (hindawi.com)
Survival1
The chimeric antigen receptor of the present disclosure has been humanized, resulting in a longer survival period in vivo, and a corresponding extended complete remission period in patients. (justia.com)
Functional1
In addition to modulate functional responsiveness, NK cell inhibitory receptors are critical for promoting their education [ 9 ]. (hindawi.com)
High2
This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. (wikipedia.org)
WRAIR-2063 binds the RBD of SARS-CoV-2 WA-1, all variants of concern (VoCs), and clade 1 to 4 sarbecoviruses with high affinity, demonstrating the conservation of this epitope and potential resiliency against variation. (bvsalud.org)
Commitment1
An additional defining characteristic is the commitment to express an immunoglobulin complex. (guidetomalariapharmacology.org)
Human2
CXCR3 is one of more than 20 distinct chemokine receptors expressed in human leukocytes. (guidetomalariapharmacology.org)
CB 2 receptor on eosinophils mainly mediates anti-inflammatory and immunomodulatory actions e.g. downregulation of pro-inflammatory mediator release. (guidetomalariapharmacology.org)