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  • abnormalities
  • These mechanisms include-though are not limited to-inflammation, oxidative stress/mitochondrial dysfunction, abnormalities in the hypothalamic-pituitary-adrenal axis, and sleep disorders. (springer.com)
  • potentially
  • That there were no associations between social cognition and the capacity to self-regulate negative emotion in SZ and BD (in the context of poor social cognition and maladaptive regulatory strategies) suggests that dysfunction in fronto-limbic brain networks may underpin both social cognitive deficits and the use of maladaptive cognitive strategies in these disorders, albeit by potentially different routes. (frontiersin.org)
  • Disease
  • Bipolar disorder has been strongly associated with cardiovascular disease although the relationship between the two conditions is complex with regard to directionality and mechanisms. (springer.com)
  • There exist a variety of mechanisms that may link bipolar disorder with cerebrovascular disease, and some risk factors may predispose vulnerable individuals to both conditions. (springer.com)
  • medications
  • Our aim here was thus to test the hypothesis that the anti-psychotic and mood stabilizing activity of some medications may be achieved, or at least augmented, through their in vivo inhibition of T. gondii replication and invasion in infected individuals. (royalsocietypublishing.org)
  • risk
  • We demonstrate that, while T. gondii appears to alter the rats' perception of predation risk turning their innate aversion into a 'suicidal' feline attraction, anti-psychotic drugs prove as efficient as anti- T. gondii drugs in preventing such behavioural alterations. (royalsocietypublishing.org)
  • Individuals with idiopathic forms of bipolar disorder further face a considerably increased risk for cerebrovascular mortality and stroke. (springer.com)
  • Mania and mortality: why the excess cardiovascular risk in bipolar disorder? (springer.com)
  • Majority are nonviolent, but overall, like any psychotic disorder, there is an above average risk of physical violence. (mentalhealth.com)