Affect telomere length. Medical search. Frequent questions

Leukocyte telomere Ends of chromosomes Shorten Longer telomeres Odds of having short te Time a cell divides Rate of telomere Lengthen telomeres Longest telomeres Maintain telomere length Positively affect telomere length Reduction in telomere length Increase in telomere length Association between telomere length Short telomere length Significantly Oxidative Role in telomere Work on telomeres Cellular Mutations Protect telomeres Genes Enzyme called telomerase Chromosomes and protect University of Califo Genetic Sequences Chromosome Researchers Binding proteins TTAGGG Exposure Structures Senescence Protective Conclusion Shortest Telomeric Study Somatic Repetitive Repeats Statistically Diseases Chronic Gene Cardiovascular Epigenetic Measured by quantitative Regulation Quantitative Peripheral blood Detrimental Humans Shortens Telomerase activation Blackburn Bone marrow Stressors Patients Abnormally Promote longevity Cell Tissues

Thus, the present study aimed to compare the leukocyte telomere length (LTL) between OSAS patients and controls, as well as to verify the correlation between LTL and sleep parameters. (oncotarget.com)
Red blood cell size is inversely associated with leukocyte telomere length in a large multi-ethnic population. (jamanetwork.com)
Honig LS, Kang MS, Schupf N, Lee JH, Mayeux R. Association of shorter leukocyte telomere repeat length with dementia and mortality. (jamanetwork.com)
However, whether patients with schizophrenia also have shorter telomeres remains inconclusive, because the results of previous studies investigating an association between leukocyte telomere length and schizophrenia have been largely inconsistent. (databasefootball.com)
Here, we investigate the association of leukocyte telomere length with schizophrenia with the quantitative polymerase chain reaction method in independent Japanese cohorts consisting of 1,241 patients with schizophrenia and 1,042 controls, which we believe is the largest ever as an independent sample set of telomere studies in schizophrenia. (databasefootball.com)
Correlations between leukocyte telomere length and age in patients with schizophrenia and healthy controls. (databasefootball.com)
The red and blue dashed lines show non-linear relationships between leukocyte telomere length and age in patients with schizophrenia and healthy controls, respectively. (databasefootball.com)
Black lines represent the mean leukocyte telomere length in each group. (databasefootball.com)
Purpose The study aimed to investigate the efect of metformin treatment on leukocyte telomere length (LTL) and the relationship of LTL with C-reactive protein (CRP), homocysteine, albumin, complete blood count, and HOMA-IR values in patients with polycystic ovary syndrome (PCOS). (afsu.edu.tr)
Purpose: Leukocyte telomere length has gained attention as a marker of oxidative damage and age-related diseases, including cancer. (aacrjournals.org)
We hypothesize that leukocyte telomere length might be able to predict future risk of cancer and examined this in a cohort of patients with Barrett's esophagus, who are at increased risk of esophageal adenocarcinoma and thus were enrolled in a long-term cancer surveillance program. (aacrjournals.org)
Leukocyte telomere length hazard ratios (HR) for risk of esophageal adenocarcinoma were calculated using multivariate Cox models. (aacrjournals.org)
TERC Variants Associated with Short Leukocyte Telomeres: Implication of Higher Early Life Leukocyte Telomere Attrition as Assessed by the Blood-and-Muscle Model. (nih.gov)
Our study shows that smoking status and cigarette quantity can result in the shortening of leukocyte telomere length, which is an indicator of tissue self-repair, regeneration and ageing. (morungexpress.com)
They found that current smoking status was statistically significantly associated with shorter leukocyte telomere length, whereas previous smokers and people who had never smoked didn't show significantly shorter leukocyte telomere length. (morungexpress.com)
People who smoked the greater number of cigarettes had significantly shorter leukocyte telomere length. (morungexpress.com)
In summary, smoking may cause the shortening of leukocyte telomere length, and the more cigarettes smoked, the stronger the shortening effect," said Dai. (morungexpress.com)
In recent years, observational studies have linked shortened leukocyte telomere length with many diseases, such as cardiovascular disease, diabetes and muscle loss. (morungexpress.com)

Chronic psychological stress is associated with detrimental effects on physical health, and may operate in part through accelerated cell aging, as indexed by shorter telomeres at the ends of chromosomes. (escholarship.org)
Just as aglets prevent a shoelace from unraveling or fraying, telomeres are structures on the ends of chromosomes that protect the chromosome from deteriorating, breaking apart or joining with other chromosomes, which can lead to mutations. (sciencedaily.com)
Telomeres are thought to reflect cell aging and overall health -- their role is to help maintain the DNA ends of chromosomes following cell division. (sciencedaily.com)
Telomeres are lengths of repetitive DNA sequences that protect the ends of chromosomes. (morungexpress.com)
all genes associated with this syndrome (ie, DKC1 , TERT, TERC, NOP10 ) encode proteins in the telomerase complex responsible for maintaining telomeres at the ends of chromosomes regarding shortening length, protection, and replication. (medscape.com)

In somatic cells such as leukocytes, telomeres gradually shorten with each cell division because of low telomerase activity. (databasefootball.com)
Researchers know that telomeres shorten and deteriorate with aging, but they are learning that stress also affects telomere length. (sciencedaily.com)
Telomeres are complex DNA-protein structures located at the end of eukaryotic chromosomes, which shorten with age in all replicating somatic cells 3 , 4 . (ersjournals.com)
Telomere length can also impact overall health, as shorter telomeres can increase our risk for age-related diseases like cancer and heart disease [ 2 ] and even shorten our lifespan. (antiaging-systems.com)
In the next stage of their research, the Glasgow scientists will look at what causes telomeres to shorten - including inherited and environmental factors - to make it possible to predict life expectancy more accurately. (bellenews.com)
Every time a cell divides, telomeres shorten, protecting the genetic material from being damaged and limiting the proliferation of the cell. (sens.org)
The passing of time means that telomeres shorten naturally, but experts believe other factors might influence this process as well. (inverse.com)
Enzymes remove the T-circles and therefore shorten the telomere. (medscape.com)

It is not understood why there are variations of telomere length but if you had a choice, you would want to be born with longer telomeres. (bellenews.com)
Those who drank just a bit of alcohol had much longer telomeres. (alsearsmd.com)
Researchers have correlated higher vitamin D levels with longer telomeres in humans. (mindbodygreen.com)
RESULTS: U-As and B-As were associated with longer telomeres and higher mtDNAcn, particularly in women with a less efficient arsenic metabolism. (lu.se)

The aim of this study was to evaluate the association between ideal cardiovascular health (Life's simple 7) and the odds of having short telomeres in a subsample of participants older than 55 years from the Seguimiento Universidad de Navarra (SUN) study. (unav.edu)
The odds of having short telomeres was defined as telomere length below the 20th percentile. (unav.edu)

Each time a cell divides, the telomeres become slightly shorter, eventually becoming so short that the cell can no longer divide successfully, and it dies. (morungexpress.com)

To test this hypothesis, the rate of telomere shortening was compared with age in circulating lymphocytes harvested from smokers with and without COPD. (ersjournals.com)
This makes telomeres a telling marker for how a body will age: After studying telomere length across multiple species, a research team out of Spain found that the rate of telomere decay over time could accurately predict the life span of that species. (mindbodygreen.com)

Studies have shown taking telomerase activation supplements can help lengthen telomeres, which can help slow down the aging process and reduce the risk of age-related diseases [ 3 ]. (antiaging-systems.com)
85% of cancer cells use the enzyme telomerase to lengthen telomeres. (sens.org)
The only scientifically proven way to lengthen telomeres is by activating an enzyme called telomerase, which is made only inside your cells. (elephantjournal.com)

But one bird in the group with the longest telomeres survived to almost nine years old. (bellenews.com)
Human beings with the highest vitamin D levels have the longest telomeres, and people with the lowest vitamin D levels have the [shortest] telomeres," Gundry told mbg co-CEO Jason Wachob , referring to research in the Archives of Medical Science 2 and the Journal of Nutrition 3 on the association between telomere length and vitamin D levels. (mindbodygreen.com)
The one in four people predicted to have the longest telomeres are at 30% increased risk of developing melanoma compared to those one in four predicted to have the shortest telomeres. (leeds.ac.uk)

TA65® capsules - plant based compound to help maintain telomere length, or rebuild where necessary. (antiaging-systems.com)
The remainder maintain telomere length with ALT, a pathway based on homologous recombination (a mechanism used for DNA repair). (sens.org)

New research out of England shows that brisk walking has the ability to positively affect telomere length, which is a genetic indicator of biological age. (livingfuel.com)

They determined that father loss is clearly associated with cellular function as estimated by telomere length: any father loss between birth and 9 years of age leads to a reduction in telomere length, and the effect is greatest for children whose fathers die, about 16 percent shorter. (sciencedaily.com)

Removal of TERF1 will therefore lead to an increase in telomere length. (wikipedia.org)
Moreover, we observed that components of the shelterin complex, Trf1 and Trf2, play an important role in telomere end protection, and their regulation may be responsible for the increase in telomere length. (cdc.gov)

Although the researchers found no significant evidence that the association between telomere length and child wellbeing differs by race or ethnicity, they did find some evidence that boys respond more negatively, as measured by telomere length, to the loss of or separation from a father than girls. (sciencedaily.com)

We predicted that chronic stress would be related to short telomere length (TL) in sedentary individuals, whereas in those who exercise, stress would not have measurable effects on telomere shortening. (escholarship.org)
Future studies will have to reveal the actual molecular mechanism by which the short telomere length causes heart attacks," says Borge Nordestgaard, and asks, "Does one cause the other or is the telomere length and the coronary event both indicative of a third - yet unknown - mechanism? (eurekalert.org)
The study "Short Telomere Length, Myocardial Infarction, Ischemic Heart Disease, and Early Death" is scheduled for the March issue of the journal Arteriosclerosis, Thrombosis and Vascular Biology published by the American Heart Association. (eurekalert.org)

Only regions that are significantly associated with telomere length independent of age, sex, race/ethnicity, and total cranial volume after correction for multiple testing are shown. (jamanetwork.com)
GLMSELECT model showed in the subgroup of inpatient workers, working length and BLB were significantly in inverse associations with PWBTL, while BLL was in weak positive association with PWBTL. (bmj.com)
In contrast to never-smokers, telomere length significantly decreased with age in smokers. (ersjournals.com)
Moderator analyses showed a trend in the direction of effect sizes being significantly larger with shorter times between the stressors and telomere measurement. (qigonginstitute.org)
Moderator analyses showed significantly higher effect sizes for studies that used a categorical method for assessing child stressor level and for assays completed with qPCR rather than with the Southern blot method. (qigonginstitute.org)
At 9 years of age, children who had lost their father had significantly shorter telomeres -- 14 percent shorter on average -- than children who had not. (sciencedaily.com)

[ 18 ] Loss of DKC1 has been reported to induce oxidative stress independent of telomere shortening. (medscape.com)

Another gene implicated in DKC, TINF2 , encodes a key component of the protein shelterin, which plays a role in telomere homeostasis. (medscape.com)

Ms. Blackburn, as you may recall from previous House Calls, won the Nobel Prize for her work on telomeres in 2009. (alsearsmd.com)
Long non-coding RNAs at work on telomeres: Functions and implications in cancer therapy. (nih.gov)

Telomere length is related to cellular aging and cardiovascular disease. (telomerescience.com)
The shortening of telomeres to a critical length leads to genomic instability and cellular apoptosis. (databasefootball.com)
There is a growing portfolio of research that suggests telomeres -the tiny caps at the end of each strand of our DNA-may hold the key to understanding why our bodies age and how we may be able to slow or even reverse the cellular aging process. (elephantjournal.com)
Alterations in telomere length are indicative of cellular aging and, possibly, neurodegeneration. (cdc.gov)
It seems that vitamin D , a hormone that's essential for a number of processes in the body, works by increasing the activity of telomerase 4 , the building blocks of telomeres that protect cellular DNA from aging. (mindbodygreen.com)
Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. (nih.gov)
While the study period wasn't long enough to see if telomere length changed, this effect on the enzymes indicates that CBT therapy can protect one from cellular aging . (inverse.com)
Does Meditation Affect Cellular Aging? (nutritionfacts.org)
video: In an ongoing study of almost 20,000 Danes, a team of researchers from the University of Copenhagen have isolated each individual's DNA to analyze their specific telomere length - a measurement of cellular aging. (eurekalert.org)
We have now shown, as has been speculated, that the increased risk is directly related to the shortening of the protective telomeres - so you can say that smoking and obesity ages the body on a cellular level, just as surely as the passing of time," says Borge Nordestgaard. (eurekalert.org)
Another possible prospect of the study is that general practitioners could conduct simple blood tests to reveal a person's telomere length and thereby the cellular wear and age. (eurekalert.org)
Because telomeres function to maintain chromosomal stability, telomerase has a critical role in preventing cellular senescence and cancer progression. (medscape.com)

Mutations in the TERC template sequence can be incorporated into the telomeres of human tumors. (nih.gov)
In a small number of individuals with dyskeratosis congenita, mutations in other genes involved with telomere maintenance have been identified. (medlineplus.gov)
Other affected individuals have no mutations in any of the genes currently associated with dyskeratosis congenita. (medlineplus.gov)
Constitutional loss-of-function telomerase mutations result in rapid telomere shortening, premature senescence and cell death. (bvsalud.org)
In addition to the mutations that directly effect telomere length, recent studies also indicate that a DKC diagnosis should not be based solely on the length of the telomere, but also the fact that there are defects in telomere replication and protection. (medscape.com)

The New York Times bestselling book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. (goodreads.com)
These are the enzymes that protect telomeres. (inverse.com)

Relative TL was calculated as the ratio of telomere genes to single-copy genes. (nih.gov)
In this article, I will tell you about telomeres, which are the protective tips of DNA molecules-the molecules where the organism's genes are stored. (frontiersin.org)
Rog O., Smolikov S., Krauskopf A., Kupiec M. The yeast VPS genes affect telomere length regulation. (utah.edu)
In these cases, the cause of the disorder is unknown, but other unidentified genes related to telomere maintenance are likely involved. (medlineplus.gov)
For the first time, we have established that the genes controlling the length of these telomeres play a part in the risk of developing melanoma. (leeds.ac.uk)
The research team created a score representing genetically-determined telomere length, based on all the established telomere associated genes and found that this score was associated with melanoma risk. (leeds.ac.uk)
A copy of the research paper, The effect on melanoma risk of genes previously associated with telomere length , by Iles et al, is available from the Press Office. (leeds.ac.uk)

Within our telomeres is an enzyme called telomerase. (antiaging-systems.com)

Telomeres are the end caps of chromosomes and protect genomic DNA from damage during cell replications. (devpsychobiology.com)

Previously she was a biological researcher at the University of California, San Francisco, who studied the telomere, a structure at the end of chromosomes that protects the chromosome. (goodreads.com)
In 1990, Prof. Blackburn left Berkeley and continued to investigate telomeres as a professor at the University of California San Francisco (UCSF). (frontiersin.org)

While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. (goodreads.com)
Telomeres consist of tandem repeats of TTAGGG and DNA binding proteins that form a cap to protect chromosomal termini from the loss of genetic material. (databasefootball.com)
The most striking finding, according to Notterman, is that the effect of father loss on telomere length was mediated by certain alleles, or genetic variants, in cells' serotonin transporter system. (sciencedaily.com)
He continued: More research is needed to better understand the relationship between melanoma and telomeres, but learning more about how an individual's genetic telomere profile influences their risk developing melanoma may help us. (leeds.ac.uk)
The risk of heart attack or early death is present whether your telomeres are shortened due to lifestyle or due to high age," says Clinical Professor of Genetic Epidemiology Borge Nordestgaard from the Faculty of Health and Medical Sciences at the University of Copenhagen. (eurekalert.org)
The methods will be applied to data from experiments designed to highlight networks of genetic interactions relevant to telomere biology. (lu.se)

Telomere sequences in humans are composed of TTAGGG sequences which provide protection and replication of chromosome ends to prevent degradation. (wikipedia.org)
AIM: Telomeres are DNA sequences of tandem TTAGGG repeats that protect chromosome ends from degradation and instability. (bvsalud.org)

Telomere-binding proteins can generate a T-loop to protect chromosome ends. (wikipedia.org)
At the end of each chromosome is a telomere, which acts as a protective cap. (antiaging-systems.com)
It now appears that another risk factor is the length of telomeres, regions at the end of every chromosome that buffer and protect against DNA deterioration and damage when cells are replicated. (leeds.ac.uk)

Researchers at Tel Aviv University wanted to expand on Elizabeth Blackburn's research on telomeres. (alsearsmd.com)
And when researchers looked at the famous Nurses' Health Study, they found that if the women drank a bit of alcohol, their telomeres were 16.4% longer. (alsearsmd.com)
In a new study, a team of researchers reports that the loss of a father has a significant adverse effect on telomeres, the protective nucleoprotein end caps of chromosomes. (sciencedaily.com)
The researchers then examined whether the type of father loss -- incarceration, death, separation or divorce -- and the timing of the loss -- in early childhood or middle childhood -- mattered, and whether telomere length was influenced by other factors, such as income, from information gathered in interviews with mothers at 1, 3, 5 and 9 years after birth. (sciencedaily.com)
To answer that question, researchers measured the telomere lengths in mothers of chronically ill children-what could be more stressful than that? (nutritionfacts.org)
Researchers have long speculated that the shortening of telomeres increases the risk of heart attack and early death. (eurekalert.org)
This tutorial reviews these methods to guide researchers in answering the following questions: When I analyze mean differences in factorial designs, where can I find the effects of central interest, and what can I learn about their effect sizes? (lu.se)

Telomere-binding proteins (also known as TERF, TRBF, TRF) function to bind telomeric DNA in various species. (wikipedia.org)
Telomere-binding proteins function to generate a T-loop, which is a specialized loop structure to cap the telomeric ends. (wikipedia.org)
Telomere-binding proteins not present may cause the exposed telomeres to undergo a DNA repair response, having mistakenly identified the ends as a double-stranded break. (wikipedia.org)

In particular, telomere-binding protein refers to TTAGGG repeat binding factor-1 (TERF1) and TTAGGG repeat binding factor-2 (TERF2). (wikipedia.org)
Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. (nih.gov)

Despite VPT infants showed longer TL at birth compared to FT controls (as they were 'younger' than FT counterparts), the cumulative exposure to pain-related stress during NICU stay was associated with progressive and greater telomere erosion from birth to discharge (Fig. 1). (devpsychobiology.com)
Fig. 1 - Dose-dependent association between cumulative exposure to NICU-related stress and progressive telomere length erosion in very preterm infants. (devpsychobiology.com)
Provenzi L, Giorda R, Fumagalli M et al (2018) Pain exposure associates with telomere length erosion in very preterm infants. (devpsychobiology.com)
Our study indicated a protective effect of Se against the TL shortening induced by heavy metal exposure, where the effect sizes were smaller after adjusting for the Se level, compared to individual metal exposure. (nih.gov)
However, it is still unclear whether lead exposure affects telomere length. (bmj.com)
This study aims to investigate the association between lead exposure and peripheral white blood cell telomere length (PWBTL) in Chinese battery manufacturing plant workers. (bmj.com)
There was also a dose-effect relationship between the cumulative long-life exposure to tobacco smoking (pack-yrs) and telomere length. (ersjournals.com)
The results of the current study confirm that smoking exposure enhances telomere shortening in circulating lymphocytes. (ersjournals.com)
It also demonstrates a dose-effect relationship between exposure to tobacco smoking and telomere length, but failed to show that this effect is amplified in smokers who develop chronic obstructive pulmonary disease. (ersjournals.com)
Evaluation of telomere length and markers of neurodegeneration after welding fume exposure. (cdc.gov)
Telomere length, DNA-methylation, gene expression of Trf1, Trf2, ATM, and APP, protein expression of p-Tau, a-synuclein, and presenilin 1 and 2 were assessed in brain tissue at 12 wk after WF exposure ended. (cdc.gov)
These findings suggest a possible correlation between epigenetic modifications, telomere length alteration, and neurodegeneration because of the presence of factors in serum after WF exposure that may cause extra-pulmonary effects as well as the translocation of potentially neurotoxic metals associated with WF to the central nervous system (CNS). (cdc.gov)
OBJECTIVE AND HYPOTHESIS: To evaluate associations between arsenic exposure and telomere length, mtDNAcn, 8-oxo-dG, and 4-HNE-MA in Bolivians. (lu.se)
The association of arsenic exposure with telomere length and mtDNAcn was only present in Bolivian women with a less efficient metabolism. (lu.se)
Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)
A recent in vitro study found that prolonged exposure to the proton pump inhibitor (PPI) esomeprazole impaired endothelial function and accelerated human endothelial senescence by reducing telomere length. (medscape.com)

Telomeres are complex DNA-protein structures located at the end of eukaryotic chromosomes. (ersjournals.com)
Consider telomeres little helmets for your DNA: These protein structures cap off both sides of our chromosomes to protect them from damage and decay over time. (mindbodygreen.com)
There's a lot we still don't understand about how telomere length is linked to cancer risk, but this new study is a step forward in unravelling the secrets of these unusual DNA structures. (leeds.ac.uk)

Telomere length is, therefore, a marker of cell ageing and senescence 5 . (ersjournals.com)

They serve as a protective safeguard against premature degradation as the telomere ends are no longer hidden from damage detection. (wikipedia.org)
Nutrients have a more immediate effect in your cells, whereas the overall protective effect of moderate alcohol consumption is something that works better over the long haul. (alsearsmd.com)
In other words, a child's genotype may lessen the association between a child's social environment and telomere length, and serve as a protective factor. (sciencedaily.com)

In conclusion, our study indicates the presence of an association between LTL and OSAS and a significant impact of severity of OSAS in telomeres shortening. (oncotarget.com)
In conclusion, telomere length is a good predictor of cardiovascular prognosis in men admitted for acute coronary syndrome, but this relation depends on the chronological age of the population studied. (telomerescience.com)
The conclusion was clear: If the telomere length was short, the risk of heart attack and early death was increased by 50 and 25 percent, respectively. (eurekalert.org)
The recent "Copenhagen General Population Study" involved almost 20,000 people, some of which were followed during almost 19 years, and the conclusion was clear: If the telomere length was short, the risk of heart attack and early death was increased by 50 and 25 per cent, respectively. (eurekalert.org)
CONCLUSION: We describe an unusual presentation of early liver failure in telomere disease patients. (bvsalud.org)

The birds with the shortest telomeres did tend to die first - from as early as seven months after the start of the trial. (bellenews.com)

Since TERF1 bends the telomeric site, it may be a critical step in properly functioning telomeres to maintain its length. (wikipedia.org)
Telomerase is an enzyme that adds telomeric repeats to the ends of telomeres using a built-in template. (sens.org)

Telomere length predicts individual lifespan and in this study we investigated whether embryonic growth rate, manipulated using incubation temperature, affects erythrocyte telomere length in a wild bird species, the common tern ( Sterna hirundo ). (biologists.com)
In our study , we measured telomere length (TL) at birth and at NICU discharge in a group of 46 very preterm (VPT) infants as well as at birth only in a group of 31 full-term (FT) counterparts (Provenzi et al. (devpsychobiology.com)
Telomere length and cognitive function in community-dwelling elders: findings from the Health ABC Study. (jamanetwork.com)
One study after after another from Dr. Blackburn's lab and others has shown that excess stress, particularly the perception of excess stress, shortens and harms our telomeres. (huffpost.com)
Whenever possible, and if appropriate, we performed a random-effect meta-analysis of study outcomes. (nih.gov)
The present study aims to explore the potential influence of leucocyte telomere length (LTL) on both a single indicator and a composite construct of physical functioning in a large European population of elderly men and women across diverse geographical locations. (frontiersin.org)
This inconsistency may be partially due to the relatively small sample sizes in each study and heterogeneity caused by various uncontrolled confounders (e.g., duration of illness or hospitalization, lifetime antipsychotic dose, and telomere length assay methods). (databasefootball.com)
Indeed, only one study has recruited more than 1,000 patients with schizophrenia (and a sufficient sample of controls), although this was a meta-analysis, including different telomere length assay protocols. (databasefootball.com)
This study design may have overcome some potential biases that could not be controlled in previous studies (e.g., small sample size, varying LTL assay protocols, different biological bases in young, middle-aged, and elderly patients with schizophrenia, the effect of duration of illness or hospitalization, and antipsychotic dose). (databasefootball.com)
A new study lend credence to the idea that improving quality of life affects stress-related biological markers and possibly the health of people with cancer. (sciencedaily.com)
Results of a study presented at the AACR 102nd Annual Meeting 2011, held in Orlando, Florida April 2-6, lend credence to the idea that improving quality of life affects stress-related biological markers and possibly the health of people with cancer. (sciencedaily.com)
For this study, we wanted to know if chronic stress was associated with accelerated telomere shortening in cancer patients, and if a psychosocial intervention that modulates the stress response could also modulate telomere length," he said. (sciencedaily.com)
We embarked on the first study of telomere length and chronic stress in a cancer population and the first longitudinal analysis in whether changes in quality of life and changes in the stress response would be associated with modulating the telomere length," he said. (sciencedaily.com)
Their first study led to a whole series of studies connecting telomere length to human health in various ways. (frontiersin.org)
The present study investigated whether this effect was further amplified in smokers who develop chronic obstructive pulmonary disease. (ersjournals.com)
In the present study, the authors hypothesised that the effects of tobacco smoking upon telomere length shortening would be enhanced in smokers who developed COPD, compared with those whose lung function was preserved despite their habit. (ersjournals.com)
The study - which used zebra finches, one of Australia's most common bird species - is the first to measure telomere lengths at regular intervals through an entire life. (bellenews.com)
Patients and Methods: In this prospective study, telomere length was measured by quantitative PCR in baseline blood samples in a cohort of 300 patients with Barrett's esophagus followed for a mean of 5.8 years. (aacrjournals.org)
There was no significant moderation of effect size by whether study assayed leukocytes or buccal cells, whether the study assessed child stressor level by memory-based recall versus archival records, and whether the study controlled for age, sex, or additional variables. (qigonginstitute.org)
A telomere study exemplifies why mental health is simply health. (inverse.com)
To determine whether the stress of losing a male parent had an effect on telomere length, Princeton researcher and pediatrician Daniel Notterman, the study's corresponding author, and his colleagues measured telomere length and analyzed other data collected through the Fragile Families and Child Wellbeing Study. (sciencedaily.com)
The study also revealed that one in four Danes has telomeres with such short length that not only will they statistically die before their time, but their risk of heart attack is also increased by almost 50 per cent. (eurekalert.org)

Telomere length shortens with age in all replicating somatic cells. (ersjournals.com)
Patients with psychiatric disorders are more likely than the general population to be affected by ailments like somatic, metabolic, and cardiovascular diseases, says Kristoffer Månsson , a clinical psychologist and primary investigator at the Karolinska Institute. (inverse.com)

Telomeres are repetitive noncoding DNA strands at the ends of eukaryotic (plants, animals, etc.) chromosomes. (sens.org)

Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. (nih.gov)

Among people who used to smoke, there was a trend towards shorter telomere length, but this was not statistically significant. (morungexpress.com)

Telomere diseases. (jamanetwork.com)
Objectives Critically shortening of telomere length caused by various factors including environmental pollutants results in genome instability and age-associated diseases. (bmj.com)
As we get older, our telomeres naturally get shorter, increasing the risk of age-related diseases and impacting overall wellness. (antiaging-systems.com)
Telomere length can affect the pace of aging and the onset of age-associated diseases. (inverse.com)
Previous research has suggested that shortened telomeres are associated with a wide range of diseases in adults, including cardiovascular disease and cancer. (sciencedaily.com)
This means that the effect of smoking on telomere length probably plays a critical role in these diseases, although more research is needed to understand the underlying mechanisms. (morungexpress.com)
In addition, studies have also shown a direct correlation between Resveratrol and telomere length effecting life expectancy, stress, DNA damage, and the onset of aging-related diseases. (positivehealth.com)

The power of exercise: buffering the effect of chronic stress on telomere length. (escholarship.org)
Together with psychology researcher Elissa Epel, she studied the relationships between telomeres and chronic stress. (frontiersin.org)
Chronic stress can decrease your supply of telomerase, an enzyme that protects telomeres. (inverse.com)

Results PWBTL averaged 1.76 (telomere/single-copy gene of albumin, T/S) in 144 battery plant workers. (bmj.com)
The enzyme consists of a protein component with reverse transcriptase activity, and an RNA component, encoded by this gene, that serves as a template for the telomere repeat. (nih.gov)
Resveratrol activates the SIRT-1 gene, known as a longevity gene, which directly affects stem cells and telomeres. (positivehealth.com)
A heterozygous mutation was found on the conserved telomere maintenance component 1 gene ( CTC1 ). (medscape.com)
Besides recombinations with traces limited to the ospC gene itself, there was evidence of lateral gene transfers that involved (i) part of the ospC gene and one of the two flanks or (ii) the entire ospC gene and different lengths of both flanks. (cdc.gov)

Its influence on many cardiovascular risk factors, combined with its proven effect in reducing the risk of cardiovascular events in primary prevention, has boosted scientific interest in this age-old nutritional model. (mdpi.com)
Introduction and objectives: Telomeres are noncoding regions located at the end of chromosomes and their shortening has been associated with risk factors and cardiovascular disease. (unav.edu)
Conclusions: An inverse association between cardiovascular health score and short telomeres was found especially for men older than 55 years in the SUN population. (unav.edu)

2015). In this recent paper, we report on a different epigenetic mechanism, namely telomere length regulation. (devpsychobiology.com)

Telomere length was measured by quantitative polymerase chain reaction in peripheral blood leukocytes of 203 men classified into 2 groups: those aged 50 to 75 years and those >75 years. (telomerescience.com)

Taz1 enforces cell cycle regulation of telomere synthesis. (utah.edu)

Telomere length and mtDNAcn were determined in peripheral blood leukocytes by quantitative PCR, and urinary 8-oxo-dG and 4-HNE-MA by LC-MS/MS. (lu.se)
Telomere length was measured using a real-time quantitative polymerase chain reaction. (unav.edu)

2013). Studies in humans show that adults reporting a history of childhood trauma and neglect have shorter telomeres in peripheral blood compared to controls and the association appears to be dose-dependent (Kiecolt-Glaser et al. (devpsychobiology.com)

The influence of LTL on functional limitation seems driven by the detrimental effect of having short telomeres rather than reflecting a linear dose-response relationship. (frontiersin.org)

The results hold huge implications for humans, whose telomeres work in the same way. (bellenews.com)
And abnormally short telomeres seem to make humans more susceptible to conditions such as bone marrow failure, pulmonary fibrosis, liver disease, and gastrointestinal disease over time. (mindbodygreen.com)

Another problem with excess cortisol production is that it shortens your telomeres. (huffpost.com)

Telomerase Activation' is the process of stimulating telomerase production to help rebuild and extend our telomeres. (antiaging-systems.com)

Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. (goodreads.com)
In 1984, Blackburn co-discovered telomerase, the enzyme that replenishes the telomere, with Carol W. Greider. (goodreads.com)
We know this from the robust work of Dr. Elizabeth Blackburn, Nobel Laureate and Professor at the University of California at San Francisco, on telomeres and stress. (huffpost.com)
In 1978, Blackburn became an assistant professor of molecular biology at the University of California Berkeley, where she continued investigating the telomeres of pond scum. (frontiersin.org)
For these discoveries Prof. Blackburn, along with Carol Greider and another telomere research collaborator, Jack Szostak, were awarded the 2009 Nobel Prize in Physiology or Medicine. (frontiersin.org)
Professor Elizabeth Blackburn won the Nobel Prize in Physiology or Medicine in 2009, jointly with professor Carol Greider and professor Jack Szostak, for the discovery of how chromosomes are protected by telomeres and the enzyme telomerase. (frontiersin.org)

The least severely affected individuals have only a few mild physical features of the disorder and normal bone marrow function. (medlineplus.gov)
More severely affected individuals have many of the characteristic physical features and experience bone marrow failure, cancer, or pulmonary fibrosis by early adulthood. (medlineplus.gov)
Rapidly proliferating tissues with the greatest need for telomere maintenance (eg, bone marrow) are at greatest risk for failure. (medscape.com)

The Tel Aviv team of scientists exposed the telomeres of yeast cells to 13 different environmental "stressors. (alsearsmd.com)
Two of those stressors you might encounter in everyday life had an effect. (alsearsmd.com)
This meta-analysis examined the association between the level of childhood psychosocial stressors and telomere length, an important health biomarker. (qigonginstitute.org)
The meta-analysis, including 27 samples and 16,238 participants, found a significant association of -0.08 between a higher level of childhood stressors and shorter telomere length at a mean age of 42 across studies. (qigonginstitute.org)
Resveratrol has an adaptogenic effect when exposed to environmental stressors, making them more resistant to stress. (positivehealth.com)

After all, making patients feel better should be an outcome that a cancer team should want to have, but whether we can draw conclusions or make recommendations about the capacity of a behavioral intervention to modulate telomere length remains an open question. (sciencedaily.com)
The relationship between telomere length and cancer risk was particularly strong among NSAID nonusers, ever smokers, and patients with low waist-to-hip ratio. (aacrjournals.org)
METHODS: A multidisciplinary long-term follow-up of two healthy and three affected patients was analysed. (bvsalud.org)
Affected patients had markedly shorter telomeres. (bvsalud.org)

Telomeres help protect chromosomes from abnormally sticking together or breaking down (degrading). (medlineplus.gov)

By understanding what telomeres are and how they work, we can take measures to help lengthen our telomeres and promote longevity. (antiaging-systems.com)
When combined with a healthy diet and regular exercise , taking a vitamin D supplement can help keep telomeres in tiptop shape and promote longevity from the inside out. (mindbodygreen.com)

Telomere length was determined as relative telomere length (RTL) by comparison with an internal cell line control (1301 cells) 4 . (ersjournals.com)
This cell line is characterised by a lack of telomere shortening (and hence, constant telomere length) during cell division due to overexpression of telomerase 4 . (ersjournals.com)
As we age, our telomeres naturally get shorter due to cell replication and the natural wear and tear of everyday life. (antiaging-systems.com)
Our telomeres get shorter with every cell division until they eventually become too small to protect the chromosomes. (antiaging-systems.com)
once telomeres are too short, cell replication stops. (sciencedaily.com)
In most cells, telomeres become progressively shorter as the cell divides. (medlineplus.gov)
After a certain number of cell divisions, the telomeres become so short that they trigger the cell to stop dividing or to self-destruct (undergo apoptosis). (medlineplus.gov)
Every cell in the body has chromosomes with so-called telomeres, which are shortened over time and also through lifestyle choices such as smoking and obesity. (eurekalert.org)
With each round of cell division, the length of telomeres is shortened and the enzyme telomerase compensates by maintaining telomere length in germline and stem cells. (medscape.com)

When telomere length drops below a critical threshold, the proliferative capacity of tissues becomes impaired. (frontiersin.org)

Anatomy2

Organisms1

Diseases1

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment1

Phenomena and Processes5

Leukocyte telomere18

Ends of chromosomes5

Shorten8

Longer telomeres4

Odds of having short te2

Time a cell divides1

Rate of telomere2

Lengthen telomeres3

Longest telomeres3

Maintain telomere length2

Positively affect telomere length1

Reduction in telomere length1

Increase in telomere length2

Association between telomere length1

Short telomere length3

Significantly6

Oxidative1

Role in telomere1

Work on telomeres2

Cellular12

Mutations5

Protect telomeres2

Genes7

Enzyme called telomerase1

Chromosomes and protect1

University of Califo2

Genetic6

Sequences2

Chromosome3

Researchers7

Binding proteins3

TTAGGG2

Exposure16

Structures3

Senescence1

Protective3

Conclusion5

Shortest1

Telomeric2

Study22

Somatic2

Repetitive1

Repeats1

Statistically1

Diseases7

Chronic3

Gene5

Cardiovascular3

Epigenetic1

Measured by quantitative1

Regulation1

Quantitative2

Peripheral blood1

Detrimental1

Humans2

Shortens1

Telomerase activation1

Blackburn6

Bone marrow3

Stressors5

Patients4

Abnormally1

Promote longevity2

Cell9

Tissues1