InsulinReceptor, InsulinInsulin ResistanceGlucoseInsulin-Secreting CellsIslets of LangerhansInsulin Receptor Substrate ProteinsGlucose Clamp TechniqueBlood GlucoseInsulinomaGlucose Tolerance TestHypoglycemic AgentsAdipose TissueDiabetes Mellitus, Type 2Muscle, SkeletalInsulin, Long-ActingSignal TransductionPhosphorylationInsulin AntibodiesCells, CulturedInsulin AntagonistsInsulin LisproInsulin Infusion SystemsInsulin AspartInsulin, IsophaneInsulin, Regular, PorkHyperinsulinismInsulinsGlucagonObesityInsulin, Regular, HumanC-PeptideProinsulinFastingHyperglycemiaLiverDiabetes Mellitus, Type 1Fatty Acids, NonesterifiedGlucose Transporter Type 4AdipocytesInsulin, Short-ActingHypoglycemiaDiabetes Mellitus, ExperimentalDiabetes MellitusGlucose IntoleranceInsulin-Like Growth Factor ILeptinDeoxyglucoseBody WeightTriglyceridesPhosphoproteinsMonosaccharide Transport ProteinsPhosphatidylinositol 3-KinasesBiphasic InsulinsKineticsProto-Oncogene Proteins c-aktHemoglobin A, GlycosylatedGlycogenHomeostasisAdiponectinPostprandial PeriodRats, WistarLipidsTime FactorsPancreasGlucagon-Like Peptide 1Cell LineBody Mass IndexMetforminDietary FatsDose-Response Relationship, DrugMice, ObeseLipid MetabolismRNA, MessengerRats, Inbred StrainsThiazolidinediones3T3-L1 CellsLipolysisMuscle ProteinsRats, Sprague-DawleyReceptor, IGF Type 1Rats, ZuckerMice, Inbred C57BLMetabolic Syndrome XTolbutamideInfusions, SubcutaneousEatingDietary CarbohydratesGene Expression RegulationBody CompositionBiological TransportDiet, High-FatReference ValuesStreptozocinMice, KnockoutEnergy MetabolismGlycogen SynthaseSomatostatinAdiposityGluconeogenesis