• Subcutaneous granuloma annulare is characterized by firm or hard asymptomatic nodules in the deep dermis or subcutaneous tissues, with individual lesions measuring from 5 mm to 4 cm in diameter. (medscape.com)
  • Even though GA produces characteristic annular plaques, the distribution patterns, locations of these plaques, and the ages of those affected can be separated into six sub-classes: generalized, subcutaneous, localized, interstitial, atypical, and perforating. (zwivel.com)
  • Subcutaneous granuloma annulare is seen exclusively in children , causing rubbery lumps to develop on the skin. (zwivel.com)
  • Granuloma annulare and lichen planus are other conditions that cause rashes across the body. (drpallavisule.com)
  • Local (intra-articular or intralesional) injection of [CV004 trade name] may be given as part of the short-term management of inflammatory joint and tendon disorders, and localised inflammatory and hypertrophic skin lesions including those of lichen simplex, lichen planus, granuloma annulare, discoid lupus erythematosus, and keloids. (who.int)
  • Lichen planus (LP) is a chronic inflammatory disorder that most often affects middle-aged adults. (hindawi.com)
  • Lichen planus (LP) is a chronic inflammatory and immune mediated disease that affects the skin, nails, hair, and mucous membranes. (hindawi.com)
  • Isotretinoin is reported to be effective in cutaneous sarcoidosis, disseminated granuloma annulare, systemic sclerosis and tumors of the cutaneous appendages. (karger.com)
  • Granuloma annulare is a benign, self-limited cutaneous condition. (aafp.org)
  • Cutaneous T-cell lymphoma is a disease caused when T-lymphocytes become malignant and affect theskin. (artemishospitals.com)
  • Granuloma annulare (GA) is a long-term ( chronic ) skin disease consisting of a rash with reddish bumps arranged in a circle or ring. (medlineplus.gov)
  • Some reports associate chronic stress with granuloma annulare as a trigger of the disease. (medscape.com)
  • A chronic skin condition, Pityriasis rubra pilaris appears as orange-red scaly plaques that can affect any part of the body but are usually found on the palms and soles. (myacare.com)
  • Hansen's disease (leprosy) is a chronic granulomatous disease that affects the skin and nerves. (aafp.org)
  • Granuloma annulare is a chronic benign skin lesion that has an unexplained etiopathogenesis. (medic-journal.com)
  • This ingredient is also used to help with several conditions that affect the nervous system like Alzheimer's disease, depression, chronic brain syndrome, or schizophrenia, and hallucinations due to drugs. (brainreference.com)
  • Schistosomiasis is total symptom to chronic exposure, granuloma annulare. (weddingadviceuk.com)
  • Granuloma annulare is a chronic skin condition characterized by small, raised bumps that form a ringwith a normal or sunken center. (artemishospitals.com)
  • Acne keloidalis nuchae is a chronic inflammatory condition which affects mainly Black men. (ocaladerm.com)
  • She suffered from Raynaud's phenomenon for 35 years, and, at the age of 29, a biopsy of nodular lesions affecting the elbows, ankles and hands revealed rheumatoid nodules/granuloma annulare. (springeropen.com)
  • Localized granuloma annulare has a predilection for the feet, ankles, lower limbs, and wrists. (medscape.com)
  • Localized granuloma annulare is a skin condition of unknown cause, tending to affect children and young to middle-aged adults, usually appearing on the lateral or dorsal surfaces of the fingers or hands, elbows, dorsal feet, and ankles. (wikipedia.org)
  • Affected areas are the joints of hands and fingers, elbows, and the tops of feet and ankles. (zwivel.com)
  • The etiology of granuloma annulare is usually unknown, and the pathogenetic mechanisms are poorly understood, with a vast majority of granuloma annulare cases occurring in patients who are otherwise healthy. (medscape.com)
  • 1 , 2 Although the etiology of granuloma annulare is unknown, theories include vasculitis, trauma, monocyte activation, and type IV delayed hypersensitivity. (aafp.org)
  • The evidence for an autoimmune etiology includes pathological findings of infiltrating T cells, the presence of antigen-antibody complexes in affected cartilage, cellular and humoral responses against collagen type II and other collagen antigens, and the observation that immunosuppressive regimens most often suppress the disease. (medscape.com)
  • Interstitial granuloma annulare, also referred to as interstitial granulomatous dermatitis, describes more widespread plaques or papules covering significant areas of the trunk - especially on the back - that cause bouts of itching and burning sensations. (zwivel.com)
  • Necrobiosis lipoidica is a rare granulomatous skin disorder which can affect the shin of insulin-dependent diabetics, although it may occur in non-diabetic subjects as well. (web.app)
  • Annular elastolytic giant cell granuloma (AEGCG) (1) is a rare granulomatous skin disease, characterized by elastolysis, elastophagocytosis, and an abundance of multinucleated giant cells. (medicaljournals.se)
  • Some authorities consider actinic granuloma (AG) to be a subset of granuloma annulare, but others view actinic annulare as a separate, but related, entity. (medscape.com)
  • Actinic granuloma (2) is generally involved in the entity of AEGCG (1), but is localized in chronically sun-exposed and damaged regions, while normally demonstrating solitary or multiple, typical annular lesions with erythematous raised borders, whereas AEGCG includes lesions showing a generalized distribution and involving both covered as well as sun-exposed areas (3). (medicaljournals.se)
  • In this study, we used bulk RNA-sequencing (RNA-Seq) to compare the transcriptomes in skin lesions of leprosy patients or controls affected by other dermal conditions such as granuloma annulare, a confounder for paucibacillary leprosy. (bvsalud.org)
  • Finally, from the main differentially expressed genes (DEG) and enriched pathways, we conclude that paucibacillary disease is characterized by epithelioid transformation and granuloma formation, with an exacerbated cellular immune response, while multibacillary leprosy features epithelial-mesenchymal transition with phagocytic and lipid biogenesis patterns in the skin. (bvsalud.org)
  • The absence of mucin deposition and the presence of a large amount of plasma cells made granuloma annulare (GA) an important differential diagnosis of NL, less likely.3 Not until the perineural inflammatory cell infiltrates were noted histologically was the differential diagnosis of leprosy considered. (web.app)
  • Arcuate dermal erythema: This is an uncommon form of granuloma annulare that manifests as infiltrated erythematous patches that may form large, hyperpigmented rings with central clearing. (medscape.com)
  • A punch biopsy (4 mm) of the right flank showed subacute spongiotic dermatitis with confluent parakeratosis and a perivascular infiltrate with lymphocytes and eosinophils, consistent with the diagnosis of superficial erythema annulare centrifugum. (cmaj.ca)
  • A) Polycyclic and annular erythematous desquamative plaques on the torso and (B) crusted plaques on the upper arms and armpit area of an 8-year-old boy with a recent diagnosis of superficial erythema annulare centrifugum. (cmaj.ca)
  • Erythema annulare centrifugum is a benign inflammatory skin disease that can occur at any age, without gender predilection. (cmaj.ca)
  • 1 Pathophysiology is still uncertain and erythema annulare centrifugum has sometimes been associated with infections (particularly dermatophytic infections), foods, drugs, hematologic and endocrine diseases, and neoplasias. (cmaj.ca)
  • Superficial erythema annulare centrifugum usually presents as erythematous squamous plaques that grow centrifugally, and evolve over a few weeks into annular or polycyclic, elevated plaques with a clear centre and an internal scaly rim. (cmaj.ca)
  • 3 Erythema annulare centrifugum predominantly affects the trunk and proximal extremities, and can sometimes be pruritic. (cmaj.ca)
  • Erythema annulare centrifugum may regress spontaneously or recur over a period of months to years. (cmaj.ca)
  • Erythema annulare centrifugum is a skin lesion of various etiologies, manifested by erythematous rashes of various (most often ring-shaped) shapes on the skin of the trunk, lower and upper extremities. (medic-journal.com)
  • Atopic dermatitis commonly affects the hands and fingers, backs of the knees, and inside the elbows. (medicalnewstoday.com)
  • The hands, especially the fingers, and elbows are commonly affected. (nsc.com.sg)
  • The lesions of granuloma annulare can occur anywhere on the body, but most often involve the dorsal surfaces of the hands, feet, elbows, or knees. (aafp.org)
  • The most common symptom of granuloma annulare is a circle of small pink, purple or skin-coloured bumps on the hands, fingers, elbows or feet. (azurewebsites.net)
  • Patients affected with rheumatoid nodules will often have a high titer of rheumatoid factor. (logicalimages.com)
  • Generalized granuloma annulare: This form occurs predominantly in adults. (medscape.com)
  • The patient reported here was a 23-year-old man with recurrent crops (every few weeks) of umbilicated papular lesions predominantly affecting trunk and extremities for 8 years, which resolved with varioliform scars. (iranjd.ir)
  • Granuloma annulare (GA) is a benign inflammatory dermatosis. (medscape.com)
  • These raised patches are often discolored and scaly, forming rings (annulare is Latin for "ring-shaped") that can be found anywhere on the body, although the arms, legs, hands and feet are often more severely affected. (zwivel.com)
  • Perforating granuloma annulare (PGA) is a rare subtype of GA. It is characterized by crops of erythematous umblicated or scaly papules. (iranjd.ir)
  • Perforating granuloma annulare is usually localized to the dorsal hands and fingers or may be generalized on the trunk and extremities. (medscape.com)
  • Generalized perforating granuloma annulare with varioliform scars: A case report', Iranian Journal of Dermatology , 10(1), pp. 78-82. (iranjd.ir)
  • Granuloma annulare is inflammation in the deep layer of the skin (dermis). (azurewebsites.net)
  • The affected skin has a reddish brown border with a yellowish centre. (nsc.com.sg)
  • Erythrodermic psoriasis is a rare type of psoriasis affecting about 2 percent of people living with psoriasis. (web.app)
  • GA most often affects children and young adults. (medlineplus.gov)
  • Young girls and young adults of both sexes are the most commonly affected, but since it arises from an immune response, anyone can develop granuloma annulare. (zwivel.com)
  • Disseminated granuloma annulare is a rash that affects the extremities, such as the fingers or the ears. (medicalnewstoday.com)
  • Affected individuals complain of significant itching and can develop an eczema-like rash, a hive-like rash, or large, fluid-filled blisters on the skin. (ocaladerm.com)
  • Granuloma annulare is a harmless type of skin rash that often presents with ring-shaped lesions. (ocaladerm.com)
  • Seborrheic dermatitis most commonly affects older adults and infants, but can occur at any age. (dpgchicago.com)
  • A skin biopsy showed interstitial lymphocytic and histiocytic infiltrates with collagenolysis, consistent with granuloma annulare. (aafp.org)
  • Acanthosis nigricans presents as a darkening and velvety thickening of the skin, most commonly affecting the neck, armpits, and groin region. (ocaladerm.com)
  • Children are most commonly affected, but the condition can occur at any age. (ocaladerm.com)
  • It affects the small blood vessels that supply blood to the extremities of the body, including the fingers and toes. (medicalnewstoday.com)
  • This usually affects the extremities and may be triggered by a multitude of factors, such as changes in weather and other irritants and allergens. (myacare.com)
  • Aside from the trunk, the extremities can also be affected. (myacare.com)
  • Localized granuloma annulare is characterized by skin-colored to violaceous lesions up to 5 cm in diameter. (medscape.com)
  • Granuloma annulare is a benign skin disease that presents as annular or ring-like lesions that may be reddish, violaceous, or skin-colored. (myacare.com)
  • Found in patients of all ages, granuloma annulare is a common and benign skin condition that produces ring-shaped lesions, generally on the hands and feet. (zwivel.com)
  • Transepithelial elimination of mucinous, degenerating collagen fibers and surrounding palisading lymphohistiocytic granulomas, are important histologic features. (iranjd.ir)
  • Areas affected are skin folds such as the armpits and groin. (zwivel.com)
  • Excessive sweating also called hyperhidrosis can affect the entire body but usually occurs in the palms,soles, armpits, and/or groin area. (artemishospitals.com)
  • When acne is not inflamed, it can form blackheads and fine, skin colored bumps that affect the texture and appearance of the skin. (dpgchicago.com)
  • Granuloma annulare is a skin condition that often looks like a ring of bumps. (azurewebsites.net)
  • Body parts such as the back, neck, chest, abdomen, legs and arms are usually affected by the condition. (drpallavisule.com)
  • Granuloma annulare is noncancerous, noncontagious condition that causes ring-shaped patches on the skin. (zwivel.com)
  • Granuloma annulare (GA), also known as necrobiotic papulosis, is a relatively common and noncontagious condition that produces smooth, thick patches on the skin. (zwivel.com)
  • Seven in every ten teenagers are affected by the condition. (jamatoderm.com)
  • Bacterial and fungal infections can affect the skin around the nails and between the fingers. (medicalnewstoday.com)
  • Atrophic LP is one of the rarer variants of LP and typically affects the legs, with progressively enlarging papules that develop a characteristic central atrophy. (jcadonline.com)
  • Generalized GA primarily affects adults, with patches or small papules that range in color from the person's normal skin tone to pink or mauve. (zwivel.com)
  • Affected individuals develop pink to flesh colored, dome shaped papules and pustules around the hair follicles on the posterior scalp and neck. (ocaladerm.com)
  • Granuloma annulare also has some predilection for the sun-exposed areas and photodamaged skin. (medscape.com)
  • The range of predisposing events and associated diseases is diverse, and granuloma annulare is thought to represent a reaction pattern with many different initiating factors. (medscape.com)
  • These final results demonstrated that GH strongly placed the neuroprotective effect on the bioactive dyes scopolamine-induced mouse button model, indicating an enhanced mixture of GL and the man could be utilized as a good content pertaining to building useful food to aid in the prevention of neurodegenerative diseases, such as Advert. (smadinhibitors.com)
  • Granuloma annulare is relatively common disease that occurs in all age groups, but it is rare in infancy. (medscape.com)
  • Proposed pathogenic mechanisms for granuloma annulare include cell-mediated immunity (type IV), immune complex vasculitis, and an abnormality of tissue monocytes. (medscape.com)
  • Granuloma annulare is a benign idiopathic disorder, which affects the dermis. (nextstepsinderm.com)
  • The therapeutic effect of UVA1 is related to the fact that its long wavelength penetrates the dermis more deeply than UVB. (skintherapyletter.com)
  • Grupo de trastornos que se caracterizan por edema, basofilia, y distorsión de los haces de colágeno en la dermis. (bvsalud.org)
  • Diabetics have high blood sugar levels which if not well-controlled can lead to long-term complications affecting various organs in the body such as the eye, kidney, nervous system and blood vessels. (nsc.com.sg)
  • The potential for bruising is a frequent concern for patients undergoing minimally invasive procedures, particularly injection-based soft tissue fillers and botulinum toxin type A. Decreasing the risk of this side effect with good technique and careful patient selection is key, but interventions that quicken the resolution of bruising are also helpful. (nextstepsinderm.com)
  • 1] [2] Differentialdiagnostiska metoder används av läkare och annan utbildad vårdpersonal för att diagnostisera sjukdomen hos en patient. (web.app)
  • Granuloma annulare usually resolves on its own, but severe forms may require treatment. (zwivel.com)
  • It may, rarely, be related to cancer, especially in older people whose granuloma annulare is severe, doesn't respond to treatment or returns after cancer treatment. (chuytuproximodestino.com)
  • However, a 2014 study found contradictory results and concluded that finger wrinkles due to water exposure did not affect how well humans could handle wet or dry objects. (medicalnewstoday.com)
  • When their legs are affected, they can have trouble seats of śleṣaka kapha (lubricating substance), which facilitates the cause, but may include medications or surgery. (xizi12.xyz)
  • In infants, AD usually affects the face or cheeks, as well as the extensor surfaces of the arms and legs. (myacare.com)
  • Itchiness that usually affects the soles of the feet and the spaces between toes. (usdermatologypartners.com)
  • It usually affects areas of skin that have been exposed to sun. (childsdermatology.com)
  • Kikuchi-Fujimoto disease, is usually a benign self-limiting disease which typically affects young females under the age of 30 years and resolves without treatment within six months. (springeropen.com)