Stroke volumeContractilitySystemic vascular rDiminished cardiac functionPerfusionIncreasesRespiratoryCritically ill patientsDiastolicForce of contractionCatheterizationRenalDecreaseMyocardial infarctionAdverselyContractionCardiovascularChanges in cardiacVenous returnHemodynamic therapyMeasurementHypotensionArterialPulmonaryDecreasesSignificantlyShockPhenylephrineAirwayPeripheral vascularClinicalSympatheticHeart failureArrestMechanical ventilationHeart'sMetabolicIncreaseEnsuesPatientsFunctionVentricularOvertPreloadCirculatoryDrugsResistanceAnatomicalOxygen deliveryVascular smoothCitationPrimarilySystolic
Stroke volume10
- The factors affecting stroke volume and heart rate also affect cardiac output. (wikipedia.org)
- and an increased heart rate, stroke volume, and cardiac output. (nih.gov)
- 3) How and when should we monitor stroke volume or cardiac output in shock? (springer.com)
- MiCardia's technology allows adjustable implants in the heart to be tuned to positively affect stroke volume and cardiac output. (news-medical.net)
- In the case of dobutamine, this increase is usually not accompanied by marked increases in heart rate (although tachycardia is occasionally observed), and the cardiac stroke volume is usually increased. (drugs.com)
- In contrast, isoproterenol increases the cardiac index primarily by increasing the heart rate while stroke volume changes little or declines. (drugs.com)
- As the heart muscle adapts to training, stroke volume increases, which increases cardiac output. (roadbikeaction.com)
- Multiple lines of clinical and experimental evidence lead us to hypothesize that the impaired stroke volume and systolic pressure of the LV are a direct consequence of the effect of pressure overload in the RV, and that atrophy in the LV plays only a minor role. (frontiersin.org)
- Nevertheless, LV atrophy played a minor role in that LV stroke volume remained lower, thereby contributing to lower LV mechanical work output. (frontiersin.org)
- Contractility is difficult to measure clinically (because it requires cardiac catheterization with pressure-volume analysis) but is reasonably reflected by the ejection fraction (EF), which is the percentage of end-diastolic volume ejected with each contraction (stroke volume/end-diastolic volume). (msdmanuals.com)
Contractility1
- Inotropic drugs allow a change in cardiac contractility to increase cardiac output and improve systemic haemodynamics. (esicm.org)
Systemic vascular r5
- The minimal hemodynamic change that defines a positive response to AVT for children should be considered as a ≥20% decrease in PAP and pulmonary vascular resistance (PVR)/systemic vascular resistance (SVR) without a decrease in cardiac output. (medscape.com)
- 4 Some studies have found no correlation between mean arterial blood pressure and heart rate, systemic vascular resistance and cardiac index, 5 while others have found a weak correlation. (vin.com)
- Food had no effect on limb blood flow and lowered total systemic vascular resistance suggesting that there were no compensatory changes in regional blood flow to help redirect blood to the gut. (bmj.com)
- Background Measurement of oxygen consumption (Vȯ 2 ) is difficult in children but is essential to calculate cardiac index and systemic vascular resistance. (medscape.com)
- Use of the breath-by-breath method may facilitate calculation of cardiac index and systemic vascular resistance in critically ill children. (medscape.com)
Diminished cardiac function1
- However, we have a poor understanding of the degree to which diminished cardiac function contributes to the reduction in fish swimming performance concomitant with acute exposure to hypoxia, or how fish cardiorespiratory physiology is altered by, or adapts to, chronic hypoxia. (biologists.com)
Perfusion4
- Because cardiac output is related to the quantity of blood delivered to various parts of the body, it is an important component of how efficiently the heart can meet the body's demands for the maintenance of adequate tissue perfusion. (wikipedia.org)
- Thyroid hormones affect cardiac output and vascular resistance, and thus can modify kidney perfusion. (medscimonit.com)
- Dopamine is a medication administered intravenously to correct imbalances in the blood circulation dynamics (hemodynamics) due to shock , including low blood pressure ( hypotension ), low cardiac output, and poor perfusion of vital organs. (medicinenet.com)
- This effect is due to a reduction in the perfusion pressure of the brain. (medscape.com)
Increases6
- 1 Intravenously administered phentolamine provoked immediate decreases in diastolic blood pressure but increases in heart rate and cardiac output. (handlebar-online.com)
- As a strong α-adrenergic agonist, NE increases blood pressure primarily through its vasoconstrictive properties with little effect on heart rate. (esicm.org)
- In the treatment of hemodynamic imbalance, dopamine stimulates cardiac muscle contraction and increases the heart rate, which results in improved cardiac output. (medicinenet.com)
- Low dose of dopamine increases blood flow to the kidneys and urine output. (medicinenet.com)
- In active labor, hyperventilation increases and tachypnea caused by pain and anxiety might result in marked hypocapnia and respiratory alkalosis, adversely affecting fetal oxygenation by reducing uterine blood flow. (medscape.com)
- The increased blood volume is associated with elevated cardiac output, which increases by 30-50% above baseline levels by 25 weeks. (medscape.com)
Respiratory6
- This is especially important during mechanical ventilation, in which cardiac output can vary by up to 50% across a single respiratory cycle. (wikipedia.org)
- Phosphine is a respiratory tract irritant that attacks primarily the cardiovascular and respiratory systems causing peripheral vascular collapse, cardiac arrest and failure, and pulmonary edema. (cdc.gov)
- Plot displaying the maximal ranges of VHS measurements for each of 14 healthy Beagles (including all cardiac and respiratory phase combinations) determined by 1 observer through review of right and left lateral fluoroscopic images. (avma.org)
- The anatomical and functional changes affect the respiratory and cardiovascular systems. (medscape.com)
- Hormonal changes in pregnancy affect the upper respiratory tract and airway mucosa, producing hyperemia, mucosal edema, hypersecretion, and increased mucosal friability. (medscape.com)
- Therefore, the most widely used research tool to measure Vȯ 2 in critically ill children, especially after cardiac surgery, has been the respiratory mass spectrometer (Amis 2000, Innovision ApS), but it is no longer manufactured. (medscape.com)
Critically ill patients1
- The intermittent manual bolus thermodilution method is the most common means of determining cardiac output in critically ill patients. (annals.edu.sg)
Diastolic3
- Cardiac output can also be affected significantly by the phase of respiration - intra-thoracic pressure changes influence diastolic filling and therefore cardiac output. (wikipedia.org)
- We hypothesize that LV systolic impairment is largely due to the acute effect of RV hypertrophy-induced reduction in diastolic filling whereas the chronic response of structural remodeling plays only a minor role. (frontiersin.org)
- BACKGROUND: Constrictive pericarditis after coronary artery bypass surgery has been known to affect cardiac output by limiting diastolic ventricular filling. (koreamed.org)
Force of contraction1
- Inotropic agents are drugs that influence the force of contraction of cardiac muscle and thereby affect cardiac output. (britannica.com)
Catheterization4
- There are a number of clinical methods to measure cardiac output, ranging from direct intracardiac catheterization to non-invasive measurement of the arterial pulse. (wikipedia.org)
- Cardiac catheterization is recommended before initiation of PAH-targeted therapy. (medscape.com)
- Cardiac catheterization should include acute vasoreactivity testing (AVT) unless there is a specific contraindication. (medscape.com)
- Repeat cardiac catheterization is recommended within 3-12 mo after initiation of therapy to evaluate response or with clinical worsening. (medscape.com)
Renal1
- Renal dysfunction does not affect lidocaine kinetics but may increase the accumulation of metabolites. (drugs.com)
Decrease2
- In animal studies, dobutamine produces less increase in heart rate and less decrease in peripheral vascular resistance for a given inotropic effect than does isoproterenol. (drugs.com)
- Acute studies with clonidine hydrochloride in humans have demonstrated a moderate reduction (15% to 20%) of cardiac output in the supine position with no change in the peripheral resistance: at a 45° tilt there is a smaller reduction in cardiac output and a decrease of peripheral resistance. (prescriptiondrugs.com)
Myocardial infarction2
- Hemodynamic imbalance can be caused by conditions such as heart attack ( myocardial infarction ), cardiac arrest , open- heart surgery, trauma , septic shock , kidney failure , and decompensated heart failure . (medicinenet.com)
- After noncardiac etiology arrests and missing hospital outcomes were excluded from the analysis (n = 8,585), 31,689 OHCA events of presumed cardiac etiology (e.g., myocardial infarction or arrhythmia) that received resuscitation efforts in the prehospital setting were analyzed. (cdc.gov)
Adversely2
- [ 1-4 ] Low cardiac output syndrome adversely affects the outcomes of critically ill children on the intensive care unit. (medscape.com)
- Heart failure is characterized by increased intracardiac pressures and declining output of blood, representing the end-result of many different etiologies that adversely affect cardiac structure and function. (lu.se)
Contraction2
- Drugs have a positive inotropic effect if they increase the force of the heart's contraction. (britannica.com)
- Normal cardiac muscle at typical heart rates exhibits a positive force-frequency relationship, so a faster rate causes stronger contraction (and corresponding greater substrate requirements). (msdmanuals.com)
Cardiovascular6
- These changes may be attributable to a direct depressant effect of the local anesthetic agent on various components of the cardiovascular system. (drugs.com)
- In general, beta-adrenergic blockers reduce cardiac output in patients in good and poor cardiovascular health. (theodora.com)
- I am currently an international fellow of American Heart Association, fellow of Australian College of Nurse Practitioners and fellow of Cardiac Society of Australia and New Zealand in recognition of my contributions to cardiovascular nursing through practice, research, and education. (edu.au)
- I was an executive committee member of the Cardiovascular Nursing Council of Cardiac Society of Australia and New Zealand for 10 years. (edu.au)
- Changes in the maternal gastrointestinal and cardiovascular systems affect drug absorption. (cdc.gov)
- An increase in cardiac output, and therefore myocardial work, is the predominant cardiovascular response to eating and this may help explain the postprandial deterioration in symptoms of some patients with cardiovascular disorders. (bmj.com)
Changes in cardiac2
- Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure. (drugs.com)
- This highlights the need to have high fidelity anatomical models in cardiac simulations and demonstrates that subtle changes in cardiac anatomy can have a large impact on cardiac function. (plos.org)
Venous return2
- Changes in arterial diameter produces little change in circulating volume space but do affect left heart cardiac output and hence venous return to the right heart, while changes in venous capacitance has dramatic effects on circulating volume space. (vin.com)
- it is also affected by venous return, peripheral vascular tone, and neurohumoral factors. (msdmanuals.com)
Hemodynamic therapy1
- Effect of perioperative goal-directed hemodynamic therapy on postoperative recovery following major abdominal surgery-a systematic review and meta-analysis of randomized controlled trials. (edwards.com)
Measurement3
- Measurement of lactate levels can be helpful as a prognostic indicator since lactate level can indicate how severely the patient's circulation has been affected. (vin.com)
- [ 11 ] However, it is difficult to measure Vȯ 2 and cardiac output, and they are rarely measured outside of research investigations, despite the suggestion that measurement of cardiac output and oxygen delivery would improve clinical outcomes of critically ill children. (medscape.com)
- In addition, in some patients after cardiac surgery, the potential or predicted inequality between systemic and pulmonary blood flow if a cardiac shunt is present renders pulmonary artery catheters unreliable for measurement of systemic blood flow. (medscape.com)
Hypotension2
- The preferential dilatation of arterioles, as compared to veins, minimizes postural hypotension and promotes the increase in cardiac output. (nih.gov)
- Decreased venous blood return leads to decreased cardiac output and hypotension. (vin.com)
Arterial3
- Mathematically this is calculated as follows: oxygen delivery = cardiac output × arterial oxygen content, giving the formula: D O 2 = C O × C a O 2 {\displaystyle D_{O2}=CO\times C_{a}O2} With a resting cardiac output of 5 L/min, a 'normal' oxygen delivery is around 1 L/min. (wikipedia.org)
- DO2 depends on the amount of blood pumped per minute, or cardiac output (CO), and the arterial oxygen content of that blood (CaO2). (medscape.com)
- [ 5-10 ] Cardiac output may be calculated by using the Fick equation if Vȯ 2 , hemoglobin level, and the arterial-venous oxygen difference are known. (medscape.com)
Pulmonary3
- 30 mmHg was abandoned because healthy individuals can exceed this threshold at high cardiac output (CO). We hypothesised that incorporating assessment of the pressure-flow relationship using the mPAP/CO ratio, i.e. total pulmonary resistance (TPR), might enhance the accuracy of diagnosing an abnormal exercise haemodynamic response. (ersjournals.com)
- and Ian Adatia is a professor of pediatrics, director of the pediatric pulmonary hypertension service, and a cardiac intensivist in the pediatric cardiac critical care unit at Stollery Children's Hospital, Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Canada. (medscape.com)
- MEASUREMENTS AND MAIN RESULTS: Body temperature was recorded in the electronic medical records at least hourly, from invasive measurements (esophageal probe, indwelling urinary catheter, pulse contour cardiac output monitoring system, or pulmonary artery catheter) or manual tympanic recordings. (lu.se)
Decreases1
- Furthermore, it decreases cardiac output and systemic blood flow while activating the sympathetic nervous system, ultimately reducing insulin sensitivity and vascular function. (researchgate.net)
Significantly5
- Acebutolol has been shown to delay AV conduction time and to increase the refractoriness of the AV node without significantly affecting sinus node recovery time, atrial refractory period, or the HV conduction time. (nih.gov)
- were significantly lower in hypoxia-acclimated cod at both levels of oxygenation, because of lower values for V S . However, hypoxia-acclimated cod were able to consume more oxygen for a given cardiac output. (biologists.com)
- Water can permeate from inside the container into the overwrap but not in amounts sufficient to affect the solution significantly. (drugs.com)
- These results indicate that small amounts of {alpha}-MyHC expression significantly augment myocyte power output. (umsystem.edu)
- Hormonal changes do not significantly affect airway function. (medscape.com)
Shock3
- Each of these variables affect CO and can be impaired in clinical shock states. (medscape.com)
- Holaday, J.: Investigation of the hypertensive effect of TRH in rabbit hemorrhagic shock (abstract). (argyleplasticsurgery.com)
- Investigation of the hypertensive effect of TRH in rabbit hemorrhage shock. (argyleplasticsurgery.com)
Phenylephrine1
- Effect of phenylephrine infusion and spinal anesthesia on cardiac output during cesarean section by point of care echocardiogram: A case series. (bvsalud.org)
Airway1
- Cardiogenic oscillations shown during the expiratory plateau and the descending limb waveform occurring as a result of movement of gases in the airway due to cardiac pulsations. (capnography.com)
Peripheral vascular1
- Although a function of cardiac output and peripheral vascular resistance, both of these variables are influenced by multiple factors. (health-care-articles.info)
Clinical1
- The management of this patient was aided by the use of a continuous thermodilution cardiac output catheter and monitor, recently introduced in clinical practice. (annals.edu.sg)
Sympathetic1
- In patients with severe impairment of myocardial function, beta-blockers may inhibit the sympathetic stimulation necessary to maintain adequate cardiac function. (theodora.com)
Heart failure1
- Commenting on the most recent patent issuance, Mr. Paul Molloy, Chief Executive Officer at MiCardia said 'MiCardia is dedicated to treating structural heart disease and the consequent incidence of heart failure which affects more than 15 million people in the US and Europe today. (news-medical.net)
Arrest3
- Because nearly half of cardiac arrest events are witnessed, efforts to increase survival rates should focus on timely and effective delivery of interventions by bystanders and emergency medical services (EMS) personnel. (cdc.gov)
- In 2004, CDC established the Cardiac Arrest Registry to Enhance Survival (CARES) in collaboration with the Department of Emergency Medicine at the Emory University School of Medicine. (cdc.gov)
- OHCA is defined in CARES as a cardiac arrest that occurred in the prehospital setting, had a presumed cardiac etiology, and involved a person who received resuscitative efforts, including CPR or defibrillation. (cdc.gov)
Mechanical ventilation1
- To analyze the behavior of cardiac autonomic modulation in different phases of weaning mechanical ventilation. (bvsalud.org)
Heart's1
- In cardiac physiology, cardiac output (CO), also known as heart output and often denoted by the symbols Q {\displaystyle Q} , Q ˙ {\displaystyle {\dot {Q}}} , or Q ˙ c {\displaystyle {\dot {Q}}_{c}} , is the volumetric flow rate of the heart's pumping output: that is, the volume of blood being pumped by a single ventricle of the heart, per unit time (usually measured per minute). (wikipedia.org)
Metabolic1
- Key physiologic parameters that affect metabolic homeostasis include tissue blood flow, the balance between oxygen delivery and demand, and the oxygen content. (medscape.com)
Increase4
- In patients with depressed cardiac function, both dobutamine and isoproterenol increase the cardiac output to a similar degree. (drugs.com)
- In the limited number of patients who were studied for 24, 48, and 72 hours, a persistent increase in cardiac output occurred in some, whereas output returned toward baseline values in others. (drugs.com)
- 9 Not all patients will respond to a bolus of fluids and increase in blood pressure and cardiac output will not be seen. (vin.com)
- High dose results in constriction of blood vessels and increase in blood pressure in addition to the cardiac effects. (medicinenet.com)
Ensues1
- When the ventricle contracts, it moves down and pushes blood out, and because the great vessels hold the heart in place, a mechanism of "cardiac suction" ensues, drawing blood into the atria. (medscape.com)
Patients2
- By extending the therapeutic window of implantable heart devices we believe we can positively affect the long-term outcomes for patients. (news-medical.net)
- Tolerance to the antihypertensive effect may develop in some patients, necessitating a reevaluation of therapy. (prescriptiondrugs.com)
Function9
- Because of the rapid rate at which lidocaine is metabolized, any condition that affects liver function may alter lidocaine kinetics. (drugs.com)
- Cardiac anatomy plays a crucial role in determining cardiac function. (plos.org)
- We performed a global sensitivity analysis to identify the different modes responsible for different simulated electrical and mechanical measures of cardiac function. (plos.org)
- As a result, in cardiac models, representing patient anatomy using a limited number of modes of anatomical variation can cause a loss in accuracy of simulated electromechanical function. (plos.org)
- These changes can in turn have significant impact on cardiac function. (plos.org)
- Simulations of cardiac electrical activation and mechanical pump function in hearts with shapes described by different combinations of shape components were performed. (plos.org)
- This will be affected by cardiorespiratory function, but also by muscular and neuromuscular adaptations. (roadbikeaction.com)
- At the time of initial PH diagnosis, a comprehensive history and physical examination, combined with diagnostic testing for assessment of PH pathogenesis/classification and formal assessment of cardiac function, should be performed before the initiation of therapy at an experienced center. (medscape.com)
- Cardiac function is rapidly and easily evaluated with echocardiography, but many etiologies cannot be readily discerned based on this modality, necessitating the use of a range of costly and time-consuming modalities with risk for adverse effects such as endomyocardial biopsy, nuclear medicine imaging, and magnetic resonance imaging. (lu.se)
Ventricular3
- To assess the reproducibility of, and determine normative data for, flow volume measurements from the right common carotid artery (CCA) and its relation to left ventricular output (LVO) in stable term and preterm babies using Doppler ultrasound. (bmj.com)
- We also aimed to assess if there was a relation between right CCA flow, left ventricular output (LVO), and traditionally assessed Doppler measurements of anterior cerebral artery blood flow velocity (ACABFV). (bmj.com)
- The effect of the pulsatile iVAC2L MCS on left ventricular loading conditions and myocardial oxygen consumption (MVO 2 ) is unknown. (kcl.ac.uk)
Overt1
- Factors such as acidosis and the use of CNS stimulants and depressants affect the CNS levels of lidocaine required to produce overt systemic effects. (drugs.com)
Preload1
- The Frank-Starling principle describes the relationship between preload and cardiac performance. (msdmanuals.com)
Circulatory1
- Lemon balm (Melissa officinalis) has a tonic effect on the heart and circulatory system. (health-care-articles.info)
Drugs1
- this relationship was not affected by age or adrenergic drugs. (lu.se)
Resistance2
- Blood pressure (BP) is determined by the balance between cardiac output and vascular resistance. (medscape.com)
- During long-term therapy, cardiac output tends to return to control values, while peripheral resistance remains decreased. (prescriptiondrugs.com)
Anatomical1
- However, there is a poor understanding of how specific and localised anatomical changes affect different cardiac functional outputs. (plos.org)
Oxygen delivery1
- Oxygen delivery (DO2 mL/min) is the resultant of blood flow (cardiac output CO) times the blood oxygen content (CaO2). (wikipedia.org)
Vascular smooth1
- HydrALAZINE apparently lowers blood pressure by exerting a peripheral vasodilating effect through a direct relaxation of vascular smooth muscle. (nih.gov)
Citation1
- citation needed] Cardiac output should therefore be measured at evenly spaced points over a single cycle or averaged over several cycles. (wikipedia.org)
Primarily2
- The vena cava and portal vein are primarily affected. (vin.com)
- Venous tone affects VR by modifying the capacitance of veins and is primarily regulated by the autonomous system. (medscape.com)
Systolic2
- In contrast, under both ex vivo and in vitro conditions, where the effect of RV pressure overload was circumvented, we found that LV was capable of developing normal systolic pressure and stress. (frontiersin.org)
- Nevertheless, it remains unclear whether LV systolic impairment is a direct mechanical effect of the pressure-overloaded and hypertrophic RV impinging on the septum wall or a longer-term atrophic structural remodeling response. (frontiersin.org)