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PseudomonasStrainsPyoverdineVirulence factorsIsolatesAcinetobacterOpportunisticInfectionsUptakeBacteriaCefiderocolStrainMicroorganismsAntibioticsBacterialPathogenicAntimicrobialBiosynthesisProducesLyticHumansPyochelinPseudomonadsAntibacterialEnzymesGenesSpeciesAureusRedundantProductionCollectiveSevere

Pseudomonas33

• Multiple conformations of the metal-bound pyoverdine PvdI, a siderophore of Pseudomonas aeruginosa: a nuclear magnetic resonance study. (igbmc.fr)
• A low-temperature heteronuclear NMR study of two exchanging conformations of metal-bound pyoverdin PaA from Pseudomonas aeruginosa. (igbmc.fr)
• Genomic information for outlier strains of Pseudomonas aeruginosa is exiguous when compared with classical strains. (frontiersin.org)
• Pseudomonas aeruginosa produces two siderophores under iron-limiting conditions, pyoverdin and pyochelin. (ku.edu)
• Collective decision-making in Pseudomonas aeruginosa involves transient segregation of quorum-sensing activities across cells. (uzh.ch)
• Coordination of siderophore gene expression among clonal cells of the bacterium Pseudomonas aeruginosa. (uzh.ch)
• Because aerobic gram-negative bacilli (eg, Pseudomonas aeruginosa) are the major pathogens associated with HAP, the pathophysiology of nosocomial pneumonia relates to the destructive effect on lung tissue. (medscape.com)
• Pseudomonas aeruginosa is a biofilm-forming opportunistic pathogen which causes chronic infections in immunocompromised patients and leads to high mortality rate. (frontiersin.org)
• For example, by using the opportunistic pathogen Pseudomonas aeruginosa , scientists showed that cheaters can exploit iron-scavenging compounds called siderophores, 3 as well as proteases used to digest nutrients. (the-scientist.com)
• Intravenous gallium therapy is a non-antibiotic approach to limit Pseudomonas aeruginosa biofilm proliferation, by outcompeting iron for siderophore binding. (whiterose.ac.uk)
• Co-colonization by Pseudomonas aeruginosa and Staphylococcus aureus is frequent in cystic fibrosis patients. (biomedcentral.com)
• We focus on Pseudomonas aeruginosa, a bacterium that can produce two siderophores-the highly efficient but metabolically expensive pyoverdine, and the inefficient but metabolically cheap pyochelin. (datadryad.org)
• Bismuth and cefiderocol showed synergistic effect both in vitro and in vivo (lung infectious model) against PAO1, a strain of Pseudomonas aeruginosa, as a metallo-sideromycin complex transported actively into bacterial cells. (hku.hk)
• Gram-negative bacterial infections, such as those caused by Pseudomonas aeruginosa , pose significant challenges in treatment due to their complicated structure. (hku.hk)
• Gram-negative bacteria, including Pseudomonas aeruginosa , can cause a range of infections in humans. (hku.hk)
• We test three specific predictions about the fitness consequences of cheating to different extents by examining the production of the iron-scavenging siderophore molecule, pyoverdin, in the bacterium Pseudomonas aeruginosa. (uea.ac.uk)
• In his research, titled "The Chemical Ecology of Siderophores in the Relationship of Aspergillus fumigatus and Pseudomonas aeruginosa," Estes will consider siderophores in the relationship between Aspergillus fumigatus and Pseudomonas aeruginosa, where little is known about their role in contributing toward metabolism in both competition and symbiosis with each other. (auburn.edu)
• FETROJA® is indicated in patients 18 years of age or older who have limited or no alternative treatment options for the treatment of complicated urinary tract infections (cUTIs), including pyelonephritis caused by the following susceptible Gram-negative microorganisms: Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, and Enterobacter cloacae complex. (globalrph.com)
• Pseudomonas is a Gram-negative non-sporulating genus that also includes Pseudomonas aeruginosa. (jackheartblog.org)
• Pseudomonas aeruginosa is a Gram-negative bacterium that rarely causes serious infections in healthy individuals. (biomedcentral.com)
• Fluorescent pseudomonads such as Pseudomonas aeruginosa or Pseudomonas fluorescens produce pyoverdine siderophores that ensure iron-supply in iron-limited environments. (uni-hannover.de)
• The cooperative trait that we examine is the production of siderophores, iron-scavenging agents, in the pathogenic bacterium Pseudomonas aeruginosa. (ox.ac.uk)
• Global concerns have been raised due to upward trend of Multi-drug Resistant (MDR) Pseudomonas aeruginosa reports in ocular infections. (springeropen.com)
• Home Vol 11 Issue 2 Comparative Effect of Pseudomonas aeruginosa, Pseudomonas fluorescens and Pseudomonas putida on the. (microbiologyjournal.org)
• Fluorescent Pseudomonas species have a number of traits like antifungal, siderophores, phosphatesolubilization, lytic enzymes, HCN, ammonia and plant growth regulators that allow them to act as plant growth promoting and biocontrol agents. (microbiologyjournal.org)
• Pseudomonas aeruginosa C , Pseudomonas fluorescens M and Pseudomonas putida L were selected for field studies. (microbiologyjournal.org)
• Other recent studies have shown that cerumen directly inhibits the growth of Staphylococcus aureus , Pseudomonas aeruginosa , and Candida albicans , but its effect on the growth of E. coli remains to be determined (22)(5)(35). (kenyon.edu)
• AbstractWe describe 2 cases of extensively drug-resistant Pseudomonas aeruginosa infection caused by a strain of public health concern, as it was recently associated with a nationwide outbreak of contaminated artificial tears. (infmed.dk)
• Cefiderocol is a last resort option for carbapenem-resistant (CR) Gram-negative bacteria, especially metallo-β-lactamase (MBL)-producing Pseudomonas aeruginosa and CR Acinetobacter baumannii. (infmed.dk)
• 20 mW/cm2), on MDR strains of Pseudomonas aeruginosa, Klebsiella pneumoniae and K. pneumoniae OXA-48 in tap water and municipal wastewater was investigated. (infmed.dk)
• Background Multidrug-resistant Pseudomonas aeruginosa has become a major cause of severe infections. (infmed.dk)
• Eight of the marine isolates inhibited the growth of different pathogenic bacteria, seven of which were identified as presumptive Pseudomonas aeruginosa. (infmed.dk)
• 1. Lahiri P., Gogoi P., and Ghosh D . (2023) Single-Step Capture and Targeted Metabolomics of Alkyl-Quinolones in Outer Membrane Vesicles (OMVs) of Pseudomonas aeruginosa . (jnu.ac.in)

Strains8

• These studies compared well-characterized laboratory strains of P. aeruginosa to clinical isolates of P. aeruginosa that have evolved within the CF-lung where they might interact with the co-colonizing S. aureus . (biomedcentral.com)
• They showed that laboratory strains of P. aeruginosa such as PA14 and early isolates from CF-patients outcompete S. aureus , while isolates after years of colonization have lost their ability to outcompete S. aureus in co-cultures [ 13 ]. (biomedcentral.com)
• Indeed, simulations parameterized from our data confirmed that strains retaining the capacity to switch between siderophores significantly outcompeted strains defective for one or the other siderophore under fluctuating iron availabilities. (datadryad.org)
• Mutant strains not synthesizing polyamine-siderophores significantly increased enterobactin production levels, though lack of enterobactin did not impact the production of serratiochelins. (biomedcentral.com)
• P. aeruginosa strains were isolated from 46 patients with conjunctivitis (2), endophthalmitis (11) and active keratitis (25) seen at our Institute, between 2016 and 2020. (springeropen.com)
• The aim of our present study was to screen P. aeruginosa strains isolated from ocular infections, for their potential to produce various phenotypic virulence factors and correlating them with biofilm formation and their antibiotic susceptibility profile. (springeropen.com)
• The integration of their important traits like production of antifungal antibiotics, iron chelating siderophores, lytic enzymes, plant growth regulators, phosphate solubilization, ammonia and HCN production with ecological fitness of the strains will be prerequisite for designing useful, efficient and effective novel bioagent. (microbiologyjournal.org)
• Cefiderocol is a siderophore cephalosporin with a novel mechanism for penetrating the outer cell membrane of Gram-negative pathogens, including MDR strains. (drugdiscoverynews.com)

Pyoverdine3

• Like most siderophores, pyoverdine is synthesized and secreted into the environment when the microorganism that produces it detects that intracellular iron concentrations have fallen below a preset threshold. (wikipedia.org)
• Pyoverdine is a so-called siderophore , which forms a part of the bacterial iron metabolism. (vetbact.org)
• This correlates with the finding that pre-elafin/trappin-2 and elafin bind to DNA in vitro and attenuate the expression of some P. aeruginosa virulence factors, namely the biofilm formation and the secretion of pyoverdine. (biomedcentral.com)

Virulence factors3

• Taken together, transcriptomic data indicate that early responses between P. aeruginosa and S. aureus involve competition for resources and metabolic adaptations, rather than the expression of bacteria- or host-directed virulence factors. (biomedcentral.com)
• Our results rather suggest that pre-elafin/trappin-2 and elafin, but not cementoin, possess the ability to modulate the expression of some P.aeruginosa virulence factors, possibly through acting on intracellular targets. (biomedcentral.com)
• A plethora of virulence factors expressed by P. aeruginosa is associated with acute and chronic infections [ 6 ]. (biomedcentral.com)

Isolates2

• Siderophore deficient P. aeruginosa isolates still demonstrate a hindered biofilm proliferation when exposed to gallium but it is currently unknown whether exogenous gallium has any disruptive influence on the exopolysaccharide (EPS), the major mucoid P. aeruginosa CF lung biofilm matrix component. (whiterose.ac.uk)
• All the twelve isolates from apple rhizosphere were morphologically, physiologically and biochemically characterized so as to select the isolates belonging to P. aeruginosa, P. putida and P. fluorescens group. (microbiologyjournal.org)

Acinetobacter1

• There was no mortality difference observed in P. aeruginosa or Enterobacterales without Acinetobacter spp. (dutchnews.nl)

Opportunistic1

• The full-length protein as well as the N-terminal "cementoin" and C-terminal "elafin" domains were also shown to possess broad antimicrobial activity, namely against the opportunistic pathogen P. aeruginosa . (biomedcentral.com)

Infections5

• Gallium therapy represents a viable therapeutic strategy for cystic fibrosis (CF) patients harbouring mucoid P. aeruginosa biofilm lung infections. (whiterose.ac.uk)
• Perhaps the most dramatic change that characterizes P. aeruginosa chronic infections is the transformation from a non-mucoid to a mucoid phenotype [ 7 ]. (biomedcentral.com)
• Chronic pseudomonal infections are thought to be virtually impossible to eradicate and the current strategy in the management of CF patients, which become infected in their early childhood, is to prevent or retard progression to chronic infection by treating P. aeruginosa infections with conventional antibiotic therapy as soon as they appear [ 9 , 10 ]. (biomedcentral.com)
• Our aim was to characterize the virulence determinants of MDR P. aeruginosa causing ocular infections. (springeropen.com)
• Phenotypic characteristics of P.aeruginosa might be responsible for increased colonization and antibiotic resistance observed in vivo and understanding these differences may lead to development of clinical guidelines for the management of MDR infections. (springeropen.com)

Uptake4

• This suggests that gallium, perhaps, is utilising a novel, possibly unknown, ferric uptake system to gain entry to siderophore deficient cells. (whiterose.ac.uk)
• Bacteria often possess multiple siderophore-based iron uptake systems for scavenging this vital resource from their environment. (datadryad.org)
• Siderophores chelate Fe 3+ for uptake into the cell, where it is reduced to soluble Fe 2+ . (biomedcentral.com)
• Some bacteria have evolved extraordinary ways to synthesize proprietary siderophores that require the expression of specialized TonB-dependent receptors (TBDRs) to allow for efficient siderophore uptake by the producer and its relatives [ 15 ]. (biomedcentral.com)

Bacteria5

• The outliers had the complete operon for the production of vibrioferrin, a siderophore present in plant growth promoting bacteria. (frontiersin.org)
• In our hospital, P. aeruginosa is one of the top coinfecting bacteria identified among COVID-19 patients. (frontiersin.org)
• For example, the high resistance of P. aeruginosa against conventional antibiotics can be attributed in part to the limited permeability of the outer membrane (OM) and the expression of 'efflux pump', specialised proteins within bacteria that actively remove antibiotics, thus reducing their effectiveness. (hku.hk)
• one way that bacteria diversify siderophore structure is by incorporating different polyamine backbones while maintaining the catechol moieties. (biomedcentral.com)
• Bacteria have not only devised ways of biosynthesizing "proprietary" siderophore molecules, but have evolved transport mechanisms that allow them to utilize foreign siderophores, or xenosiderophores, as well [ 8 , 9 ]. (biomedcentral.com)

Cefiderocol2

• Cefiderocol: a siderophore cephalosporin. (cdc.gov)
• Cefiderocol functions as a siderophore [see Microbiology ]. (globalrph.com)

Strain3

• We sequenced and constructed the complete genome of an environmental strain CR1 of P. aeruginosa and performed the comparative genomic analysis. (frontiersin.org)
• We collected a strong biofilm-forming P. aeruginosa strain displaying small colony variant morphology from a severe COVID-19 patient. (frontiersin.org)
• Methods P. aeruginosa 24Pae112 as a reference strain was retrieved from GenBank database. (infmed.dk)

Microorganisms1

• More generally, the scale of competition is likely to be of particular importance for the evolution of cooperation in microorganisms, and also the virulence of pathogenic microorganisms, because cooperative traits such as siderophore production have an important role in determining virulence. (ox.ac.uk)

Antibiotics1

• Sideromycin is a novel type of antibiotic where the parent antibiotics or prodrug incorporates a siderophore molecule that utlises iron transport system for delivery. (hku.hk)

Bacterial2

• Bacterial siderophores are small molecules with unmatched capacity to scavenge iron from proteins and the extracellular milieu, where it mostly occurs as insoluble Fe 3+ . (biomedcentral.com)
• This study shows the natural occurrence of serratiochelins, photobactin, enterobactin, and aerobactin in a single bacterial species and illuminates the interplay between siderophore biosynthetic pathways and polyamine production, indicating routes of molecular diversification. (biomedcentral.com)

Pathogenic2

• Pyoverdines are important siderophores that guarantee iron supply to important pathogenic and non-pathogenic pseudomonads in host habitats. (uni-hannover.de)
• P. aeruginosa has low nutritional requirements and can high tolerance to a range of physical conditions, thus making it more pathogenic. (springeropen.com)

Antimicrobial2

• A potential new target for antimicrobial drugs is the production of siderophores. (ku.edu)
• However, unlike numerous linear polycationic antimicrobial peptides, membrane disruption does not appear to be the main function of either cementoin, elafin or full-length pre-elafin/trappin-2 against P. aeruginosa . (biomedcentral.com)

Biosynthesis1

• A third, independent operon is responsible for biosynthesis of the hydroxamate siderophore aerobactin, initially described in Enterobacter aerogenes . (biomedcentral.com)

Produces2

• We report that Serratia plymuthica V4 produces a variety of siderophores, which we term the siderome , and which are assembled by the concerted action of enzymes encoded in two independent gene clusters. (biomedcentral.com)
• P. aeruginosa produces, in addition to LPS , also exotoxins. (vetbact.org)

Lytic1

• However, pre-elafin/trappin-2 and its domains display only weak lytic properties, as assessed by scanning electron micrography, outer and inner membrane depolarization studies with P. aeruginosa and leakage of liposome-entrapped calcein. (biomedcentral.com)

Humans1

• phage therpy has been used treat otitis caused by P. aeruginosa in humans. (vetbact.org)

Pyochelin2

• Crystallization studies of the NADPH reductases involved in the synthesis of pyochelin from P. aeruginosa (PchG) and yersiniabactin from Yersinia enterocolitica (Irp3) are also being performed. (ku.edu)
• This suggests that pyochelin is not redundant, but that switching between siderophore strategies might be beneficial to trade off efficiencies versus costs of siderophores. (datadryad.org)

Pseudomonads1

• Pyoverdines (alternatively, and less commonly, spelled as pyoverdins) are fluorescent siderophores produced by certain pseudomonads. (wikipedia.org)

Antibacterial1

• The aim of the present study was to determine the secondary structures of the cementoin domain and to characterize the antibacterial properties of these peptides against P. aeruginosa . (biomedcentral.com)

Enzymes1

• Besides assembling serratiochelin A and B with diaminopropane, S. plymuthica utilizes putrescine and the same set of enzymes to assemble photobactin, a siderophore found in the bacterium Photorhabdus luminescens . (biomedcentral.com)

Genes1

• They have devised complex regulatory mechanisms responding to Fe 2+ unavailability that induce the expression of a series of genes to produce small iron chelators, termed siderophores [ 5 , 6 , 7 ], secrete them, and take up their iron-bound forms. (biomedcentral.com)

Species1

• One such innovative way is the incorporation of polyamines into the nascent siderophore, which has evolved in multiple species that naturally produce polyamines. (biomedcentral.com)

Aureus2

• Both organisms also induced lysogenic mechanisms related to prophage induction ( S. aureus ) and R- and F- pyocin synthesis ( P. aeruginosa ), possibly as a response to stress resulting from nutrient limitation or cell damage. (biomedcentral.com)
• Co-infection by P. aeruginosa and S. aureus frequently occurs and is associated with poor patient prognosis [ 5 , 9 ]. (biomedcentral.com)

Redundant1

• However, some siderophores seem redundant, because they have limited iron-binding efficiency and are seldom expressed under iron limitation. (datadryad.org)

Production3

• As expected, our results show that higher levels of cooperative siderophore production evolve in the higher relatedness treatments. (ox.ac.uk)
• However, our results also show that more local competition selects for lower levels of siderophore production and that there is a significant interaction between relatedness and the scale of competition, with relatedness having less effect when the scale of competition is more local. (ox.ac.uk)
• P. aeruginosa , P. fluorescens and P. putida in individual and consortial combination to act as biofertilizer which can become one of the most promising biotechnologies to solve apple replant disease and can also improve production with low inputs in fertilizer. (microbiologyjournal.org)

Collective1

• Finally, we discuss how siderophore switching can be viewed as a form of collective decision-making, whereby a coordinated shift in behaviour at the group level emerges as a result of positive and negative feedback loops operating among individuals at the local scale. (datadryad.org)

Severe1

• P. aeruginosa bacteremia is a common and severe infection carrying high mortality in older adults. (infmed.dk)